3Clinical applications of LHRH analogues

Abbasi, 1986, Predicting the predisposition to osteoporosis. Gonadotrop-inreleasing hormone antagonist for acute estrogen deficiency test, Journal of the American Medical Association, 255, 1600, 10.1001/jama.1986.03370120078026

Abdalla, 1984, Differential bone loss and effects of long-term estrogen therapy after oophorectomy, vol. 2, 621

Aitken, 1973, Oestrogen replacement therapy for prevention of osteoporosis after ovariectomy, British Medical Journal, iii, 515, 10.1136/bmj.3.5879.515

Akhtar, 1983, Reversible induction of azoospermia in rhesus monkeys by constant infusion of a gonadotropin-releasing hormone agonist using osmotic minipumps, Journal of Clinical Endocrinology and Metabolism, 56, 534, 10.1210/jcem-56-3-534

Balmaceda, 1981, The effects of an LH-RH antagonist ([N-Ac-D-Trp1,3, D-p-Cl-Phe2, D-Phe6,D-Ala10]-LH-RH) during the preovulatory period in the rhesus monkey, Contraception, 24, 275, 10.1016/0010-7824(81)90040-8

Balmaceda, 1983, Suppression of post-ovulatory gonadotropin levels does not affect corpus luteum function in rhesus monkeys, Journal of Clinical Endocrinology and Metabolism, 57, 866, 10.1210/jcem-57-4-866

Balmaceda, 1984, The effects of chronic administration of LHRH agonists and antagonists on the menstrual cycle and endometrium of the rhesus monkey, Contraception, 29, 83, 10.1016/0010-7824(84)90061-1

Bancroft, 1986, The use of an LHRH agonist in the treatment and investigation of the premenstrual syndrome, 456

Barden, 1985, Pituitary levels of glycoprotein hormone alpha subunit mRNAs following long term treatment with an LHRH agonist in the rat, 281

Belchetz, 1978, Hypophyseal responses to continuous and intermittent delivery of hypothalamic gonadotropin releasing hormone (GnRH), Science, 202, 631, 10.1126/science.100883

Bergquist, 1983, Ultrasonic measurement of ovarian follicles during chronic LRH agonist treatment for contraception, Contraception, 28, 125, 10.1016/0010-7824(83)90012-4

Bergquist, 1981, Endometrial patterns in women on chronic luteinizing hormone-releasing hormone agonist treatment for contraception, Fertility and Sterility, 36, 339, 10.1016/S0015-0282(16)45735-3

Bergquist, 1982, Long-term intranasal luteinizing hormone-releasing hormone agonist treatment for contraception in women, Fertility and Sterility, 38, 190, 10.1016/S0015-0282(16)46458-7

Bergquist, 1982, Failure of positive feedback of oestradiol during chronic intranasal luteinizing hormone-releasing hormone agonist treatment, Clinical Endocrinology, 16, 147, 10.1111/j.1365-2265.1982.tb03158.x

Bhasin, 1986, Mechanism of gonadotropin-releasing hormone agonist action in the human male, Endocrine Reviews, 7, 106, 10.1210/edrv-7-1-106

Boepple, 1986, Use of a potent, long acting agonist of gonadotropin-releasing hormone in the treatment of precocious puberty, Endocrine Reviews, 7, 24, 10.1210/edrv-7-1-24

Borghi, 1983, Administration of LHRH analogs delays ovulation without affecting the luteal function in rhesus monkeys, Fertility and Sterility, 40, 678, 10.1016/S0015-0282(16)47430-3

Bramley, 1985, Specific binding of gonadotrophin-releasing hormone and an agonist to human corpus luteum homogenates: characterization, properties and luteal phase levels, Journal of Clinical Endocrinology and Metabolism, 61, 834, 10.1210/jcem-61-5-834

Casper, 1981, Menopausal flushes: effect of pituitary gonadotropin desensitization by a potent luteinizing hormone releasing factor agonist, Journal of Clinical Endocrinology and Metabolism, 51, 1056, 10.1210/jcem-53-5-1056

Casper, 1980, Chorionic gonadotropin prevents LRF-agonist-induced luteolysis in the human, Contraception, 21, 471, 10.1016/0010-7824(80)90012-8

Casper, 1984, Studies on the effect of gonadotropin-releasing hormone and its agonist on human luteal steroidogenesis in vitro, Fertility and Sterility, 42, 39, 10.1016/S0015-0282(16)47955-0

Chang, 1983, Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist, Journal of Clinical Endocrinology and Metabolism, 56, 897, 10.1210/jcem-56-5-897

Clayton, 1982, GnRH modulation of its own pituitary receptors: evidence for biphasic regulation, Endocrinology, 111, 152, 10.1210/endo-111-1-152

Comite, 1984, LHRH analog effect on pubertal development, growth and maturation in precocious puberty, 438

Comite, 1984, Cyclical ovarian function resistant to treatment with analogue of LHRH in McCune-Albright syndrome, New England Journal of Medicine, 311, 1032, 10.1056/NEJM198410183111607

DeFazio, 1983, Induction of hot flushes in premenopausal women with a long-acting GnRH agonist, Journal of Clinical Endocrinology and Metabolism, 56, 445, 10.1210/jcem-56-3-445

Dewart, 1986, LHRH agonist buserelin as a post-partum contraceptive: lack of biological activity of buserelin in breast milk, Acta Endocrinologica

Doelle, 1983, Combined treatment with an LHRH agonist and testosterone in man, Journal of Andrology, 4, 298, 10.1002/j.1939-4640.1983.tb02373.x

Doll, 1975, The epidemiology of cancers of the breast and reproductive system, Scottish Medical Journal, 20, 305, 10.1177/003693307502000615

Faure, 1984, Buserelin therapy for prostate carcinoma, 337

Fleming, 1986, Induction of multiple follicular growth in normally menstruating women with endogenous gonadotropin suppression, Fertility and Sterility, 45, 226, 10.1016/S0015-0282(16)49159-4

Fleming, 1982, A new systemic treatment for infertile women with abnormal hormone profiles, British Journal of Obstetrics and Gynaecology, 89, 80, 10.1111/j.1471-0528.1982.tb04642.x

Fleming, 1985, Successful treatment of infertile women with oligomenorrhoea using a combination of an LHRH agonist and exogenous gonadotrophins, British Journal of Obstetrics and Gynaecology, 92, 369, 10.1111/j.1471-0528.1985.tb01111.x

Filicori, 1983, A conservative approach to the management of uterine leiomyoma: pituitary desensitization by a luteinizing hormone-releasing hormone analogue, American Journal of Obstetrics and Gynecology, 147, 726, 10.1016/0002-9378(83)90463-5

Fraser, 1981, Effect of oestrogen on gonadotrophin release in stumptailed monkeys (Macaca arctoides) treated chronically with an agonist analogue of LHRH, Journal of Endocrinology, 91, 525, 10.1677/joe.0.0910525

Fraser, 1987, LHRH antagonists and female reproductive function

Fraser, 1985, Control of the menstrual cycle by LHRH and its analogues, Bibliography of Reproduction, 46, C1

Fraser, 1985, Suppression of follicular maturation by infusion of a luteinizing hormone releasing hormone agonist starting during the late luteal phase in the stumptailed macaque monkey, Journal of Clinical Endocrinology and Metabolism, 60, 579, 10.1210/jcem-60-3-579

Fraser, 1980, Decreased pituitary responsiveness and inhibition of the luteinizing hormone surge and ovulation in the stumptailed monkey (Macaca arctoides)by chronic treatment with an agonist of luteinizing hormone-releasing hormone, Endocrinology, 106, 452, 10.1210/endo-106-2-452

Fraser, 1983, Antibody production against an agonist analogue of luteinizing hormone releasing hormone: evaluation of immunochemical and physiological consequences, Acta Endocrinologica, 103, 151, 10.1530/acta.0.1030151

Fraser, 1985, Suppression of luteal progesterone secretion in the stumptailed macaque by an antagonist analogue of luteinizing hormone releasing hormone, Journal of Endocrinology, 104, R1, 10.1677/joe.0.104R001

Fraser, 1986, Effects of an LHRH antagonist on the secretion of LH, FSH, prolactin and ovarian steroids at different stages of the luteal phase in the stumptailed macaque (Macaca arctoides), Journal of Endocrinology, 111, 83, 10.1677/joe.0.1110083

Fraser, 1986, Extra pituitary actions of LHRH analogues in tissues of the human female and investigation of the existence and function of LHRH-like peptides

Gudmundsson, 1986, Intranasal peptide contraception by inhibition of ovulation with the gonadotropin-releasing hormone superagonist nafarelin: six months' clinical results, Fertility and Sterility, 45, 617, 10.1016/S0015-0282(16)49331-3

Hardt, 1984, Sustained gonadal suppression in fertile women with the LHRH agonist buserelin, Clinical Endocrinology, 19, 613, 10.1111/j.1365-2265.1983.tb00039.x

Hardt, 1984, Antifertility by discontinuous treatment with buserelin in women, 235

Harvey, 1984, LHRH analogs for human mammary carcinoma, 329

Healy, 1986, Towards removing uterine fibroids without surgery: subcutaneous infusion of a luteinizing hormone-releasing hormone agonist commencing in theluteal phase, Journal of Clinical Endocrinology and Metabolism, 63, 619, 10.1210/jcem-63-3-619

Hsueh, 1981, Extrapituitary actions of the gonadotropin-releasing hormone, Endocrine Reviews, 2, 437, 10.1210/edrv-2-4-437

Johansson, 1975, On some late effects of bilateral oophorectomy in the age range 15–30 years, Acta Obstetrica et Gynecologica Scandinavica, 54, 449, 10.3109/00016347509157108

Karten, 1986, Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspective, Endocrine Reviews, 7, 44, 10.1210/edrv-7-1-44

Kenigsberg, 1986, Ovulation inhibition by administration of weekly gonadotropin-releasing hormone antagonist, Journal of Clinical Endocrinology and Metabolism, 62, 734, 10.1210/jcem-62-4-734

Kenigsberg, 1986, Induction of ovulation in primate models, Endocrine Reviews, 1, 34, 10.1210/edrv-7-1-34

Klibanski, 1980, Decreased bone density in hyperprolactinaemic women, New England Journal of Medicine, 303, 1511, 10.1056/NEJM198012253032605

Klijn, 1984, Anti-tumour and endocrine effects of chronic LHRH agonist treatment (buserelin) with or without tamoxifen in premenopausal metastatic breast cancer, Breast Cancer Research and Treatment, 4, 209, 10.1007/BF01806487

Klijn, 1985, Combined treatment with buserelin and cyproterone acetate in metastatic prostatic carcinoma, Lancet, ii, 493, 10.1016/S0140-6736(85)90415-5

Knuth, 1984, Effect of flutamide or cyproterone acetate on pituitary and testicular hormones in normal men, Journal of Clinical Endocrinology and Metabolism, 59, 963, 10.1210/jcem-59-5-963

Koppelman, 1984, Vertebral body bone mineral content in hyperprolactinaemic women, Journal of Clinical Endocrinology and Metabolism, 59, 1050, 10.1210/jcem-59-6-1050

Kuhl, 1984, Contraception with an LHRH agonist: effect on gonadotrophin and steroid secretion patterns, Clinical Endocrinology, 21, 179, 10.1111/j.1365-2265.1984.tb03458.x

Kumar, 1979, Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation, Journal of Clinical Investigation, 63, 343, 10.1172/JCI109308

Labrie, 1986, Treatment of prostate cancer with gonadotrop-inreleasing hormone agonists, Endocrine Reviews, 7, 67, 10.1210/edrv-7-1-67

Lemay, 1982, Sensitivity of pituitary and corpus luteum responses to single intranasal administration of (D-Ser(TBU)6-des-Gly-NH210)LHRH ethylamide (buserelin) in normal women, Fertility and Sterility, 37, 193, 10.1016/S0015-0282(16)46038-3

Lemay, 1983, Gonadotropins and estradiol responses to a single intranasal or subcutaneous administration of a luteinizing hormone-releasing hormone agonist inthe early follicular phase, Fertility and Sterility, 39, 668, 10.1016/S0015-0282(16)47063-9

Lemay, 1984, Reversible hypogonadism induced by a luteinizing hormone-releasing hormone (LHRH) agonist (buserelin) as a new therapeutic approach forendometriosis, Fertility and Sterility, 41, 863, 10.1016/S0015-0282(16)47899-4

Lemay, 1985, Inhibition of ovulation during discontinuous intranasal luteinizing hormone-releasing hormone agonist dosing in combination with gestagen-inducedbleeding, Fertility and Sterility, 43, 868, 10.1016/S0015-0282(16)48614-0

Linde, 1981, Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotropin-releasing hormone agonist in normal men, New England Journal of Medicine, 305, 663, 10.1056/NEJM198109173051203

Luder, 1984, Intranasal and subcutaneous treatment of central precocious puberty in both sexes with a long-acting analog of luteinizing hormone-releasing hormone, Journal of Clinical Endocrinology and Metabolism, 58, 966, 10.1210/jcem-58-6-966

Maheux, 1985, Luteinising hormone-releasing hormone agonist and uterine leiomyoma: a pilot study, American Journal of Obstetrics and Gynecology, 152, 1035, 10.1016/0002-9378(85)90554-X

Manni, 1986, Treatment of breast cancer with gonadotropin-releasing hormone, Endocrine Reviews, 7, 89, 10.1210/edrv-7-1-89

Meldrum, 1985, Clinical management of endometriosis with luteinizing hormone-releasing hormone analogues, Seminars in Reproductive Endocrinology, 3, 371, 10.1055/s-2007-1022638

Meldrum, 1982, ‘Medical oophorectomy’ using a long-acting GnRH agonist—a possible new approach to the treatment of endometriosis, Journal of Clinical Endocrinology and Metabolism, 54, 1081, 10.1210/jcem-54-5-1081

Meldrum, 1984, Stimulation of LH fragments with reduced bioactivity following GnRH agonist administration in women, Journal of Clinical Endocrinology and Metabolism, 58, 755, 10.1210/jcem-58-4-755

Michel, 1985, Failure of high-dose sustained release luteinizing hormone releasing hormone agonist (buserelin) plus oral testosterone to suppress male fertility, Clinical Endocrinology, 23, 663, 10.1111/j.1365-2265.1985.tb01127.x

Miller, 1985, Growth of human breast cancer cell line inhibited by a luteinizing hormone-releasing hormone agonist, Nature, 313, 231, 10.1038/313231a0

Muse, 1984, The premenstrual syndrome. Effects of ‘medical ovariectomy’, New England Journal of Medicine, 311, 1345, 10.1056/NEJM198411223112104

Nicholson, 1986, The British experience with the LHRH agonist Zoladex (ICI 118630) in the treatment of breast cancer

Nillius, 1984, Superagonists of LHRH for contraception in women, 261

Oliver, 1959, Effect of bilateral ovariectomy on coronary artery disease and serum lipid levels, Lancet, ii, 690, 10.1016/S0140-6736(59)92129-4

Petri, 1984, A pharmaceutical approach to long-term therapy with peptides, 63

Porter, 1984, Letter. Induction of ovulation for in-vitro fertilization using buserelin and gonadotropins, Lancet, ii, 1284, 10.1016/S0140-6736(84)92840-X

Roger, 1986, Long term treatment of male and female precocious puberty by periodic administration of a long-acting preparation of D-Trp6-luteinizinghormone-releasing hormone microcapsules, Journal of Clinical Endocrinology and Metabolism, 62, 670, 10.1210/jcem-62-4-670

Rosenberg, 1981, Early menopause and the risk of myocardial infarction, American Journal of Obstetrics and Gynecology, 139, 47, 10.1016/0002-9378(81)90410-5

Sanders, 1984, An injectable biodegradable controlled release delivery system for nafarelin acetate, 53

Sandow, 1982, Inhibition of pituitary and testicular function by LHRH analogues, 19

Sandow, 1986, Pharmacology and experimental basis of therapy with LHRH agonists in women

Santen, 1984, Long term effects of administration of a gonadotropin-releasing hormone superagonist analog in men with prostate carcinoma, Journal of Clinical Endocrinology, 58, 397, 10.1210/jcem-58-2-397

Santen, 1984, GnRH superagonist treatment of prostate cancer: hormonal effects with and without an androgen biosynthesis inhibitor, 336

Schmidt, 1984, [Ac-D-NAL(2)1,4FD-Phe2,D-Trp3,D-Arg6]-LHRH, a potent antagonist of LHRH, produced transient edema and behavioral changes in rats, Contraception, 29, 283, 10.1016/S0010-7824(84)80008-6

Schmidt-Gollwitzer, 1984, Risks and benefits of LHRH agonists as antifertility agents, 243

Schmidt-Gollwitzer, 1981, Influence of the LHRH analogue buserelin on cyclic ovarian function and on endometrium. A new approach to fertility control?, Contraception, 23, 187, 10.1016/0010-7824(81)90104-9

Schriock, 1985, Treatment of endometriosis with a potent agonist of gonadotropin-releasing hormone (nafarelin), Fertility and Sterility, 44, 583, 10.1016/S0015-0282(16)48970-3

Schürmeyer, 1984, Suppression of pituitary and testicular function in normal men by constant gonadotrophin-releasing hormone agonist infusion, Journal of Clinical Endocrinology and Metabolism, 59, 19, 10.1210/jcem-59-1-19

Shaw, 1984, Use of a superactive LHRH agonist in the treatment of menorrhagia, British Journal of Obstetrics and Gynaecology, 91, 913, 10.1111/j.1471-0528.1984.tb03708.x

Shaw, 1985, Effect of an intranasal LHRH agonist on gonadotrophins and hot flushes in post-menopausal women, Maturitas, 7, 161, 10.1016/0378-5122(85)90022-2

Stanhope, 1985, The treatment of central precocious puberty using an intranasal LHRH analogue (buserelin), Clinical Endocrinology, 22, 795, 10.1111/j.1365-2265.1985.tb00170.x

Swerdloff, 1984, Hormonal effects of GnRH agonist in the human male: an approach to male contraception using combined androgen and GnRH agonist treatment, 287

Trichopoulos, 1972, Menopause and breast cancer, Journal of the National Cancer Institute, 48, 605

Tureck, 1982, Inhibition of human granulosa cell progesterone secretion by a gonadotrophin-releasing hormone agonist, Journal of Clinical Endocrinology and Metabolism, 54, 1078, 10.1210/jcem-54-5-1078

Vickery, 1986, Comparison of the potential for therapeutic utilities with gonadotropin-releasing hormone agonists and antagonists, Endocrine Reviews, 7, 115, 10.1210/edrv-7-1-115

Walker, 1984, Treatment of patients with advanced cancer of the prostate using a slow-release (depot) formulation of the LHRH agonist ICI 118630 (Zoladex), Journal of Endocrinology, 103, R1, 10.1677/joe.0.103R001

Walker, 1986, Preliminary endocrinological evaluation of a sustained-release formulation of the LH-releasing hormone agonist D-Ser(But)6 Azgly10LHRH in premenopausal women with advanced breast cancer, Journal of Endocrinology, 111, 349, 10.1677/joe.0.1110349

Weinbauer, 1984, Reversible inhibition of testicular function by a gonadotrophin hormone-releasing hormone antagonist in monkeys (Macaca fascicularis), Fertility and Sterility, 42, 906, 10.1016/S0015-0282(16)48264-6

Wenderoth, 1984, Three years experience with the GnRH-analogue buserelin in 100 patients with advanced prostatic cancer, 349

West, 1987, Suppression of ovarian activity by Zoladex depot (ICI 118630), a long acting LHRH agonist analogue, Clinical Endocrinology, 10.1111/j.1365-2265.1987.tb00779.x

Zarate, 1981, Anovulatory effect of a LHRH antagonist in women, Contraception, 24, 315, 10.1016/0010-7824(81)90044-5