3D-Printed Scaffolds Promote Angiogenesis by Recruiting Antigen-Specific T Cells

Keating, 2005, The management of fractures with bone loss, J Bone Joint Surg Br, 87-B, 142, 10.1302/0301-620X.87B2.15874 Zhang, 2019, Three-dimensional (3D) printed scaffold and material selection for bone repair, Acta Biomater, 84, 16, 10.1016/j.actbio.2018.11.039 Wang, 2018, The effect of 3D-printed Ti6Al4V scaffolds with various macropore structures on osteointegration and osteogenesis: a biomechanical evaluation, J Mech Behav Biomed Mater, 88, 488, 10.1016/j.jmbbm.2018.08.049 Du, 2020, A systematic approach for making 3D-printed patient-specific implants for craniomaxillofacial reconstruction, Engineering, 6, 1291, 10.1016/j.eng.2020.02.019 Hao, 2020, 3D printing hip prostheses offer accurate reconstruction, stable fixation, and functional recovery for revision total hip arthroplasty with complex acetabular bone defect, Engineering, 6, 1285, 10.1016/j.eng.2020.04.013 Wang, 2020, 3D printing of cell-container-like scaffolds for multicell tissue engineering, Engineering, 6, 1276, 10.1016/j.eng.2020.08.001 Raisian, 2017, Customized titanium mesh based on the 3D printed model vs. manual intraoperative bending of titanium mesh for reconstructing of orbital bone fracture: a randomized clinical trial, Rev Recent Clin Trials, 12, 154, 10.2174/1574887112666170821165206 Laschke, 2006, Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes, Tissue Eng, 12, 2093, 10.1089/ten.2006.12.2093 Rouwkema, 2008, Vascularization in tissue engineering, Trends Biotechnol, 26, 434, 10.1016/j.tibtech.2008.04.009 Stegen, 2015, Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration, Bone, 70, 19, 10.1016/j.bone.2014.09.017 Kanczler, 2008, Osteogenesis and angiogenesis: the potential for engineering bone, Eur Cell Mater, 15, 100, 10.22203/eCM.v015a08 Cao, 2007, Spatiotemporal control over growth factor signaling for therapeutic neovascularization, Adv Drug Deliv Rev, 59, 1340, 10.1016/j.addr.2007.08.012 Fahimipour, 2017, 3D printed TCP-based scaffold incorporating VEGF-loaded PLGA microspheres for craniofacial tissue engineering, Dent Mater, 33, 1205, 10.1016/j.dental.2017.06.016 Place, 2009, Complexity in biomaterials for tissue engineering, Nat Mater, 8, 457, 10.1038/nmat2441 Chen, 2007, Host immune competence and local ischemia affects the functionality of engineered vasculature, Microcirculation, 14, 77, 10.1080/10739680601131101 Li, 2018, 3D-printed IFN-γ-loading calcium silicate-β-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone, Acta Biomater, 71, 96, 10.1016/j.actbio.2018.03.012 Sun, 2021, Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus, Bioact Mater, 6, 757, 10.1016/j.bioactmat.2020.08.030 Niu, 2020, An “all-in-one” scaffold targeting macrophages to direct endogenous bone repair in situ, Acta Biomater, 111, 153, 10.1016/j.actbio.2020.05.023 Spiller, 2015, Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds, Biomaterials, 37, 194, 10.1016/j.biomaterials.2014.10.017 Roh, 2010, Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling, Proc Natl Acad Sci USA, 107, 4669, 10.1073/pnas.0911465107 Feng, 2017, A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis, Biomaterials, 134, 128, 10.1016/j.biomaterials.2017.04.042 Spiller, 2014, The role of macrophage phenotype in vascularization of tissue engineering scaffolds, Biomaterials, 35, 4477, 10.1016/j.biomaterials.2014.02.012 Takeda, 2011, Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis, Nature, 479, 122, 10.1038/nature10507 Murray, 2017, Macrophage polarization, Annu Rev Physiol, 79, 541, 10.1146/annurev-physiol-022516-034339 Sica, 2012, Macrophage plasticity and polarization: in vivo veritas, J Clin Invest, 122, 787, 10.1172/JCI59643 Kong, 2019, Overview of RAW264.7 for osteoclastogensis study: phenotype and stimuli, J Cell Mol Med, 23, 3077, 10.1111/jcmm.14277 Eger, 2018, Mechanism and prevention of titanium particle-induced inflammation and osteolysis, Front Immunol, 9, 2963, 10.3389/fimmu.2018.02963 Loi F, Córdova LA, Zhang R, Pajarinen J, Lin TH, Goodman SB, et al. The effects of immunomodulation by macrophage subsets on osteogenesis in vitro. Stem Cell Res Ther 2016;7:15. Könnecke, 2014, T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion, Bone, 64, 155, 10.1016/j.bone.2014.03.052 Croes, 2016, Proinflammatory T cells and IL-17 stimulate osteoblast differentiation, Bone, 84, 262, 10.1016/j.bone.2016.01.010 Grassi, 2016, T cell subsets differently regulate osteogenic differentiation of human mesenchymal stromal cells in vitro, J Tissue Eng Regen Med, 10, 305, 10.1002/term.1727 Stabile, 2003, Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice, Circulation, 108, 205, 10.1161/01.CIR.0000079225.50817.71 van Weel, 2007, Natural killer cells and CD4+ T-cells modulate collateral artery development, Arterioscler Thromb Vasc Biol, 27, 2310, 10.1161/ATVBAHA.107.151407 Kwee, 2018, CD4 T-cells regulate angiogenesis and myogenesis, Biomaterials, 178, 109, 10.1016/j.biomaterials.2018.06.003 Puxeddu, 2005, Human peripheral blood eosinophils induce angiogenesis, Int J Biochem Cell Biol, 37, 628, 10.1016/j.biocel.2004.09.001 Kwee, 2019, Treating ischemia via recruitment of antigen-specific T cells, Sci Adv, 5, 10.1126/sciadv.aav6313 Li, 2017, RhBMP-2 loaded 3D-printed mesoporous silica/calcium phosphate cement porous scaffolds with enhanced vascularization and osteogenesis properties, Sci Rep, 7, 41331, 10.1038/srep41331 Kim, 2015, Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy, Nat Biotechnol, 33, 64, 10.1038/nbt.3071 Li, 2014, Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention, Biomaterials, 35, 3903, 10.1016/j.biomaterials.2014.01.050 Li, 2020, Patient-specific scaffolds with a biomimetic gradient environment for articular cartilage-subchondral bone regeneration, ACS Appl Bio Mater, 3, 4820, 10.1021/acsabm.0c00334 Zou, 2011, Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold, Biomaterials, 32, 9707, 10.1016/j.biomaterials.2011.09.005 Li, 2018, A facile approach to enhance antigen response for personalized cancer vaccination, Nat Mater, 17, 528, 10.1038/s41563-018-0028-2 St John, 2012, Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes, Nat Mater, 11, 250, 10.1038/nmat3222 Moon, 2012, Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction, Proc Natl Acad Sci USA, 109, 1080, 10.1073/pnas.1112648109 Hammer, 2013, Molecular control of steady-state dendritic cell maturation and immune homeostasis, Annu Rev Immunol, 31, 743, 10.1146/annurev-immunol-020711-074929 Banchereau, 1998, Dendritic cells and the control of immunity, Nature, 392, 245, 10.1038/32588 Nguyen, 2019, Mesoporous silica as a versatile platform for cancer immunotherapy, Adv Mater, 31 Zhang, 2013, RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration, Biomaterials, 34, 9381, 10.1016/j.biomaterials.2013.08.059 Yan, 2019, Vascularized 3D printed scaffolds for promoting bone regeneration, Biomaterials, 190–191, 97, 10.1016/j.biomaterials.2018.10.033 Wang, 2021, Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration, Adv Drug Deliver Rev, 174, 504, 10.1016/j.addr.2021.05.007