3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications

2000, High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery, Annu. Rev. Pharmacol. Toxicol., 40, 133, 10.1146/annurev.pharmtox.40.1.133

2015, Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro, Ann. Biomed. Eng., 43, 2361, 10.1007/s10439-015-1298-3

2011, High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array, Analyst, 136, 473, 10.1039/C0AN00609B

2013, Three-dimensional cell culture: The missing link in drug discovery, Drug Discovery Today, 18, 240, 10.1016/j.drudis.2012.10.003

2007, Origin and evolution of high throughput screening, Br. J. Pharmacol., 152, 53, 10.1038/sj.bjp.0707373

2010, Predictors of a true complete response among disappearing liver metastases from colorectal cancer after chemotherapy, Cancer, 116, 1502, 10.1002/cncr.24912

2018, Applications of bioengineered 3D tissue and tumor organoids in drug development and precision medicine: Current and future, BioDrugs, 32, 53, 10.1007/s40259-017-0258-x

2007, The third dimension bridges the gap between cell culture and live tissue, Nat. Rev. Mol. Cell Biol., 8, 839, 10.1038/nrm2236

2016, Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling, Drug Discovery Today, 21, 1399, 10.1016/j.drudis.2016.07.003

2013, Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines, PLoS One, 8, e59689, 10.1371/journal.pone.0059689

2013, Multi-cell type human liver microtissues for hepatotoxicity testing, Arch. Toxicol., 87, 209, 10.1007/s00204-012-0968-2

2014, Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments, Adv. Drug Delivery Rev., 69–70, 1, 10.1016/j.addr.2014.02.008

2017, Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy, Biofabrication, 9, 021002, 10.1088/1758-5090/aa7484

2010, Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells, Biomaterials, 31, 8494, 10.1016/j.biomaterials.2010.07.064

2006, Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures, Biomaterials, 27, 5259, 10.1016/j.biomaterials.2006.05.044

2012, Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions, Biomaterials, 33, 8304, 10.1016/j.biomaterials.2012.07.068

2012, Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function, Biomaterials, 33, 4565, 10.1016/j.biomaterials.2012.03.034

2013, The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination, Biomaterials, 34, 9486, 10.1016/j.biomaterials.2013.08.077

2009, Complexity in biomaterials for tissue engineering, Nat. Mater., 8, 457, 10.1038/nmat2441

2009, Hydrogels as extracellular matrix mimics for 3D cell culture, Biotechnol. Bioeng., 103, 655, 10.1002/bit.22361

2017, Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform, Sci. Rep., 7, 8837, 10.1038/s41598-017-08879-x

2014, 3D bioprinting of tissues and organs, Nat. Biotechnol., 32, 773, 10.1038/nbt.2958

2006, Review: Bioprinting: A beginning, Tissue Eng., 12, 631, 10.1089/ten.2006.12.631

2016, A 3D bioprinting system to produce human-scale tissue constructs with structural integrity, Nat. Biotechnol., 34, 312, 10.1038/nbt.3413

2015, Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering, Sensors(Basel), 15, 31142, 10.3390/s151229848

2015, Dynamic phototuning of 3D hydrogel stiffness, Proc. Natl. Acad. Sci. U. S. A., 112, 1953, 10.1073/pnas.1421897112

2018, Advanced development of primary pancreatic organoid tumor models for high-throughput phenotypic drug screening, SLAS Discovery, 23, 574, 10.1177/2472555218766842

2013, High-throughput printing via microvascular multinozzle arrays, Adv. Mater., 25, 96, 10.1002/adma.201203321

2011, A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform, Biotechnol. J., 6, 204, 10.1002/biot.201000340

2013, Laser assisted cell printing, Curr. Pharm. Biotechnol., 14, 91, 10.2174/138920113804805368

2010, High-throughput laser printing of cells and biomaterials for tissue engineering, Acta Biomater., 6, 2494, 10.1016/j.actbio.2009.09.029

2010, Laser-assisted cell printing: Principle, physical parameters versus cell fate and perspectives in tissue engineering, Nanomedicine (London), 5, 507, 10.2217/nnm.10.14

2016, Drop-on-demand inkjet-based cell printing with 30-μm nozzle diameter for cell-level accuracy, Biomicrofluidics, 10, 064110, 10.1063/1.4968845

2017, Rapid continuous multimaterial extrusion bioprinting, Adv. Mater., 29, 1604630, 10.1002/adma.201604630

2015, A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs, Acta Biomater., 25, 24, 10.1016/j.actbio.2015.07.030

2016, Current advances and future perspectives in extrusion-based bioprinting, Biomaterials, 76, 321, 10.1016/j.biomaterials.2015.10.076

2014, Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels, Biofabrication, 6, 024105, 10.1088/1758-5082/6/2/024105

2016, Microfluidic bioprinting of heterogeneous 3D tissue constructs using low-viscosity bioink, Adv. Mater., 28, 677, 10.1002/adma.201503310

2015, A novel bioprinting method and system for forming hybrid tissue engineering constructs, Biofabrication, 7, 045008, 10.1088/1758-5090/7/4/045008

2013, Cellular behavior in micropatterned hydrogels by bioprinting system depended on the cell types and cellular interaction, J. Biosci. Bioeng., 116, 224, 10.1016/j.jbiosc.2013.02.011

2015, Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels, Sci. Adv., 1, e1500758, 10.1126/sciadv.1500758

2018, Engineering innervated secretory epithelial organoids by magnetic three-dimensional bioprinting for stimulating epithelial growth in salivary glands, Biomaterials, 180, 52, 10.1016/j.biomaterials.2018.06.011

2018, 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling, Adv. Drug Delivery Rev., 132, 235, 10.1016/j.addr.2018.06.011

2015, Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer, Oncol. Rep., 33, 1837, 10.3892/or.2015.3767

2014, A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies, Arch. Toxicol., 88, 1083, 10.1007/s00204-014-1215-9

2016, A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening, Biotechnol. Bioeng., 113, 2020, 10.1002/bit.25950

2014, A three-dimensional human neural cell culture model of Alzheimer's disease, Nature, 515, 274, 10.1038/nature13800

2009, 3D cell culture opens new dimensions in cell-based assays, Drug Discovery Today, 14, 102, 10.1016/j.drudis.2008.11.006

2011, Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer, Dis. Models Mech., 4, 165, 10.1242/dmm.004077

2007, Engineering the stem cell microenvironment, Biotechnol. Prog., 23, 18, 10.1021/bp060350a

2015, Modes of cancer cell invasion and the role of the microenvironment, Curr. Opin. Cell Biol., 36, 13, 10.1016/j.ceb.2015.06.004

2011, From 3D cell culture to organs-on-chips, Trends Cell Biol., 21, 745, 10.1016/j.tcb.2011.09.005

2015, Hydrogel: Preparation, characterization, and applications: A review, J. Adv. Res., 6, 105, 10.1016/j.jare.2013.07.006

2016, Bioink properties before, during and after 3D bioprinting, Biofabrication, 8, 032002, 10.1088/1758-5090/8/3/032002

2017, The bioink: A comprehensive review on bioprintable materials, Biotechnol. Adv., 35, 217, 10.1016/j.biotechadv.2016.12.006

2013, Evaluation of hydrogels for bio-printing applications, J. Biomed. Mater. Res., Part A, 101, 272, 10.1002/jbm.a.34326

2015, Biomaterials for integration with 3-D bioprinting, Ann. Biomed. Eng., 43, 730, 10.1007/s10439-014-1207-1

2015, To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices, Tissue Eng., Part B, 21, 298, 10.1089/ten.teb.2014.0290

2017, A generalizable strategy for the 3D bioprinting of hydrogels from nonviscous photo-crosslinkable inks, Adv. Mater., 29, 1604983, 10.1002/adma.201604983

2011, Elucidating the role of matrix stiffness in 3D cell migration and remodeling, Biophys. J., 100, 284, 10.1016/j.bpj.2010.11.082

2016, Advanced bioinks for 3D printing: A materials science perspective, Ann. Biomed. Eng., 44, 2090, 10.1007/s10439-016-1638-y

2017, Synthetic hydrogels for human intestinal organoid generation and colonic wound repair, Nat. Cell Biol., 19, 1326, 10.1038/ncb3632

2018, RGD-functionalized polyethylene glycol hydrogels support proliferation and in vitro chondrogenesis of human periosteum-derived cells, J. Biomed. Mater. Res., Part A, 106, 33, 10.1002/jbm.a.36208

2015, Peptide hydrogels - Versatile matrices for 3D cell culture in cancer medicine, Front. Oncol., 5, 92, 10.3389/fonc.2015.00092

2010, Reconstituting organ-level lung functions on a chip, Science, 328, 1662, 10.1126/science.1188302

2012, Microengineered physiological biomimicry: Organs-on-chips, Lab Chip, 12, 2156, 10.1039/c2lc40089h

2014, Physiologically relevant organs on chips, Biotechnol. J., 9, 16, 10.1002/biot.201300187

2009, The extracellular matrix: Not just pretty fibrils, Science, 326, 1216, 10.1126/science.1176009

2014, Remodelling the extracellular matrix in development and disease, Nat. Rev. Mol. Cell Biol., 15, 786, 10.1038/nrm3904

2014, Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink, Nat. Commun., 5, 3935, 10.1038/ncomms4935

2016, Bioprinting cellularized constructs using a tissue-specific hydrogel bioink, J. Visualized Exp., 110, e53606, 10.3791/53606

2007, Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands, Biophys. J., 92, 2964, 10.1529/biophysj.106.089730

2005, Differential regulation of osteoblasts by substrate microstructural features, Biomaterials, 26, 1837, 10.1016/j.biomaterials.2004.06.035

2009, Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D, J. Biomech., 42, 1114, 10.1016/j.jbiomech.2009.02.012

2006, Matrix elasticity directs stem cell lineage specification, Cell, 126, 677, 10.1016/j.cell.2006.06.044

2014, Interplay of matrix stiffness and protein tethering in stem cell differentiation, Nat. Mater., 13, 979, 10.1038/nmat4051

2011, The role of body-on-a-chip devices in drug and toxicity studies, Annu. Rev. Biomed. Eng., 13, 55, 10.1146/annurev-bioeng-071910-124629

2000, Lab-on-a-chip: A revolution in biological and medical sciences, Anal. Chem., 72, 330A, 10.1021/ac002800y

2012, Drug discovery in pharmaceutical industry: Productivity challenges and trends, Drug Discovery Today, 17, 1088, 10.1016/j.drudis.2012.05.007

2013, A high-throughput three-dimensional cell migration assay for toxicity screening with mobile device-based macroscopic image analysis, Sci. Rep., 3, 3000, 10.1038/srep03000

2016, miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer, Oncotarget, 7, 25930, 10.18632/oncotarget.8412

2017, Drug metabolism in the liver, Clin. Liver Dis., 21, 1, 10.1016/j.cld.2016.08.001

2006, Human hepatocyte transplantation: Worldwide results, Transplantation, 82, 441, 10.1097/01.tp.0000231689.44266.ac

2014, In vitro platforms for evaluating liver toxicity, Exp. Biol. Med. (Maywood), 239, 1180, 10.1177/1535370214531872

2016, Bioprinted 3D primary liver tissues allow assessment of organ-level response to clinical drug induced toxicity in vitro, PLoS One, 11, e0158674, 10.1371/journal.pone.0158674

2015, Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D, Biofabrication, 7, 044102, 10.1088/1758-5090/7/4/044102

2016, Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting, Proc. Natl. Acad. Sci. U. S. A., 113, 2206, 10.1073/pnas.1524510113

2014, Light-assisted direct-write of 3D functional biomaterials, Lab Chip, 14, 268, 10.1039/C3LC50634G

2017, Three-dimensional bio-printing: A new frontier in oncology research, World J. Clin. Oncol., 8, 21, 10.5306/wjco.v8.i1.21

2015, 3-Dimensional bioprinting makes its mark: New tissue and organ printing methods are yielding critical new tools for the laboratory and clinic, Cancer Cytopathol., 123, 203, 10.1002/cncy.21543

2017, 3D bioprinting for drug discovery and development in pharmaceutics, Acta Biomater., 57, 26, 10.1016/j.actbio.2017.05.025

2015, Precision medicine for cancer with next-generation functional diagnostics, Nat. Rev. Cancer, 15, 747, 10.1038/nrc4015

2015, Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases, Proc. Natl. Acad. Sci. U. S. A., 112, 13308, 10.1073/pnas.1516689112

2018, In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening, Sci. Rep., 8, 2886, 10.1038/s41598-018-21200-8

2015, A new initiative on precision medicine, N. Engl. J. Med., 372, 793, 10.1056/NEJMp1500523

2015, Precision medicine–personalized, problematic, and promising, N. Engl. J. Med., 372, 2229, 10.1056/NEJMsb1503104

2013, Next-generation regenerative medicine: Organogenesis from stem cells in 3D culture, Cell Stem Cell, 12, 520, 10.1016/j.stem.2013.04.009

2011, Harnessing the potential of induced pluripotent stem cells for regenerative medicine, Nat. Cell Biol., 13, 497, 10.1038/ncb0511-497

2007, Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens, Circulation, 115, 896, 10.1161/CIRCULATIONAHA.106.655209

2017, Human periosteal-derived cell expansion in a perfusion bioreactor system: Proliferation, differentiation and extracellular matrix formation, J. Tissue Eng. Regener. Med., 11, 519, 10.1002/term.1951

2017, Optimizing human induced pluripotent stem cell expansion in stirred-suspension culture, Stem Cells Dev., 26, 1804, 10.1089/scd.2017.0090

2011, Scalable expansion of human pluripotent stem cells in suspension culture, Nat. Protoc., 6, 689, 10.1038/nprot.2011.318