5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility

Škovierová, 2016, The molecular and cellular effect of homocysteine metabolism imbalance on human health, Int J Mol Sci, 17 Berker, 2009, Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction, Hum Reprod, 24, 2293, 10.1093/humrep/dep069 Ebisch, 2006, Homocysteine, glutathione and related thiols affect fertility parameters in the (sub) fertile couple, Hum Reprod, 21, 1725, 10.1093/humrep/del081 Marques, 2010, Methylation defects of imprinted genes in human testicular spermatozoa, Fertil Steril, 94, 585, 10.1016/j.fertnstert.2009.02.051 Kobayashi, 2007, Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients, Hum Mol Genet, 16, 2542, 10.1093/hmg/ddm187 Enciso, 2016, Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy, Hum Genet, 135, 555, 10.1007/s00439-016-1652-z Menezo, 2016, Oxidative stress and alterations in DNA methylation: two sides of the same coin in reproduction, Reprod Biomed Online, 33, 668, 10.1016/j.rbmo.2016.09.006 Branco, 2016, Maternal DNA methylation regulates early trophoblast development, Dev Cell, 36, 152, 10.1016/j.devcel.2015.12.027 Serman, 2011, Impact of DNA methylation on trophoblast function, Clin Epigenetics, 3 Koukoura, 2012, DNA methylation in the human placenta and fetal growth, Mol Med Rep, 5, 883, 10.3892/mmr.2012.763 Menezo, 1989, Regulation of S-adenosyl methionine synthesis in the mouse embryo, Life Sci, 44, 1601, 10.1016/0024-3205(89)90455-4 Hoffman, 2011, Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress, Med Hypotheses, 77, 1088, 10.1016/j.mehy.2011.09.009 Van der Put, 2000, Neural tube defects and a disturbed folate dependent homocysteine metabolism, Eur J Obstet Gynecol Reprod Biol, 92, 57, 10.1016/S0301-2115(00)00426-7 Lucock, 2005, Folic acid - vitamin and panacea or genetic time bomb?, Nat Rev Genet, 6, 235, 10.1038/nrg1558 Lucock, 2009, Folic acid fortification: a double-edged sword, Curr Opin Clin Nutr Metab Care, 12, 555, 10.1097/MCO.0b013e32833192bc Crider, 2011, Folic acid food fortification-its history, effect, concerns, and future directions, Nutrients, 3, 370, 10.3390/nu3030370 Plumptre, 2015, High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood, Am J Clin Nutr, 102, 848, 10.3945/ajcn.115.110783 Kim, 2008, Folic acid supplementation and cancer risk: point, Cancer Epidemiol Biomark Prev, 17, 2220, 10.1158/1055-9965.EPI-07-2557 Dattilo, 2016, Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet, J Assist Reprod Genet, 33, 1633, 10.1007/s10815-016-0767-4 Venn, 2003, Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study, Am J Clin Nutr, 77, 658, 10.1093/ajcn/77.3.658 Lamers, 2004, Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equa)lly reduces plasma total homocysteine concentrations in healthy women, Am J Clin Nutr, 79, 473, 10.1093/ajcn/79.3.473 Servy, 2018, MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series, J Assist Reprod Genet, 35, 1431, 10.1007/s10815-018-1225-2 Silvestris, 2017, Supporting the one-carbon cycle restores ovarian reserve in subfertile women: absence of correlation with urinary bisphenol a concentration, Biores Open Access, 6, 104, 10.1089/biores.2017.0016 Jacquesson-Fournols, 2017, MTHFR testing in ART should be compulsory for both male and female patients including oocyte donation programs, J Gynecol Women’s Health, 7, 555706 Goyco Ortiz, 2019, A successful treatment with 5 methyltetrahydrofolate of a 677 TT MTHFR woman suffering premature ovarian insufficiency post a NHL (non-Hodgkin’s lymphoma) and RPL (repeat pregnancy losses), J Assist Reprod Genet, 36, 65, 10.1007/s10815-018-1332-0 Yu, 2019, Hyperhomocysteinemia in men with a reproductive history of fetal neural tube defects: three case reports and literature review, Medicine (Baltimore), 98 Boxmeer, 2008, Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation, Hum Reprod, 23, 2570, 10.1093/humrep/den292 Singh, 2013, One-carbon metabolism, spermatogenesis, and male infertility, Reprod Sci, 20, 622, 10.1177/1933719112459232 Aarabi, 2018, Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation, Hum Mol Genet, 27, 1123, 10.1093/hmg/ddy021 Bailey, 2009, The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake, Proc Natl Acad Sci U S A, 106, 15424, 10.1073/pnas.0902072106 Qin, 2012, Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?, Pharmacogenet Genomics, 22, 421, 10.1097/FPC.0b013e32834ac5e8 Qin, 2012, MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults, Nutr J, 11, 2, 10.1186/1475-2891-11-2 Aarabi, 2015, High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism, Hum Mol Genet, 24, 6301, 10.1093/hmg/ddv338 Zappacosta, 2014, 5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults, Cell Biochem Funct, 32, 1, 10.1002/cbf.3019 van der Put, 1998, A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects, Am J Hum Genet, 62, 1044, 10.1086/301825