5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain

Pain - Tập 117 - Trang 326-339 - 2005
S. Pathirathna1, S.M. Todorovic1, D.F. Covey2, V. Jevtovic-Todorovic1
1Department of Anesthesiology, University of Virginia Health System, P.O. Box 800710, Charlottesville, VA 22908, USA
2Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110 USA

Tài liệu tham khảo

Benedetti, 1998, Dose-response relationship of opioids in nociceptive and neuropathic postoperative pain., Pain, 74, 205, 10.1016/S0304-3959(97)00172-3 Bennett, 1988, A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man., Pain, 33, 87, 10.1016/0304-3959(88)90209-6 Benoit, 1988, Mechanism of action of a structural analog of alphaxalone on myelinated nerve fibre., Eur J Pharmacol, 158, 1, 10.1016/0014-2999(88)90246-4 Bourinet, 2005, Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception., EMBO J, 24, 315, 10.1038/sj.emboj.7600515 Cardenas, 1995, Variation in serotonergic inhibition of calcium channel currents in four types of rat sensory neurons differentiated by membrane properties., J Neurophysiol, 74, 1870, 10.1152/jn.1995.74.5.1870 Carlton, 1999, Peripheral GABA(A) receptors: evidence for peripheral primary afferent depolarization., Neuroscience, 93, 713, 10.1016/S0306-4522(99)00101-3 Chaplan, 1995, Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia., J Pharmacol Exp Ther, 269, 1117 Chaplan, 1997, Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat., J Pharmacol Exp Ther, 280, 829 Coderre, 1993, Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence., Pain, 52, 259, 10.1016/0304-3959(93)90161-H Crosby, 2000, The safety and efficacy of a single dose (500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer., J Pain Symptom Manag, 19, 35, 10.1016/S0885-3924(99)00135-9 Dellemijn, 1999, Are opioids effective in relieving neuropathic pain?, Pain, 80, 453, 10.1016/S0304-3959(98)00256-5 Dogrul, 2003, Reversal of experimental neuropathic pain by T-type calcium channel blockers., Pain, 105, 159, 10.1016/S0304-3959(03)00177-5 Gilron, 1996, Preemptive analgesic effects of steroid anesthesia with alphaxalone in the rat formalin test. Evidence for differential GABA (A) receptor modulation in persistent nociception., Anesthesiology, 84, 572, 10.1097/00000542-199603000-00013 Han, 1996, Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors., J Med Chem, 39, 4218, 10.1021/jm960304p Hargreaves, 1988, A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia., Pain, 32, 77, 10.1016/0304-3959(88)90026-7 Hwang, 1997, The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat., Pain, 70, 15, 10.1016/S0304-3959(96)03249-6 Inoue, 1986, Intracellular calcium ions decrease the affinity of the GABA receptor., Nature, 324, 156, 10.1038/324156a0 Jevtovic-Todorovic, 1998, Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects., Brain Res, 781, 202, 10.1016/S0006-8993(97)01247-X Jevtovic-Todorovic, 2003, Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats., Neuropharmacology, 44, 739, 10.1016/S0028-3908(03)00069-8 Jiang, 2003, Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18, 21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha, 5alpha)- and (3alpha, 5beta)-3-hydroxypregnan-20-one., J Med Chem, 46, 5334, 10.1021/jm030302m Kajander, 1992, Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons., J Neurophysiol, 68, 734, 10.1152/jn.1992.68.3.734 Kaneko, 1997, Role of spinal gamma-aminobutyric acid A receptors in formalin-induced nociception in the rat., J Pharmacol Exp Ther, 282, 928 Lambert, 1995, Neurosteroids and GABAA receptor function., Trends Pharmacol Sci, 16, 295, 10.1016/S0165-6147(00)89058-6 Lee, 1995, Analysis of drug interaction between intrathecal clonidine and MK-801 in peripheral neuropathic pain rat model., Anesthesiology, 82, 741, 10.1097/00000542-199503000-00016 Malan, 2002, Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain., Anesthesiology, 96, 1161, 10.1097/00000542-200205000-00020 Nakashima, 1998, The anesthetic steroid ()-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2 current in hippocampal and dorsal root ganglion neurons of the rat., Mol Pharmacol, 54, 559, 10.1124/mol.54.3.559 Oyelese, 1997, Differential effects of NGF and BDNF on axotomy-induced changes in GABA(A)-receptor-mediated conductance and sodium currents in cutaneous afferent neurons., J Neurophysiol, 78, 31, 10.1152/jn.1997.78.1.31 Pathirathna, 2005, New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids., Pain, 114, 429, 10.1016/j.pain.2005.01.009 Perez-Reyes, 2003, Molecular physiology of low-voltage-activated T-type calcium channels., Physiol Rev, 83, 117, 10.1152/physrev.00018.2002 Scroggs, 1992, Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size., J Physiol, 445, 639, 10.1113/jphysiol.1992.sp018944 Sear, 1996, Steroid anesthetics: old compounds, new drugs., J Clin Anesth, 8, 91S, 10.1016/S0952-8180(96)90021-5 Sokolova, 2001, Negative cross talk between anionic GABAA and cationic P2X ionotropic receptors of rat dorsal root ganglion neurons., J Neurosci, 21, 4958, 10.1523/JNEUROSCI.21-14-04958.2001 Talley, 1999, Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels., J Neurosci, 19, 1895, 10.1523/JNEUROSCI.19-06-01895.1999 Todorovic, 1998, Pharmacological properties of T-type Ca2 current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents., J Neurophysiol, 79, 240, 10.1152/jn.1998.79.1.240 Todorovic, 1998, Enantioselective blockade of T-type Ca2 current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity., Mol Pharmacol, 54, 918, 10.1124/mol.54.5.918 Todorovic, 2001, Redox modulation of T-type calcium channels in rat peripheral nociceptors., Neuron, 31, 75, 10.1016/S0896-6273(01)00338-5 Todorovic, 2004, Redox modulation of peripheral T-type Ca2 channels in vivo: alteration of nerve injury-induced thermal hyperalgesia., Pain, 109, 328, 10.1016/j.pain.2004.01.026 White, 1998, Effect of subcutaneous administration of calcium channel blockers on nerve injury-induced hyperalgesia., Brain Res, 801, 50, 10.1016/S0006-8993(98)00539-3 Yang, 2004, Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord., Eur J Neurosci, 19, 871, 10.1111/j.0953-816X.2004.03121.x Zorumski, 2000, Potential clinical uses of neuroactive steroids., Curr Opin Investig Drugs, 1, 360