1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity

Whiteman, 2016, The fractions of cancer attributable to modifiable factors: a global review, Cancer Epidemiol., 44, 203, 10.1016/j.canep.2016.06.013

Nagle, 2006, Antimitotic agents of natural origin, Curr. Drug Target., 7, 305, 10.2174/138945006776054933

Perez, 2009, Microtubule inhibitors: differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance, Mol. Cancer Ther., 8, 2086, 10.1158/1535-7163.MCT-09-0366

Stanton, 2011, Drugs that target dynamic microtubules: a new molecular perspective, Med. Res. Rev., 31, 443, 10.1002/med.20242

Simona, 2008, Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade, Carcinogenesis, 29, 371, 10.1093/carcin/bgm265

Gregor, 2005, Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster, Prostaglandins Leukot. Essent. Fatty Acids, 73, 89, 10.1016/j.plefa.2005.04.016

R. Wisastra, F.J. Dekker, Inflammation, cancer and oxidative lipoxygenase activity are intimately linked, in:Cancers 6 (2014) 1500–1521.

Sameena, 2011, Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agent, Eur. J. Med. Chem., 46, 5763, 10.1016/j.ejmech.2011.08.015

Parveen, 2015, Synthesis, characterization and cytotoxic investigations of novel bis(indole) analogues besides antimicrobial study, Arabian J. Chem., 1878

Hao, 2016, Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy, Eur. J. Med. Chem., 108, 89, 10.1016/j.ejmech.2015.11.013

Nagendra, 2016, Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents, Eur. J. Med. Chem., 12, 289

Narsimha, 2013, 5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties, Bioorg. Med. Chem. Lett., 23, 1442, 10.1016/j.bmcl.2012.12.053

Bhale, 2017, Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents, Bioorg. Med. Chem. Lett., 27, 1502, 10.1016/j.bmcl.2017.02.052

Nasir, 2013, Chemistry and biology of indoles and indazoles: a mini-review, Mini Rev. Med. Chem., 13, 1792, 10.2174/1389557511313120009

Antonio, 2011, Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization, Eur. J. Med. Chem., 46, 3519, 10.1016/j.ejmech.2011.05.020

Sultan, 2014, Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors, Bioorg. Med. Chem., 22, 3096, 10.1016/j.bmc.2014.04.027

Dalip, 2014, Synthesis and identification of α-cyano bis(indolyl)chalcones as novel anticancer agents, Bioorg. Med. Chem. Lett., 24, 5170, 10.1016/j.bmcl.2014.09.085

Guangcheng, 2014, Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents, Bioorg. Med. Chem., 22, 2060, 10.1016/j.bmc.2014.02.028

Srinivasa, 2016, Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents, Eur. J. Med. Chem., 112, 289, 10.1016/j.ejmech.2016.02.025

Syed, 2012, Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities, Eur. J. Med. Chem., 49, 324, 10.1016/j.ejmech.2012.01.032

Palwinder, 2015, Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: dual inhibition of 5-LOX and COX-2 enzymes, Eur. J. Med. Chem., 97, 104, 10.1016/j.ejmech.2015.04.044

Copeland, 1994, Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase, Proc. Natl. Acad. Sci., 23, 11202, 10.1073/pnas.91.23.11202

Pagels, 1983, Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxide-dependent oxidations by ram seminal vesicle microsomes, J. Biol. Chem., 258, 6517, 10.1016/S0021-9258(18)32442-6

Egan, 1976, Mechanism for irreversible self-deactivation of prostaglandin synthetase, J. Biol. Chem., 251, 7329, 10.1016/S0021-9258(17)32853-3

Winter, 1962, Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs, Proc. Soc. Exp. Biol. Med., 111, 544, 10.3181/00379727-111-27849

Ferreira, 1979, A new method for measuring variations of rat paw volume, J. Pharm. Pharmacol., 31, 648, 10.1111/j.2042-7158.1979.tb13616.x

Daidone, 1994, Synthesis and pharmacological study of ethyl 1-methyl-5-[2-substituted-4-oxo-3(4H)-quinazolinyl]-1H-pyrazole-4-acetates, Eur. J. Med. Chem., 29, 707, 10.1016/0223-5234(94)90033-7

Ahmed, 2016, Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors, Bioorg. Chem., 65, 126, 10.1016/j.bioorg.2016.02.007

Smaranda, 2017, COX inhibition profile and molecular docking studies of some 2-(Trimethoxyphenyl)-thiazoles, Molecules, 22, 1507, 10.3390/molecules22091507

Parteek, 2014, Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors, Bioorg. Med. Chem., 22, 1642, 10.1016/j.bmc.2014.01.027

Lu, 2017, Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design, Biochem. Biophys. Res. Commun., 493, 718, 10.1016/j.bbrc.2017.08.125

Kolb, 2003, The growing impact of click chemistry on drug discovery, Drug Discov. Today, 24, 1128, 10.1016/S1359-6446(03)02933-7

Hélio, 2013, One-pot three-component synthesis of indole-3-glyoxyl derivatives and indole-3-glyoxyl triazoles, Tetrahedron Lett., 43, 5821

Mangiatordi, 2017, Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein, Eur. J. Med. Chem., 139, 792, 10.1016/j.ejmech.2017.07.037