4-Hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity

Dupertuis, 2007, Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids, Curr Opin Clin Nutr Metab Care, 10, 427, 10.1097/MCO.0b013e3281e2c9d4 Law, 2000, Dietary fat and adult diseases and the implications for childhood nutrition: an epidemiologic approach, Am J Clin Nutr, 72, 3, 10.1093/ajcn/72.5.1291s Barrera, 2008, Lipid peroxidation: control of cell proliferation, cell differentiation and cell death, Mol Aspects Med, 29, 1, 10.1016/j.mam.2007.09.012 Eckl, 2003, Genotoxicity of HNE, Mol Aspects Med, 24, 161, 10.1016/S0098-2997(03)00010-4 Hu, 2002, The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma, Carcinogenesis, 23, 1781, 10.1093/carcin/23.11.1781 Leonarduzzi, 2004, Signaling kinases modulated by 4-hydroxynonenal, Free Radic Biol Med, 37, 1694, 10.1016/j.freeradbiomed.2004.08.027 Awasthi, 2008, Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death, Free Radic Biol Med, 45, 111, 10.1016/j.freeradbiomed.2008.04.007 Barrera, 1991, Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation, Exp Cell Res, 197, 148, 10.1016/0014-4827(91)90416-R Fazio, 1992, 4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells, Cancer Res, 52, 4866 Rinaldi, 2001, Growth inhibition and differentiation induction in murine erythroleukemia cells by 4-hydroxynonenal, Free Radic Res, 34, 629, 10.1080/10715760100300521 Barrera, 1994, Inhibition of c-myc expression induced by 4-hydroxynonenal, a product of lipid peroxidation, in the HL-60 human leukemic cell line, Biochem Biophys Res Commun, 203, 553, 10.1006/bbrc.1994.2218 Barrera, 1996, 4-hydroxynonenal specifically inhibits c-myc but does not affect c-fos expressions in HL-60 cells, Biochem Biophys Res Commun, 227, 589, 10.1006/bbrc.1996.1550 Pizzimenti, 1999, Inhibition of D1, D2, and A-cyclin expression in HL-60 cells by the lipid peroxydation product 4-hydroxynonenal, Free Radic Biol Med, 26, 1578, 10.1016/S0891-5849(99)00022-2 Barrera, 2002, U. 4-Hydroxynonenal affects pRb/E2F pathway in HL-60 human leukemic cells, Biochem Biophys Res Commun, 295, 267, 10.1016/S0006-291X(02)00649-6 Pizzimenti, 2002, Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation, Free Radic Biol Med, 32, 233, 10.1016/S0891-5849(01)00798-5 Laurora, 2005, 4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line, Free Radic Biol Med, 38, 215, 10.1016/j.freeradbiomed.2004.10.014 Matés, 2008, Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis, Arch Toxicol, 82, 273, 10.1007/s00204-008-0304-z Wang, 2008, Cancer cell killing via ROS: to increase or decrease, that is the question, Cancer Biol Ther, 7, 1875, 10.4161/cbt.7.12.7067 Chen, 2006, 4-hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects, IUBMB Life, 58, 372, 10.1080/15216540600686896 Uchida, 2003, 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress, Prog Lipid Res, 42, 318, 10.1016/S0163-7827(03)00014-6 Pizzimenti, 2006, 4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines, Free Radic Biol Med, 40, 1578, 10.1016/j.freeradbiomed.2005.12.024 Hiyama, 1995, Activation of telomerase in human lymphocytes and hematopoietic progenitor cells, J Immunol, 155, 3711, 10.4049/jimmunol.155.8.3711 Bodnar, 1998, Extension of Life-Span by Introduction of Telomerase into Normal Human Cells, Science, 279, 349, 10.1126/science.279.5349.349 Kim, 1994, Specific association of human telomerase activity with immortal cells and cancer, Science, 266, 2011, 10.1126/science.7605428 Bestilny, 1996, Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines, Cancer Res, 56, 3796 Xu, 1996, Suppression of telomerase activity in HL60 cells after treatment with differentiating agents, Leukemia, 10, 1354 Xu, 2001, Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells, Proc Natl Acad Sci. U. S. A., 98, 3826, 10.1073/pnas.071043198 Shay, 1997, A survey of telomerase activity in human cancer, Eur J Cancer, 33, 787, 10.1016/S0959-8049(97)00062-2 Gryfe, 1997, Molecular biology of colorectal cancer, Curr Probl Cancer, 21, 233, 10.1016/S0147-0272(97)80003-7 Kanamaru, 2002, Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer, Int J Mol Med, 10, 205 Boldrini, 2002, Evaluation of telomerase in the development and progression of colon cancer, Int J Oncol, 10, 589 Biasi, 2007, TGFB1 expression in colonic mucosa: modulation by dietary lipids, Genes Nutr, 2, 233, 10.1007/s12263-007-0053-2 Pierre, 2007, Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats, Carcinogenesis, 28, 321, 10.1093/carcin/bgl127 Esterbauer, 1991, Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes, Free Radic Biol Med, 11, 81, 10.1016/0891-5849(91)90192-6 Borras, 2004, Glutathione regulates telomerase activity in 3T3 fibroblasts, J Biol Chem, 279, 34332, 10.1074/jbc.M402425200 Kyo, 2000, Sp-1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT), Nucleic Acids Res, 28, 669, 10.1093/nar/28.3.669 Cong, 1999, The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter, Hum Mol Genet, 8, 137, 10.1093/hmg/8.1.137 Chantret, 1988, Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines, Cancer Res, 48, 1936 Gelmini, 1998, Rapid, quantitative nonisotopic assay for telomerase activity in human tumors, Clin Chem, 44, 2133, 10.1093/clinchem/44.10.2133 Owens, 1965, colorimetric micro-method for the determination of glutathione, Biochem J, 94, 75, 10.1042/bj0940705 Horikawa, 1999, Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene, Cancer Res, 59, 826 Kyo, 2008, Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers, Cancer Sci, 99, 1528, 10.1111/j.1349-7006.2008.00878.x Shagin, 2004, GFP-like proteins as ubiquitous metazoan superfamily: evolution of functional features and structural complexity, Mol Biol Evol, 21, 841, 10.1093/molbev/msh079 Cerbone, 2007, 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells, Free Radic Biol Med, 42, 1661, 10.1016/j.freeradbiomed.2007.02.009 Calonghi, 2002, Cytotoxic and cytostatic effects induces by 4-hydroxynonenal in human osteosarcoma cells, Biochem. Biophys Res Commun, 292, 1502, 10.1016/S0006-291X(02)00397-2 Ulaner, 2001, Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development, Int J Cancer, 91, 644, 10.1002/1097-0215(200002)9999:9999<::AID-IJC1103>3.0.CO;2-V Liu, 2001, Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation, J Immunol, 166, 4826, 10.4049/jimmunol.166.8.4826 Toogun, 2008, The hsp90 molecular chaperone modulates multiple telomerase activities, Mol Cell Biol, 28, 457, 10.1128/MCB.01417-07 Poole, 2001, Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT), Gene, 269, 1, 10.1016/S0378-1119(01)00440-1 Gunes, 2000, Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1, Cancer Res, 60, 2116 Bouwman, 2002, Regulation of the activity of Sp1-related transcription factors, Mol Cell Endocrinol, 195, 27, 10.1016/S0303-7207(02)00221-6 Spengler, 2008, Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation, Cell Cycle, 7, 623, 10.4161/cc.7.5.5402 Bollmann, 2008, The many faces of telomerase: emerging extratelomeric effects, Bioessays, 30, 728, 10.1002/bies.20793 Rahman, 2005, hTERT antagonizes p53-induced apoptosis independently of telomerase activity, Oncogene, 24, 1320, 10.1038/sj.onc.1208232 Lai, 2007, Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop, Exp Cell Res, 313, 322, 10.1016/j.yexcr.2006.10.014 Jagadeesh, 2006, Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1, Biochem Biophys Res Commun, 347, 774, 10.1016/j.bbrc.2006.06.172 Biasi, 2002, Associated changes of lipid peroxidation and transforming growth factor beta1 levels in human colon cancer during tumour progression, Gut, 50, 361, 10.1136/gut.50.3.361 Chiarpotto, 1997, Oxidative damage and transforming growth factor beta 1 expression in pretumoral and tumoral lesions of human intestine, Free Radic Biol Med, 22, 889, 10.1016/S0891-5849(96)00481-9