Assessing the significance of chromosome‐loss data: Where are suppressor genes for bladder cancer?

Statistics in Medicine - Tập 13 Số 8 - Trang 839-858 - 1994
Michael A. Newton1, Shiqi Wu2, Catherine A. Reznikoff2
1Department of Biostatistics, University of Wisconsin-Madison 53792.
2Department of Human Oncology, Universiry of Wisconsin Comprehensiiv Cancer Center, 600 Highland Avenue, Madison. WI 53792, U.S.A.

Tóm tắt

AbstractCytogenetic analysis reveals alterations of chromosome structure (losses, gains, and rearrangements of genetic material) in bladder cancer cells generated using an in oitrolin oioo transformation system. To predict possible locations of bladder cancer suppressor genes, we performed a robust Bayesian analysis of the chromosome‐loss data. We postulated a simple stochastic model to describe chromosome loss during tumour progression. Posterior computations are enabled by a dynamic simulation algorithm. Ordered by decreasing posterior probability of putatively harbouring a suppressor gene, we observe significant losses on chromosomes 3, 18, 13, 10, 11, and y.

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Statistics in Medicine

Tập 13 Số 8

839-858

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