1-(Ethoxymethyl)-6-(phenylselenyl)-5-ethyl uracil: a nucleoside analog
Tóm tắt
The compound, 1-(ethoxymethyl)-6-(phenylselenyl)-5-ethyl uracil, crystallizes in the monoclinic space group P21/n with unit cell parameters a = 5.304(1), b = 21.261(4), c = 13.996(4) Å, β = 94.30(2)°, and Z = 4. The acyclic chain C1′, O4′, C4′, C5′ is in fully extended form and nearly perpendicular to the uracil base. The molecules are held together by van der Waal's forces.
Tài liệu tham khảo
Elion, G.B.; Furman, P.A.; Fyfe, J.A.; de Miranda, P.; Beauchamp, L.; Schaeffer, H.J. Proc. Natl. Acad Sci. 1977, 74, 5717.
Schaeffer, H.J.; Beauchamp, L.; de Miranda, P.; Elion, G.B.; Bauer, D.J.; Collins, P. Nature 1978, 272, 583.
Birnbaum, G.I.; Gygler, M.; Shugar, D. Can. J. Chem. 1984, 62, 2646.
Goudgaon, N.M.; Schinazi, R.F. J. Med. Chem. 1991, 34, 3305.
Enraf-Nonious, CAD-4 software, Enraf-Nonious: Delft, Holland, 1988.
North, A.C.T.; Phillips, D.C.; Mathews, F.S. Acta Crystallogr. 1968, A24,351
Sheldrick, G.M. SHELXS86: Program for the Solution of Crystal Structures: University of Go¨ttingen: Germany, 1986.
Sheldrick, G.M. SHELXL93: Program for Refinement of Crystal Structures; University of Go¨ttingen: Germany, 1993.
Allen, F.H.; Kennard, O.; Watson, D.G.; Brammer, L.; Orpen, A.G.; Taylor, R. J. Chem. Soc. Perkin Trans. 2, 1987, S1–S19.
Johnson, C.K. ORTEP-II, Report ORNL-5138: Oak Ridge National Laboratory: TN.