3 The immunology of coeliac disease

Alp, 1971, Autoantibodies to reticulin in patients with idiopathic steatorrhoea, coeliac disease and Crohn's disease, and their relation to immunoglobulins and dietary antibodies, Lancet, ii, 682, 10.1016/S0140-6736(71)92249-5 Anand, 1977, Isolating the component of gluten which causes the mucosal damage in coeliac disease, Gut, 18, A408 Anand, 1978, The role of various cereals in coeliac disease, Quarterly Journal of Medicine, 47, 101 Arnaud-Battandier, 1986, Increased HLA-DR expression by enterocytes in children with celiac disease, Gastroenterology, 91, 1206, 10.1016/S0016-5085(86)80018-X Askenase, 1983, Delayed-type hypersensitivity: activation of mast cells by antigen-specific T cell factors initiates the cascade of cellular interactions, Immunology Today, 4, 259, 10.1016/0167-5699(83)90046-4 Autran, 1979, N-terminal amino acid sequencing of prolamins from wheat and related species, Nature, 282, 527, 10.1038/282527a0 Baer, 1980, Intestinal ulceration and malabsorption syndromes, Gastroenterology, 79, 754, 10.1016/0016-5085(80)90259-0 Baker, 1976, Oats and barley toxicity in coeliac patients, Postgraduate Medical Journal, 52, 264, 10.1136/pgmj.52.607.264 Baker, 1975, The immune response to øX174 in man. III. Evidence for an association between hyposplenism and immunodeficiency in patients with coeliac disease, Gut, 16, 538, 10.1136/gut.16.7.538 Bayless, 1967, Intestinal ulceration—a complication of celiac disease, New England Journal of Medicine, 276, 996, 10.1056/NEJM196705042761802 Bienenstock, 1985, The gastrointestinal tract as an immune organ, 1 Bienenstock, 1983, The mucosal immunological network: compartmentalisation of lymphocytes, natural killer cells and mast cells, Annals of the New York Academy of Sciences, 409, 164, 10.1111/j.1749-6632.1983.tb26866.x Bjarnason, 1984, In vitro determination of small intestinal permeability: demonstration of a persistent defect in patients with coeliac disease, Gut, 15, 145, 10.1136/gut.25.2.145 Bockman, 1983, The role of epithelial cells in gut-associated immune reactivity, Annals of the New York Academy of Sciences, 409, 129, 10.1111/j.1749-6632.1983.tb26864.x Bohs, 1976, T-lymphocyte depletion in peripheral blood of sheep undergoing chronic thoracic duct drainage, Journal of the Reticuloendothelial Society, 19, 383 Booth, 1970, Relationship between wheat proteins, Journal of the Science of Food and Agriculture, 21, 188, 10.1002/jsfa.2740210406 Booth, 1977, Immunopathology of coeliac disease, 329 Borda, 1973, Cerebral venous thrombosis in ulcerative colitis, Gastroenterology, 64, 116, 10.1016/S0016-5085(73)80099-X Brandtzaeg, 1976, Immunoglobulin-producing cells in the intestine in health and disease, Clinics in Gastroenterology, 5, 251, 10.1016/S0300-5089(21)00287-X Brostoff, 1974, Critique of present in vitro methods for the detection of cell-mediated immunity, 67, 514 Bullen, 1978, Lymphocyte subpopulations in adult coeliac disease, Gut, 19, 892, 10.1136/gut.19.10.892 Bullen, 1979, Consequences of impaired splenic function, Clinical Science, 57, 129, 10.1042/cs0570129 Bullen, 1980, Circulating immune complexes in coeliac disease, Gut, 21, A915 Bullen, 1981, Hyposplenism, adult coeliac disease and autoimmunity, Gut, 22, 28, 10.1136/gut.22.1.28 Challacombe, 1980, Childhood coeliac disease is disappearing, Lancet, ii, 1360 Ciclitira, 1983, A solid-phase radioimmunoassay for measurement of circulating antibody titres to wheat gliadin and its subfractions in patients with adult coeliac disease, Journal of Immunological Methods, 62, 231, 10.1016/0022-1759(83)90250-8 Ciclitira, 1984, Clinical testing of gliadin fractions in coeliac patients, Clinical Science, 66, 357, 10.1042/cs0660357 Ciclitira, 1985, Relation of antigenic structure of cereal proteins to their toxicity in coeliac patients, British Journal of Nutrition, 53, 39, 10.1079/BJN19850008 Ciclitira, 1986, The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease, Clinical and Experimental Immunology, 63, 101 Ciclitira, 1986, Secretion of gliadin antibody by coeliac jejunal mucosal biopsies cultured in vitro, Clinical and Experimental Immunology, 64, 119 Ciclitira, 1986, Circulating antibodies to gliadin subfractions in dermatitis herpetiformis and linear IgA dermatosis of adults and children, Clinical and Experimental Dermatology, 11, 502, 10.1111/j.1365-2230.1986.tb00498.x Cobden, 1978, Intestinal permeability assessed by excretion ratios of two molecules: results in coeliac disease, British Medical Journal, ii, 1060, 10.1136/bmj.2.6144.1060 Cooke, 1984, Coeliac Disease, 225 Cooper, 1980, Celiac disease and malignancy, Medicine, 59, 249, 10.1097/00005792-198007000-00002 Corazza, 1983, Defective splenic function and its relation to bowel disease, Clinics in Gastroenterology, 12, 651, 10.1016/S0300-5089(21)00600-3 Corazza, 1981, Simple method of assessing splenic function in coeliac disease, Clinical Science, 60, 109, 10.1042/cs0600109 Corazza, 1983, T-lymphocyte subsets in adult coeliac disease, Clinical Science, 65, 89, 10.1042/cs0650089 Corazza, 1983, Effect of gluten-free diet on splenic hypofunction in adult coeliac disease, Gut, 24, 228, 10.1136/gut.24.3.228 Corazza, 1984, Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased?, Gut, 25, 158, 10.1136/gut.25.2.158 Corazza, 1985, Specificity of leucocyte migration inhibition test in coeliac disease, 60, 117 Corazza, 1986, Gluten specific suppressor T cell dysfunction in coeliac disease, Gut, 27, 392, 10.1136/gut.27.4.392 Cornell, 1974, The toxicity of certain cereal proteins in coeliac disease, Gut, 15, 862, 10.1136/gut.15.11.862 Cunningham-Rundles, 1978, Response to wheat antigen in in vitro lymphocyte transformation among HLA-B8-positive normal donors, 10, 977 Dahan, 1984, Coeliac disease in the RehovatAshdod region of Israel: incidence and ethnic distribution, Journal of Epidemiology and Community Health, 38, 58, 10.1136/jech.38.1.58 Dawson, 1986, Mucosal permeability to gliadin is normal in treated coeliac disease, Gut, 27, A1273 de Rooij, 1978, The heterogeneity of α-gliadin, 17 Dicke, 1950, Coeliac disease: a study of the damaging effect of some cereals (especially wheat), caused by a factor outside of their starch on the fat absorption of children with coeliac disease, 117 Dicke, 1953, Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease, Acta Paediatrica Scandinavica, 42, 34, 10.1111/j.1651-2227.1953.tb05563.x Dissanayake, 1973, Nature of toxic components of wheat gluten in coeliac disease, Lancet, ii, 709, 10.1016/S0140-6736(73)92541-5 Dissanayake, 1974, Lack of harmful effect of oats on small-intestinal mucosa in coeliac disease, British Medical Journal, 4, 189, 10.1136/bmj.4.5938.189 Dissanayake, 1974, Identifying toxic fractions of wheat gluten and their effect on the jejunal mucosa in coeliac disease, Gut, 15, 931, 10.1136/gut.15.12.931 Dissanayake, 1974, Jejunal mucosal recovery in coeliac disease in relation to the degree of adherence to a gluten-free diet, Quarterly Journal of Medicine, 43, 161 Dobbins, 1986, Human intestinal intraepithelial lymphocytes, Gut, 27, 972, 10.1136/gut.27.8.972 Doe, 1973, Evidence for complement binding immune complexes in adult coeliac disease, Crohn's disease and ulcerative colitis, Lancet, i, 402, 10.1016/S0140-6736(73)90254-7 Doe, 1974, Complement in coeliac disease, 189 Dossetor, 1981, Childhood coeliac disease is disappearing, Lancet, i, 322, 10.1016/S0140-6736(81)91926-7 Douglas, 1976, The distribution and enteric loss of 51Cr-labelled lymphocytes in normal subjects and in patients with coeliac disease and other disorders of the small intestine, Digestion, 14, 29, 10.1159/000197797 Eade, 1977, IgA and IgG reticulin antibodies in coeliac disease and non-coeliac patients, Gut, 18, 991, 10.1136/gut.18.12.991 Elson, 1985, T cell-B cell regulation in the intestinal lamina propria in Crohn's disease, Gastroenterology, 89, 321, 10.1016/0016-5085(85)90332-4 Elson, 1986, Intestinal immunity and inflammation: recent progress, Gastroenterology, 91, 746, 10.1016/0016-5085(86)90649-9 Evans, 1974, Chemistry of wheat proteins and the nature of the damaging substances, Clinics in Gastroenterology, 3, 199, 10.1016/S0300-5089(21)00360-6 Fairley, 1937, The clinical and biochemical syndrome in lymphadenoma and allied diseases involving mesenteric lymph nodes, British Medical Journal, i, 375, 10.1136/bmj.1.3972.375 Falchuk, 1974, An in vitro model of gluten-sensitive enteropathy, 53, 487 Ferguson, 1977, Intraepithelial lymphocytes of the small intestine, Gut, 18, 921, 10.1136/gut.18.11.921 Ferguson, 1972, Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children, British Medical Journal, i, 75, 10.1136/bmj.1.5792.75 Ferguson, 1971, Quantitation of intraepithelial lymphocytes in human jejunum, Gut, 12, 988, 10.1136/gut.12.12.988 Ferguson, 1986, Intraepithelial lymphocyte mitosis in a jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis, Gut, 27, 675, 10.1136/gut.27.6.675 Ferguson, 1975, Cell mediated immunity to gliadin within the small-intestinal mucosa in coeliac disease, Lancet, i, 895, 10.1016/S0140-6736(75)91689-X Fish, 1970, Circulating lymphocyte depletion: effect on lymphoid tissue, Surgery, 67, 658 Frazer, 1959, Gluten-induced enteropathy, ii, 252 Freeman, 1986, Small bowel malignant lymphoma complicating celiac sprue and the mesenteric lymph node cavitation syndrome, Gastroenterology, 90, 2008, 10.1016/0016-5085(86)90275-1 Freeman, 1977, Primary abdominal lymphoma, 63, 585 Fry, 1974, Dermatitis herpetiformis: an evaluation of diagnostic criteria, British Journal of Dermatology, 90, 137, 10.1111/j.1365-2133.1974.tb06377.x Fry, 1967, Small intestinal structure and function and haematological changes in dermatitis herpetiformis, Lancet, ii, 729, 10.1016/S0140-6736(67)91942-3 Gough, 1962, Intestinal reticulosis as a complication of idiopathic steatorrhoea, Gut, 3, 232, 10.1136/gut.3.3.232 Greco, 1985, The effect of early feeding on the onset of symptoms in coeliac disease, Journal of Paediatric Gastroenterology and Nutrition, 4, 52, 10.1097/00005176-198502000-00010 Greenwood, 1983, In vitro characterisation of human intestinal intraepithelial lymphocytes, Gastroenterology, 85, 1023, 10.1016/S0016-5085(83)80067-5 Haakenstad, 1974, Saturation of the reticuloendothelial system with soluble immune complexes, Journal of Immunology, 112, 1939, 10.4049/jimmunol.112.5.1939 Hall, 1981, IgA-containing circulating immune complexes in gluten-sensitive enteropathy, Clinical and Experimental Immunology, 45, 234 Hamilton, 1982, Intestinal permeability in coeliac disease: the response to gluten withdrawal and single dose gluten challenge, Gut, 23, 202, 10.1136/gut.23.3.202 Hanson, 1980, The biological properties of secretory IgA, Journal of the Reticuloendothelial Society, 28, 1 Harris, 1967, Malignancy in adult coeliac disease and idiopathic steatorrhoea, American Journal of Medicine, 42, 899, 10.1016/0002-9343(67)90071-X Hekkens, 1970, Some aspects of gliadin fractionation and testing by a histochemical method, 11 Hodges, 1979, Malignant histiocytosis of the intestine, Digestive Diseases and Sciences, 24, 631, 10.1007/BF01333708 Holmes, 1978, Malignant lymphoma in coeliac disease, 301 Howdle, 1984, Organ culture of human small intestinal mucosa with particular reference to coeliac disease Howdle, 1986, Coeliac disease, 243 Howdle, 1981, Gluten sensitivity of small intestinal mucosa in vitro: quantitative assessment of histologic change, Gastroenterology, 80, 442, 10.1016/0016-5085(81)90004-4 Howdle, 1982, Cell-mediated immunity to gluten within the small intestinal mucosa in coeliac disease, Gut, 23, 115, 10.1136/gut.23.2.115 Howdle, 1984, Are all gliadins toxic in coeliac disease?, 19, 41 Howdle, 1986, Murine T-cell responses to wheat gliadins, Pediatric Research, 20, 697, 10.1203/00006450-198607000-00069 Howdle, 1986, The distribution of gluten-sensitive lymphocytes in coeliac patients—is it related to dietary gluten?, Clinical and Experimental Immunology, 66, 393 Isaacson, 1978, Intestinal lymphoma associated with malabsorption, Lancet, i, 67, 10.1016/S0140-6736(78)90004-1 Isaacson, 1980, Malabsorption and intestinal lymphomas, Clinics in Gastroenterology, 9, 193 Isaacson, 1985, Malignant histiocytosis of the intestine: a T-cell lymphoma, Lancet, ii, 688, 10.1016/S0140-6736(85)92930-7 Jones, 1959, Electrophoresis and fractionation of wheat gluten, Archives of Biochemistry and Biophysics, 84, 363, 10.1016/0003-9861(59)90599-5 Jos, 1982, The toxic fraction of gliadin digests in coeliac disease, 119, 263 Kagnoff, 1982, Two genetic loci control the murine immune response to A-gliadin, a wheat protein that activates coeliac sprue, Nature, 296, 158, 10.1038/296158a0 Kagnoff, 1984, Possible role for a human adenovirus in the pathogenesis of celiac disease, Journal of Experimental Medicine, 160, 1544, 10.1084/jem.160.5.1544 Karagiannis, 1986, Cellular hypersensitivity in coeliac disease to a synthetic dodecapeptide sequence from A-gliadin resembles an early protein of human adenovirus 12, Gut, 27, A1274 Kasarda, 1984, Nucleic acid (cDNA) and amino acid sequences of α-type gliadins from wheat (Triticum aestivum), 81, 4712 Katz, 1968, Intestinal antibodies to wheat fractions in celiac disease, Annals of Internal Medicine, 69, 1149, 10.7326/0003-4819-69-6-1149 Kendall, 1972, Gluten subfractions in coeliac disease, Lancet, ii, 1065, 10.1016/S0140-6736(72)92344-6 Kendall, 1972, Testing gluten sensitivity by the xylose test, Lancet, i, 667, 10.1016/S0140-6736(72)90466-7 Kenrick, 1970, Immunoglobulins and dietary protein antibodies in childhood coeliac disease, Gut, 11, 635, 10.1136/gut.11.8.635 Klaeveman, 1975, In vitro studies of ulcerative ileojejunitis, Gastroenterology, 68, 572, 10.1016/S0016-5085(75)80098-9 Koninckx, 1984, IgA antigliadin antibodies in celiac and inflammatory bowel disease, Journal of Pediatric Gastroenterology and Nutrition, 3, 676, 10.1097/00005176-198411000-00006 Kumar, 1976, Food antibodies in patients with dermatitis herpetiformis and adult coeliac disease—relationship to jejunal morphology, Scandinavian Journal of Gastroenterology, 11, 5, 10.1080/00365521.1976.12097065 Lancaster-Smith, 1974, Jejunal mucosal immunoglobulin-containing cells and jejunal fluid immunoglobulins in adult coeliac disease and dermatitis herpetiformis, Gut, 15, 371, 10.1136/gut.15.5.371 Lancaster-Smith, 1975, The cellular infiltrate of the jejunum in adult coeliac disease and dermatitis herpetiformis following the re-introduction of dietary gluten, Gut, 16, 683, 10.1136/gut.16.9.683 Langman, 1985, Changing patterns of coeliac disease frequency: an analysis of Coeliac Society membership records, Gut, 26, 175, 10.1136/gut.26.2.175 Levenson, 1985, Specificity of antigliadin antibody in celiac disease, Gastroenterology, 89, 1, 10.1016/0016-5085(85)90737-1 Lindberg, 1981, Coeliac disease and infant feeding practices, Lancet, i, 449, 10.1016/S0140-6736(81)91837-7 Littlewood, 1980, Childhood coeliac disease is disappearing, Lancet, ii, 1359, 10.1016/S0140-6736(80)92417-4 Lockwood, 1979, Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange, New England Journal of Medicine, 300, 524, 10.1056/NEJM197903083001003 Mackintosh, 1978, HLA and coeliac disease, British Medical Bulletin, 34, 291, 10.1093/oxfordjournals.bmb.a071514 Magalhaes, 1974, Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease, Gut, 15, 284, 10.1136/gut.15.4.284 Malizia, 1985, The microenvironment of coeliac disease: T cell phenotypes and expression of the T2 “T-blast” antigen by small bowel lymphocytes, Clinical and Experimental Immunology, 60, 437 Mann, 1976, Specific B-cell antigens associated with gluten-sensitive enteropathy and dermatitis herpetiformis, Lancet, i, 110, 10.1016/S0140-6736(76)93153-6 Marks, 1966, Small bowel changes in dermatitis herpetiformis, Lancet, ii, 1280, 10.1016/S0140-6736(66)91692-8 Marsh, 1980, Studies of intestinal lymphoid tissue. III. Quantitative analyses of epithelial lymphocytes in the small intestine of human control subjects and of patients with celiac sprue, Gastroenterology, 79, 481, 10.1016/0016-5085(80)90373-X Marsh, 1983, Immunocytes, enterocytes and the lamina propria: an immunopathologic framework of coeliac disease, Journal of the Royal College of Physicians, 17, 205 Marsh, 1985, Inflammatory component of celiac sprue mucosa. I. Mast cells, basophils and eosinophils, Gastroenterology, 89, 92, 10.1016/0016-5085(85)90749-8 Matuchansky, 1984, Cavitation of mesenteric lymph nodes, splenicatrophy and a flat small intestinal mucosa, 87, 606 McCarthy, 1966, Lymphoreticular dysfunction in idiopathic steatorrhoea, Gut, 7, 140, 10.1136/gut.7.2.140 Mearin, 1983, HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease, Gut, 24, 532, 10.1136/gut.24.6.532 Mills, 1980, Idiopathic chronic ulcerative enteritis, Quarterly Journal of Medicine, 194, 133 Mohammed, 1976, Multiple immune complexes and hypocomple mentaemia in dermatitis herpetiformis and coeliac disease, Lancet, ii, 487, 10.1016/S0140-6736(76)90787-X O'Donoghue, 1986, Fatal pneumococcal septicaemia in coeliac disease, Postgraduate Medical Journal, 62, 229, 10.1136/pgmj.62.725.229 O'Donoghue, 1976, T cell depletion in untreated adult coeliac disease, Gut, 17, 328, 10.1136/gut.17.5.328 O'Farrelly, 1984, Increased concanavalin A induced suppression in treated and untreated coeliac disease, Gut, 25, 644, 10.1136/gut.25.6.644 O'Farrelly, 1984, Suppressor cell activity in coeliac disease induced by alpha gliadin, a dietary antigen, Lancet, ii, 1305, 10.1016/S0140-6736(84)90822-5 O'Farrelly, 1986, Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma, British Medical Journal, 293, 908, 10.1136/bmj.293.6552.908 Offord, 1978, Further subfractionation of digests of gluten, 25 Osoba, 1978, HLA-B8 phenotype associated with an increased mixed leukocyte reaction, Immunogenetics, 6, 425, 10.1007/BF01563934 Owen, 1974, Epithelial cell specialization with human Peyer's patches, Gastroenterology, 66, 189, 10.1016/S0016-5085(74)80102-2 Packer, 1978, Gluten challenge in treated coeliac disease, Archives of Disease in Childhood, 53, 449, 10.1136/adc.53.6.449 Palmer, 1980, Bacteriological and endotoxin studies in cases of ulcerative colitis submitted to surgery, Gut, 21, 851, 10.1136/gut.21.10.851 Patey, 1974, Gliadin: the protein mixture toxic to coeliac patients, Lancet, i, 722, 10.1016/S0140-6736(74)92920-1 Patey, 1980, Toxicity of gliadin in coeliac patients, Lancet, ii, 427, 10.1016/S0140-6736(80)90477-8 Patey, 1975, Sequence comparison of γ-gliadin and coelic toxic α-gliadin, Lancet, ii, 718, 10.1016/S0140-6736(75)90830-2 Paulley, 1954, Observations on the aetiology of idiopathic steatorrhoea, ii, 1318 Pignata, 1985, Impaired suppressor activity in children affected by coeliac disease, Gut, 26, 285, 10.1136/gut.26.3.285 Platt, 1974, Varietal relationships of the α-gliadin proteins in wheat, Journal of the Science of Food and Agriculture, 25, 1555, 10.1002/jsfa.2740251217 Pollock, 1970, The effect on jejunal mucosa of withdrawing and adding dietary gluten in cases of idiopathic steatorrhoea, Gut, 11, 567, 10.1136/gut.11.7.567 Rawcliffe, 1981, The toxic fraction of wheat gluten, Vol. 9, 53 Rawcliffe, 1985, Antigenic reactivity of peptides derived from wheat gluten with sera from patients with coeliac disease, Clinical Science, 69, 97, 10.1042/cs0690097 Rawcliffe, 1985, Specific IgG sub-class antibodies, IgE and IgG S-TS antibodies to wheat gluten fraction B in patients with coeliac disease, Clinical Allergy, 15, 155, 10.1111/j.1365-2222.1985.tb02268.x Robertson, 1982, Suppressor cell activity, splenic function and HLA B8 status in man, Journal of Clinical and Laboratory Immunology, 9, 133 Robertson, 1983, Small intestinal ulceration: diagnostic difficulties in relation to coeliac disease, Gut, 24, 565, 10.1136/gut.24.6.565 Robinson, 1980, Splenic size and function in adult coeliac disease, British Journal of Radiology, 53, 532, 10.1259/0007-1285-53-630-532 Rossipal, 1974, Precipitating antibodies and complement in coeliac children, 200 Rubin, 1962, Biopsy studies on the pathogenesis of coeliac sprue, 67 Rubin, 1965, Immunofluorescent studies in adult celiac disease, Journal of Clinical Investigation, 44, 475, 10.1172/JCI105161 Ryan, 1978, Hyposplenism in inflammatory bowel disease, Gut, 19, 50, 10.1136/gut.19.1.50 Scott, 1975, Coeliac disease: a cause of various associated diseases, Lancet, ii, 956, 10.1016/S0140-6736(75)90365-7 Scott, 1977, Jejunal mucosal immunoglobulins and complement in untreated coeliac disease, Journal of Pathology, 121, 219, 10.1002/path.1711210405 Scott, 1984, Small intestinal plasma cells in coeliac disease, Gut, 25, 41, 10.1136/gut.25.1.41 Seah, 1971, Tissue antibodies in dermatitis herpetiformis and adult coeliac disease, Lancet, i, 834, 10.1016/S0140-6736(71)91499-1 Seah, 1973, Antireticulin antibody: incidence and diagnostic significance, Gut, 14, 311, 10.1136/gut.14.4.311 Seah, 1976, A comparison of histocompatibility antigens in dermatitis herpetiformis and adult coeliac disease, British Journal of Dermatology, 94, 131, 10.1111/j.1365-2133.1976.tb04361.x Segal, 1974, Oats and coeliac disease, British Medical Journal, 4, 589, 10.1136/bmj.4.5944.589 Selby, 1981, Immunohistological characterization of intraepithelial lymphocytes of the human gastrointestinal tract, Gut, 22, 169, 10.1136/gut.22.3.169 Selby, 1983, Lymphocyte subpopulations in the human small intestine, 52, 219 Shiner, 1972, Antigen-antibody reactions in jejunal mucosa in childhood coeliac disease after gluten challenge, Lancet, i, 1202, 10.1016/S0140-6736(72)90924-5 Silk, 1977, Intestinal lymphoma complicating dermatitis herpetiformis, British Journal of Dermatology, 96, 555, 10.1111/j.1365-2133.1977.tb07162.x Simmonds, 1981, Lymphadenopathy in coeliac disease, Gut, 22, 756, 10.1136/gut.22.9.756 Simpson, 1981, HLA-B8 and cellular immune response to gluten, Gut, 22, 633, 10.1136/gut.22.8.633 Simpson, 1983, Leucocyte migration inhibition test in coeliac disease—a reappraisal, Gut, 24, 311, 10.1136/gut.24.4.311 Sollid, 1986, The role of the CD8-Positive subset of T cells in proliferative responses to soluble antigens, Scandinavian Journal of Immunology, 23, 461, 10.1111/j.1365-3083.1986.tb03077.x Strobel, 1983, Human intestinal mucosal mast cells: expanded population in untreated coeliac disease, Gut, 24, 222, 10.1136/gut.24.3.222 Strober, 1981, The influence of histocompatibility genes on the pathogenesis of gluten sensitive enteropathy, 183 Swarbrick, 1979, Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance, Gut, 20, 121, 10.1136/gut.20.2.121 Swinson, 1980, Is coeliac disease underdiagnosed?, British Medical Journal, 281, 1258, 10.1136/bmj.281.6250.1258 Swinson, 1983, Coeliac disease and malignancy, Lancet, i, 111, 10.1016/S0140-6736(83)91754-3 Taylor, 1961, An immunological study of coeliac disease and idiopathic steatorrhoea, ii, 1727 Taylor, 1964, Serologic responses to gluten and cow's milk proteins in gastrointestinal disease, Gastroenterology, 46, 99, 10.1016/S0016-5085(64)80046-9 Teisberg, 1977, Complement system studies in adult coeliac disease, Scandinavian Journal of Gastroenterology, 12, 873, 10.3109/00365527709181733 Thaysen, 1932 Tomasi, 1965, Characteristics of an immune system common to certain external secretions, Journal of Experimental Medicine, 121, 101, 10.1084/jem.121.1.101 Tosi, 1983, Evidence that coeliac disease is primarily associated with a DC locus allelic specificity, Clinical Immunology and Immunopathology, 28, 395, 10.1016/0090-1229(83)90106-X Trejdosiewicz, 1985, Macrophages in the microenvironment of coeliac disease, Gut, 26, A1140 Unsworth, 1982, IgA in dermatitis herpetiformis skin is dimeric, Lancet, i, 478, 10.1016/S0140-6736(82)91452-0 Van de Kamer, 1953, Coeliac disease. IV. An investigation into the injurious constituents of wheat in connection with their action on patients with coeliac disease, Acta Paediatrica Scandinavica, 42, 223, 10.1111/j.1651-2227.1953.tb05586.x Van Loveren, 1984, Different mechanisms of release of vasoactive amines by mast cells occur in T cell-dependent compared to IgE-dependent cutaneous hypersensitivity responses, European Journal of Immunology, 14, 40, 10.1002/eji.1830140108 Volta, 1985, Antibodies to gliadin detected by immunofluorescence and a micro-ELISA method: markers of active childhood and adult coeliac disease, Gut, 26, 667, 10.1136/gut.26.7.667 Walker, 1981, Intestinal transport of macromolecules, 1271 Warshaw, 1971, Small intestinal permeability to macromolecules, Laboratory Investigation, 25, 675 Weiser, 1976, An alternative mechanism for gluten toxicity in coeliac disease, Lancet, i, 567, 10.1016/S0140-6736(76)90361-5 Weiss, 1983, Gluten-sensitive enteropathy: IgG heavy-chain (Gin) allotypes and the immune response to wheat gliadin, Journal of Clinical Investigation, 72, 96, 10.1172/JCI110988 Wieser, 1982, Toxicity of different wheat gliadins in coeliac disease, Zeitschshift für Lebensmittel-Untersuchung und-Forschung, 175, 321, 10.1007/BF01136247 Williamson, 1976, Anticonnective tissue and other antitissue ‘antibodies’ in the sera of patients with coeliac disease compared with the findings in a mixed hospital population, Journal of Clinical Pathology, 29, 484, 10.1136/jcp.29.6.484 Wood, 1986, Immunoglobulin production by coeliac biopsies in organ culture, Gut, 27, 1151, 10.1136/gut.27.10.1151 Wood, 1987, Jejunal plasma cells and in vitro immunoglobulin production in adult coeliac disease, Clinical and Experimental Immunology Woychik, 1961, Starch gel electrophoresis of wheat gluten proteins with concentrated urea, Archives of Biochemistry and Biophysics, 94, 477, 10.1016/0003-9861(61)90075-3