1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) Selectively Inhibits Kir3 and BK Channels in a Phospholipase C-Independent Fashion

Cho, 2001, Inhibition of acetylcholine-activated K+ currents by U73122 is mediated by the inhibition of PIP2-channel interaction, Br J Pharmacol, 134, 1066, 10.1038/sj.bjp.0704347

Depiereux, 1997, Match-Box_server: a multiple sequence alignment tool placing emphasis on reliability, Comput Appl Biosci, 13, 249

Du, 2005, Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder, Nat Genet, 37, 733, 10.1038/ng1585

Du, 2004, Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators, J Biol Chem, 279, 37271, 10.1074/jbc.M403413200

Filippov, 2004, Activation and inhibition of neuronal G protein-gated inwardly rectifying K+ channels by P2Y nucleotide receptors, Mol Pharmacol, 66, 468, 10.1016/S0026-895X(24)05629-3

Horowitz, 2005, Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current, J Gen Physiol, 126, 243, 10.1085/jgp.200509309

Huang, 1997, Binding of the G protein βgamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels, FEBS Lett, 405, 291, 10.1016/S0014-5793(97)00197-X

Huang, 1995, Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation, Neuron, 15, 1133, 10.1016/0896-6273(95)90101-9

Huth T, Schmidtmayer J, Alzheimer C, and Hansen UP (2008) Four-mode gating model of fast inactivation of sodium channel Nav1.2a. Pflugers Arch, in press.

Jin, 1999, Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q, Biochemistry, 38, 14294, 10.1021/bi991206j

Jin, 1994, U73122 inhibits phospholipase C-dependent calcium mobilization in neuronal cells, Brain Res, 642, 237, 10.1016/0006-8993(94)90927-X

Jin, 1998, A novel high-affinity inhibitor for inward-rectifier K+ channels, Biochemistry, 37, 13291, 10.1021/bi981178p

Kanjhan, 2005, Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner, J Pharmacol Exp Ther, 314, 1353, 10.1124/jpet.105.085928

Kwon, 2004, Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization, Proc Natl Acad Sci U S A, 101, 15237, 10.1073/pnas.0404877101

Lei, 2001, Receptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves Gαq family subunits, phospholipase C, and a readily diffusible messenger, J Biol Chem, 276, 16720, 10.1074/jbc.M100207200

Logothetis, 2007, Phosphoinositide-mediated gating of inwardly rectifying K+ channels, Pflugers Arch, 455, 83, 10.1007/s00424-007-0276-5

Lu, 2006, MaxiK channel partners: physiological impact, J Physiol, 570, 65, 10.1113/jphysiol.2005.098913

Magleby, 2003, Gating mechanism of BK (Slo1) channels: so near, yet so far, J Gen Physiol, 121, 81, 10.1085/jgp.20028721

Marescaux, 1992, GABAB receptor antagonists: potential new anti-absence drugs, J Neural Transm Suppl, 35, 179

Mark, 2000, G-protein mediated gating of inward-rectifier K+ channels, Eur J Biochem, 267, 5830, 10.1046/j.1432-1327.2000.01670.x

Meera, 1997, Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus, Proc Natl Acad Sci U S A, 94, 14066, 10.1073/pnas.94.25.14066

Meyer, 2001, Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes, J Biol Chem, 276, 5650, 10.1074/jbc.M009179200

Mogami, 1997, Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells, Biochem J, 324, 645, 10.1042/bj3240645

Piskorowski, 2002, Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains, Nature, 420, 499, 10.1038/nature01199

Salkoff, 2006, High-conductance potassium channels of the SLO family, Nat Rev Neurosci, 7, 921, 10.1038/nrn1992

Schmalhofer, 2005, Role of the C-terminus of the high-conductance calcium-activated potassium channel in channel structure and function, Biochemistry, 44, 10135, 10.1021/bi050527u

Schroeder, 2007, Saturation and microsecond gating of current indicate depletion-induced instability of the MaxiK selectivity filter, J Gen Physiol, 130, 83, 10.1085/jgp.200709802

Sickmann, 2002, Agonist-specific maturation of GIRK current responses in acutely isolated pyramidal neurons of rat neocortex, Brain Res, 929, 166, 10.1016/S0006-8993(01)03386-8

Sickmann, 2003, Short-term desensitization of G-protein-activated, inwardly rectifying K+ (GIRK) currents in pyramidal neurons of rat neocortex, J Neurophysiol, 90, 2494, 10.1152/jn.00112.2003

Sickmann, 2008, Unexpected suppression of neuronal G protein-activated, inwardly rectifying K+ current by common phos-pholipase C inhibitor, Neurosci Lett, 436, 102, 10.1016/j.neulet.2008.02.067

Slesinger, 1995, Identification of structural elements involved in G protein gating of the GIRK1 potassium channel, Neuron, 15, 1145, 10.1016/0896-6273(95)90102-7

Sodickson, 1996, GABAB receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons, J Neurosci, 16, 6374, 10.1523/JNEUROSCI.16-20-06374.1996

Sodickson, 1998, Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: Interactions among multiple receptors, J Neurosci, 18, 8153, 10.1523/JNEUROSCI.18-20-08153.1998

Vickers, 1993, U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets, J Pharmacol Exp Ther, 266, 1156

Zhang, 1999, Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions, Nat Cell Biol, 1, 183, 10.1038/11103

Zhou, 2001, Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels, Proc Natl Acad Sci U S A, 98, 6482, 10.1073/pnas.111447798