4 Animal models and in vitro models for the study of aetiopathogenesis of spondyloarthropathies

Aiko, 1995, Spontaneous intestinal inflammation and nitric oxide metabolism in HLA-B27 transgenic rats, Gastroenterology, 109, 142, 10.1016/0016-5085(95)90279-1 Bertrand V, Quere S, Guimbaud R et al (in press) Effects of murine recombinant IL-10 on the inflammatory disease of rats transgenic for HLA-B27 and human β2-microglobulin. European Cytokine Network. Boisgérault, 1996, Differences in endogenous peptides presented by HLA-B*2705 and B*2703 allelic variants. Implications for susceptibility to spondylarthropathies, 98, 2764 Braun, 1995, Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis, Arthritis and Rheumatism, 38, 499, 10.1002/art.1780380407 Breban, 1993, Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment, Journal of Experimental Medicine, 178, 1607, 10.1084/jem.178.5.1607 Breban, 1996, T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats, Journal of Immunology, 156, 794 Brewerton, 1973, Ankylosing spondylitis and HL-A 27, Lancet, i, 904, 10.1016/S0140-6736(73)91360-3 Burmester, 1996, Immunology of reactive arthritis, Annual Review of Immunology, 13, 229, 10.1146/annurev.iy.13.040195.001305 Christophers, 1989, Patient subgroups and the inflammatory pattern in psoriasis, Acta Dermato-Venereologica, 69, 88 Creamer, 1992, Measurement of HLA class I expression in ankylosing spondylitis, Annals of the Rheumatic Diseases, 51, 1138, 10.1136/ard.51.10.1138 Ebringer, 1978, Sequential studies in ankylosing spondylitis: association of Klebsiella pneumoniae with active disease, Annals of the Rheumatic Diseases, 37, 146, 10.1136/ard.37.2.146 Gaede, 1992, Experimental Yersinia enterocolitica infection in rats: analysis of the human response to plasmid-encoded antigens of arthritis-susceptible Lewis rats and arthritis-resistant Fischer rats, Medical Microbiology and Immunology, 181, 165, 10.1007/BF00202056 Hammer, 1990, Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: an animal model of HLA-B27-associated human disorders, Cell, 63, 1099, 10.1016/0092-8674(90)90512-D Hammer, 1995, High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease, Journal of Investigative Medicine, 43, 262 Hermann, 1993, HLA-CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis, Lancet, 342, 646, 10.1016/0140-6736(93)91760-J Hermann, 1995, Klebsiella pneumoniae-reactive T cells in blood and synovial fluid of patients with ankylosing spondylitis. Comparison with HLA-B27+ healthy control subjects in a limiting dilution study and determination of the specificity of synovial fluid T cell clones, Arthritis and Rheumatism, 38, 1277, 10.1002/art.1780380916 Hermann, 1995, Synovial fluid MHC-unrestricted γδ T lymphocytes contribute to antibacterial and anti-self cytotoxicity in the spondylarthropathies, Clinical and Experimental Rheumatology, 13, 187 Hill, 1987, Development of an experimental model for reactive arthritis by Yersinia enterocolitica infection, Infection and Immunity, 5, 721, 10.1128/IAI.55.3.721-726.1987 Hocini, 1991, Increased levels of serum IgA as IgGA1 monomers in ankylosing spondylitis, Annals of the Rheumatic Diseases, 50, 790 Huppertz, 1996, The influence of HLA-B27 and interferon-γ on the invasion and persistence of yersinia in primary human fibroblasts, Medical Microbiology and Immunology, 185, 163, 10.1007/s004300050027 Ikawa, 1998, Expression of arthritis-causing HLA-B27 on Hela cells promotes induction of c-fos in response to in vitro invasion by Salmonella typhimurium, Journal of Clinical Investigation, 101, 263, 10.1172/JCI471 Ismail, 1994, Persistence and dissemination of Yersinia enterocolitica (Ye) 0:8 after intragastric challenge in B27-transgenic mice, Arthritis and Rheumatism, 37, S211 Kahn, 1979, Ankylosing spondylitis and multiple sclerosis: a possible association, Arthritis and Rheumatism, 22, 784, 10.1002/art.1780220716 Kapasi, 1992, HLA-B27 expression modulates invasion by gram-negative bacteria into transfected L cells, Journal of Immunology, 148, 3554 Kapasi, 1994, ME1 epitope of HLA-B27 confers class I-mediated modulation of gram-negative bacterial invasion, Journal of Immunology, 153, 833 Khare, 1995, Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking β2-microglobulin: a model of human spondylarthropathies, Journal of Experimental Medicine, 182, 1153, 10.1084/jem.182.4.1153 Khare, 1996, HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human β2-microglobulin (β2m) transgenic mice with disrupted mouse β2m, Journal of Clinical Investigation, 98, 2746, 10.1172/JCI119100 Khare, 1998, Spontaneous inflammatory disease in HLA-B27 transgenic mice is independent of MHC class II molecules: a direct role for B27 heavy chains and not B27-derived peptides, Journal of Immunology, 160, 101 Krimpenfort, 1987, Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA-B27) and light (β2-microglobulin) chains of HLA class I antigens, EMBO Journal, 6, 1673, 10.1002/j.1460-2075.1987.tb02416.x Kuon, 1997, Recognition of chlamydial antigen by HLA-B27-restricted cytotoxic T cells in HLA-B*2705 transgenic CBA (H-2k) mice, Arthritis and Rheumatism, 40, 945, 10.1002/art.1780400524 Liatio, 1997, HLA-B27 modulates intracellular survival of Salmonella enteritidis in human monocytic cells, European Journal of Immunology, 27, 1331, 10.1002/eji.1830270606 Lundin, 1997, Intestinal inflammation and barrier function in HLA-B27/β2-microglobulin transgenic rats, Scandinavian Journal of Gastroenterology, 32, 700, 10.3109/00365529708996521 Luthra, 1990, HLA-B27 and arthritis, 259 McLean, 1997, Cytokine profiles and site-directed B27 mutation in the HLA-B27 transgenic rat, 656 Mallas, 1976, Histocompatibility antigens in inflammatory bowel disease: their clinical significance and their association with arthropathy with special reference to HLA-B27 (W27), Gut, 17, 906, 10.1136/gut.17.11.906 Märker-Hermann, 1997, HLA-B27-derived peptides as autoantigens for T lymphocytes in ankylosing spondylitis, Arthritis and Rheumatism, 40, 2047, 10.1002/art.1780401118 Mertz, 1991, Cationic Yersinia-induced chronic allergic arthritis in rats: a model for reactive arthritis in humans, Journal of Clinical Investigation, 88, 632, 10.1172/JCI115348 Mertz, 1998, Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis, Arthritis and Rheumatism, 41, 315, 10.1002/1529-0131(199802)41:2<315::AID-ART16>3.0.CO;2-# Nickerson, 1990, Susceptibility of HLA-B27 transgenic mice to Yersinia entrocolitica infection, Human Immunology, 28, 382, 10.1016/0198-8859(90)90033-L Nuki, 1998, Ankylosing spondylitis, HLA B27, and beyond, Lancet, 351, 767, 10.1016/S0140-6736(05)78922-4 Podolsky, 1991, Inflammatory bowel disease (Part 1), New England Journal of Medicine, 325, 928, 10.1056/NEJM199109263251306 Podolsky, 1991, Inflammatory bowel disease (Part 2), New England Journal of Medicine, 325, 1008, 10.1056/NEJM199110033251406 Rath, 1995, Metronidazole attenuates colitis in HLA-B27/hβ2 microglobulin transgenic rats: a pathogenic role for anaerobic bacteria, Clinical Immunology and Immunopathology, 76, S45 Rath, 1996, Normal luminal bacteria, especially Bacteroides species, mediates chronic colitis, gastritis, and arthritis in HLA-B27/human β2 micro-globulin transgenic rats, Journal of Clinical Investigation, 98, 945, 10.1172/JCI118878 Scofield, 1993, A hypothesis for the HLA-B27 immune dysregulation in spondylarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution, 90, 9330 Scofield, 1995, HLA-B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondylarthropathies, Lancet, 345, 1542, 10.1016/S0140-6736(95)91089-1 Simmons, 1993, Sharing of an HLA-B27-restricted H-Y antigen between rat and mouse, Immunogenetics, 38, 351, 10.1007/BF00210477 Simmons, 1996, Rat MHC-linked peptide transporter alleles srongly influence peptide binding to HLA-B27 but not B27-associated inflammatory disease, Journal of Immunology, 156, 1661 Simmons, 1997, Novel HY peptide antigen presented by HLA-B27, Journal of Immunology, 159, 2750 Simon, 1994, Divergent T-cell cytokine patterns in inflammatory arthritis, 91, 8562 Stagg, 1995, Defective dendritic cell function in a HLA-B27 transgenic rat model of spondyloarthropathy, Advances in Experimental Medicine and Biology, 378, 557, 10.1007/978-1-4615-1971-3_125 Stagg, 1996, Antigen-presenting cells but not lymphocytes in the joints may indicate the cause of reactive arthritis, British Journal of Rheumatology, 35, 1082, 10.1093/rheumatology/35.11.1082 Starnbach, 1994, Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis, Journal of Immunology, 153, 5183 Stichtenoth, 1995, Elevated serum nitrate concentrations in active spondylarthropathies, British Journal of Rheumatology, 34, 616, 10.1093/rheumatology/34.7.616 Suarez-Almazor, 1987, B27 homozygosity and ankylosing spondylitis, Journal of Rheumatology, 14, 302 Taurog, 1998, Animal models of the spondyloarthropathies, 223 Taurog, 1998, HLA-B27 subtypes, disease susceptibility, and peptide binding specificity, 267 Taurog, 1988, HLA-B27 in inbred and non-inbred transgenic mice. Cell surface expression and recognition as an alloantigen in the absence of human β2-microglobulin, Journal of Immunology, 141, 4020 Taurog, 1990, HLA-B27 transgenic mice as potential models of human disease, 268 Taurog, 1993, Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of expression of B27, Journal of Immunology, 150, 4168 Taurog, 1994, The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats, Journal of Experimental Medicine, 180, 2359, 10.1084/jem.180.6.2359 Toivanen, 1985, Pathogenesis of Yersinia-triggered reactive arthritis: immunological, microbiological and clinical aspects, Immunological Reviews, 86, 47, 10.1111/j.1600-065X.1985.tb01137.x Ugrinovic, 1997, A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis, Journal of Immunology, 159, 5715 Veys, 1973, Serum IgG, IgM, and IgA levels in ankylosing spondylitis, Annals of the Rheumatic Diseases, 32, 493, 10.1136/ard.32.6.493 Virtala, 1997, HLA-B27 modulates the survival of Salmonella entritidis in transfected L cells possibly by impaired nitric oxide production, Infection and Immunity, 65, 4236, 10.1128/IAI.65.10.4236-4242.1997 de Vries, 1992, Absence of autoantibodies to peptides shared by HLA-B27.5 and Klebsiella pneumoniae nitrogenase in serum samples from HLA-B27 positive patients with ankylosing spondylitis and Reiter's syndrome, Annals of the Rheumatic Diseases, 51, 783, 10.1136/ard.51.6.783 Warner, 1996, Human HLA-B27 gene enhances susceptibility of rats to oral infection by Listeria monocytogenes, American Journal of Pathology, 149, 1737 Weinreich, 1995, HLA-B27 as a relative risk factor in ankylosing enthesopathy in transgenic mice, Human Immunology, 42, 103, 10.1016/0198-8859(94)00034-N Weiss, 1990, Copy number and the presence of human β2-microglobulin control cell surface expression of HLA-B27 antigen in trangenic mice with a 27 kb B27 gene fragment, 205 Yin, 1997, Crucial role of interleukin-10/interleukin-12 balance in the regulation of type 2 T helper cytokine response in reactive arthritis, Arthritis and Rheumatism, 40, 1788, 10.1002/art.1780401010 Zhang, 1997, Experimental Yersinia-triggered reactive arthritis: effect of a 3-week course of ciprofloxacin, British Journal of Rheumatology, 36, 541, 10.1093/rheumatology/36.5.541 Zhou, 1997, Peptide blockade of HLA-B27 affects disease manifestations in transgenic rats, Arthritis and Rheumatism, 40, S172