5-HT1A-iCre, a new transgenic mouse line for genetic analyses of the serotonergic pathway

Albert, 2001, Receptor signaling and structure: insights from serotonin-1 receptors, Trends Endocrinol. Metab., 12, 453, 10.1016/S1043-2760(01)00498-2 Ase, 2001, Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout, J. Neurochem., 78, 619, 10.1046/j.1471-4159.2001.00437.x Blier, 1999, Serotonin and drug-induced therapeutic responses in major depression, obsessive–compulsive and panic disorders, Neuropsychopharmacology, 21, 91S, 10.1016/S0893-133X(99)00036-6 Bonnin, 2006, Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development, Neuroscience, 141, 781, 10.1016/j.neuroscience.2006.04.036 Chalmers, 1991, Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain—a combined in situ hybridisation/in vitro receptor autoradiographic study, Brain Res., 561, 51, 10.1016/0006-8993(91)90748-K Daval, 1987, Transient expression of 5-HT1A receptor binding sites in some areas of the rat CNS during postnatal development, Int. J. Dev. Neurosci., 5, 171, 10.1016/0736-5748(87)90027-X de Lecea, 1997, Cortistatin is expressed in a distinct subset of cortical interneurons, J. Neurosci., 17, 5868, 10.1523/JNEUROSCI.17-15-05868.1997 del Olmo, 1998, Early localization of mRNA coding for 5-HT1A receptors in human brain during development, Brain Res. Mol. Brain Res., 60, 123, 10.1016/S0169-328X(98)00149-1 Diaz-Mataix, 2005, Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action, J. Neurosci., 25, 10831, 10.1523/JNEUROSCI.2999-05.2005 Feng, 2001, Position effects are influenced by the orientation of a transgene with respect to flanking chromatin, Mol. Cell. Biol., 21, 298, 10.1128/MCB.21.1.298-309.2001 Gaspar, 2003, The developmental role of serotonin: news from mouse molecular genetics, Nat. Rev., Neurosci., 4, 1002, 10.1038/nrn1256 Giraldo, 2001, Size matters: use of YACs, BACs and PACs in transgenic animals, Transgenic Res., 10, 83, 10.1023/A:1008918913249 Gordon, 2004, The serotonergic system and anxiety, Neuromol. Med., 5, 27, 10.1385/NMM:5:1:027 Gross, 2002, Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult, Nature, 416, 396, 10.1038/416396a Hariri, 2006, Genetics of emotional regulation: the role of the serotonin transporter in neural function, Trends Cogn. Sci., 10, 182, 10.1016/j.tics.2006.02.011 Heintz, 2001, BAC to the future: the use of bac transgenic mice for neuroscience research, Nat. Rev., Neurosci., 2, 861, 10.1038/35104049 Heisler, 1998, Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice, Proc. Natl. Acad. Sci. U. S. A., 95, 15049, 10.1073/pnas.95.25.15049 Heisler, 2003, Central serotonin and melanocortin pathways regulating energy homeostasis, Ann. N. Y. Acad. Sci., 994, 169, 10.1111/j.1749-6632.2003.tb03177.x Hillion, 1993, Prenatal developmental expression of rat brain 5-HT1A receptor gene followed by PCR, Biochem. Biophys. Res. Commun., 191, 991, 10.1006/bbrc.1993.1315 Hammes, 2000, Generation of transgenic mice from plasmids, BACs and YACs, 217 Hoyer, 2002, Molecular, pharmacological and functional diversity of 5-HT receptors, Pharmacol. Biochem. Behav., 71, 533, 10.1016/S0091-3057(01)00746-8 Kellendonk, 1999, Inducible site-specific recombination in the brain, J. Mol. Biol., 285, 175, 10.1006/jmbi.1998.2307 Kia, 1996, Ultrastructural localization of 5-hydroxytryptamine1A receptors in the rat brain, J. Neurosci. Res., 46, 697, 10.1002/(SICI)1097-4547(19961215)46:6<697::AID-JNR7>3.0.CO;2-A Kusserow, 2004, Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors, Brain Res. Mol. Brain Res., 129, 104, 10.1016/j.molbrainres.2004.06.028 Laaris, 1997, Stress-induced alterations of somatodendritic 5-HT1A autoreceptor sensitivity in the rat dorsal raphe nucleus—In vitro electrophysiological evidence, Fundam. Clin. Pharmacol., 11, 206, 10.1111/j.1472-8206.1997.tb00187.x Lee, 2001, A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA, Genomics, 73, 56, 10.1006/geno.2000.6451 Luttgen, 2005, Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat, Neuropharmacology, 48, 830, 10.1016/j.neuropharm.2005.01.007 Luttgen, 2005, 5-HT1A receptor mRNA and immunoreactivity in the rat medial septum/diagonal band of Broca—relationships to GABAergic and cholinergic neurons, J. Chem. Neuroanat., 29, 93, 10.1016/j.jchemneu.2004.09.001 Mannoury la Cour, 2006, Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain., Mol. Pharmacol., 70, 1013, 10.1124/mol.106.022756 Matthiessen, 1993, Immunocytochemical localization of 5-HT1A receptors in the rat immature cerebellum, NeuroReport, 4, 763, 10.1097/00001756-199306000-00042 Menard, 1999, Effects of centrally administered anxiolytic compounds in animal models of anxiety, Neurosci. Biobehav. Rev., 23, 591, 10.1016/S0149-7634(98)00056-6 Meneses, 1999, 5-HT system and cognition, Neurosci. Biobehav. Rev., 23, 1111, 10.1016/S0149-7634(99)00067-6 Miquel, 1994, Postnatal development and localization of 5-HT1A receptor mRNA in rat forebrain and cerebellum, Brain Res. Dev. Brain Res., 80, 149, 10.1016/0165-3806(94)90099-X Moiseiwitsch, 1995, Serotonin regulates mouse cranial neural crest migration, Proc. Natl. Acad. Sci. U. S. A., 92, 7182, 10.1073/pnas.92.16.7182 Parks, 1998, Increased anxiety of mice lacking the serotonin1A receptor, Proc. Natl. Acad. Sci. U. S. A., 95, 10734, 10.1073/pnas.95.18.10734 Patel, 2005, Ontogeny of 5-HT1A receptor expression in the developing hippocampus, Brain Res. Dev. Brain Res., 157, 42, 10.1016/j.devbrainres.2005.03.006 Pompeiano, 1992, Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding, J. Neurosci., 12, 440, 10.1523/JNEUROSCI.12-02-00440.1992 Ramboz, 1998, Serotonin receptor 1A knockout: an animal model of anxiety-related disorder, Proc. Natl. Acad. Sci. U. S. A., 95, 14476, 10.1073/pnas.95.24.14476 Shimshek, 2002, Codon-improved Cre recombinase (iCre) expression in the mouse, Genesis, 32, 19, 10.1002/gene.10023 Slater, 1998, Abnormal persistence of cerebellar serotonin-1A receptors in schizophrenia suggests failure to regress in neonates, J. Neural Transm., 105, 305, 10.1007/s007020050060 Soriano, 1999, Generalized lacZ expression with the ROSA26 Cre reporter strain, Nat. Genet., 21, 70, 10.1038/5007 Sotelo, 1990, Direct immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei, Eur. J. Neurosci., 2, 1144, 10.1111/j.1460-9568.1990.tb00026.x Tronche, 2002, When reverse genetics meets physiology: the use of site-specific recombinases in mice, FEBS Lett., 529, 116, 10.1016/S0014-5793(02)03266-0 Verge, 1986, Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats, J. Neurosci., 6, 3474, 10.1523/JNEUROSCI.06-12-03474.1986 Winsauer, 1999, Full and partial 5-HT1A receptor agonists disrupt learning and performance in rats, J. Pharmacol. Exp. Ther., 288, 335 Winstanley, 2005, Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders, Neuropsychopharmacology, 30, 669, 10.1038/sj.npp.1300610 Yuen, 2005, Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism, J. Neurosci., 25, 5488, 10.1523/JNEUROSCI.1187-05.2005