3D-printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect

Laurencin, 2006, Bone graft substitutes, Expet Rev. Med. Dev., 3, 49, 10.1586/17434440.3.1.49 Woodruff, 2012, Bone tissue engineering: from bench to bedside, Mater. Today, 15, 430, 10.1016/S1369-7021(12)70194-3 Zeiter, 2020, Evaluation of preclinical models for the testing of bone tissue-engineered constructs, Tissue Eng. C Methods, 26, 107, 10.1089/ten.tec.2019.0213 Oryan, 2014, Bone regenerative medicine: classic options, novel strategies, and future directions, J. Orthop. Surg. Res., 9, 18, 10.1186/1749-799X-9-18 Reichert, 2012, A tissue engineering solution for segmental defect regeneration in load-bearing long bones, Sci. Transl. Med., 4, 141ra93, 10.1126/scitranslmed.3003720 Tan, 2017, Metallic powder-bed based 3D printing of cellular scaffolds for orthopaedic implants: a state-of-the-art review on manufacturing, topological design, mechanical properties and biocompatibility, Mater Sci Eng C Mater Biol Appl, 76, 1328, 10.1016/j.msec.2017.02.094 Sheikh, 2015, Biodegradable materials for bone repair and tissue engineering applications, Materials, 8, 5744, 10.3390/ma8095273 Cheng, 2019, Advances in porous scaffold design for bone and cartilage tissue engineering and regeneration, Tissue Eng. B Rev., 25, 14, 10.1089/ten.teb.2018.0119 Ricles, 2018, Regulating 3D-printed medical products, Sci. Transl. Med., 10, 10.1126/scitranslmed.aan6521 Youssef, 2017, Additive manufacturing of polymer melts for implantable medical devices and scaffolds, Biofabrication, 9, 10.1088/1758-5090/aa5766 Liang, 2019, Structural mechanics of 3D-printed poly(lactic acid) scaffolds with tetragonal, hexagonal and wheel-like designs, Biofabrication, 11, 10.1088/1758-5090/ab0f59 Cipitria, 2013, Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae, Biomaterials, 34, 9960, 10.1016/j.biomaterials.2013.09.011 Brennan, 2014, Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate, Stem Cell Res. Ther., 5, 114, 10.1186/scrt504 Urist, 1965, Bone - formation by autoinduction, Science, 150, 10.1126/science.150.3698.893 Santo, 2013, Controlled release strategies for bone, cartilage, and osteochondral engineering--Part II: challenges on the evolution from single to multiple bioactive factor delivery, Tissue Eng. B Rev., 19, 327, 10.1089/ten.teb.2012.0727 Zara, 2011, High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo, Tissue Eng., 17, 1389, 10.1089/ten.tea.2010.0555 James, 2016, A review of the clinical side effects of bone morphogenetic protein-2, Tissue Eng. B Rev., 22, 284, 10.1089/ten.teb.2015.0357 Seeherman, 2019, A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix, Sci. Transl. Med., 11, 10.1126/scitranslmed.aar4953 King, 2012, Growth factor delivery: how surface interactions modulate release in vitro and in vivo, Adv. Drug Deliv. Rev., 64, 1239, 10.1016/j.addr.2012.03.004 Migliorini, 2016, Tuning cellular responses to BMP-2 with material surfaces, Cytokine Growth Factor Rev., 27, 43, 10.1016/j.cytogfr.2015.11.008 Bouyer, 2016, Surface delivery of tunable doses of BMP-2 from an adaptable polymeric scaffold induces volumetric bone regeneration, Biomaterials, 104, 168, 10.1016/j.biomaterials.2016.06.001 McGovern, 2018, Animal models for bone tissue engineering and modelling disease, Disease models & mechanisms, 11, 10.1242/dmm.033084 Crouzier, 2011, Presentation of BMP-2 from a soft biopolymeric film unveils its activity on cell adhesion and migration, Adv. Mater., 23, H111, 10.1002/adma.201004637 Crouzier, 2009, Layer-by-Layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts, Small, 5, 598, 10.1002/smll.200800804 Guillot, 2013, The stability of BMP loaded polyelectrolyte multilayer coatings on titanium, Biomaterials, 34, 5737, 10.1016/j.biomaterials.2013.03.067 Crouzier, 2011, The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating, Biomaterials, 32, 7543, 10.1016/j.biomaterials.2011.06.062 Kunert-Keil, 2019, Histological comparison between laser microtome sections and ground specimens of implant-containing tissues, Ann. Anat., 222, 153, 10.1016/j.aanat.2018.12.001 Stembirek, 2012, The pig as an experimental model for clinical craniofacial research, Lab. Anim, 46, 269, 10.1258/la.2012.012062 Saka, 2002, Experimental and comparative study of the blood supply to the mandibular cortex in Gottingen minipigs and in man, J. Cranio-Maxillo-Fac. Surg., 30, 219, 10.1054/jcms.2002.0305 Sun, 2014, Establishing a critical-size mandibular defect model in growing pigs: characterization of spontaneous healing, J. Oral Maxillofac. Surg., 72, 1852, 10.1016/j.joms.2014.02.024 Ma, 2009, Determination of critical size defect of minipig mandible, J Tissue Eng Regen Med, 3, 615, 10.1002/term.203 Probst, 2020, Bone regeneration of minipig mandibular defect by adipose derived mesenchymal stem cells seeded tri-calcium phosphate- poly(D,L-lactide-co-glycolide) scaffolds, Sci. Rep., 10, 2062, 10.1038/s41598-020-59038-8 Hutmacher, 2000, Scaffolds in tissue engineering bone and cartilage, Biomaterials, 21, 2529, 10.1016/S0142-9612(00)00121-6 Cipitria, 2012, Porous scaffold architecture guides tissue formation, J. Bone Miner. Res., 27, 1275, 10.1002/jbmr.1589 Cipitria, 2015, BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: a multiscale analysis, Acta Biomater., 23, 282, 10.1016/j.actbio.2015.05.015 Bergsma, 1995, Late degradation tissue response to poly(L-lactide) bone plates and screws, Biomaterials, 16, 25, 10.1016/0142-9612(95)91092-D Garot, 2020, Additive manufacturing of material Scaffolds for bone regeneration: toward application in the clinics, Adv. Funct. Mater., 2006967 Kuterbekov, 2018, Solvent-free preparation of porous poly(l-lactide) microcarriers for cell culture, Acta Biomater., 75, 300, 10.1016/j.actbio.2018.06.009 Farah, 2016, Physical and mechanical properties of PLA, and their functions in widespread applications - a comprehensive review, Adv. Drug Deliv. Rev., 107, 367, 10.1016/j.addr.2016.06.012 Boerckel, 2011, Effects of protein dose and delivery system on BMP-mediated bone regeneration, Biomaterials, 32, 5241, 10.1016/j.biomaterials.2011.03.063 Boden, 2002, Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies, Spine, 27, 2662, 10.1097/00007632-200212010-00005 Kamal, 2019, Various dosages of BMP-2 for management of massive bone defect in Sprague Dawley rat, Arch Bone Jt Surg, 7, 498 Durham, 2018, Optimizing bone wound healing using BMP2 with absorbable collagen sponge and Talymed nanofiber scaffold, J. Transl. Med., 16, 321, 10.1186/s12967-018-1697-y Sun, 2012, BMP2/7 heterodimer is a stronger inducer of bone regeneration in peri-implant bone defects model than BMP2 or BMP7 homodimer, Dent. Mater. J., 31, 239, 10.4012/dmj.2011-191 Wang, 2012, Low-dose rhBMP2/7 heterodimer to reconstruct peri-implant bone defects: a micro-CT evaluation, J. Clin. Periodontol., 39, 98, 10.1111/j.1600-051X.2011.01807.x Pelletier, 2014, Lumbar spinal fusion with beta-TCP granules and variable Escherichia coli-derived rhBMP-2 dose, Spine J., 14, 1758, 10.1016/j.spinee.2014.01.043 Hoshino, 2006, Repair of long intercalated rib defects using porous beta-tricalcium phosphate cylinders containing recombinant human bone morphogenetic protein-2 in dogs, Biomaterials, 27, 4934, 10.1016/j.biomaterials.2006.04.044 Guillot, 2016, Assessment of a polyelectrolyte multilayer film coating loaded with BMP-2 on titanium and PEEK implants in the rabbit femoral condyle, Acta Biomater., 36, 310, 10.1016/j.actbio.2016.03.010 Gilde, 2016, Stiffness-dependent cellular internalization of matrix-bound BMP-2 and its relation to Smad and non-Smad signaling, Acta Biomater., 46, 55, 10.1016/j.actbio.2016.09.014