2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats

Vascular Pharmacology - Tập 51 - Trang 190-197 - 2009
Stevan P. Tofovic1, Xinchen Zhang1, Edwin K. Jackson1, Hong Zhu1, Gordana Petrusevska1
1Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, United States

Tài liệu tham khảo

Artlett, 2002, Influence of prior pregnancies on disease course and cause of death in systemic sclerosis, Ann. Rheum. Dis., 61, 346, 10.1136/ard.61.4.346 Ball, 1990, Formation, metabolism and physiological significance of catechol estrogens, Am. J. Obstet. Gynecol., 163, 2163, 10.1016/0002-9378(90)90558-O Beretta, 2006, Hormone replacement therapy may prevent the development of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement, Scand. J. Rheumatol., 35, 468, 10.1080/03009740600844498 Chauhan, 2003, Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cell using oligonucleotide arrays, Blood, 101, 3606, 10.1182/blood-2002-10-3146 Dubey, 2004, Cardiovascular pharmacology of estradiol metabolites, J. Pharmacol. Exp. Ther., 308, 403, 10.1124/jpet.103.058057 Espinosa, 1996, 17beta-estradiol and smooth muscle cell proliferation in aortic cells of male and female rats, Biochem. Biophys. Res. Commun., 221, 8, 10.1006/bbrc.1996.0535 Farhat, 1992, In vitro effects of oestradiol on thymidine uptake in pulmonary vascular smooth muscle cell: role of the endothelium, Br. J. Pharmacol., 107, 678, 10.1111/j.1476-5381.1992.tb14506.x Farhat, 1993, Protection of oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats, Br. J. Pharmacol., 110, 719, 10.1111/j.1476-5381.1993.tb13871.x Frazier-Jessen, 1995, Estrogen modulation of JE/monocyte chemoattractant protein-1 mRNA expression in murine macrophages, J. Immunol., 154, 1838, 10.4049/jimmunol.154.4.1838 Gharaee-Kermani, 2005, Animal models of pulmonary fibrosis, Methods Mol. Med., 117, 251 Gharaee-Kermani, 2005, Gender-base differences in bleomycin-induced pulmonary hypertension, Am. J. Pathol., 166, 1593, 10.1016/S0002-9440(10)62470-4 Hirano, 2007, Physiologically high concentrations of 17b-estradiol enhance NF-kB activity in human T cells, Am. J. Physiol. Regul. Integr. Comp. Physiol., 292, R1465, 10.1152/ajpregu.00778.2006 Issekutz, 2008, Modulation of adjuvant arthritis in the rat by 2-methoxyestardiol: an effect independent of anti-angiogenic action, Int. Immunopharmacol., 8, 708, 10.1016/j.intimp.2008.01.016 Khalil, 1993, Regulation of alveolar macrophage transforming growth factor-β secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat, J. Clin. Invest., 92, 1812, 10.1172/JCI116771 Kondo, 1983, Effects of various steroids on in vitro lifespan and cell growth of human fetal lung fibroblasts (WI-38), Mech. Ageing Dev., 21, 335, 10.1016/0047-6374(83)90050-7 Kurokawa, 2007, 2-methoxyestradiol reduces monocytes adhesion to aortic endothelial cells in ovariectomized rats, Endocrinology J., 54, 1027 Lazo, 1984, Pulmonary fate of [3H] bleomycin A2 in mice, J. Pharmacol. Exp. Ther., 228, 13 Lekgabe, 2006, The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs, Endocrinology, 147, 5575, 10.1210/en.2006-0533 Lettieri, 2006, Prevalence and outcomes of pulmonary arterial hypertension in idiopathic pulmonary fibrosis, Chest, 129, 746, 10.1378/chest.129.3.746 Liu, 2004, Suppressive effects of 17b-estradiol on hepatic fibrosis in CCI4-induced rat model, World J. Gastroenterol., 10, 1315, 10.3748/wjg.v10.i9.1315 Olson, 2007, Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003, Am. J. Respir. Crit. Care Med., 176, 227, 10.1164/rccm.200701-044OC Pan, 1993, Strain differences in the response of Fisher 344 and Sprague–Dawley rats to monocrotaline induced pulmonary vascular disease, Toxicology, 79, 21, 10.1016/0300-483X(93)90203-5 Pribluda, 2000, 2-methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate, Cancer Metastasis Rev., 19, 173, 10.1023/A:1026543018478 Proudman, 2007, Pulmonary arterial hypertension in systemic sclerosis: the need for early detection and treatment, Intern. Med. J., 37, 485, 10.1111/j.1445-5994.2007.01370.x Scorza, 2002, Post-menopause is the main risk factor for developing isolated pulmonary hypertension in systemic sclerosis, Ann. N. Y. Acad. Sci., 996, 238, 10.1111/j.1749-6632.2002.tb04221.x Seeger, 2006, Effects of estradiol, tamoxifen and 2-methoxyestradiol on TNF-α induced changes of biochemical markers for growth and invasion of human breast cancer cells, J. Menaupose, 13, 15 Speyer, 2005, Regulatory effects of estrogen on acute lung inflammation in mice, Am. J. Physiol. Cell Physiol., 288, C881, 10.1152/ajpcell.00467.2004 Straub, 2007, The complex role of estrogens in inflammation, Endocr. Rev., 28, 521, 10.1210/er.2007-0001 Takata, 2004, 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferative oral cancer cells through suppression of NFkB activity, Acta Med. Okayama, 58, 181 Tofovic, 2003, 2-methoxyestradiol attenuates hypertension and cardiac and vascular remodeling in constricted aorta rat model, J. Am. Soc. Nephrol., 14, 620A Tofovic, 2005, Estradiol metabolites attenuates monocrotaline-induced pulmonary hypertension in rats, J. Cardiovasc. Pharmacol., 46, 430, 10.1097/01.fjc.0000175878.32920.17 Tofovic, 2005, 2-methoxyestradiol attenuates pulmonary hypertension induced by α-naphthylthiourea, FASEB J., 19 Tofovic, 2006, 2-methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension, Vasc. Pharmacol., 45, 358, 10.1016/j.vph.2006.05.007 Tofovic, 2007, Dysregulated estradiol metabolism in preeclampsia, Physiologist, 50, 10 Tofovic, 2008, 2-ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling, Vasc. Pharmacol., 48, 174, 10.1016/j.vph.2008.02.001 Tomaszewski, 2003, Effects of 17 beta-estradiol and phytoestrogen daidzein on the proliferation of pubocervial fascia and skin fibroblast derived from women suffering from stress urinary incontinence, Ginekol. Pol., 74, 1410 Yasuda, 1999, Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats, Hepathology, 29, 719, 10.1002/hep.510290307 Zhang, 2007, 2-methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats, J. Cardiovasc. Pharmacol., 49, 56, 10.1097/FJC.0b013e31802cb88e