Identification of Disease- and Nutrient-Related Metabolic Fingerprints in Osteoarthritic Guinea Pigs

Watkins, 2000, Comprehensive lipid analysis: a powerful metanomic tool for predictive and diagnostic medicine, Isr. Med. Assoc. J, 2, 722 van Ommen, 2002, Nutrigenomics: exploiting systems biology in the nutrition and health area, Curr. Opin. Biotechnol, 13, 517, 10.1016/S0958-1669(02)00349-X Watkins, 2001, Individual metabolism should guide agriculture toward foods for improved health and nutrition, Am. J. Clin. Nutr, 74, 283, 10.1093/ajcn/74.3.283 Nicholson, 1999, ”Metabonomics“: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data, Xenobiotica, 29, 1181, 10.1080/004982599238047 van der Greef, J. (2002) The role of metabolomics in Systems Biology, a new vision for drug discovery and development. In: Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Harrigan, G. G. & Goodacre, R., eds.). Kluwer Academic Publishing. Boston, MA. Ideker, 2001, A new approach to decoding life: systems biology, Annu. Rev. Genomics Hum. Genet, 2, 343, 10.1146/annurev.genom.2.1.343 Vogels, 1996, Partial linear fit: a new NMR spectroscopy preprocessing tool for pattern recognition applications, J. Chemom, 10, 425, 10.1002/(SICI)1099-128X(199609)10:5/6<425::AID-CEM442>3.0.CO;2-S Lindon, 2000, Metabonomics: metabolic processes studies by NMR spectroscopy of biofluids combined with pattern recognition, Concepts Magn. Reson, 12, 289, 10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W Creamer, 1997, Osteoarthritis, Lancet, 350, 503, 10.1016/S0140-6736(97)07226-7 Felson, 2000, Osteoarthritis: new insights. Part 1: The disease and its risk factors, Ann. Intern. Med, 133, 635, 10.7326/0003-4819-133-8-200010170-00016 DeGroot, 2002, Molecular markers for osteoarthritis: the road ahead, Curr. Opin. Rheumatol, 14, 585, 10.1097/00002281-200209000-00019 Huebner, 1998, Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis, Arthritis Rheum, 41, 877, 10.1002/1529-0131(199805)41:5<877::AID-ART16>3.0.CO;2-# Bendele, 2001, Animal models of osteoarthritis, J. Musculoskel. Neuron Interact, 1, 363 Huebner, 2002, A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis, Osteoarthritis Cartilage, 10, 758, 10.1053/joca.2002.0821 Hoogerbrugge, 1983, Discriminant analysis by double stage principal component analysis, Anal. Chem, 55, 1710, 10.1021/ac00261a016 Bendele, 1989, Osteoarthrosis in guinea pigs: histopathologic and scanning electron microscopic features, Lab. Anim. Sci, 39, 115 Timbrell, J. (2000) Principles of Biochemical Toxicology, pp. 117–171. Taylor and Francis, London, UK. Damyanovich, 1999, 1H NMR investigation of changes in the metabolic profile of synovial fluid in bilateral canine osteoarthritis with unilateral joint denervation, Osteoarthritis Cartilage, 7, 165, 10.1053/joca.1998.0205 Herbert, 1988, Nucleosides and bases in synovial fluid from patients with rheumatoid arthritis and osteoarthritis, Clin. Sci. (Lond.), 74, 97, 10.1042/cs0740097 McAlindon, 1996, Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?, Arthritis Rheum, 39, 648, 10.1002/art.1780390417