Diffusion tensor tractography of the human brain cortico‐ponto‐cerebellar pathways: A quantitative preliminary study

Journal of Magnetic Resonance Imaging - Tập 32 Số 4 - Trang 809-817 - 2010
Arash Kamali1, Larry A. Kramer2, Richard E. Frye3, Ian J. Butler3, Khader M. Hasan2
1Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA
2Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston Texas, USA.
3Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas, USA

Tóm tắt

AbstractPurposeTo investigate the utility of diffusion tensor tractography at 1mm slice thickness to map and quantify the whole trajectory of different cortico‐ponto‐cerebellar pathways of the healthy adult human brain.Materials and MethodsThis work was approved by the local Institutional Review Board, and was Health Insurance Portability and Accountability Act (HIPAA) compliant. Five healthy right‐handed men (age range, 24–37 years) were studied and written informed consent was obtained. Diffusion tensor imaging data acquired with 1‐mm slice thickness at a 3.0 Tesla (T) clinical MRI scanner were prepared and analyzed using tractography methods to reconstruct the cortico‐ponto‐cerebellar pathways which included the fronto‐ponto‐cerebellar, parieto‐ponto‐cerebellar, occipito‐ponto‐cerebellar, and temporo‐ponto‐cerebellar tracts.ResultsWe demonstrate the feasibility of tractographic mapping and quantification of the four cortico‐ponto‐cerebellar system components based on their cortical connections in the healthy human brain using DTI data with thin 1‐mm sections.ConclusionIn vivo quantification of different cortico‐ponto‐cerebellar pathways based on cortical connection is feasible, using 1‐mm slices at 3.0T. J. Magn. Reson. Imaging 2010;32:809–817. © 2010 Wiley‐Liss, Inc.

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Journal of Magnetic Resonance Imaging

Tập 32 Số 4

809-817

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