5,10-Methylene-5,6,7,8-tetrahydrofolate conformational transitions upon binding to thymidylate synthase: molecular mechanics and continuum solvent studies

Adam Jarmuła1, Piotr Cieplak2, W.R. Montfort3
1Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
2Department of Chemistry, Warsaw University, 1 Pasteur St., Warszawa, 02-093, Poland
3Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, USA

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