18F-FDOPA PET/CT Findings in a Patient With Primary Cerebral Amyloidoma

Clinical Nuclear Medicine - Tập 45 Số 4 - Trang e206-e207 - 2020
Laura Rozenblum1, Marc Bertaux1, Franck Bielle2, Morgan Ollivier3, Sylvain Choquet4, Ytel Garcilazo5, Karima Mokhtari2, Aurélie Kas6,1
1Nuclear Medicine
2Neuropathology, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris, Sorbonne Université
3Department of Functional and Diagnostic Neuroradiology, Pitié-Salpétrière Hospital, AP-HP; Sorbonne Université, UPMC Univ
4Department of Hematology, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris, Sorbonne Université
5Department of Neurology, France, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris, Sorbonne Université; Sorbonne Université, INSERM, CNRS, Assistance Publique-Hôpitaux de Paris, Institut du Cerveau et de la Moelle épinière
6CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, LIB, Sorbonne Université, Paris, France.

Tóm tắt

Abstract Amino acid PET, including 18F-FDOPA, is recommended for initial characterization, delineation of tumor extent, and follow-up of gliomas because of its high diagnostic performances. 18F-FDOPA accumulates inside tumor cells via the l-type amino acid transporter 1 (LAT1) whose expression is increased in gliomas. We report here a case of a histopathologically proven brain amyloidoma that was first addressed for a suspected glioma. Congo red staining showed scattered extracellular deposits of amyloid and immunohistochemistry-highlighted LAT1 expression, explaining the high 18F-FDOPA uptake found in this lesion. This case indicates that differential diagnosis of the 18F-FDOPA uptake in brain lesions should include amyloidoma.

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Tài liệu tham khảo

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Thông tin xuất bản

Clinical Nuclear Medicine

Tập 45 Số 4

e206-e207

Thông tin tác giả