12 Autografting for chronic myeloid leukaemia

Allan, 1995, UK Medical Research Council randomised, multicentre trial of interferon-alpha nl for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response, Lancet, 345, 1392, 10.1016/S0140-6736(95)92596-1 Anafi, 1993, Tyrphostin-induced inhibition of p210BCR-ABL tyrosine kinase activity induces K562 to differentiate, Blood, 82, 3524, 10.1182/blood.V82.12.3524.3524 Aulitzky, 1996, Preliminary results of stem cell mobilization in chronic myeloid leukemia with a moderate intensity chemotherapy regimen and G-CSF or G-CSF plus IL-3, Bone Marrow Transplantation, 17, S67 Barnett, 1994, Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study, Blood, 84, 724, 10.1182/blood.V84.3.724.724 Bergan, 1995, Inhibition of protein-tyrosine kinase activity in intact cells by the aptameric action of oligodeoxynucleotides, Antisense Research and Development, 5, 33, 10.1089/ard.1995.5.33 Brito-Babapulle, 1987, Complete remission after autografting for chronic myeloid leukaemia, Leukemia Research, 11, 1115, 10.1016/0145-2126(87)90165-2 Brito-Babapulle, 1989, Autografting for patients with chronic myeloid leukaemia in chronic phase: peripheral blood stem cells may have a finite capacity for maintaining haemopoiesis, British Journal of Haematology, 73, 76, 10.1111/j.1365-2141.1989.tb00223.x Buckner, 1978, Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow, Experimental Hematology, 6, 96 Butler, 1993, Peripheral blood stem cells (PBSC) harvested post-chemotherapy for autologous bone marrow transplantation (ABMT) in chronic granulocytic leukaemia, Stem Cells, 11, S135 Carella, 1991, Therapy of acute phase chronic myelogenous leukemia with intensive chemotherapy, blood cell autotransplant and cyclosporine A, Leukemia, 5, 517 Carella, 1993, Collection of ‘normal’ blood repopulating cells during early hemopoietic recovery after intensive conventional chemotherapy in chronic myelogenous leukemia, Bone Marrow Transplantation, 12, 267 Carella, 1996, High-dose chemoradiotherapy followed by autologous Philadelphia chromosome-negative blood progenitor cell transplantation in patients with chronic myelogenous leukemia, Bone Marrow Transplantation, 17, 201 Carella, 1997, Mobilization and transplantation of Philadelphianegative peripheral-blood progenitor cells early in chronic myelogenous leukemia, Journal of Clinical Oncology, 15, 1575, 10.1200/JCO.1997.15.4.1575 Carlo Stella, 1988, Synergistic antiproliferative effect of recombinant interferon-gamma with recombinant interferon-alpha on chronic myelogenous leukemia hematopoietic progenitor cells (CFU-GEMM, CFU-MK, BFU-E, and CFU-GM), Blood, 72, 1293, 10.1182/blood.V72.4.1293.1293 Carlo Stella, 1991, In vitro marrow purging in chronic myelogenous leukemia: effect of mafosfamide and recombinant granulocyte-macrophage colony-stimulating factor, Bone Marrow Transplantation, 8, 265 Carlo Stella, 1994, Identification of Philadelphia-negative granulocytemacrophage colony-forming units generated by stroma-adherent cells from chronic myelogenous leukemia patients, Blood, 83, 1373, 10.1182/blood.V83.5.1373.1373 Carreras, 1997, Successful autografting in chronic myeloid leukaemia using Philadelphia-negative blood progenitor cells mobilized with rHu G-CSF alone in a patient responding to alpha-interferon, British Journal of Haematology, 96, 421, 10.1046/j.1365-2141.1997.d01-2039.x Chalmers, 1995, Duration of chronic phase correlates with the ability to mobilize peripheral blood stem cells in chronic myeloid leukemia, Experimental Hematology, 23, 791 Chalmers, 1997, Treatment of chronic myeloid leukaemia in chronic phase with idarubicin and cytarabine: mobilisation of Ph-negative peripheral blood stem cells, British Journal of Haematology, 96, 627, 10.1046/j.1365-2141.1997.d01-2058.x Charak, 1991, Interaction of various cytokines with interleukin 2 in the generation of killer cells from human bone marrow: application in purging of leukemia, Leukemia Research, 15, 801, 10.1016/0145-2126(91)90464-5 Chervenick, 1971, Human leukemic cells: in vitro growth of colonies containing the Philadelphia (Ph) chromosome, Science, 174, 1134, 10.1126/science.174.4014.1134 Choo, 1994, In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence, Nature, 372, 642, 10.1038/372642a0 Coulombel, 1983, Long-term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia, New England Journal of Medicine, 306, 1493, 10.1056/NEJM198306233082502 Craddock, 1992, Circulating stem cells in mice treated with cyclophosphamide, Blood, 80, 264, 10.1182/blood.V80.1.264.264 Cunningham, 1979, Results of treatment of Ph-positive chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol), Blood, 53, 375, 10.1182/blood.V53.3.375.bloodjournal533375 Daley, 1991, Blast crisis in a murine model of chronic myelogenous leukemia, 88, 11335 Deisseroth, 1994, Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to rekapse after autologous bone marrow in CML, Blood, 83, 3068, 10.1182/blood.V83.10.3068.3068 van Denderen, 1992, Antibody recognition of the tumor-specific b3–a2 junction of bcr-abl chimeric proteins in Philadelphia-chromosome-positive leukemias, Leukemia, 6, 1107 Druker, 1996, Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells, Nature Medicine, 2, 561, 10.1038/nm0596-561 Dube, 1984, Cytogenetic studies of early myeloid progenitor compartments in Ph1-positive chronic myeloid leukemia. II. Long-term culture reveals the persistence of Ph1-negative progenitors in treated as well as newly diagnosed patients, Blood, 63, 1172, 10.1182/blood.V63.5.1172.1172 Dunbar, 1992, Separating the wheat from the chaff: selection of benign hematopoietic cells in chronic myeloid leukemia, Blood, 79, 1107, 10.1182/blood.V79.5.1107.1107 Dunlop, 1992, Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo, Blood, 79, 2221, 10.1182/blood.V79.9.2221.2221 de Fabritiis, 1994, Autograft after in vitro purging with BCR-ABL antisense oligonucleotides for patients with CML in advanced phase, Bone Marrow Transplantation, 14, S80 de Fabritiis, 1995, In vitro purging with BCR-ABL antisense oligodeoxynucleotides does not prevent haematologic reconstitution after autologous bone marrow transplantation, Leukemia, 9, 662 de Fabritiis, 1995, Bone marrow purging with BCR-ABL antisense oligonucleotides and autograft for patients with chronic myelogenous leukaemia, Bone Marrow Transplantation, 15, S107 Ferraris, 1989, Clonal B lymphocytes lack bcr rearrangement in Phpositive chronic myelogenous leukaemia, British Journal of Haematology, 73, 48, 10.1111/j.1365-2141.1989.tb00218.x Fialkow, 1981, Evidence for a multistep pathogenesis of chronic myelogenous leukemia, Blood, 58, 158, 10.1182/blood.V58.1.158.158 Finney, 1972, Chronic granulocytic leukaemia with Ph 1 negative cells in bone marrow and a ten year remission after busulphan hypoplasia, British Journal of Haematology, 23, 283, 10.1111/j.1365-2141.1972.tb08874.x Gale, 1992, How do transplants cure chronic myelogenous leukemia?, Bone Marrow Transplantation, 9, 83 Geissler, 1992, Benzopyranones and benzothiopyranones: a class of tyrosine protein kinase inhibitors with selectivity for the v-abl kinase, Cancer Research, 52, 4492 Gishizky, 1993, Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice, 90, 3755 Goldman, 1994, Management of chronic myeloid leukaemia, Blood Reviews, 8, 21, 10.1016/0268-960X(94)90004-3 Goldman, 1979, Cryopreserved peripheral blood cells functioning as autografts in patients with chronic granulocytic leukaemia in transformation, British Medical Journal, 1, 1310, 10.1136/bmj.1.6174.1310 Goldman, 1981, Buffy coat autografts for patients with chronic granulocytic leukaemia in transformation, Blut, 42, 149, 10.1007/BF01026384 Goto, 1982, Growth characteristics of leukemic and normal hematopoietic cells in Ph-positive chronic myelogenous leukemia and effects of intensive treatment, Blood, 59, 793, 10.1182/blood.V59.4.793.793 Haines, 1984, Chemotherapy and autografting for chronic granulocytic leukaemia in transformation: probable prolongation of survival for some patients, British Journal of Haematology, 58, 711, 10.1111/j.1365-2141.1984.tb06118.x Hazel, 1996, Peripheral blood stem cell transplantation (PBSCT) for chronic granulocytic leukaemia, British Journal of Haematology, 93, 17 Hehlmann, 1994, Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia (CML), Blood, 84, 4064, 10.1182/blood.V84.12.4064.bloodjournal84124064 Henon, 1993, Difficulties in collecting peripheral blood stem cells in chronic myeloid leukemia related to persistence of the leukemic cell clone, Stem Cells, 11, S43 Hochhaus, 1996, Quantification of residual disease in chronic myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction, Blood, 87, 1549, 10.1182/blood.V87.4.1549.bloodjournal8741549 Hogge, 1987, Nonclonal hemopoietic progenitors in a G6PD heterozygote with chronic myelogenous leukemia revealed after long-term marrow culture, American Journal of Hematology, 24, 389, 10.1002/ajh.2830240408 Hoyle, 1994, Autografting for patients with CML in chronic phase: an update, British Journal of Haematology, 86, 76, 10.1111/j.1365-2141.1994.tb03255.x Hughes, 1997, Mobilization of predominantly Philadelphia chromosomenegative blood progenitors using cyclophosphamide and rHUG-CSF in early chronic-phase chronic myeloid leukaemia: correlation with Sokal prognostic index and haematological control, British Journal of Haematology, 96, 635, 10.1046/j.1365-2141.1997.d01-2068.x 1994, Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia, New England Journal of Medicine, 330, 820, 10.1056/NEJM199403243301204 James, 1996, Investigating and improving the specificity of ribozymes directed against the BCR-ABL translocation, Leukemia, 10, 1054 Johnson, 1996, Mobilization of Philadelphia-negative peripheral blood mononuclear cells in chronic myeloid leukaemia using hydroxyurea and G-CSF (filgrastim), British Journal of Haematology, 93, 863, 10.1046/j.1365-2141.1996.d01-1717.x Kantarjian, 1995, Collection of peripheral blood diploid cells from chronic myelogenous leukemia patients early in the recovery phase from myelosuppression induced by intensive chemotherapy, Journal of Clinical Oncology, 13, 553, 10.1200/JCO.1995.13.3.553 Keating, 1993, Photodynamic elimination of clonogenic Ph+ chronic myeloid leukemia cells, Leukemia and Lymphoma, 11, S265, 10.3109/10428199309047897 Khouri, 1996, Results with high-dose chemotherapy and unpurged autologous stem cell transplantation in 73 patients with chronic myelogenous leukemia: the MD Anderson experience, Bone Marrow Transplantation, 17, 775 Kirkland, 1993, BCR-ABL antisense purging in chronic myeloid leukaemia, Lancet, 342, 614, 10.1016/0140-6736(93)91438-R Korbling, 1981, Successful engraftment of blood derived normal hemopoietic stem cells in chronic myelogenous leukemia, Experimental Hematology, 9, 684 Kuss, 1993, High dose hydroxyurea in collection of Philadelphia chromosome-negative stem cells in chronic myeloid leukaemia, Leukemia and Lymphoma, 10, 73, 10.3109/10428199309147359 Leopold, 1995, Multi-unit ribozyme-mediated cleavage of bcr-abl mRNA in myeloid leukemias, Blood, 85, 2162, 10.1182/blood.V85.8.2162.bloodjournal8582162 Lisker, 1980, Late-appearing Philadelphia chromosome in two patients with chronic myelogenous leukemia, Blood, 56, 812, 10.1182/blood.V56.5.812.812 Luger, 1994, Autografting for chronic myeloid leukemia (CML) with C-MYB antisense oligodeoxynucleotide purged bone marrow: a preliminary report, Blood, 84, 151a Martiat, 1991, Philadelphia-negative (Ph-) chronic myeloid leukemia (CML): comparison with Ph+CML and chronic myelomonocytic leukemia, Blood, 78, 205, 10.1182/blood.V78.1.205.205 McGlave, 1990, Autologous transplantation for CML using marrow treated ex vivo with recombinant human interferon gamma, Bone Marrow Transplantation, 6, 115 McGlave, 1994, Autologous transplants for chronic myelogenous leukaemia: results from eight transplant groups, Lancet, 343, 1486, 10.1016/S0140-6736(94)92589-5 McGlave, 1996, Cyclophosphamide/GM-CSF priming in autotransplant therapy for CML, Bone Marrow Transplantation, 17, S65 Mehta, 1996, Myelosuppressive chemotherapy to mobilize normal stem cells in chronic myeloid leukemia, Bone Marrow Transplantation, 17, 25 Meloni, 1990, Autologous bone marrow transplantation or peripheral blood stem cell transplantation for patients with chronic myelogenous leukemia in chronic phase, Bone Marrow Transplantation, 4, S92 O'Brien, 1994, Autografting in chronic myeloid leukaemia, Blood Reviews, 8, 63, 10.1016/S0268-960X(05)80009-8 O'Brien, 1995, Current approaches to hemopoietic stem cell purging in chronic myeloid leukemia, Journal of Clinical Oncology, 13, 541, 10.1200/JCO.1995.13.3.541 O'Brien, 1995, Autografting for CML using bone marrow purged with MYB antisense oligonucleotide, Experimental Hematology, 23, 804 O'Brien, 1995, Autografting for CML using bone marrow purged with MYB antisense oligonucleotide, British Journal of Haematology, 89, 12 O'Brien SG, Apperley JF, Szydlo R et al (in press) High dose busulphan alone as cytoreduction before autografting in chronic myeloid leukemia—a feasibility study. British Journal of Haematology. Osman, 1995, Enhanced elimination of Ph+ chromosome cells in vitro by combined hyperthermia and other drugs (AZT, IFN-alpha and quercetin): its application to autologous bone marrow transplantation for CML, Experimental Hematology, 23, 444 Ozer, 1993, Blood, 82, 2975, 10.1182/blood.V82.10.2975.2975 Petzer, 1996, Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia, Blood, 88, 2162, 10.1182/blood.V88.6.2162.bloodjournal8862162 Raskind, 1993, Further evidence for the existence of a clonal Phnegative stage in some cases of Ph-positive chronic myelocytic leukemia, Leukemia, 7, 1163 Ratajczak, 1992, Acute- and chronic-phase chronic myelogenous leukemia colony-forming units are highly sensitive to the growth inhibitory effects of c-myb antisense oligodeoxynucleotides, Blood, 79, 1956, 10.1182/blood.V79.8.1956.1956 Reiffers, 1987, Autologous transplantation of Ph-positive cell depleted marrow in chronic granulocytic leukemia, 199 Reiffers, 1993, Peripheral blood stem cell transplantation followed by recombinant alpha interferon for chronic myelogenous leukemia in chronic phase: preliminary results, Stem Cells, 11, 23, 10.1002/stem.5530110908 Reiffers, 1994, Autologous stem cell transplantation in chronic myelogenous leukemia: a retrospective analysis of the European Group for Bone Marrow Transplantation, Bone Marrow Transplantation, 14, 407 Reiffers, 1996, Ph-negative blood progenitor cells can be successfully collected with lenograstim in patients with chronic myeloid leukemia good responders to alphainterferon, Bone Marrow Transplantation, 17, S46 Rizzoli, 1989, Pharmacological-mediated purging with mafosfamide in acute and chronic myeloid leukemias. The Italian Study Group, Progress in Clinical and Biological Research in Experimental Hematology, 17, 429 Rizzoli, 1993, Fractionation of chronic myelogenous leukemia marrow cells by stroma adherence: implications for marrow purging, Leukemia and Lymphoma, 11, S109, 10.3109/10428199309047872 Rule, 1996, Intermediate dose busulphan before autografting for advanced phase chronic myeloid leukaemia, British Journal of Haematology, 94, 694, 10.1046/j.1365-2141.1996.00709.x Sharp, 1979, Karyotypic conversion in Phl-positive chronic myeloid leukaemia with combination chemotherapy, Lancet, 1, 1370, 10.1016/S0140-6736(79)92008-7 Simonsson, 1994, Intensive treatment in order to minimize the Phpositive clone in chronic myelogenic leukemia (CML), Bone Marrow Transplantation, 14, S55 Smalley, 1977, Chronic granulocytic leukemia: cytogenetic conversion of the bone marrow with cycle-specific chemotherapy, Blood, 50, 107, 10.1182/blood.V50.1.107.107 Snyder, 1993, Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line, Blood, 82, 600, 10.1182/blood.V82.2.600.600 Spencer, 1995, Options for therapy in chronic myeloid leukaemia, British Journal of Haematology, 91, 2, 10.1111/j.1365-2141.1995.tb05236.x Storey, 1996, Is there a future for peripheral blood progenitor cell mobilisation and transplantation in CML?, British Journal of Haematology, 93, 15 Talpaz, 1991, Interferon-alpha produces sustained cytogenetic responses in chronic myelogenous leukemia, Annals of Internal Medicine, 114, 532, 10.7326/0003-4819-114-7-532 Tringali, 1994, High-dose cyclophosphamide for mobilization of circulating stem cells in chronic myeloid leukemia, European Journal of Haematology, 53, 1, 10.1111/j.1600-0609.1994.tb00170.x Turhan, 1990, Detection of breakpoint cluster region-negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow, Blood, 76, 2404, 10.1182/blood.V76.11.2404.2404 Verdonck, 1990, Selective killing of malignant cells from leukemia patients by alkyl-lysophospholipid, Cancer Research, 50, 4020 Verfaillie, 1992, Selection of benign primitive hematopoietic progenitors in chronic myclogenous leukemia on the basis of HLA-DR antigen expression, Blood, 79, 1003, 10.1182/blood.V79.4.1003.bloodjournal7941003 Verma, 1994, Interleukin-2 activation of human bone marrow in long-term cultures: an effective strategy for purging and generation of anti-tumour cytotoxic effectors, Bone Marrow Transplantation, 13, 115 Weinberger, 1978, A 13-years remission in chronic myelocytic leukemia after a single course of busulfan, Acta Haematologica, 59, 354, 10.1159/000207787 Wognum, 1992, Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia, Blood, 79, 642, 10.1182/blood.V79.3.642.642