2-Gy whole-body irradiation significantly alters the balance of CD4+CD25−T effector cells and CD4+CD25+Foxp3+T regulatory cells in mice
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Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M . Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151–1164.
Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M et al. Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001; 182: 18–32.
Piccirillo CA, Shevach EM . Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 2001; 167: 1137–1140.
Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z et al. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006; 212: 8–27.
Toda A, Piccirillo CA . Development and function of naturally occurring CD4+CD25+ regulatory T cells. J Leukoc Biol 2006; 80: 458–470.
Sakaguchi S . Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22: 531–562.
Hiura T, Kagamu H, Miura S, Ishida A, Tanaka H, Tanaka J et al. Both regulatory T cells and antitumor effector T cells are primed in the same draining lymph nodes during tumor progression. J Immunol 2005; 175: 5058–5066.
Fontenot JD, Gavin MA, Rudensky AY . Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330–336.
Hori S, Nomura T, Sakaguchi S . Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057–1061.
Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY . Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22: 329–341.
d'Hennezel E, Ben-Shoshan M, Ochs HD, Torgerson TR, Russell LJ, Lejtenyi C et al. FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. N Engl J Med 2009; 361: 1710–1713.
Le Bras S, Geha RS . IPEX and the role of Foxp3 in the development and function of human Tregs. J Clin Invest 2006; 116: 1473–1475.
Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001; 27: 18–20.
Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 2007; 204: 57–63.
Sakaguchi S . Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345–352.
Yagi H, Nomura T, Nakamura K, Yamazaki S, Kitawaki T, Hori S et al. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 2004; 16: 1643–1656.
Khattri R, Cox T, Yasayko SA, Ramsdell F . An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003; 4: 337–342.
Ramsdell F . Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity 2003; 19: 165–168.
Zhang C, Todorov I, Lin CL, Atkinson M, Kandeel F, Forman S et al. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci USA 2007; 104: 2337–2342.
Kudo-Saito C, Schlom J, Camphausen K, Coleman CN, Hodge JW . The requirement of multimodal therapy (vaccine, local tumor radiation, and reduction of suppressor cells) to eliminate established tumors. Clin Cancer Res 2005; 11: 4533–4544.
Cunha-Rodrigues M, Portugal S, Febbraio M, Mota MM . Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection. Malar J 2007; 6: 32.
Zhang SX, Geddes JW, Owens JL, Holmberg EG . X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord. Histol Histopathol 2005; 20: 519–530.
Kajioka EH, Andres ML, Li J, Mao XW, Moyers MF, Nelson GA et al. Acute effects of whole-body proton irradiation on the immune system of the mouse. Radiat Res 2000; 153: 587–594.
Park HR, Jo SK, Paik SG . The NK1.1+ T cells alive in irradiated mice play an important role in a Th1/Th2 balance. Int J Radiat Biol 2006; 82: 161–170.
Pecaut MJ, Nelson GA, Gridley DS . Dose and dose rate effects of whole-body gamma-irradiation: I. Lymphocytes and lymphoid organs. In Vivo 2001; 15: 195–208.
Tsukimoto M, Nakatsukasa H, Sugawara K, Yamashita K, Kojima S . Repeated 0.5-Gy gamma irradiation attenuates experimental autoimmune encephalomyelitis with up-regulation of regulatory T cells and suppression of IL17 production. Radiat Res 2008; 170: 429–436.
Qu Y, Jin S, Zhang A, Zhang B, Shi X, Wang J et al. Gamma-ray resistance of regulatory CD4+CD25+Foxp3+ T cells in mice. Radiat Res 2010; 173: 148–157.
Liu R, Xiong S, Zhang L, Chu Y . Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatory cells. Cell Mol Immunol 2010; 7: 157–162.
Kipnis J, Avidan H, Markovich Y, Mizrahi T, Hauben E, Prigozhina TB et al. Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells. Eur J Neurosci 2004; 19: 1191–1198.
Sun Y, Li H, Langnas AN, Zhao Y . Altered allogeneic immune responses in middle-aged mice. Cell Mol Immunol 2004; 1: 440–446.
Sun Z, Zhao L, Wang H, Sun L, Yi H, Zhao Y . Presence of functional mouse regulatory CD4+CD25+ T cells in xenogeneic neonatal porcine thymus-grafted athymic mice. Am J Transplant 2006; 6: 2841–2850.
Sun Y, Ge BS, Kasai M, Diffendaffer C, Parks N, Li H et al. Induction of regulatory T cells from mature T cells by allogeneic thymic epithelial cells in vitro. Transpl Int 2006; 19: 404–414.
Yi H, Zhen Y, Zeng C, Zhang L, Zhao Y . Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence on regulatory CD4+CD25+Foxp3+ T cells in mice. Transplantation 2008; 85: 1167–1174.
Wang H, Zhao L, Sun Z, Sun L, Zhang B, Zhao Y . A potential side effect of cyclosporin A: inhibition of CD4+CD25+ regulatory T cells in mice. Transplantation 2006; 82: 1484–1492.
Zhao L, Sun L, Wang H, Ma H, Liu G, Zhao Y . Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice. J Leukoc Biol 2007; 81: 1386–1394.
Jones CM, Callaghan JM, Gleeson PA, Mori Y, Masuda T, Toh BH . The parietal cell autoantigens recognized in neonatal thymectomy-induced murine gastritis are the alpha and beta subunits of the gastric proton pump [corrected]. Gastroenterology 1991; 101: 287–294.
Zhao Y, Swenson K, Sergio JJ, Arn JS, Sachs DH, Sykes M . Skin graft tolerance across a discordant xenogeneic barrier. Nat Med 1996; 2: 1211–1216.
Yao Z, Liu Y, Jones J, Strober S . Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells. Eur J Immunol 2009; 39: 763–775.
Piccirillo CA, Thornton AM . Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells. Trends Immunol 2004; 25: 374–380.
Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AI . Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure. Nucl Med Biol 2006; 33: 1055–1063.
Shinomiya N . New concepts in radiation-induced apoptosis: ‘premitotic apoptosis’ and ‘postmitotic apoptosis’. J Cell Mol Med 2001; 5: 240–253.
Taibi N, Aka P, Kirsch-Volders M, Bourgeois P, Fruhling J, Szpireer C . Radiobiological effect of 99mTechnetium-MIBI in human peripheral blood lymphocytes: ex vivo study using micronucleus/FISH assay. Cancer Lett 2006; 233: 68–78.
Sprung CN, Chao M, Leong T, McKay MJ . Chromosomal radiosensitivity in two cell lineages derived from clinically radiosensitive cancer patients. Clin Cancer Res 2005; 11: 6352–6358.
Park HR, Jo SK, Paik SG . Factors effecting the Th2-like immune response after gamma-irradiation: low production of IL-12 heterodimer in antigen-presenting cells and small expression of the IL-12 receptor in T cells. Int J Radiat Biol 2005; 81: 221–231.
Chen X, Murakami T, Oppenheim JJ, Howard OM . Differential response of murine CD4+CD25+ and CD4+CD25− T cells to dexamethasone-induced cell death. Eur J Immunol 2004; 34: 859–869.
Banz A, Pontoux C, Papiernik M . Modulation of Fas-dependent apoptosis: a dynamic process controlling both the persistence and death of CD4 regulatory T cells and effector T cells. J Immunol 2002; 169: 750–757.
Pati N, Ghosh S, Hessner MJ, Khoo HJ, Wang X . Difference in gene expression profiles between human CD4+CD25+ and CD4+CD25− T cells. Ann NY Acad Sci 2003; 1005: 279–283.
Akbar AN, Vukmanovic-Stejic M, Taams LS, Macallan DC . The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat Rev Immunol 2007; 7: 231–237.
Feuerer M, Hill JA, Mathis D, Benoist C . Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009; 10: 689–695.
Comerci GD Jr, Williams TM, Kellie S . Immune tolerance after total lymphoid irradiation for heart transplantation: immunosuppressant-free survival for 8 years. J Heart Lung Transplant 2009; 28: 743–745.
Sharabi Y, Abraham VS, Sykes M, Sachs DH . Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant 1992; 9: 191–197.
Tomita Y, Khan A, Sykes M . Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. Transplantation 1996; 61: 477–485.
Higuchi M, Zeng D, Shizuru J, Gworek J, Dejbakhsh-Jones S, Taniguchi M et al. Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletion. J Immunol 2002; 169: 5564–5570.
Cao M, Cabrera R, Xu Y, Liu C, Nelson D . Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells. Cell Biol Int 2009; 33: 565–571.