5-Aminoimidazole-4-Carboxamide Riboside Enhances Effect of Ionizing Radiation in PC3 Prostate Cancer Cells

Jemal, 2010, Cancer statistics, 2010, CA Cancer J Clin, 60, 277, 10.3322/caac.20073 Hardie, 2004, The AMP-activated protein kinase pathway—New players upstream and downstream, J Cell Sci, 117, 5479, 10.1242/jcs.01540 Hardie, 2006, AMP-activated protein kinase—Development of the energy sensor concept, J Physiol, 574, 7, 10.1113/jphysiol.2006.108944 Park, 2009, AMP-activated protein kinase promotes human prostate cancer cell growth and survival, Mol Cancer Ther, 8, 733, 10.1158/1535-7163.MCT-08-0631 Dynlacht, 2008, Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions, Cancer Cell, 13, 1, 10.1016/j.ccr.2007.12.017 Sanli, 2010, Ionizing radiation activates AMP-activated kinase (AMPK): A target for radiosensitization of human cancer cells, Int J Radiat Oncol Biol Phys, 78, 221, 10.1016/j.ijrobp.2010.03.005 Fogarty, 2010, Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer, Biochim Biophys Acta, 1804, 581, 10.1016/j.bbapap.2009.09.012 Lopez, 2003, 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved, Biochem J, 370, 1027, 10.1042/bj20021053 Viana, 2008, Role of AMP-activated protein kinase in autophagy and proteasome function, Biochem Biophys Res Commun, 369, 964, 10.1016/j.bbrc.2008.02.126 Jacobs, 2007, Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation, J Biol Chem, 282, 4516, 10.1074/jbc.M605702200 Rattan, 2005, 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase, J Biol Chem, 280, 39582, 10.1074/jbc.M507443200 Swinnen, 2005, Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype, Cancer Res, 65, 2441, 10.1158/0008-5472.CAN-04-3025 Xiang, 2004, AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms, Biochem Biophys Res Commun, 321, 161, 10.1016/j.bbrc.2004.06.133 Dixon, 1991, AICA-riboside: Safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent, J Clin Pharmacol, 31, 342, 10.1002/j.1552-4604.1991.tb03715.x Sabina, 1985, 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells, J Biol Chem, 260, 6107, 10.1016/S0021-9258(18)88943-8 De Schutter, 2009, A systematic assessment of radiation dose enhancement by 5-Aza-2′-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma, Int J Radiat Oncol Biol Phys, 73, 904, 10.1016/j.ijrobp.2008.10.032 Beckers, 2006, Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside, Mol Cancer Ther, 5, 2211, 10.1158/1535-7163.MCT-06-0001 McGuire, 2006, 5-Amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism, Cancer Res, 66, 3836, 10.1158/0008-5472.CAN-05-3226 Kang, 2008, Role of p38 MAPK and JNK in enhanced cervical cancer cell killing by the combination of arsenic trioxide and ionizing radiation, Oncol Rep, 20, 637 Rodemann, 2007, Radiation-induced EGFR-signaling and control of DNA-damage repair, Int J Radiat Biol, 83, 781, 10.1080/09553000701769970 Toulany, 2008, PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro, DNA Repair (Amst), 7, 1746, 10.1016/j.dnarep.2008.06.017 Cai, 2007, Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation, Free Radic Biol Med, 42, 64, 10.1016/j.freeradbiomed.2006.09.018 Kim, 2007, AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic beta-cell apoptosis, Cell Signal, 19, 791, 10.1016/j.cellsig.2006.10.004 Allen, 2006, Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization, Int J Radiat Oncol Biol Phys, 65, 1544, 10.1016/j.ijrobp.2006.03.051 Bussink, 2008, Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer, Lancet Oncol, 9, 288, 10.1016/S1470-2045(08)70073-1 McKenna, 2003, The RAS signal transduction pathway and its role in radiation sensitivity, Oncogene, 22, 5866, 10.1038/sj.onc.1206699 King, 2006, AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3, Biochem Pharmacol, 71, 1637, 10.1016/j.bcp.2006.03.005 Bradbury, 2001, Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase, Cancer Res, 61, 7689 Kim, 2008, c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation, Mol Cancer Res, 6, 1872, 10.1158/1541-7786.MCR-08-0084 Han, 2009, Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition, J Cell Physiol, 218, 104, 10.1002/jcp.21573 Jung, 2004, 5-Aminoimidazole-4-carboxamide-ribonucleoside enhances oxidative stress-induced apoptosis through activation of nuclear factor-kappaB in mouse Neuro 2a neuroblastoma cells, Neurosci Lett, 354, 197, 10.1016/j.neulet.2003.10.012