8 Osteoporosis: pathogenesis, diagnosis, prevention and management

Angus, 1988, Osteoporosis: the role of calcium intake and supplementation, Medical Journal of Australia, 148, 630, 10.5694/j.1326-5377.1988.tb116337.x Bergman, 1990, Effect of oral caffeine on renal handling of calcium and magnesium in adult women, Life Sciences, 47, 557, 10.1016/0024-3205(90)90616-Y Black, 1988, Quantitative analysis of pyridinium cross-links of collagen in urine using ion-paired reversed phase high-performance liquid chromatography, Analytical Biochemistry, 169, 197, 10.1016/0003-2697(88)90274-6 Black Sandler, 1985, Postmenopausal bone density and milk consumption in childhood and adolescence, American Journal of Clinical Nutrition, 42, 270, 10.1093/ajcn/42.2.270 Block, 1987, Does exercise prevent osteoporosis?, Journal of the American Medical Association, 257, 3115, 10.1001/jama.1987.03390220113033 Brown, 1984, Serum bone gla-protein: a specific marker for bone formation in postmenopausal osteoporosis, Lancet, i, 1091, 10.1016/S0140-6736(84)92506-6 Cann, 1980, Precise measurement of vertebral mineral content using computed tomography, Journal of Computer Assisted Tomography, 4, 493, 10.1097/00004728-198008000-00018 Chesnut, 1992, Osteoporosis and its treatment, New England Journal of Medicine, 326, 406, 10.1056/NEJM199202063260609 Chesnut, 1983, Stanozolol in postmenopausal osteoporosis: therapeutic efficacy and possible mechanisms of action, Metabolism, 32, 571, 10.1016/0026-0495(83)90027-6 Chow, 1987, Effect of two randomised exercise programmes on bone mass of healthy postmenopausal women, British Medical Journal, 295, 1441, 10.1136/bmj.295.6611.1441 Christiansen, 1990, 17β-estradiol and continuous norethisterone: a unique treatment for established osteoporosis in elderly women, Journal of Clinical Endocrinology and Metabolism, 71, 836, 10.1210/jcem-71-4-836 Christiansen, 1985, Uncoupling of bone formation and resorption by combined oestrogen and progestagen therapy in postmenopausal osteoporosis, Lancet, ii, 800, 10.1016/S0140-6736(85)90794-9 Christiansen, 1987, Prediction of rapid bone loss in postmenopausal women, Lancet, i, 1105, 10.1016/S0140-6736(87)91671-0 Compston, 1990, Structural mechanisms of trabecular bone loss, 35 Cummings, 1987, Position papers. Bone mineral densitometry, Annals of Internal Medicine, 107, 932, 10.7326/0003-4819-107-6-932 Cummings, 1985, Epidemiology of osteoporosis and osteoporotic fractures, Epidemiologic Reviews, 7, 178, 10.1093/oxfordjournals.epirev.a036281 Cummings, 1990, Should prescription of postmenopausal hormone therapy be based on the results of bone densitometry?, Annals of Internal Medicine, 113, 565, 10.7326/0003-4819-113-8-565 Davidson, 1990, Multiple forms of mechanosensitive ion channels in osteoblast-like cells, Pflügers Archiv. European Journal of Physiology (Berlin), 416, 646, 10.1007/BF00370609 Dawson-Hughes, 1990, A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women, New England Journal of Medicine, 323, 878, 10.1056/NEJM199009273231305 Delmas, 1991, Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis, Journal of Bone and Mineral Research, 6, 639, 10.1002/jbmr.5650060615 Diamond, 1989, Ethanol reduces bone formation and may cause osteoporosis, American Journal of Medicine, 86, 282, 10.1016/0002-9343(89)90297-0 Drinkwater, 1990, Menstrual history as a determinant of current bone density in young athletes, Journal of the American Medical Association, 263, 545, 10.1001/jama.1990.03440040084033 Duda, 1988, Concurrent assays of circulating bone-gla protein and bone alkaline phosphatase: effects of sex, age and metabolic bone disease, Journal of Clinical Endocrinology and Metabolism, 66, 951, 10.1210/jcem-66-5-951 Dure-Smith, 1991, Fluoride therapy for osteoporosis: a review of dose response, duration of treatment, and skeletal sites of action, Calcified Tissue International, 49, S64, 10.1007/BF02555092 Eastell, 1989, Unequal decrease in bone density of lumbar spine and ultradistal radius in Colles' and vertebral fracture syndromes, Journal of Clinical Investigation, 83, 168, 10.1172/JCI113854 Ebeling, 1992, Utility of type I procollagen propeptide assays for assessing abnormalities in metabolic bone diseases, Journal of Bone and Mineral Research, 10.1016/0169-6009(92)92159-N Eisman, 1991, Osteoporosis—prevention, prevention, prevention and prevention, Australian and New Zealand Journal of Medicine, 21, 205, 10.1111/j.1445-5994.1991.tb00443.x Epstein, 1988, Serum and urinary markers of bone remodelling: assessment of bone turnover, Endocrine Reviews, 9, 437, 10.1210/edrv-9-4-437 Eriksen, 1988, Evidence of estrogen receptors in normal human osteoblast-like cells, Science, 241, 84, 10.1126/science.3388021 Eyre, 1984, Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography, Analytical Biochemistry, 137, 380, 10.1016/0003-2697(84)90101-5 Farley, 1983, Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone forming cells, Science, 222, 330, 10.1126/science.6623079 Farrugia, 1991, The effect of uninephrectomy on osteocalcin metabolism in sheep: a direct evaluation of renal osteocalcin clearance, Journal of Endocrinology, 130, 213, 10.1677/joe.0.1300213 Fenton, 1991, A potent inhibitor of osteoclastic bone resorption within a highly conservated pentapeptide region of parathyroid hormone-related protein; PTHrP[107–111], Endocrinology, 129, 3424, 10.1210/endo-129-6-3424 Fogelman, 1991, The bone scan in metastatic disease, 31 Frost, 1979, Treatment of osteoporosis by manipulation of coherent bone cell populations, Clinical Orthopaedics and Related Research, 143, 227 Gallagher, 1991, Effect of progestin therapy on cortical and trabecular bone: comparison with estrogen, American Journal of Medicine, 90, 171, 10.1016/0002-9343(91)90538-9 Genant, 1989, Appropriate use of bone densitometry, Radiology, 170, 817, 10.1148/radiology.170.3.2916037 Gennari, 1987, The effect of nandrolone decanoate therapy on bone loss in postmenopausal osteoporosis, 1221 Geusens, 1986, Long-term effect of nandrolone decanoate, 1α-hydroxyvitamin D3 or intermittent calcium infusion therapy on bone mineral content, bone remodeling and fracture rate in symptomatic osteoporosis: a double-blind controlled study, Bone and Mineral, 1, 347 Gilsanz, 1988, Vertebral bone density in children: effect of puberty, Radiology, 166, 847, 10.1148/radiology.166.3.3340782 Goldman, 1991, Uncertainty about postmenopausal estrogen. Time for action, not debate, New England Journal of Medicine, 325, 800, 10.1056/NEJM199109123251108 Goulding, 1986, Sodium and osteoporosis, Vol. 2, 10 Gruber, 1984, Long-term calcitonin therapy in postmenopausal osteoporosis, Metabolism, 33, 295, 10.1016/0026-0495(84)90187-2 Haliqua, 1989, Lifetime calcium intake and physical activity habits: independent and combined effects on the radial bone of healthy premenopausal caucasian women, American Journal of Clinical Nutrition, 49, 534, 10.1093/ajcn/49.3.534 Hansen, 1991, Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study, British Medical Journal, 303, 961, 10.1136/bmj.303.6808.961 Hanson, 1991, A specific immunoassay for bone resorption based on cross-linked collagen peptides in urine, Journal of Bone and Mineral Research, 6, S251 Harvey, 1991, Measurement of bone collagen degradation in hyperthyroidism and during thyroxine replacement therapy using pyridinium cross-links as specific urinary markers, Journal of Clinical Endocrinology and Metabolism, 72, 1189, 10.1210/jcem-72-6-1189 Hassager, 1987, Body composition in osteoporotic subjects during nandrolone decanoate therapy, 958 Hassager, 1991, The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones, Metabolism, 40, 205, 10.1016/0026-0495(91)90176-W Hauschka, 1989, Osteocalcin and matrix gla protein: vitamin K-dependent proteins in bone, Physiological Reviews, 69, 990, 10.1152/physrev.1989.69.3.990 Heaney, 1989, Fluoride therapy for the vertebral crush fracture syndrome. A status report, Annals of Internal Medicine, 111, 678, 10.7326/0003-4819-111-8-678 Hemenway, 1988, Fractures and lifestyle: effect of cigarette smoking, alcohol intake, and relative weight on the risk of hip and forearm fractures in middle-aged women, American Journal of Public Health, 78, 1554, 10.2105/AJPH.78.12.1554 Hui, 1988, Age and bone mass as predictors of fracture in a prospective study, Journal of Clinical Investigation, 81, 1804, 10.1172/JCI113523 Hui, 1989, Baseline measurement of bone mass predicts fracture in white women, Annals of Internal Medicine, 111, 355, 10.7326/0003-4819-111-5-355 Inkovaara, 1991, Is fluoride treatment justified today?, Calcified Tissue International, 49, S68, 10.1007/BF02555093 Johansen, 1987, Treatment of postmenopausal osteoporosis with nandrolone decanoate, 1221 Johnston, 1989, Clinical indications for bone mass measurements, Journal of Bone and Mineral Research, 4, 1 Kanis, 1990, Osteoporosis: causes and therapeutic implications, 45 Kelly, 1990, Sex differences in peak adult bone mineral density, Journal of Bone and Mineral Research, 5, 1169, 10.1002/jbmr.5650051112 Kelly, 1988, Quantitative digital radiography versus dual photon absorptiometry of the lumbar spine, Journal of Clinical Endocrinology and Metabolism, 67, 839, 10.1210/jcem-67-4-839 Kelsey, 1987, Risk factors for hip fracture, New England Journal of Medicine, 316, 404, 10.1056/NEJM198702123160709 Komm, 1988, Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells, Science, 241, 81, 10.1126/science.3164526 Krall, 1991, Smoking and bone loss among postmenopausal women, Journal of Bone and Mineral Research, 6, 331, 10.1002/jbmr.5650060404 Laitenen, 1991, Alcohol and bone, Calcified Tissue International, 49, S70, 10.1007/BF02555094 Lang, 1991, Osteoporosis. Current techniques and recent developments in quantitative bone densitometry, Radiologic Clinics of North America, 29, 49 Lichtenstein, 1990, Conversion of an old gamma camera to a bone mineral densitometer, Nuclear Medicine Communications, 11, 801, 10.1097/00006231-199011000-00010 Lidor, 1990, Osteoporosis as the sole presentation of bone marrow mastocytosis, Journal of Bone and Mineral Research, 5, 871, 10.1002/jbmr.5650050811 Lindsay, 1990, Fluoride and bone-quantity versus quality, New England Journal of Medicine, 322, 45, 10.1056/NEJM199003223221210 Lindsay, 1990, Estrogen treatment of patients with established postmenopausal osteoporosis, Obstetrics and Gynaecology, 76, 290 Lord, 1986, Femoral neck fractures: admissions, bed use, outcome and projections, Medical Journal of Australia, 145, 493, 10.5694/j.1326-5377.1986.tb139447.x McClung, 1989, Correlation of bone density measurements by 153-Gd and X-ray dual photon absorptiometry, Journal of Bone and Mineral Research, 4, S368 MacIntyre, 1988, Calcitonin for prevention of postmenopausal bone loss, Lancet, i, 900, 10.1016/S0140-6736(88)91712-6 Mamelle, 1988, Risk—benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis, Lancet, ii, 361, 10.1016/S0140-6736(88)92834-6 Marcus, 1987, Calcium intake and skeletal integrity: is there a critical relationship?, Journal of Nutrition, 117, 631, 10.1093/jn/117.4.631 Marcus, 1991, Skeletal aging. Understanding the functional and structural basis of osteoporosis, Trends in Endocrinology and Metabolism, 2, 53, 10.1016/1043-2760(91)90040-T Massey, 1991, Caffeine and bone: directions for research, Journal of Bone and Mineral Research, 6, 1149, 10.1002/jbmr.5650061102 Matkovic, 1979, Bone status and fracture rates in two regions of Yugoslavia, American Journal of Clinical Nutrition, 32, 540, 10.1093/ajcn/32.3.540 Mayo-Smith, 1991, Radiographic appearance of osteopenia, Radiologic Clinics of North America, 29, 37 Mazess, 1982, On aging bone loss, Clinical Orthopedics and Related Research, 165, 239 Mazess, 1983, The noninvasive measurement of skeletal mass, Vol. 1, 223 Mazess, 1983, Errors in measuring trabecular bone by computed tomography due to marrow and bone composition, Calcified Tissue International, 35, 148, 10.1007/BF02405022 Mazess, 1983, Immobilization and bone, Calcified Tissue International, 35, 265, 10.1007/BF02405043 Mazess, 1984, Does bone measurement on the radius indicate skeletal status?, Journal of Nuclear Medicine, 25, 281 Mazess, 1989, Performance evaluation of a dual-energy x-ray bone densitometer, Calcified Tissue International, 44, 228, 10.1007/BF02556569 Mazess, 1991, DEXA measurement of spine density in the lateral projection. I: Methodology, Calcified Tissue International, 49, 235, 10.1007/BF02556210 Melick, 1988, The metabolic clearance rate of osteocalcin in sheep, Calcified Tissue International, 42, 185, 10.1007/BF02556332 Melton, 1990, Screening for osteoporosis, Annals of Internal Medicine, 112, 516, 10.7326/0003-4819-112-7-516 Munk-Jensen, 1988, Reversal of postmenopausal vertebral bone loss by oestrogen and progestogen: a double blind placebo controlled study, British Medical Journal, 296, 1150, 10.1136/bmj.296.6630.1150 Need, 1987, Effects of nandrolone decanoate on forearm mineral density and calcium metabolism in osteoporotic postmenopausal women, Calcified Tissue International, 41, 7, 10.1007/BF02555124 Need, 1989, Effects of nandrolone decanoate and antiresorptive therapy on vertebral density in osteoporotic postmenopausal women, Archives of Internal Medicine, 149, 57, 10.1001/archinte.1989.00390010075007 Nicholson, 1986, Abundant calcitonin receptors in isolated rat osteoclasts, Journal of Clinical Investigation, 78, 355, 10.1172/JCI112584 Nordin, 1987, The definition and diagnosis of osteoporosis, Calcified Tissue International, 40, 57, 10.1007/BF02555705 Notelovitz, 1991, Estrogen therapy and variable-resistance weight training increase bone mineral in surgically menopausal women, Journal of Bone and Mineral Research, 6, 583, 10.1002/jbmr.5650060609 Ott, 1991, Bone density in adolescents, New England Journal of Medicine, 325, 1646, 10.1056/NEJM199112053252310 Overgaard, 1990, Discontinuous calcitonin treatment of established osteoporosis—effects of withdrawal of treatment, American Journal of Medicine, 89, 1, 10.1016/0002-9343(90)90089-V Pacifici, 1987, Single and dual energy tomographic analysis of spinal trabecular bone: a comparative study in normal and osteoporotic women, Journal of Clinical Endocrinology and Metabolism, 64, 209, 10.1210/jcem-64-2-209 Papapoulos, 1987, Serum osteocalcin in Paget's disease of bone: basal concentrations and response to bisphosphonate treatment, Journal of Clinical Endocrinology and Metabolism, 65, 89, 10.1210/jcem-65-1-89 Parfitt, 1987, Trabecular bone architecture in the pathogenesis and prevention of fracture, American Journal of Medicine, 82, 68, 10.1016/0002-9343(87)90274-9 Passeri, 1991, Intermittent treatment with intravenous 4-amino-1-hydroxybutylidene-1,1-bisphosphonate, Bone and Mineral, 15, 237, 10.1016/0169-6009(91)90129-N Paterson, 1984, Osteogenesis imperfecta after the menopause, New England Journal of Medicine, 310, 1694, 10.1056/NEJM198406283102602 Plantalech, 1991, Impairment of gamma carboxylation of circulating osteocalcin (bone gla protein) in elderly women, Journal of Bone and Mineral Research, 6, 1211, 10.1002/jbmr.5650061111 Pocock, 1987, Genetic determinants of bone mass in adults, Journal of Clinical Investigation, 80, 706, 10.1172/JCI113125 Prior, 1990, Progesterone as a bone-trophic hormone, Endocrine Reviews, 11, 386, 10.1210/edrv-11-2-386 Prior, 1990, Spinal bone loss and ovulatory disturbances, New England Journal of Medicine, 323, 1221, 10.1056/NEJM199011013231801 Raisz, 1989, Pathogenesis, prevention and treatment of osteoporosis, 40, 251 Ray, 1987, Psychotropic drug use and the risk of hip fracture, New England Journal of Medicine, 316, 363, 10.1056/NEJM198702123160702 Reeve, 1990, Restoring trabecular bone mass in established osteoporosis, 143 Reginster, 1987, 1-Year controlled randomised trial of prevention of early postmenopausal bone loss by intranasal calcitonin, Lancet, ii, 1481, 10.1016/S0140-6736(87)92619-5 Reid, 1989, Pathogenesis and treatment of steroid osteoporosis, Clinical Endocrinology, 30, 83, 10.1111/j.1365-2265.1989.tb03730.x Riggs, 1986, Involutional osteoporosis, New England Journal of Medicine, 314, 1676, 10.1056/NEJM198606263142605 Riggs, 1988, Bone densitometry and clinical decision-making in osteoporosis, Annals of Internal Medicine, 108, 293, 10.7326/0003-4819-108-2-293 Riggs, 1982, Changes in bone mineral density of the proximal femur with ageing: differences between the postmenopausal and senile osteoporotic syndromes, Journal of Clinical Investigation, 70, 716, 10.1172/JCI110667 Riggs, 1990, Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis, New England Journal of Medicine, 322, 802, 10.1056/NEJM199003223221203 Riis, 1987, The effect of percutaneous estradiol and natural progesterone on postmenopausal bone loss, American Journal of Obstetrics and Gynecology, 156, 61, 10.1016/0002-9378(87)90203-1 Rodan, 1991, Perspectives, Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption, Journal of Bone and Mineral Research, 6, 527, 10.1002/jbmr.5650060602 Rodan, 1981, Role of osteoblasts in hormonal control of bone resorption: a hypothesis, Calcified Tissue International, 33, 349, 10.1007/BF02409454 Rodan, 1984, Expression of the osteoblast phenotype, Vol. 2, 244 Ross, 1988, Detection of prefracture spinal osteoporosis using bone mineral densitometry, Journal of Bone and Mineral Research, 3, 1, 10.1002/jbmr.5650030103 Rudman, 1990, Effects of human growth hormone in men over 60 years old, New England Journal of Medicine, 323, 1, 10.1056/NEJM199007053230101 Russell, 1990, Bone cell biology: the role of cytokines and other mediators, 9 Sartoris, 1989, Dual-energy radiographic absorptiometry for bone densitometry: current status and perspective, American Journal of Radiology, 152, 241 Seeman, 1989, Risk factors for osteoporosis, Australian and New Zealand Journal of Medicine, 19, 69, 10.1111/j.1445-5994.1989.tb01682.x Slemenda, 1991, Calcium supplementation enhances bone mineral accretion in growing children, Journal of Bone and Mineral Research, 6, S136 Smith, 1991, Physical activity effects on bone metabolism, Calcified Tissue International, 49, S50, 10.1007/BF02555089 Somjen, 1980, Bone remodelling induced by physical stress is prostaglandin E2 mediated, Biochimica et Biophysica Acta, 627, 91, 10.1016/0304-4165(80)90126-9 Spotila, 1991, Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta, 88, 5423 Stevenson, 1990, Epidemiology of postmenopausal osteoporosis, 11 Storm, 1990, Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis, New England Journal of Medicine, 322, 1265, 10.1056/NEJM199005033221803 Sweeney, 1981, Forecasting hospital bed needs, British Medical Journal, 283, 331, 10.1136/bmj.283.6286.331 Taylor, 1988, Development of a new radioimmunoassay for human osteocalcin: evidence for a midmolecule epitope, Metabolism, 37, 872, 10.1016/0026-0495(88)90122-9 Tilyard, 1992, Treatment of postmenopausal osteoporosis with calcitriol or calcium, New England Journal of Medicine, 326, 357, 10.1056/NEJM199202063260601 Turner, 1987, Demonstration that ethanol inhibits bone matrix synthesis and mineralization in the rat, Journal of Bone and Mineral Research, 2, 61, 10.1002/jbmr.5650020110 Uebelhart, 1990, Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease, Bone and Mineral, 8, 87, 10.1016/0169-6009(91)90143-N Uebelhart, 1991, Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links, Journal of Clinical Endocrinology and Metabolism, 72, 367, 10.1210/jcem-72-2-367 von Stetten, 1991, Paired AP and lateral spine dual X-ray absorptiometry improves precision of repeat lateral scans, Journal of Bone and Mineral Research, 6, S171 Wark, 1992, Osteoporosis and the menopause, Australian Prescriber, 15 Wark, 1992, Bone density measurement, Australian Prescriber, 15, 62 Wasnich, 1987, The relative strengths of osteoporotic risk factors in a prospective study of postmenopausal osteoporosis, Journal of Bone and Mineral Research, 2, S343 Watts, 1990, Intermittent cyclical etidronate treatment of postmenopausal osteoporosis, New England Journal of Medicine, 323, 73, 10.1056/NEJM199007123230201 Whitaker, 1989, An immunoassay of human band 5 (‘tartrate-resistant’) acid phosphatase that involves the use of anti-porcine uteroferrin antibodies, Clinical Chemistry, 35, 86, 10.1093/clinchem/35.1.86 Whitehead, 1990, The role and use of progestogens, Obstetrics and Gynaecology, 75, 59S, 10.1097/00006250-199004001-00013