1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex

Ordás, 2012, Ulcerative colitis, Lancet, 380, 1606, 10.1016/S0140-6736(12)60150-0 Feuerstein, 2019, Ulcerative colitis, Mayo Clin. Proc., 94, 1357, 10.1016/j.mayocp.2019.01.018 Xavier, 2007, Unravelling the pathogenesis of inflammatory bowel disease, Nature, 448, 427, 10.1038/nature06005 Saleh, 2011, Innate immune mechanisms of colitis and colitis-associated colorectal cancer, Nat. Rev. Immunol., 11, 9, 10.1038/nri2891 Rodenak-Kladniew, 2020, 1,8-cineole promotes G0/G1 cell cycle arrest and oxidative stress-induced senescence in HepG2 cells and sensitizes cells to anti-senescence drugs, Life Sci., 243, 10.1016/j.lfs.2020.117271 Y. Wang, D. Zhen, D. Fu, et al., 1,8-cineole attenuates cardiac hypertrophy in heart failure by inhibiting the miR-206-3p/SERP1 pathway, Phytomedicine 91 (2021), 153672. Yin, 2020, Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis, Br. J. Pharmacol., 177, 2042, 10.1111/bph.14967 Yadav, 2017, Suppression of inflammatory and infection responses in lung macrophages by eucalyptus oil and its constituent 1,8-cineole: Role of pattern recognition receptors TREM-1 and NLRP3, the MAP kinase regulator MKP-1, and NFκB, PLoS One, 12, 10.1371/journal.pone.0188232 Lomenick, 2009, Target identification using drug affinity responsive target stability (DARTS), Proc. Natl. Acad. Sci. U S A, 106, 21984, 10.1073/pnas.0910040106 Pai, 2015, Drug affinity responsive target stability (DARTS) for small-molecule target identification, Methods Mol. Biol., 1263, 287, 10.1007/978-1-4939-2269-7_22 G. Xu, S. Fu, X. Zhan, et al., Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90, JCI Insight 6 (2021), e134601. Ponce de León-Rodríguez, 2019, Intestinal in vitro cell culture models and their potential to study the effect of food components on intestinal inflammation, Crit. Rev. Food Sci. Nutr., 59, 3648, 10.1080/10408398.2018.1506734 Horst, 2010, Quantification of 1,8-cineole and of its metabolites in humans using stable isotope dilution assays, Mol. Nutr. Food Res., 54, 1515, 10.1002/mnfr.200900528 Mayor, 2007, A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses, Nat. Immunol., 8, 497, 10.1038/ni1459 Hirten, 2021, New therapeutics for ulcerative colitis, Annu. Rev. Med., 72, 199, 10.1146/annurev-med-052919-120048 Salim, 2011, Importance of disrupted intestinal barrier in inflammatory bowel diseases, Inflamm. Bowel Dis., 17, 362, 10.1002/ibd.21403 Kuo, 2019, Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression, Gastroenterology, 157, 1323, 10.1053/j.gastro.2019.07.058 Marincola Smith, 2021, Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice, Am. J. Physiol. Gastrointest. Liver Physiol., 320, G936, 10.1152/ajpgi.00053.2021 Thanaraj, 2010, Systematic review: Granulocyte/monocyte adsorptive apheresis for ulcerative colitis, Aliment. Pharmacol. Ther., 32, 1297, 10.1111/j.1365-2036.2010.04490.x Hardbower, 2017, EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis, Oncogene, 36, 3807, 10.1038/onc.2017.23 Liu, 2021, DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization, Cell Death Dis., 12 Hamilton, 2020, GM-CSF in inflammation, J. Exp. Med., 217, 10.1084/jem.20190945 Crayne, 2019, The immunology of macrophage activation syndrome, Front. Immunol., 10, 10.3389/fimmu.2019.00119 Widmer, 1993, Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines, J. Immunol., 150, 4996, 10.4049/jimmunol.150.11.4996 Kaminsky, 2021, IL-1β and the intestinal epithelial tight junction barrier, Front. Immunol., 12, 10.3389/fimmu.2021.767456 Rawat, 2020, IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p, which degrades occludin mRNA, Gastroenterology, 159, 1375, 10.1053/j.gastro.2020.06.038 Wang, 2006, IFN-γ-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction, Gastroenterology, 131, 1153, 10.1053/j.gastro.2006.08.022 Nakamura, 2017, Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury, J. Hepatol., 67, 1232, 10.1016/j.jhep.2017.08.010 Zhang, 2020, A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis, Nature, 586, 434, 10.1038/s41586-020-2799-2 Zhang, 2020, Protective role of microRNA-27a upregulation and HSP90 silencing against cerebral ischemia-reperfusion injury in rats by activating PI3K/AKT/mTOR signaling pathway, Int. Immunopharmacol., 86, 10.1016/j.intimp.2020.106635 Zhang, 2021, Fibrinogen/AKT/microfilament axis promotes colitis by enhancing vascular permeability, Cell Mol. Gastroenterol. Hepatol., 11, 683, 10.1016/j.jcmgh.2020.10.007 Liu, 2020, Kuijieyuan decoction improved intestinal barrier injury of ulcerative colitis by affecting TLR4-dependent PI3K/AKT/NF-κB oxidative and inflammatory signaling and gut microbiota, Front. Pharmacol., 11, 10.3389/fphar.2020.01036 Shi, 2021, TGR5 regulates macrophage inflammation in nonalcoholic steatohepatitis by modulating NLRP3 inflammasome activation, Front. Immunol., 11, 10.3389/fimmu.2020.609060