Integrating mechanisms of pulmonary fibrosis

Asangani, 2008, MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer, Oncogene., 27, 2128, 10.1038/sj.onc.1210856

Atabai, 2009, Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages, J. Clin. Invest., 119, 3713, 10.1172/JCI40053

Bauman, 2010, The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice, J. Clin. Invest., 120, 1950, 10.1172/JCI38369

Bechtel, 2010, Methylation determines fibroblast activation and fibrogenesis in the kidney, Nat. Med., 16, 544, 10.1038/nm.2135

Belperio, 2001, Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome, J. Clin. Invest., 108, 547, 10.1172/JCI200112214

Belperio, 2002, Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis, Am. J. Respir. Cell Mol. Biol., 27, 419, 10.1165/rcmb.2002-0009OC

Belperio, 2002, Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome, J. Immunol., 169, 1037, 10.4049/jimmunol.169.2.1037

Belperio, 2005, Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome, J. Clin. Invest., 115, 1150, 10.1172/JCI200524233

Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature., 441, 235, 10.1038/nature04753

Blackburn, 2003, Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway, J. Clin. Invest., 112, 332, 10.1172/JCI200316815

Border, 1994, Transforming growth factor beta in tissue fibrosis, N. Engl. J. Med., 331, 1286, 10.1056/NEJM199411103311907

Bringardner, 2008, The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis, Antioxid. Redox Signal., 10, 287, 10.1089/ars.2007.1897

Brodlie, 2011, Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease, Eur. Respir. J., 37, 1378, 10.1183/09031936.00067110

Burdick, 2005, CXCL11 attenuates bleomycin-induced pulmonary fibrosis via inhibition of vascular remodeling, Am. J. Respir. Crit. Care Med., 171, 261, 10.1164/rccm.200409-1164OC

Burgess, 2005, PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis, Am. J. Physiol. Lung Cell. Mol. Physiol., 288, L1146, 10.1152/ajplung.00383.2004

Cassel, 2008, The Nalp3 inflammasome is essential for the development of silicosis, Proc. Natl. Acad. Sci. USA., 105, 9035, 10.1073/pnas.0803933105

Chan, 2005, MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells, Cancer Res., 65, 6029, 10.1158/0008-5472.CAN-05-0137

Chen, 2005, Bleomycins: towards better therapeutics, Nat. Rev. Cancer., 5, 102, 10.1038/nrc1547

Chiaramonte, 1999, An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response, J. Clin. Invest., 104, 777, 10.1172/JCI7325

Chiaramonte, 1999, IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs, J. Immunol., 162, 920, 10.4049/jimmunol.162.2.920

Chiaramonte, 2003, Regulation and function of the interleukin 13 receptor α2 during a T helper cell type 2-dominant immune response, J. Exp. Med., 197, 687, 10.1084/jem.20020903

Chilosi, 2003, Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis, Am. J. Pathol., 162, 1495, 10.1016/S0002-9440(10)64282-4

Cho, 2004, Inhibition of airway remodeling in IL-5-deficient mice, J. Clin. Invest., 113, 551, 10.1172/JCI19133

Coward, 2010, Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis, Mol. Cell. Biol., 30, 2874, 10.1128/MCB.01527-09

Crystal, 2002, Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group, Am. J. Respir. Crit. Care Med., 166, 236, 10.1164/rccm.2201069

Decraene, 2010, Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable cystic fibrosis patients, Respir. Res., 11, 177, 10.1186/1465-9921-11-177

Demedts, 2005, High-dose acetylcysteine in idiopathic pulmonary fibrosis, N. Engl. J. Med., 353, 2229, 10.1056/NEJMoa042976

Denham, 2002, The radiotherapeutic injury—a complex ‘wound’, Radiother. Oncol., 63, 129, 10.1016/S0167-8140(02)00060-9

Dostert, 2008, Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica, Science., 320, 674, 10.1126/science.1156995

Duffield, 2005, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair, J. Clin. Invest., 115, 56, 10.1172/JCI200522675

Fort, 2001, IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo, Immunity., 15, 985, 10.1016/S1074-7613(01)00243-6

Fubini, 2003, Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis, Free Radic. Biol. Med., 34, 1507, 10.1016/S0891-5849(03)00149-7

Fulkerson, 2006, Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling, Am. J. Pathol., 169, 2117, 10.2353/ajpath.2006.060617

Gasse, 2007, IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice, J. Clin. Invest., 117, 3786

Gasse, 2009, Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis, Am. J. Respir. Crit. Care Med., 179, 903, 10.1164/rccm.200808-1274OC

Genovese, 2005, Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury, Eur. Respir. J., 25, 225, 10.1183/09031936.05.00049704

Genovese, 2005, Role of endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha in the development of bleomycin-induced lung injury, Shock., 24, 547, 10.1097/01.shk.0000190825.28783.a4

Hancock, 1998, Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung, Am. J. Respir. Cell Mol. Biol., 18, 60, 10.1165/ajrcmb.18.1.2627

Hariyawasam, 2009, Effects of Anti-IL-13 (Novartis QAX576) on Inflammatory Responses Following Nasal Allergen Challenge (NAC), Am. J. Respir. Crit. Care Med., 179, A3642

Hasegawa, 1997, Elevated serum tumor necrosis factor-alpha levels in patients with systemic sclerosis: association with pulmonary fibrosis, J. Rheumatol., 24, 663

Hecker, 2009, NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury, Nat. Med., 15, 1077, 10.1038/nm.2005

Hsu, 2011, Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension, Arthritis Rheum., 63, 783, 10.1002/art.30159

Huang, 2005, The pathophysiological function of peroxisome proliferator-activated receptor-gamma in lung-related diseases, Respir. Res., 6, 102, 10.1186/1465-9921-6-102

Huaux, 2003, Dual roles of IL-4 in lung injury and fibrosis, J. Immunol., 170, 2083, 10.4049/jimmunol.170.4.2083

Huaux, 2003, Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis, J. Immunol., 171, 5470, 10.4049/jimmunol.171.10.5470

Ingram, 2004, IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha, FASEB J., 18, 1132, 10.1096/fj.03-1492fje

Iredale, 2007, Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ, J. Clin. Invest., 117, 539, 10.1172/JCI30542

Jiang, 2004, Regulation of pulmonary fibrosis by chemokine receptor CXCR3, J. Clin. Invest., 114, 291, 10.1172/JCI16861

Jiang, 2005, Regulation of lung injury and repair by Toll-like receptors and hyaluronan, Nat. Med., 11, 1173, 10.1038/nm1315

Jiang, 2010, Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4, J. Clin. Invest., 120, 2049, 10.1172/JCI38644

Keane, 2007, IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome, J. Immunol., 178, 511, 10.4049/jimmunol.178.1.511

Kelly, 2002, A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis, Am. J. Respir. Crit. Care Med., 166, 510, 10.1164/rccm.2103058

Kim, 2009, Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis, J. Clin. Invest., 119, 213

Kim, 2009, MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue, Stem Cells., 27, 3093, 10.1002/stem.235

Kinder, 2008, Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosis, Chest., 133, 226, 10.1378/chest.07-1948

Kisseleva, 2008, Mechanisms of fibrogenesis, Exp. Biol. Med. (Maywood)., 233, 109, 10.3181/0707-MR-190

Kolb, 2001, Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis, J. Clin. Invest., 107, 1529, 10.1172/JCI12568

Kolodsick, 2004, Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts, J. Immunol., 172, 4068, 10.4049/jimmunol.172.7.4068

Königshoff, 2008, Functional Wnt signaling is increased in idiopathic pulmonary fibrosis, PLoS ONE., 3, e2142, 10.1371/journal.pone.0002142

Königshoff, 2009, WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis, J. Clin. Invest., 119, 772

Kostadinova, 2005, PPARs in diseases: control mechanisms of inflammation, Curr. Med. Chem., 12, 2995, 10.2174/092986705774462905

Kumar, 2002, Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma, Clin. Exp. Allergy., 32, 1104, 10.1046/j.1365-2222.2002.01420.x

Lama, 2006, Obligatory role for interleukin-13 in obstructive lesion development in airway allografts, Am. J. Pathol., 169, 47, 10.2353/ajpath.2006.050975

Langrish, 2005, IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, J. Exp. Med., 201, 233, 10.1084/jem.20041257

Lanone, 2002, Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling, J. Clin. Invest., 110, 463, 10.1172/JCI0214136

Lappalainen, 2005, Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung, Am. J. Respir. Cell Mol. Biol., 32, 311, 10.1165/rcmb.2004-0309OC

Lee, 2001, Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1), J. Exp. Med., 194, 809, 10.1084/jem.194.6.809

Lee, 2009, Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis, J. Exp. Med., 206, 1149, 10.1084/jem.20081271

Liu, 2008, Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis, Antioxid. Redox Signal., 10, 303, 10.1089/ars.2007.1903

Liu, 2010, miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis, J. Exp. Med., 207, 1589, 10.1084/jem.20100035

Lovgren, 2011, beta-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix, Sci. Transl. Med., 3, 74ra23, 10.1126/scitranslmed.3001564

Lupardus, 2010, Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2, Structure., 18, 332, 10.1016/j.str.2010.01.003

Ma, 2004, The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling, J. Immunol., 172, 1872, 10.4049/jimmunol.172.3.1872

Madala, 2010, MMP12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis, J. Immunol., 184, 3955, 10.4049/jimmunol.0903008

Meng, 2007, MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer, Gastroenterology., 133, 647, 10.1053/j.gastro.2007.05.022

Milam, 2008, PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis, Am. J. Physiol. Lung Cell. Mol. Physiol., 294, L891, 10.1152/ajplung.00333.2007

Miyazaki, 1995, Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis, J. Clin. Invest., 96, 250, 10.1172/JCI118029

Moore, 2008, Murine models of pulmonary fibrosis, Am. J. Physiol. Lung Cell. Mol. Physiol., 294, L152, 10.1152/ajplung.00313.2007

Moore, 2001, Protection from pulmonary fibrosis in the absence of CCR2 signaling, J. Immunol., 167, 4368, 10.4049/jimmunol.167.8.4368

Moore, 2005, CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury, Am. J. Pathol., 166, 675, 10.1016/S0002-9440(10)62289-4

Moore, 2006, The role of CCL12 in the recruitment of fibrocytes and lung fibrosis, Am. J. Respir. Cell Mol. Biol., 35, 175, 10.1165/rcmb.2005-0239OC

Murray, 2008, Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2, Int. J. Biochem. Cell Biol., 40, 2174, 10.1016/j.biocel.2008.02.016

Nagase, 2002, A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis, Nat. Med., 8, 480, 10.1038/nm0502-480

Naik, 2011, Mitochondrial reactive oxygen species drive proinflammatory cytokine production, J. Exp. Med., 208, 417, 10.1084/jem.20110367

Nana-Sinkam, 2009, Integrating the MicroRNome into the study of lung disease, Am. J. Respir. Crit. Care Med., 179, 4, 10.1164/rccm.200807-1042PP

Oga, 2009, Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta, Nat. Med., 15, 1426, 10.1038/nm.2066

Ortiz, 2007, Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury, Proc. Natl. Acad. Sci. USA., 104, 11002, 10.1073/pnas.0704421104

Pandit, 2010, Inhibition and role of let-7d in idiopathic pulmonary fibrosis, Am. J. Respir. Crit. Care Med., 182, 220, 10.1164/rccm.200911-1698OC

Park, 2006, Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases, Am. J. Physiol. Lung Cell. Mol. Physiol., 290, L797, 10.1152/ajplung.00513.2005

Park, 2009, Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function, J. Korean Med. Sci., 24, 614, 10.3346/jkms.2009.24.4.614

Pesce, 2006, The IL-21 receptor augments Th2 effector function and alternative macrophage activation, J. Clin. Invest., 116, 2044, 10.1172/JCI27727

Pesce, 2009, Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis, PLoS Pathog., 5, e1000371, 10.1371/journal.ppat.1000371

Peters-Golden, 2002, Protection from pulmonary fibrosis in leukotriene-deficient mice, Am. J. Respir. Crit. Care Med., 165, 229, 10.1164/ajrccm.165.2.2104050

Phillips, 2004, Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis, J. Clin. Invest., 114, 438, 10.1172/JCI200420997

Piguet, 1994, Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice, Eur. Respir. J., 7, 515, 10.1183/09031936.94.07030515

Piguet, 1990, Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis, Nature., 344, 245, 10.1038/344245a0

Piguet, 1993, Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis, Am. J. Pathol., 143, 651

Prasse, 2006, A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18, Am. J. Respir. Crit. Care Med., 173, 781, 10.1164/rccm.200509-1518OC

Prasse, 2009, Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis, Am. J. Respir. Crit. Care Med., 179, 717, 10.1164/rccm.200808-1201OC

Raghu, 2008, Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial, Am. J. Respir. Crit. Care Med., 178, 948, 10.1164/rccm.200709-1446OC

Ramalingam, 2008, Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain, Nat. Immunol., 9, 25, 10.1038/ni1544

Ramalingam, 2009, Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin, J. Immunol., 182, 6452, 10.4049/jimmunol.0900181

Ramos, 2001, Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression, Am. J. Respir. Cell Mol. Biol., 24, 591, 10.1165/ajrcmb.24.5.4333

Rankin, 1996, Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity, Proc. Natl. Acad. Sci. USA., 93, 7821, 10.1073/pnas.93.15.7821

Rankin, 2010, IL-33 induces IL-13-dependent cutaneous fibrosis, J. Immunol., 184, 1526, 10.4049/jimmunol.0903306

Reiman, 2006, Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity, Infect. Immun., 74, 1471, 10.1128/IAI.74.3.1471-1479.2006

Sanders, 2008, Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis, Am. J. Respir. Cell Mol. Biol., 39, 610, 10.1165/rcmb.2007-0322OC

Schmitz, 2005, IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines, Immunity., 23, 479, 10.1016/j.immuni.2005.09.015

Selman, 2001, Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy, Ann. Intern. Med., 134, 136, 10.7326/0003-4819-134-2-200101160-00015

Shao, 2008, Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation, J. Leukoc. Biol., 83, 1323, 10.1189/jlb.1107782

Sime, 2008, The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis, J. Investig. Med., 56, 534, 10.2310/JIM.0b013e31816464e9

Simonian, 2009, Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis, J. Immunol., 182, 657, 10.4049/jimmunol.0900013

Simonian, 2010, γδ T cells protect against lung fibrosis via IL-22, J. Exp. Med., 207, 2239, 10.1084/jem.20100061

Siwik, 2000, Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro, Circ. Res., 86, 1259, 10.1161/01.RES.86.12.1259

Smith, 1994, Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury, J. Immunol., 153, 4704, 10.4049/jimmunol.153.10.4704

Song, 2000, Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts, Cell. Immunol., 204, 19, 10.1006/cimm.2000.1687

Strieter, 2007, The role of CXC chemokines in pulmonary fibrosis, J. Clin. Invest., 117, 549, 10.1172/JCI30562

Tager, 2008, The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak, Nat. Med., 14, 45, 10.1038/nm1685

Thannickal, 2004, Mechanisms of pulmonary fibrosis, Annu. Rev. Med., 55, 395, 10.1146/annurev.med.55.091902.103810

Thavarajah, 2009, Pulmonary complications of tumor necrosis factor-targeted therapy, Respir. Med., 103, 661, 10.1016/j.rmed.2009.01.002

Thiery, 2006, Complex networks orchestrate epithelial-mesenchymal transitions, Nat. Rev. Mol. Cell Biol., 7, 131, 10.1038/nrm1835

Thompson, 2008, Cationic amino acid transporter-2 regulates immunity by modulating arginase activity, PLoS Pathog., 4, e1000023, 10.1371/journal.ppat.1000023

Thum, 2008, MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts, Nature., 456, 980, 10.1038/nature07511

Tokuda, 2000, Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice, J. Immunol., 164, 2745, 10.4049/jimmunol.164.5.2745

Wilborn, 1996, Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis, J. Clin. Invest., 97, 1827, 10.1172/JCI118612

Wilson, 2007, IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice, J. Clin. Invest., 117, 2941, 10.1172/JCI31546

Wilson, 2010, Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent, J. Exp. Med., 207, 535, 10.1084/jem.20092121

Wolff, 2002, Progressive interstitial fibrosis of the lung in sclerodermoid chronic graft-versus-host disease, Bone Marrow Transplant., 29, 357, 10.1038/sj.bmt.1703386

Wynn, 2004, Fibrotic disease and the T(H)1/T(H)2 paradigm, Nat. Rev. Immunol., 4, 583, 10.1038/nri1412

Wynn, 2007, Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases, J. Clin. Invest., 117, 524, 10.1172/JCI31487

Wynn, 2010, Macrophages: master regulators of inflammation and fibrosis, Semin. Liver Dis., 30, 245, 10.1055/s-0030-1255354

Wynn, 1995, An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection, Nature., 376, 594, 10.1038/376594a0

Xia, 2008, Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis, J. Exp. Med., 205, 1659, 10.1084/jem.20080001

Yang, 2004, Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling, Cytokine., 28, 224, 10.1016/j.cyto.2004.08.007

Ye, 2001, Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense, J. Exp. Med., 194, 519, 10.1084/jem.194.4.519

Young, 2007, Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis, Rheumatology (Oxford)., 46, 350, 10.1093/rheumatology/kel253

Zhang, 1993, Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure, J. Immunol., 150, 4188, 10.4049/jimmunol.150.9.4188

Zheng, 2008, IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung, J. Immunol., 180, 522, 10.4049/jimmunol.180.1.522

Zhou, 2005, Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice, Nat. Immunol., 6, 1047, 10.1038/ni1247

Zhou, 2011, A role for mitochondria in NLRP3 inflammasome activation, Nature., 469, 221, 10.1038/nature09663

Zhu, 1999, Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production, J. Clin. Invest., 103, 779, 10.1172/JCI5909

Zhu, 2002, IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling, J. Immunol., 168, 2953, 10.4049/jimmunol.168.6.2953

Zhu, 2004, Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation, Science., 304, 1678, 10.1126/science.1095336

Zhu, 2007, MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1), J. Biol. Chem., 282, 14328, 10.1074/jbc.M611393200

Zhu, 2008, MicroRNA-21 targets tumor suppressor genes in invasion and metastasis, Cell Res., 18, 350, 10.1038/cr.2008.24

Zuo, 2002, Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans, Proc. Natl. Acad. Sci. USA., 99, 6292, 10.1073/pnas.092134099