IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

Journal of Experimental Medicine - Tập 202 Số 4 - Trang 473-477 - 2005
Vanda A. Lennon1,2,3, Thomas J. Kryzer3, Sean J. Pittock2,3, A. S. Verkman4, Shannon R. Hinson3
11Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905
22Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905
33Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905
44Cardiovascular Research Institute, University of California, San Francisco, CA 94143

Tóm tắt

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. NMO may represent the first example of a novel class of autoimmune channelopathy.

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Journal of Experimental Medicine

Tập 202 Số 4

473-477

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