4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats

Reproductive Toxicology - Tập 32 - Trang 26-32 - 2011
Laura E. Wright1, Jennifer B. Frye1, Ashley L. Lukefahr2, Samuel L. Marion2, Patricia B. Hoyer2, David G. Besselsen3, Janet L. Funk1
1Department of Medicine, The University of Arizona, 1656 E Mabel St., PO Box 245218, Tucson, AZ 85724, United States
2Department of Physiology, The University of Arizona, 1501 North Campbell Ave., PO Box 245051, Tucson, AZ 85724, United States
3University Animal Care, The University of Arizona, 1127 East Lowell St., PO Box 210101, Tucson, AZ 85721, United States

Tài liệu tham khảo

El-Wakeel, 2003, Systematic review of fibroadenoma as a risk factor for breast cancer, Breast, 12, 302, 10.1016/S0960-9776(03)00123-1 Glenn, 1959, A method of assay of antitumor activity using a rat mammary fibroadenoma, Endocrinology, 64, 379, 10.1210/endo-64-3-379 Huggins, 1956, Hormonal influences on mammary tumors of the rat. I. Acceleration of growth of transplanted fibroadenoma in ovariectomized and hypophysectomized rats, J Exp Med, 104, 525, 10.1084/jem.104.4.525 Durbin, 1966, Development of spontaneous mammary tumors over the life-span of the female Charles River (Sprague Dawley) rat: the influence of ovariectomy, thyroidectomy and adrenalectomy–ovariectomy, Cancer Res, 26, 400 Chandra, 1992, Spontaneous neoplasms in aged Sprague Dawley rats, Arch Toxicol, 66, 496, 10.1007/BF01970675 Brix, 2005, Incidences of selected lesions in control female Harlan Sprague Dawley rats from two-year studies performed by the National Toxicology Program, Toxicol Pathol, 33, 447, 10.1080/01926230590961836 Planas-Silva, 2008, Prevention of age-related spontaneous mammary tumors in outbred rats by late ovariectomy, Cancer Detect Prev, 32, 65, 10.1016/j.cdp.2008.01.004 LeFevre, 1988, Reproductive senescence in female rats: a longitudinal study of individual differences in estrous cycles and behavior, Biol Reprod, 38, 780, 10.1095/biolreprod38.4.780 Goldman, 2007, The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies, Birth Defects Res Part B: Dev Reprod Toxicol, 80, 84, 10.1002/bdrb.20106 Andersen, 1997, Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors, J Toxicol Environ Health, 52, 189, 10.1080/00984109708984060 National Toxicology Program, 1989 Hoyer, 2007, Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study, Birth Defects Res Part B: Dev Reprod Toxicol, 80, 113, 10.1002/bdrb.20103 Fernandez, 2008, Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats, Biol Reprod, 79, 318, 10.1095/biolreprod.108.067744 Mayer, 2004, The follicle-deplete mouse ovary produces androgen, Biol Reprod, 71, 130, 10.1095/biolreprod.103.016113 Wright, 2008, Comparison of the skeletal effects of ovariectomy versus chemically induced ovarian failure in mice, J Bone Miner Res, 23, 1296, 10.1359/jbmr.080309 Mayer, 2002, Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide, Reprod Toxicol, 16, 775, 10.1016/S0890-6238(02)00048-5 Xie, 1999, Sex hormone-induced mammary carcinogenesis in female Noble rats: the role of androgens, Carcinogenesis, 20, 1597, 10.1093/carcin/20.8.1597 Russo, 1978, Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[α]anthracene, J Natl Cancer Inst, 61, 1439 Funk, 2006, Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis, Arthritis Rheum, 54, 3452, 10.1002/art.22180 Maffini, 2008, Lack of c-kit receptor promotes mammary tumor in N-nitrosomethylurea-treated Ws/Ws rats, Cancer Cell Int, 8, 5, 10.1186/1475-2867-8-5 Ciocca, 1982, Endocrinologic milieu and susceptibility of the rat mammary gland to carcinogenesis, Am J Pathol, 109, 47 Shan, 2005, Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas, Toxicol Pathol, 33, 768, 10.1080/01926230500437027 Shull, 2007, The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis, Breast Dis, 28, 69, 10.3233/BD-2007-28108 Trichopoulos, 2008, Early life events and conditions and breast cancer risk: from epidemiology to etiology, Int J Cancer, 122, 481, 10.1002/ijc.23303 Fokerd, 2010, Influence of sex hormones on cancer progression, J Clin Oncol, 28, 4038, 10.1200/JCO.2009.27.4290 Thompson, 2000, Rat models of premalignant breast disease, J Mammary Gland Biol Neoplasia, 5, 409, 10.1023/A:1009582012493 Gear, 2007, Charles River Sprague Dawley rats lack early age-dependent susceptibility to DMBA-induced mammary carcinogenesis, Int J Biol Sci, 3, 408, 10.7150/ijbs.3.408 Medina, 2007, Chemical carcinogenesis of rat and mouse mammary glands, Breast Dis, 28, 63, 10.3233/BD-2007-28107 Russo, 1997, Role of differentiation in pathogenesis and prevention of breast cancer, Endocr Rel Cancer, 4, 7, 10.1677/erc.0.0040007 Currier, 2005, Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors, Toxicol Pathol, 33, 726, 10.1080/01926230500352226 Papacontantinon, 2006, Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[α]anthracene, Int J Cancer, 118, 17, 10.1002/ijc.21247 Natali, 1992, Expression of c-kit receptor in normal and transformed human nonlymphoid tissues, Cancer Res, 52, 6139 Natali, 1995, Transformation of thyroid epithelium is associated with loss of c-kit receptor, Cancer Res, 55, 1787 Tsuura, 1994, Preferential localization of c-kit product in tissue mast cells, basal cell of skin, epithelial cells of breast, small cell lung carcinoma, and siminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues, Virchows Arch, 424, 135, 10.1007/BF00193492 Natali, 1992, Breast cancer is associated with loss of the c-kit oncogene product, Int J Cancer, 52, 713, 10.1002/ijc.2910520508 Ko, 2003, The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium, Clin Exp Metastasis, 20, 593, 10.1023/A:1027323210736 Yared, 2004, Expression of c-kit proto-oncogene product in breast tissue, Breast J, 10, 323, 10.1111/j.1075-122X.2004.21351.x Ulivi, 2004, c-kit and SCF expression in normal and breast tissue, Breast Cancer Res Treat, 83, 33, 10.1023/B:BREA.0000010694.35023.9e