3D‐Printed Multidrug‐Eluting Stent from Graphene‐Nanoplatelet‐Doped Biodegradable Polymer Composite

Advanced healthcare materials - Tập 6 Số 11 - 2017
Santosh K. Misra1, Fatemeh Ostadhossein1, R Narendra Babu1, Joseph Kus1, Divya Tankasala1, Andre Sutrisno2, Kathleen A. Walsh3, Corinne Bromfield4, Dipanjan Pan1
1Department of Bioengineering Beckman Institute of Advanced Science and Technology Department of Materials Science and Engineering Institute for Sustainability in Energy and Environment University of Illinois at Urbana–Champaign Carle Foundation Hospital 611 West Park Street Urbana IL 61801 USA
2NMR/EPR Laboratory School of Chemical Sciences University of Illinois at Urbana–Champaign IL USA
3Frederick Seitz Materials Research Laboratory University of Illinois at Urbana–Champaign IL USA
4Agricultural Animal Care and Use Program University of Illinois at Urbana–Champaign IL USA

Tóm tắt

Patients with percutaneous coronary intervention generally receive either bare metal stents or drug‐eluting stents to restore the normal blood flow. However, due to the lack of stent production with an individual patient in mind, the same level of effectiveness may not be possible in treating two different clinical scenarios. This study introduces for the first time the feasibility of a patient‐specific stenting process constructed from direct 3D segmentation of medical images using direct 3D printing of biodegradable polymer–graphene composite with dual drug incorporation. A biodegradable polymer–carbon composite is prepared doped with graphene nanoplatelets to achieve controlled release of combinatorics as anticoagulation and antirestenosis agents. This study develops a technology prototyped for personalized stenting. An in silico analysis is performed to optimize the stent design for printing and its prediction of sustainability under force exerted by coronary artery or blood flow. A holistic approach covering in silico to in situ–in vivo establishes the structural integrity of the polymer composite, its mechanical properties, drug loading and release control, prototyping, functional activity, safety, and feasibility of placement in coronary artery of swine.

Từ khóa


Tài liệu tham khảo

10.1161/CIRCINTERVENTIONS.115.003405

10.1038/srep17213

10.1016/j.jcin.2015.08.013

10.1016/j.ahj.2015.07.009

10.1111/1755-5922.12160

10.1253/circj.CJ-14-1352

10.1016/j.mehy.2015.08.023

10.1055/s-0031-1278368

10.1093/rb/rbu005

10.1007/s00330-011-2274-4

10.1002/cmmi.1571

10.1016/j.carbon.2012.09.031

10.3390/ma8095309

10.1002/app.43194

10.1039/c1jm10749f

10.1016/j.actbio.2013.08.016

10.1016/j.addr.2016.05.015

10.1016/j.bios.2015.05.007

10.1021/acsami.5b01440

10.1038/pj.2013.34

10.1002/jbm.b.33549

10.1088/1748-6041/6/5/055010

10.1039/C5RA07210G

10.1163/156855511X615696

10.1016/j.carbon.2015.09.011

10.1161/01.CIR.102.4.399

10.1056/NEJMoa062598

10.1016/S0140-6736(14)61038-2

10.1007/s10439-010-0075-6

10.1016/j.jacc.2013.07.041

10.1016/j.gie.2006.12.018

10.1016/j.amjcard.2004.02.027

Neal M. L., 2009, Briefings Bioinf., 049, 111

10.1146/annurev.bioeng.10.061807.160521

10.1109/TMI.2013.2250991

10.1002/cmmi.449

10.1166/jnn.2010.3034

10.1016/j.biomaterials.2012.08.005

10.1021/mp400044j

10.1161/STROKEAHA.110.598656

10.1021/ja906797z

10.1161/CIRCULATIONAHA.107.693739

Patrício T., 2013, Chem. Eng. Trans., 32, 1645

10.1046/j.1523-1755.1998.06720.x

10.1016/j.jacc.2011.10.903

10.1007/s10439-005-7598-2

Tambaca J., 2011, Tex. Heart Inst. J., 38, 491

Ajayan P. M., 2006, Nanocomposite Science and Technology

10.1016/S0032-3861(98)00253-5

10.1016/j.polymer.2004.11.013

10.1039/b718180a

10.1038/nchem.281

10.1016/j.jinorgbio.2005.06.014

10.1021/cg300784v

10.1021/acs.cgd.5b00106

He Z., 2013, J. Food, Agric. Environ., 11, 965

10.1002/bip.20551

10.1039/c0jm01944e

10.1016/j.jconrel.2012.07.004

10.1016/j.matlet.2014.11.119

10.1007/s10856-012-4779-z

10.4236/jbise.2012.54028

Thông tin
Thông tin xuất bản

Advanced healthcare materials

Tập 6 Số 11

Thông tin tác giả