An animal model of schizophrenia based on chronic LSD administration: Old idea, new results

Neuropharmacology - Tập 61 - Trang 503-512 - 2011
Danuta Marona-Lewicka1, Charles D. Nichols2, David E. Nichols1
1Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, 575 Stadium Mall Dr., Purdue University, West Lafayette, IN 47906-2091, USA
2Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, 70112, USA

Tài liệu tham khảo

Bortolozzi, 2010, Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT1A receptors but not 5-HT2A receptors, Int. J. Neuropsychopharmacol., 1 Dall’Olio, 1999, The non-competitive NMDA receptor blocker dizocilpine potentiates serotonergic function, Behav. Pharmacol, 10, 63, 10.1097/00008877-199902000-00006 Arnt, 1996, Inhibitory effects on the discriminative stimulus properties of d-amphetamine by classical and newer antipsychotics do not correlate with antipsychotic activity. Relation to effects on the reward system?, Psychopharmacology, 124, 117, 10.1007/BF02245611 Bardgett, 2002, The effects of excitocic hippocampal lesions in rats on resperidone- and olanzapine-induced locomotor suppression, Neuropsychopharmacology, 27, 930, 10.1016/S0893-133X(02)00376-7 Bradford, 2010, Validation and pharmacological characterizataion of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics, Psychopharmacology, 212, 155, 10.1007/s00213-010-1938-0 Castensson, 2003, Decrease of serotonin receptor 2C in schizophrenia brains identified by high-resolution mRNA expression analysis, Biol. Psychiatry, 54, 1212, 10.1016/S0006-3223(03)00526-2 Freedman, 1986, Hallucinogenic drug research -If so, so what?: symposium summary and commentary, Pharmacol. Biochem. Behav., 24, 407, 10.1016/0091-3057(86)90371-0 Frye, 2003, Olanzapine’s effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats, Psychoneuroendocrynology, 28, 657, 10.1016/S0306-4530(02)00049-5 Gordon, 2010, Testing the glutamate hypothesis of schizophrenia, Nat. Neurosci., 13, 2, 10.1038/nn0110-2 Hofmann, 1979, How LSD originated, J. Psychedelic Drugs, 11, 53, 10.1080/02791072.1979.10472092 Jones, 2008, Developing new drugs in schizophrenia: from animals to the clinic, Vol 1 Kim, 1999, NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in PCPA-treated mice, Arch. Pharm.Res., 22, 113, 10.1007/BF02976533 Large, 2007, Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?, J. Psychopharmacol., 21, 283, 10.1177/0269881107077712 Litchfield, 1949, A simplified method of evaluating dose-effect experiments, J. Pharmacol. Exp. Ther., 96, 99 Marona-Lewicka, 1994, Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan, Eur. J. Pharmacol., 258, 1, 10.1016/0014-2999(94)90051-5 Marona-Lewicka, 2007, Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action, Pharmacol. Biochem. Behav., 87, 453, 10.1016/j.pbb.2007.06.001 Marona-Lewicka, 2005, Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis, Psychopharmacology (Berl), 180, 427, 10.1007/s00213-005-2183-9 Marona-Lewicka, 2008, Dopamine D(4) receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI, Psychopharmacology (Berl), 203, 265, 10.1007/s00213-008-1238-0 Meil, 1997, Olanzapine attenuates the reinforcing effects of cocaine, Eur. J. Pharmacol., 340, 17, 10.1016/S0014-2999(97)01351-4 Moghaddam, 1997, Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex, J. Neurosci., 17, 2921, 10.1523/JNEUROSCI.17-08-02921.1997 Muschamp, 2004, Lysergic acid diethylamide and [-]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortex, Brain Res., 1023, 134, 10.1016/j.brainres.2004.07.044 Nichols, 2004, Hallucinogens. Pharmacol. Ther., 101, 131, 10.1016/j.pharmthera.2003.11.002 Nichols, 2002, A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain, Neuropsychopharmacology, 26, 634, 10.1016/S0893-133X(01)00405-5 Nichols, 2004, Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta and ILAD-1, a novel gene with homology to arrestins, J. Neurochem., 90, 576, 10.1111/j.1471-4159.2004.02515.x Nichols, 2003, Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration, Brain Res. Mol. Brain Res., 111, 182, 10.1016/S0169-328X(03)00029-9 Passie, 1997 Takahata, 2003, Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine, Neuropsychopharmacology, 28, 1117, 10.1038/sj.npp.1300127 Tallerico, 2001, Schizophrenia: elevated mRNA for dopamine D2(Longer) receptors in frontal cortex, Brain Res. Mol. Brain Res., 87, 160, 10.1016/S0169-328X(00)00293-X van Elst, 2005, Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study, Biol. Psychiatry, 58, 724, 10.1016/j.biopsych.2005.04.041 Vollenweider, 2001, A systems model of altered consciousness: integrating natural and drug-induced psychoses, Brain Res. Bull., 56, 495, 10.1016/S0361-9230(01)00646-3 Wadenberg, 2001, Dopamine D2 receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects, Neuropsychopharmacology, 25, 633, 10.1016/S0893-133X(01)00261-5 Winter, 2000, Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists. A link between the glutamatergic and serotonergic hypothesis of schizophrenia, Life Sci., 68, 337, 10.1016/S0024-3205(00)00934-6 Winter, 2004, Serotonergic/glutamatergic interactions: the effects of mGlu2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuli, Psychopharmacology (Berl), 172, 233, 10.1007/s00213-003-1636-2 Zar, 1999