3D Amide Proton Transfer-Weighted Imaging for Grading Glioma and Correlating IDH Mutation Status: Added Value to 3D Pseudocontinuous Arterial Spin Labelling Perfusion

Rasmussen B, Hansen S, Laursen R et al (2017) Epidemiology of glioma: clinical characteristics, symptoms, and predictors of glioma patients grade I-IV in the the Danish Neuro-Oncology Registry. J Neurooncol 135:571–579

Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 131:803–820

Gerlinger M, Rowan AJ, Horswell S et al (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366:883–892

Sottoriva A, Spiteri I, Piccirillo SG et al (2013) Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci U S A 110:4009–4014

Scott J, Brasher PA, Sevick R et al (2002) How often are nonenhancing supratentorial gliomas malignant? A population study. Neurology 59:947–949

Ryu YJ, Choi YH, Cheon JE et al (2018) Pediatric brain: gadolinium deposition in dentate nucleus and globus pallidus on unenhanced T1-weighted images is dependent on the type of contrast agent. Invest Radiol 53:246–255

McDonald RJ, McDonald JS, Kallmes DF et al (2017) Gadolinium deposition in human brain tissues after contrast-enhanced MR imaging in adult patients without intracranial abnormalities. Radiology 285:546–554

Jiang S, Zou T, Eberhart CG et al (2017) Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI. Magn Reson Med 78:1100–1109

Paech D, Windschuh J, Oberhollenzer J et al (2018) Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T. Neuro Oncol 20:1661–1671

Joo B, Han K, Ahn SS et al (2019) Amide proton transfer imaging might predict survival and IDH mutation status in high-grade glioma. Eur Radiol 29:6643–6652

Xu Z, Ke C, Liu J et al (2021) Diagnostic performance between MR amide proton transfer (APT) and diffusion kurtosis imaging (DKI) in glioma grading and IDH mutation status prediction at 3T. Eur J Radiol 134:109466

Brendle C, Hempel JM, Schittenhelm J et al (2018) Glioma grading and determination of IDH mutation status and ATRX loss by DCE and ASL perfusion. Clin Neuroradiol 28:421–428

Liu T, Cheng G, Kang X et al (2018) Noninvasively evaluating the grading and IDH1 mutation status of diffuse gliomas by three-dimensional pseudo-continuous arterial spin labeling and diffusion-weighted imaging. Neuroradiology 60:693–702

Yoo RE, Yun TJ, Hwang I et al (2020) Arterial spin labeling perfusion-weighted imaging aids in prediction of molecular biomarkers and survival in glioblastomas. Eur Radiol 30:1202–1211

Ningning D, Haopeng P, Xuefei D et al (2017) Perfusion imaging of brain gliomas using arterial spin labeling: correlation with histopathological vascular density in MRI-guided biopsies. Neuroradiology 59:51–59

Zeng Q, Jiang B, Shi F et al (2017) 3D pseudocontinuous arterial spin-labeling MR imaging in the preoperative evaluation of gliomas. AJNR Am J Neuroradiol 38:1876–1883

Wang N, Xie SY, Liu HM et al (2019) Arterial spin labeling for glioma grade discrimination: correlations with IDH1 genotype and 1p/19q status. Transl Oncol 12:749–756

Hales PW, d’Arco F, Cooper J et al (2019) Arterial spin labelling and diffusion-weighted imaging in paediatric brain tumours. Neuroimage Clin 22:101696

Jones CK, Schlosser MJ, van Zijl PC et al (2006) Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med 56:585–592

Zhou J, Lal B, Wilson DA et al (2003) Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 50:1120–1126

Togao O, Yoshiura T, Keupp J et al (2014) Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Neuro Oncol 16:441–448

Zou T, Yu H, Jiang C et al (2018) Differentiating the histologic grades of gliomas preoperatively using amide proton transfer-weighted (APTW) and intravoxel incoherent motion MRI. NMR Biomed 31https://doi.org/10.1002/nbm.3850

Schon S, Cabello J, Liesche-Starnecker F et al (2020) Imaging glioma biology: spatial comparison of amino acid PET, amide proton transfer, and perfusion-weighted MRI in newly diagnosed gliomas. Eur J Nucl Med Mol Imaging 47:1468–1475

Durmo F, Rydhog A, Testud F et al (2020) Assessment of amide proton transfer weighted (APTw) MRI for pre-surgical prediction of final diagnosis in gliomas. PLoS One 15:e0244003

Zhou J, Zaiss M, Knutsson L et al (2022) Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: application to brain tumors. Magn Reson Med.

Keupp J, Baltes C, Harvey PR, Jvd B (2011) Parallel RF transmission based MRI technique for highly sensitive detection of amide proton transfer in the human brain at 3T. Proc Int Soc Magn Reson Med 19:710

Keupp J, Doneva M, Sénégas J et al (2014) 3D fast spin-echo amide proton transfer MR with intrinsic field homogeneity correction for neuro-oncology applications. Proc Int Soc Magn Reson Med 22:3150

Zhou J, Payen JF, Wilson DA et al (2003) Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 9:1085–1090

Jiang S, Eberhart CG, Zhang Y et al (2017) Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas. Eur J Cancer 83:9–18

van Zijl PC, Zhou J, Mori N et al (2003) Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids. Magn Reson Med 49:440–449

Baldewpersad Tewarie NM, Burgers IA, Dawood Y et al (2013) NADP+ -dependent IDH1 R132 mutation and its relevance for glioma patient survival. Med Hypotheses 80:728–731

Regnery S, Adeberg S, Dreher C et al (2018) Chemical exchange saturation transfer MRI serves as predictor of early progression in glioblastoma patients. Oncotarget 9:28772–28783

Paech D, Dreher C, Regnery S et al (2019) Relaxation-compensated amide proton transfer (APT) MRI signal intensity is associated with survival and progression in high-grade glioma patients. Eur Radiol 29:4957–4967

Park JE, Kim HS, Park SY et al (2020) Identification of early response to anti-angiogenic therapy in recurrent glioblastoma: amide proton transfer-weighted and perfusion-weighted MRI compared with diffusion-weighted MRI. Radiology 295:397–406

Hua J, Jones CK, Blakeley J et al (2007) Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain. Magn Reson Med 58:786–793

Zaiss M, Bachert P (2013) Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods. Phys Med Biol 58:R221–R269

Heo HY, Lee DH, Zhang Y et al (2017) Insight into the quantitative metrics of chemical exchange saturation transfer (CEST) imaging. Magn Reson Med 77:1853–1865

Zu Z (2018) Towards the complex dependence of MTRasym on T1w in amide proton transfer (APT) imaging. NMR Biomed 31:e3934

Sakata A, Okada T, Yamamoto A et al (2015) Grading glial tumors with amide proton transfer MR imaging: different analytical approaches. J Neurooncol 122:339–348