The action of 5α-dihydrotestosterone and antiandrogens on the activities of 5α-reductase and 3α-hydroxysteroid dehydrogenase in the pituitary gland of gonadectomized rats

Martini, 1976, Androgen reduction by neuroendocrine tissues: physiological significance, 327 Karavolas, 1976, Progesterone metabolism by neuroendocrine tissues, 305 McEwen, 1978, Gonadal steroid receptors in neuroendocrine tissues, Vol. II, 353 Jouan, 1980, Metabolism of steroid hormones in the brain, 95 Krause, 1980, Pituitary 5α-dihydroprogesterone 3α-hydroxysteroid oxidoreductases: subcellular location and properties of NADH- and NADPH-linked activities, J. biol. Chem., 255, 11807, 10.1016/S0021-9258(19)70205-1 Ghraf, 1982, Subcellular distribution of 3α-hydroxysteroid dehydrogenase and antiestrogen actiopn on androgen-metabolizing enzymes in rat pituitary gland, J. Neurochem., 38, 10.1111/j.1471-4159.1982.tb05324.x Nguyen, 1975, Properties of 3α-hydroxysteroid dehydrogenase of the male rat pituitary gland, J. steroid Biochem., 6, 1165, 10.1016/0022-4731(75)90097-7 Krause, 1981, Ovarian regulation of hypothalamic and pituitary progestin-metabolizing enzyme activities, Endocrinology, 108, 1, 10.1210/endo-108-1-1 Massa, 1972, The transformation of testosterone into dihydrotestosterone by the brain and the anterior pituitary, J. steroid Biochem., 3, 385, 10.1016/0022-4731(72)90085-4 Denef, 1973, Sex differences and hormonal control of testosterone metabolism in rat pituitary and brain, J. Endocr., 59, 605, 10.1677/joe.0.0590605 Denef, 1974, Sex-dependent changes in pituitary 5α-dihydrotestosterone and 3α-androstanediol formation during postnatal development and puberty in the rat, Endocrinology, 94, 1265, 10.1210/endo-94-5-1265 Nguyen, 1974, Testosterone 5α-reductase of microsomes from rat anterior hypophysis: properties, increase by castration, and hormonal control, Biochimie, 56, 899, 10.1016/S0300-9084(74)80513-4 Kato, 1977, Steroid hormone receptors in brain, hypothalamus and hypophysis, Vol. II, 603 Naess, 1977, Receptors for testosterone and 5α-dihydrotestosterone in the anterior pituitary and various areas of the brain, 227 Lieberburg, 1979, Steroid hormone receptors in the central nervous system, Vol. VI, 415 Muldoon, 1980, Role of receptors in the mechanism of steroid hormone action in the brain, 51 Neumann, 1974, Antiandrogens, Vol. 35/2, 235 Neumann, 1977, Central actions of antiandrogens, 163 Neri, 1977, Studies on the biology and mechanism of action of nonsteroidal antiandrogens, 179 Davidson, 1977, Comparative analysis of the roles of androgen in feedback mechanisms and sexual behaviour, 137 Kalra, 1980, Modulation of hypothalamic luteinizing hormone-releasing hormone levels by intracranial and subcutaneous implants of gonadal steroids in castrated rats: effects of androgen and estrogen antagonists, Endocrinology, 106, 390, 10.1210/endo-106-1-390 Sar, 1973, Effects of progesterone or cyproterone acetate on androgen uptake in the brain, pituitary and peripheral tissues, 144, 26 Lieberburg, 1977, 5α-Dihydrotestosterone (DHT) receptors in rat brain and pituitary cell nuclei, Endocrinology, 100, 598, 10.1210/endo-100-2-598 Lieberburg, 1980, Androgen receptors in the perinatal rat brain, Brain Res., 196, 125, 10.1016/0006-8993(80)90721-0 Lowry, 1951, Protein measurement with the Folin phenol reagent, J. biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 Lax, 1979, An improved method for the determination of cytoplasmic 3α- and 17β- and microsomal 3α-hydroxysteroid dehydrogenase activities in rat liver, Hoppe Seylers Z. Physiol. Chem., 360, 897, 10.1515/bchm2.1979.360.2.897 Duncan, 1955, Multiple range and multiple F-tests, Biometrics, 11, 1, 10.2307/3001478 Swerdloff, 1972, Control of LH and FSH secretion in the male: evidence that aromatization of androgens to estradiol is not required for inhibition of gonadotropin secretion, Steroids, 20, 13, 10.1016/0039-128X(72)90115-8 Verjans, 1974, Effects of testosterone propionate, 5α-dihydrotestosterone propionate and oestradiol benzoate on serum levels of LH and FSH in the castrated adult male rat, Acta endocr., Copenh., 77, 643 Denef, 1978, Parallel changes in the plasma concentration of follicle-stimulating hormone and pituitary 5α-dihydrotestosterone formation after cryptorchidectomy in the rat, J. Endocr., 77, 279, 10.1677/joe.0.0770279 Denef, 1979, Evidence that pituitary 5α-dihydrotestosterone formation is regulated through changes in the proportional number and size of the gonadotrophic cell, Neuroendocrinology, 29, 132, 10.1159/000122914 Kingsley, 1973, Direct feedback of androgens: localized effects of intrapituitary implants of androgens on gonadotrophic cells and hormone stores, Endocrinology, 93, 1398, 10.1210/endo-93-6-1398 Schally, 1973, Effect of sex steroids on pituitary responses to LH- and FSH-releasing hormone in vitro, Endocrinology, 93, 893, 10.1210/endo-93-4-893 Labrie, 1980, Mechanism of action of hypothalamic hormones and interaction with peripheral hormones at the pituitary level, 207 Naess, 1975, Characterization of the androgen receptor in the anterior pituitary of the rat, Endocrinology, 97, 1355, 10.1210/endo-97-6-1355 Naess, 1976, Androgen receptors in the anterior pituitary and central nervous system of the androgen “insensitive” (Tfm) rat: correlation between receptor binding and effects of androgens on gonadotropin secretion, Endocrinology, 99, 1295, 10.1210/endo-99-5-1295 Barley, 1975, An androgen receptor in rat brain and pituitary, Brain Res., 100, 383, 10.1016/0006-8993(75)90490-4 Lloyd, 1975, Uptake and conversion of progesterone and testosterone to 5α-reduced products by enriched gonadotropic and chromophobic rat anterior pituitary cell fractions, Endocrinology, 97, 517, 10.1210/endo-97-3-517 Costoff, 1973