3 What do we know about biochemical bone markers?

Akesson, 1990, Biochemical evidence for decreased bone formation and increased bone resorption in women with hip fracture, vol. 1, 362 Bataille, 1987, Serum bone gla-protein in multiple myeloma, Cancer, 59, 329, 10.1002/1097-0142(19870115)59:2<329::AID-CNCR2820590227>3.0.CO;2-S Black, 1988, Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reversed-phase high-performance liquid chromatography, Annals of Clinical Biochemistry, 169, 197, 10.1016/0003-2697(88)90274-6 Brown, 1984, Serum bone gla-protein: A specific marker for bone formation in postmenopausal osteoporosis, Lancet, i, 1091, 10.1016/S0140-6736(84)92506-6 Brown, 1987, Active bone turnover of the cortico-endosteal envelope in postmenopausal osteoporosis, Journal of Clinical Endocrinology and Metabolism, 64, 954, 10.1210/jcem-64-5-954 Chenu, 1990, Radioimmunoassay for bone sialoprotein: assessment of circulating levels, 247 Civitelli, 1988, Bone turnover in postmenopausal osteoporosis. Effect of calcitonin treatment, Journal of Clinical Investigation, 82, 1268, 10.1172/JCI113725 Colwell, 1990, Effect of diet on deoxypyrinoline excretion, vol. 2, 520 Delmas, 1988, Biochemical markers of bone turnover in osteoporosis, 297 Delmas, 1990, Biochemical markers of bone turnover for the clinical assessment of metabolic disease, Endocrinology and Metabolism Clinics of North America, 19, 1, 10.1016/S0889-8529(18)30336-0 Delmas, 1983, Serum bone gla-protein increases with aging in normal women: implications for the mechanism of age-related bone loss, Journal of Clinical Investigation, 71, 1316, 10.1172/JCI110882 Delmas, 1985, Serum bone gla-protein compared to bone histomorphometry in endocrine diseases, Bone, 6, 329, 10.1016/8756-3282(85)90326-6 Delmas, 1986, Serum bone gla-protein (osteocalcin) in primary hyperparathyroidism and in malignant hypercalcemia. Comparison with bone histomorphometry, Journal of Clinical Investigation, 77, 985, 10.1172/JCI112400 Delmas, 1987, Circadian rhythm in serum bone gla-protein (sBGP) concentration in the human: correlation with serum 1,25 dihydroxy-vitamin D (1,25(OH)2D), 593 Delmi, 1990, Dietary supplementation in elderly patients with fractured neck of femur, Lancet, 335, 1013, 10.1016/0140-6736(90)91073-J Duda, 1988, Concurrent assays of circulating bone gla-protein and bone alkaline phosphatase: effects of sex, age, and metabolic bone disease, Journal of Clinical Endocrinology and Metabolism, 66, 951, 10.1210/jcem-66-5-951 Eastell, 1988, Bone formation rate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics and biochemical markers, Journal of Clinical Endocrinology and Metabolism, 67, 741, 10.1210/jcem-67-4-741 Eastell, 1990, Prediction of response to estrogen therapy using urine deoxypyridinoline, Journal of Bone and Mineral Research, 5, S2 Eyre, 1987, Collagen crosslinking amino-acids, Methods in Enzymology, 144, 115, 10.1016/0076-6879(87)44176-1 Eyre, 1984, Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography, Annals of Clinical Biochemistry, 137, 380, 10.1016/0003-2697(84)90101-5 Eyre, 1988, Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues, Biochemical Journal, 252, 495, 10.1042/bj2520495 Farley, 1981, Improved method for quantitative determination in serum alkaline phosphatase of skeletal origin, Clinical Chemistry, 27, 2002, 10.1093/clinchem/27.12.2002 Fournier, 1989, Evidence that free gamma-carboxyglutamic acid circulates in serum, Clinica Chimica Acta, 182, 173, 10.1016/0009-8981(89)90076-4 Garrel, 1988, Effect of moderate physical training on prednisone-induced protein wasting: a study of whole bone and bone protein metabolism, Metabolism: Clinical and Experimental, 37, 257, 10.1016/0026-0495(88)90105-9 Gundberg, 1986, Multiple immunoreactive forms in uremic serum, Journal of Clinical Investigation, 77, 1762, 10.1172/JCI112499 Gundberg, 1983, Urinary gamma-carboxyglutamic acid and serum osteocalcin as bone markers: studies in osteoporosis and Paget's disease, Journal of Clinical Endocrinology and Metabolism, 57, 1221, 10.1210/jcem-57-6-1221 Hill, 1989, The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase, Clinica Chimica Acta, 186, 315, 10.1016/0009-8981(90)90050-3 Johansen, 1988, Plasma BGP: an indicator of spontaneous bone loss and effect of estrogen treatment in postmenopausal women, European Journal of Clinical Investigation, 18, 191, 10.1111/j.1365-2362.1988.tb02412.x Kivirikko, 1983, Excretion of urinary hydroxyproline peptide in the assessment of bone collagen deposition and resorption, 105 Kraenzlin, 1989, Development of a radioimmunoassay for the N-terminal type I procollagen: potential use to assess bone formation, European Journal of Clinical Investigation, 19, A86 Kraenzlin, 1990, Development of an immunoassay for human serum osteoclastic tartrate-resistant acid phosphatase, Journal of Clinical Endocrinology and Metabolism, 71, 442, 10.1210/jcem-71-2-442 Li, 1973, Acid phosphatase in human plasma, Journal of Laboratory and Clinical Medicine, 82, 446 Lian, 1988, Osteocalcin. Biochemical considerations and clinical applications, Clinical Orthopaedics and Related Research, 226, 267 Lowry, 1985, Hydroxyproline metabolism by the rat kidney: distribution of renal enzymes of hydroxyproline catabolism and renal conversion of hydroxyproline to glycine and serine, Metabolism, 39, 955, 10.1016/0026-0495(85)90145-3 Malaval, 1987, Radioimmunoassay for osteonectin. Concentrations in bone, nonmineralized tissues and blood, Journal of Bone and Mineral Research, 2, 457, 10.1002/jbmr.5650020514 Malaval, 1988, Monoclonal antibody recognizing osteonectin from bone but not from platelet, Journal of Bone and Mineral Research, 3, S2 Minkin, 1982, Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function, Calcified Tissue International, 34, 285, 10.1007/BF02411252 Moro, 1988, Urinary β-1-galactosyl-O-hydroxylysine (GH) as a marker of collagen turnover of bone, Calcified Tissue International, 42, 87, 10.1007/BF02556339 Moro, 1988, Determination of galactosyl hydroxylysine in urine as a mean for the identification of osteoporotic women, Bone and Mineral, 3, 271 Moss, 1982, Alkaline phosphatase isoenzymes, Clinical Chemistry, 28, 2007, 10.1093/clinchem/28.10.2007 Nielsen, 1990, Changes in biochemical markers of osteoblastic activity during the menstrual cycle, Journal of Clinical Endocrinology and Metabolism, 70, 1431, 10.1210/jcem-70-5-1431 Parfitt, 1987, Procollagen type I Carboxyterminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase, Journal of Bone and Mineral Research, 2, 427, 10.1002/jbmr.5650020510 Piedra, 1989, Serum tartrate resistant acid phosphatase and bone mineral content in postmenopausal osteoporosis, Calcified Tissue International, 45, 58, 10.1007/BF02556662 Podenphant, 1987, Bone turnover in spinal osteoporosis, Journal of Bone and Mineral Research, 2, 497, 10.1002/jbmr.5650020606 Price, 1987, Vitamin K-dependent bone proteins, vol. 9, 419 Price, 1980, New biochemical marker for bone metabolism, Journal of Clinical Investigation, 66, 878, 10.1172/JCI109954 Price, 1981, Origin of vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone, Journal of Biological Chemistry, 256, 12760, 10.1016/S0021-9258(18)42960-2 Prockop, 1968, Hydroxyproline and the metabolism of collagen, vol. 2, 215 Prockop, 1979, The biosynthesis of collagen and its disorders, New England Journal of Medicine, 301, 13, 10.1056/NEJM197907053010104 Reid, 1986, Low serum osteocalcin levels in glucocorticoid-treated asthmatics, Journal of Clinical Endocrinology and Metabolism, 62, 379, 10.1210/jcem-62-2-379 Simon, 1983, Procollagen extension peptides as markers of collagen synthesis, 108 Slemenda, 1987, Sex steroids and bone mass. A study of changes about the time of menopause, Journal of Clinical Investigation, 80, 1261, 10.1172/JCI113201 Stenner, 1986, Human platelets contain and secrete osteonectin, a major protein of mineralized bone, 83, 6892 Stepan, 1983, Relationship of plasma tartrate-resistant acid phosphatase to the bone isoenzyme of serum alkaline phosphatase in hyperparathyroidism, Clinica Chimica Acta, 133, 189, 10.1016/0009-8981(83)90404-7 Stepan, 1987, Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women, Bone, 8, 279, 10.1016/8756-3282(87)90002-0 Taylor, 1990, Partial characterization of a novel growth factor from the blood of women with preeclampsia, Journal of Clinical Endocrinology and Metabolism, 70, 1285, 10.1210/jcem-70-5-1285 Thompson, 1989, Changes in osteocalcin after femoral neck fracture, Annals of Clinical Biochemistry, 26, 487, 10.1177/000456328902600605 Thomsen, 1987, Bone turnover determined by urinary excretion of [99mTc]-disphosphonate in the prediction of postmenopausal bone loss, Bone and Mineral, 2, 125 Tracy, 1990, Comparison of monoclonal and polyclonal antibody-based immunoassays for osteocalcin. A study of sources of variation in assay results, Journal of Bone and Mineral Research, 5, 451, 10.1002/jbmr.5650050506 Uebelhart, 1990, Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease, Bone and Mineral, 8, 87, 10.1016/0169-6009(91)90143-N Uebelhart, 1991, Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium crosslinks, Journal of Clinical Endocrinology and Metabolism, 72, 367, 10.1210/jcem-72-2-367