1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ahmad, 2018, Pyrrole: an insight into recent pharmacological advances with structure activity relationship, Eur J Med Chem, 157, 527, 10.1016/j.ejmech.2018.08.002
Parker, 2009, Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer, Chem Rev, 109, 2880, 10.1021/cr900028p
Bozorov, 2017, 2-Aminothiophene scaffolds: diverse biological and pharmacological attributes in medicinal chemistry, Eur J Med Chem, 140, 465, 10.1016/j.ejmech.2017.09.039
Bozorov, 2015, Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties, Eur J Med Chem, 102, 552, 10.1016/j.ejmech.2015.08.018
Bozorov, 2014, Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1, Eur J Med Chem, 84, 739, 10.1016/j.ejmech.2014.07.065
Bozorov, 2017, Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2, RSC Adv, 7, 31417, 10.1039/C7RA04808D
Khanam, 2015, Bioactive Benzofuran derivatives: a review, Eur J Med Chem, 97, 483, 10.1016/j.ejmech.2014.11.039
Naik, 2015, Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry, Eur J Med Chem, 90, 379, 10.1016/j.ejmech.2014.11.047
Majumdar, 2014, Acid hydrazides, potent reagents for synthesis of oxygen-, nitrogen-, and/or sulfur-containing heterocyclic rings, Chem Rev, 114, 2942, 10.1021/cr300122t
Ayati, 2016, The importance of triazole scaffold in the development of anticonvulsant agents, Eur J Med Chem, 109, 380, 10.1016/j.ejmech.2016.01.009
Briguglio, 2015, Benzotriazole: an overview on its versatile biological behavior, Eur J Med Chem, 97, 612, 10.1016/j.ejmech.2014.09.089
Abdellatif, 2018, New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds, Bioorg Chem, 78, 341, 10.1016/j.bioorg.2018.03.032
Herr, 2002, 5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods, Bioorg Med Chem, 10, 3379, 10.1016/S0968-0896(02)00239-0
Dymińska, 2015, Imidazopyridines as a source of biological activity and their pharmacological potentials—infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials, Bioorg Med Chem, 23, 6087, 10.1016/j.bmc.2015.07.045
Reports regarding the use of triazoles in the Scopus database in: www.scopus.com, 2018.
Dheer, 2017, Medicinal attributes of 1,2,3-triazoles: current developments, Bioorg Chem, 71, 30, 10.1016/j.bioorg.2017.01.010
Carmona, 2018, Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors, Eur J Med Chem, 151, 765, 10.1016/j.ejmech.2018.04.008
Guo, 2018, Selective inhibitors of human neuraminidase 3, J Med Chem, 61, 1990, 10.1021/acs.jmedchem.7b01574
Gonzalez, 2018, The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: application to 18F-radiolabeling, Eur J Med Chem, 148, 314, 10.1016/j.ejmech.2018.02.017
Fjellaksel, 2018, Copper-mediated late-stage iodination and 123 I-labelling of triazole-benzimidazole bioactives, Synlett, 29, 1491, 10.1055/s-0036-1591985
Kommidi, 2018, 18F-positron emitting/trimethine cyanine-fluorescent contrast for image-guided prostate cancer management, J Med Chem, 61, 4256, 10.1021/acs.jmedchem.8b00240
Huang, 2018, Radiosynthesis and biological evaluation of 18F-labeled 4-anilinoquinazoline derivative (18F-FEA-Erlotinib) as a potential EGFR PET agent, Bioorg Med Chem Lett, 28, 1143, 10.1016/j.bmcl.2017.08.066
Valdomir, 2018, Oxa/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells, New J Chem, 42, 13784, 10.1039/C8NJ02388C
Zhou, 2018, Boronic acid inhibitors of the class A β-lactamase KPC-2, Bioorg Med Chem, 26, 2921, 10.1016/j.bmc.2018.04.055
Lopes, 2018, Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile, Eur J Med Chem, 143, 1010, 10.1016/j.ejmech.2017.11.052
Fletcher, 2018, Antimicrobial 1,3,4-trisubstituted-1,2,3-triazolium salts, Bioorg Med Chem Lett, 28, 3320, 10.1016/j.bmcl.2018.09.011
Rezaei-Matehkolaei, 2018, In vitro antifungal activity of novel triazole efinaconazole and five comparators against dermatophyte isolates, Antimicrob Agents Chemother, 62, 10.1128/AAC.02423-17
Savanur, 2018, Click chemistry inspired design, synthesis and molecular docking studies of coumarin, quinolinone linked 1,2,3-triazoles as promising anti-microbial agents, ChemistrySelect, 3, 5296, 10.1002/slct.201800319
Tarawneh, 2018, Evaluation of triazole and isoxazole derivatives as potential anti-infective agents, Med Chem Res, 27, 1269, 10.1007/s00044-018-2146-4
Batra, 2018, Synthesis and antimalarial evaluation of [1,2,3]-triazole-tethered sulfonamide-berberine hybrids, ChemistrySelect, 3, 9790, 10.1002/slct.201801905
Rajavelu, 2018, Synthesis, optical properties, and antioxidant and anticancer activity of benzoheterazole dendrimers with triazole bridging unit, New J Chem, 42, 3282, 10.1039/C7NJ04060A
Kumar, 2018, Synthesis and in-vitro antioxidant activities of some coumarin derivatives containing 1,2,3-triazole ring, Phosphorus, Sulfur Silicon Relat Elem, 193, 294, 10.1080/10426507.2017.1417293
Santosh, 2018, Synthesis, characterization, antibacterial and antioxidant studies of some heterocyclic compounds from triazole-linked chalcone derivatives, ChemistrySelect, 3, 6338, 10.1002/slct.201800905
Liu, 2018, A general approach towards triazole-linked adenosine diphosphate ribosylated peptides and proteins, Angew Chem Int Ed, 57, 1659, 10.1002/anie.201710527
Ben Haj Salah, 2018, How are 1,2,3-triazoles accommodated in helical secondary structures?, Org Biomol Chem, 16, 3576, 10.1039/C8OB00686E
Kacprzak, 2016, Alkaloids and isoprenoids modification by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (click chemistry): toward new functions and molecular architectures, Chem Rev, 116, 5689, 10.1021/acs.chemrev.5b00302
Johansson, 2016, Ruthenium-catalyzed azide alkyne cycloaddition reaction: scope, mechanism, and applications, Chem Rev, 116, 14726, 10.1021/acs.chemrev.6b00466
Efimov, 2019, Recent methods for the synthesis of NH-1,2,3-triazoles (microreview), Chem Heterocycl Compd, 55, 28, 10.1007/s10593-019-02414-8
Totobenazara, 2015, New click-chemistry methods for 1,2,3-triazoles synthesis: recent advances and applications, Tetrahedron Lett, 56, 2853, 10.1016/j.tetlet.2015.03.136
Usachev, 2018, Chemistry of fluoroalkyl-substituted 1,2,3-triazoles, J Fluorine Chem, 210, 6, 10.1016/j.jfluchem.2018.02.012
Bonandi, 2017, The 1,2,3-triazole ring as a bioisostere in medicinal chemistry, Drug Discov Today, 22, 1572, 10.1016/j.drudis.2017.05.014
Rejhová, 2018, Natural compounds and combination therapy in colorectal cancer treatment, Eur J Med Chem, 144, 582, 10.1016/j.ejmech.2017.12.039
Prasad, 2018, Chapter 5 – chemosensitization by ursolic acid: a new avenue for cancer therapy, Vol 2, 99
Lal, 2018, Recent advancements in 1,4-disubstituted 1H-1,2,3-triazoles as potential anticancer agents, Anti-Cancer Agents Med Chem, 18, 21, 10.2174/1871520616666160811113531
Ding, 2018, Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities, Eur J Med Chem, 156, 216, 10.1016/j.ejmech.2018.06.058
Janganati, 2018, MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells, Eur J Med Chem, 157, 562, 10.1016/j.ejmech.2018.08.010
Yu, 2018, Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents, Eur J Med Chem, 151, 434, 10.1016/j.ejmech.2018.04.005
Ke, 2018, Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents, Eur J Med Chem, 157, 1249, 10.1016/j.ejmech.2018.08.056
Ke, 2018, Design, synthesis and biological mechanisms research on 1,2,3-triazole derivatives of Jiyuan Oridonin A, Bioorg Med Chem, 26, 4761, 10.1016/j.bmc.2017.11.005
Wei, 2018, Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway, Eur J Med Chem, 157, 759, 10.1016/j.ejmech.2018.08.036
Li, 2018, Synthesis, antitumor activity evaluation and mechanistic study of novel hederacolchiside A1 derivatives bearing an aryl triazole moiety, Biorg Med Chem, 26, 4025, 10.1016/j.bmc.2018.06.026
Wu, 2018, Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1,2,3-triazole pharmacophore, Bioorg Med Chem Lett, 28, 2543, 10.1016/j.bmcl.2018.05.038
Boratyński, 2018, Triazole biheterocycles from cinchona alkaloids: coordination and antiproliferative properties, ChemistrySelect, 3, 9368, 10.1002/slct.201801810
Abou Samra, 2018, Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A, Eur J Med Chem, 148, 26, 10.1016/j.ejmech.2018.01.100
Bębenek, 2018, Novel triazoles of 3-acetylbetulin and betulone as anticancer agents, Med Chem Res, 27, 2051, 10.1007/s00044-018-2213-x
Reddy, 2018, 4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer, Eur J Med Chem, 144, 595, 10.1016/j.ejmech.2017.12.050
Bian, 2018, Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity, Bioorg Chem, 81, 373, 10.1016/j.bioorg.2018.08.028
Gupta, 2018, Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents, Eur J Med Chem, 145, 511, 10.1016/j.ejmech.2018.01.006
Safavi, 2018, Novel quinazolin-4(3H)-one linked to 1,2,3-triazoles: synthesis and anticancer activity, Chem Biol Drug Des, 92, 1373, 10.1111/cbdd.13203
Vasu, 2018, 2-((1H-1,2,3-Triazol-1-yl)methyl)-3-phenylquinazolin-4(3H)-ones: design, synthesis and evaluation as anti-cancer agents, Curr Bioact Compd, 14, 254, 10.2174/1573407213666170329131557
Le-Nhat-Thuy, 2018, Design, synthesis and evaluation of novel hybrids between 4-anilinoquinazolines and substituted triazoles as potent cytotoxic agents, Bioorg Med Chem Lett, 28, 3741, 10.1016/j.bmcl.2018.10.016
Srinivas, 2018, Design and synthesis of 1,4-substituted 1H–1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity, Bioorg Med Chem Lett, 28, 1005, 10.1016/j.bmcl.2018.02.032
Kettle, 2018, Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors, J Med Chem, 61, 8797, 10.1021/acs.jmedchem.8b00938
Chen, 2018, Identification of novel and selective non-peptide inhibitors targeting the polo-box domain of polo-like kinase 1, Bioorg Chem, 81, 278, 10.1016/j.bioorg.2018.08.030
Matthiesen, 2018, α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors, Bioorg Med Chem, 26, 376, 10.1016/j.bmc.2017.10.023
Cao, 2018, Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry, Bioorg Med Chem, 26, 3145, 10.1016/j.bmc.2018.04.041
Compain, 2018, A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy, Eur J Med Chem, 158, 1, 10.1016/j.ejmech.2018.08.100
Chen, 2018, Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors, Bioorg Med Chem, 26, 3958, 10.1016/j.bmc.2018.06.016
Gao, 2018, Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors, Bioorg Med Chem, 26, 2420, 10.1016/j.bmc.2018.03.045
Geng, 2018, Design, synthesis and in vitro biological evaluation of novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing a thiosemicarbazide moiety, Eur J Med Chem, 146, 147, 10.1016/j.ejmech.2018.01.031
Yamada, 2018, Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles, Bioorg Med Chem Lett, 28, 152, 10.1016/j.bmcl.2017.11.038
Gilandoust, 2018, Synthesis, characterization and cytotoxicity studies of 1,2,3-triazoles and 1,2,4-triazolo [1,5-a] pyrimidines in human breast cancer cells, Bioorg Med Chem Lett, 28, 2314, 10.1016/j.bmcl.2018.05.020
Allam, 2018, Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents, Eur J Med Chem, 156, 43, 10.1016/j.ejmech.2018.06.055
Li, 2018, Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells, Bioorg Med Chem Lett, 28, 700, 10.1016/j.bmcl.2018.01.011
Wang, 2018, Discovery of thinopyrimidine-triazole conjugates as c-Met targeting and apoptosis inducing agents, Bioorg Chem, 77, 370, 10.1016/j.bioorg.2018.01.037
Sayeed, 2018, Imidazopyridine linked triazoles as tubulin inhibitors, effectively triggering apoptosis in lung cancer cell line, Bioorg Chem, 80, 714, 10.1016/j.bioorg.2018.07.026
Bistrović, 2018, Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer, Eur J Med Chem, 143, 1616, 10.1016/j.ejmech.2017.10.061
Borowiecki, 2018, Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity, Eur J Med Chem, 150, 307, 10.1016/j.ejmech.2018.02.077
Costa, 2018, Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells, Eur J Med Chem, 156, 524, 10.1016/j.ejmech.2018.07.018
Dadmal, 2018, Synthesis and biological evaluation of triazole and isoxazole-tagged benzothiazole/benzoxazole derivatives as potent cytotoxic agents, New J Chem, 42, 15546, 10.1039/C8NJ01249K
Kumar, 2018, Design, synthesis, anti-proliferative evaluation and docking studies of 1: H-1,2,3-triazole tethered ospemifene-isatin conjugates as selective estrogen receptor modulators, New J Chem, 42, 3703, 10.1039/C7NJ04964A
Naaz, 2018, 1,2,3-Triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: their anti-proliferative & anti-inflammatory activity, Bioorg Chem, 81, 1, 10.1016/j.bioorg.2018.07.029
Schlapbach, 2018, N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity, Bioorg Med Chem Lett, 28, 2153, 10.1016/j.bmcl.2018.05.017
Wang, 2018, Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance, Eur J Med Chem, 143, 1535, 10.1016/j.ejmech.2017.10.041
Wang, 2018, Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R, Eur J Med Chem, 143, 123, 10.1016/j.ejmech.2017.11.008
Marepu, 2018, 1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: regioselective synthesis and identification of potent N-heteroarenes, Bioorg Med Chem Lett, 28, 3302, 10.1016/j.bmcl.2018.09.021
Szałaj, 2018, Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase, Eur J Med Chem, 157, 1346, 10.1016/j.ejmech.2018.08.086
Lal, 2018, Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1,2,3-triazole hybrids, Bioorg Chem, 77, 236, 10.1016/j.bioorg.2018.01.016
Maddili, 2018, Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents, Eur J Med Chem, 150, 228, 10.1016/j.ejmech.2018.02.056
Mishra, 2018, Rational modification of a lead molecule: improving the antifungal activity of indole – triazole – amino acid conjugates, Eur J Med Chem, 155, 658, 10.1016/j.ejmech.2018.06.039
Yu, 2018, Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties, Eur J Med Chem, 150, 729, 10.1016/j.ejmech.2018.03.034
Bi, 2018, Substitution of terminal amide with 1H-1,2,3-triazole: identification of unexpected class of potent antibacterial agents, Bioorg Med Chem Lett, 28, 884, 10.1016/j.bmcl.2018.02.001
Sall, 2018, Towards smart biocide-free anti-biofilm strategies: click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria, Bioorg Med Chem Lett, 28, 155, 10.1016/j.bmcl.2017.11.039
Gatadi, 2018, Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus, Eur J Med Chem, 157, 1056, 10.1016/j.ejmech.2018.08.070
Yadav, 2018, Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates, Eur J Med Chem, 155, 263, 10.1016/j.ejmech.2018.05.055
Srinivasarao, 2018, Design, synthesis and biological evaluation of triazole-containing 2-phenylindole and salicylic acid as quorum sensing inhibitors against Pseudomonas aeruginosa, ChemistrySelect, 3, 9170, 10.1002/slct.201801622
Govindaiah, 2018, Regioselective synthesis, antibacterial, molecular docking and fingerprint applications of 1-benzhydrylpiperazine derivatized 1,4-disubstituted 1,2,3-triazoles, ChemistrySelect, 3, 8111, 10.1002/slct.201801364
Kaushik, 2018, Convenient synthesis, antimalarial and antimicrobial potential of thioethereal 1,4-disubstituted 1,2,3-triazoles with ester functionality, Med Chem Res, 27, 458, 10.1007/s00044-017-2072-x
Moghimi, 2018, Synthesis, evaluation, and molecular docking studies of aryl urea-triazole-based derivatives as anti-urease agents, Arch Pharm, 351, 10.1002/ardp.201800005
Faidallah, 2018, Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates, Eur J Med Chem, 143, 1524, 10.1016/j.ejmech.2017.10.042
Yang, 2018, 1,3,5-Triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity, Eur J Med Chem, 144, 262, 10.1016/j.ejmech.2017.12.017
Spain, 2018, Antitubercular bis-substituted cyclam derivatives: structure-activity relationships and in vivo studies, J Med Chem, 61, 3595, 10.1021/acs.jmedchem.7b01569
Carta, 2019, Design synthesis and antitubercular activity of 4-alkoxy-triazoloquinolones able to inhibit the M. tuberculosis DNA gyrase, Eur J Med Chem, 161, 399, 10.1016/j.ejmech.2018.10.031
Yan, 2018, Synthesis and in vitro evaluation of novel substituted isatin-propylene-1H-1,2,3-triazole-4-methylene-moxifloxacin hybrids for their anti-mycobacterial activities, Eur J Med Chem, 143, 899, 10.1016/j.ejmech.2017.11.090
Srivastava, 2018, Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole, Eur J Med Chem, 150, 268, 10.1016/j.ejmech.2018.02.067
Danne, 2018, Triazole-diindolylmethane conjugates as new antitubercular agents: synthesis, bioevaluation, and molecular docking, MedChemComm, 9, 1114, 10.1039/C8MD00055G
Ashok, 2018, 1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation, RSC Adv, 8, 16997, 10.1039/C8RA03197E
Giroud, 2018, 2H-1,2,3-triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design, J Med Chem, 61, 3370, 10.1021/acs.jmedchem.7b01870
Negi, 2018, Synthesis, antiamoebic activity and docking studies of metronidazole-triazole-styryl hybrids, Eur J Med Chem, 150, 633, 10.1016/j.ejmech.2018.03.033
Zimmermann, 2018, Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity, Bioorg Med Chem, 26, 4850, 10.1016/j.bmc.2018.08.025
Zhang, 2018, Synthesis and evaluation of novel arctigenin derivatives as potential anti-Toxoplasma gondii agents, Eur J Med Chem, 158, 414, 10.1016/j.ejmech.2018.08.087
Hu, 2018, Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents, Curr Top Med Chem, 18, 114, 10.2174/1568026618666171215101158
Jarrahpour, 2018, Design, synthesis, activity evaluation and QSAR studies of novel antimalarial 1,2,3-triazolo-β-lactam derivatives, J Iran Chem Soc, 15, 1311, 10.1007/s13738-018-1330-2
Brandão, 2018, Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds, Eur J Med Chem, 145, 191, 10.1016/j.ejmech.2017.12.051
Chopra, 2018, Pyrimidine-chloroquinoline hybrids: synthesis and antiplasmodial activity, Eur J Med Chem, 148, 39, 10.1016/j.ejmech.2018.02.021
Yadav, 2018, In vitro antiplasmodial efficacy of synthetic coumarin-triazole analogs, Eur J Med Chem, 145, 735, 10.1016/j.ejmech.2018.01.017
Thakur, 2018, Synthesis and antiplasmodial activity of glyco-conjugate hybrids of phenylhydrazono-indolinones and glycosylated 1,2,3-triazolyl-methyl-indoline-2,3-diones, Eur J Med Chem, 155, 764, 10.1016/j.ejmech.2018.06.042
Oliveira, 2018, Design, synthesis and antileishmanial activity of naphthotriazolyl-4-oxoquinolines, Curr Top Med Chem, 18, 1454, 10.2174/1568026618666181002110116
Temraz, 2018, Anti-leishmanial click modifiable thiosemicarbazones: design, synthesis, biological evaluation and in silico studies, Eur J Med Chem, 151, 585, 10.1016/j.ejmech.2018.04.003
Teixeira, 2018, Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities, Eur J Med Chem, 146, 274, 10.1016/j.ejmech.2018.01.046
Upadhyay, 2018, Synthesis and evaluation of novel triazolyl quinoline derivatives as potential antileishmanial agents, Eur J Med Chem, 154, 172, 10.1016/j.ejmech.2018.05.014
Maji, 2018, Potential antileishmanial activity of a triazole-based hybrid peptide against leishmania major, ChemistrySelect, 3, 10220, 10.1002/slct.201802002
Gonzaga, 2018, Identification of 1-aryl-1H-1,2,3-triazoles as potential new antiretroviral agents, Med Chem, 14, 242, 10.2174/1573406413666170906121318
Liu, 2018, Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2′-deoxy-2′-fluoro- 4′-azido nucleoside derivatives as potent anti-HBV agents, Eur J Med Chem, 143, 137, 10.1016/j.ejmech.2017.11.028
Karypidou, 2018, Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents, Bioorg Med Chem Lett, 28, 3472, 10.1016/j.bmcl.2018.09.019
Yan, 2018, Synthesis of pentacyclic iminosugars with constrained butterfly-like conformation and their HIV-RT inhibitory activity, Bioorg Med Chem Lett, 28, 425, 10.1016/j.bmcl.2017.12.025
Liu, 2018, Design, synthesis, and structure-activity relationships of novel imidazo[4,5-c]pyridine derivatives as potent non-nucleoside inhibitors of hepatitis C virus NS5B, Bioorg Med Chem, 26, 2621, 10.1016/j.bmc.2018.04.029
Kaoukabi, 2018, Dihydropyrimidinone/1,2,3-triazole hybrid molecules: synthesis and anti-varicella-zoster virus (VZV) evaluation, Eur J Med Chem, 155, 772, 10.1016/j.ejmech.2018.06.028
Wu, 2018, Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library, Eur J Med Chem, 158, 478, 10.1016/j.ejmech.2018.09.029
Tian, 2018, Targeting the entrance channel of NNIBP: discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus, Eur J Med Chem, 151, 339, 10.1016/j.ejmech.2018.03.059
Saeedi, 2019, Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro α-glucosidase inhibition, kinetic, and docking study, Bioorg Chem, 83, 161, 10.1016/j.bioorg.2018.10.023
Avula, 2018, Synthesis of 1H–1,2,3-triazole derivatives as new α-glucosidase inhibitors and their molecular docking studies, Bioorg Chem, 81, 98, 10.1016/j.bioorg.2018.08.008
Kumari, 2018, Synthesis, docking and ADME prediction of novel 1,2,3-triazole-tethered coumarin derivatives as potential neuroprotective agents, Res Chem Intermed, 44, 1989, 10.1007/s11164-017-3210-2
Reddy, 2018, Synthesis and biological evaluation of longanlactone analogues as neurotrophic agents, Bioorg Med Chem Lett, 28, 673, 10.1016/j.bmcl.2018.01.020
Sweeney, 2018, Riluzole-triazole hybrids as novel chemical probes for neuroprotection in amyotrophic lateral sclerosis, ACS Med Chem Lett, 9, 552, 10.1021/acsmedchemlett.8b00103
Giraudo, 2018, 4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site, Eur J Med Chem, 158, 311, 10.1016/j.ejmech.2018.08.094
Chrovian, 2018, A Dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate, J Med Chem, 61, 207, 10.1021/acs.jmedchem.7b01279
Luo, 2018, Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents, Eur J Med Chem, 150, 796, 10.1016/j.ejmech.2018.03.035
Gilbertson, 2018, Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907, Bioorg Med Chem Lett, 28, 1381, 10.1016/j.bmcl.2018.02.058
Jalili-Baleh, 2018, Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds, Eur J Med Chem, 152, 600, 10.1016/j.ejmech.2018.04.058
Jalili-Baleh, 2018, Novel 3-phenylcoumarin–lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease, Bioorg Chem, 79, 223, 10.1016/j.bioorg.2018.04.030
Wang, 2018, Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: design, synthesis and biological evaluation, Eur J Med Chem, 151, 351, 10.1016/j.ejmech.2018.03.082
Wu, 2018, Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors, MedChemComm, 9, 149, 10.1039/C7MD00457E
Moussa, 2018, Novel click modifiable thioquinazolinones as anti-inflammatory agents: design, synthesis, biological evaluation and docking study, Eur J Med Chem, 144, 635, 10.1016/j.ejmech.2017.12.065
Rama Krishna, 2018, Synthesis of some novel orcinol based coumarin triazole hybrids with capabilities to inhibit RANKL-induced osteoclastogenesis through NF-κB signaling pathway, Bioorg Chem, 78, 94, 10.1016/j.bioorg.2018.03.005
Yu, 2018, Structure-guided modification of heterocyclic antagonists of the P2Y14 receptor, J Med Chem, 61, 4860, 10.1021/acs.jmedchem.8b00168
More, 2018, Acetazolamide-based [18F]-PET tracer: in vivo validation of carbonic anhydrase IX as a sole target for imaging of CA-IX expressing hypoxic solid tumors, Bioorg Med Chem Lett, 28, 915, 10.1016/j.bmcl.2018.01.060
Kumar, 2018, Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors, Eur J Med Chem, 155, 545, 10.1016/j.ejmech.2018.06.021
Vats, 2018, Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors, Eur J Med Chem, 150, 678, 10.1016/j.ejmech.2018.03.030
Wu, 2018, Click chemistry-based discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as orally active hypoxia-inducing factor prolyl hydroxylase inhibitors with favorable safety profiles for the treatment of anemia, J Med Chem, 61, 5332, 10.1021/acs.jmedchem.8b00549
Rajan, 2018, Novel indole and triazole based hybrid molecules exhibit potent anti-adipogenic and antidyslipidemic activity by activating Wnt3a/β-catenin pathway, Eur J Med Chem, 143, 1345, 10.1016/j.ejmech.2017.10.034
Narsimha, 2018, One-pot synthesis of novel 1,2,3-triazole-pyrimido[4,5-c]isoquinoline hybrids and evaluation of their antioxidant activity, Synth Commun, 48, 1220, 10.1080/00397911.2018.1440315
Chekir, 2018, Design, synthesis and biological evaluation of novel 1,2,3-triazole linked coumarinopyrazole conjugates as potent anticholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents, Bioorg Chem, 80, 189, 10.1016/j.bioorg.2018.06.005
Kayet, 2018, 1,5-Disubstituted 1,2,3-triazole linked disaccharides: metal-free syntheses and screening of a new class of ribonuclease A inhibitors, Bioorg Med Chem, 26, 455, 10.1016/j.bmc.2017.12.004
Kozarski, 2018, 7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: synthesis and evaluation as the inhibitors of cNIIIB nucleotidase, Bioorg Med Chem, 26, 191, 10.1016/j.bmc.2017.11.032
Peterson, 2018, Systematic tuning of fluoro-galectin-3 interactions provides thiodigalactoside derivatives with single-digit nM affinity and high selectivity, J Med Chem, 61, 1164, 10.1021/acs.jmedchem.7b01626
Lu, 2018, Design, synthesis, and biological evaluation of novel substituted benzamide derivatives bearing a 1,2,3-triazole moiety as potent human dihydroorotate dehydrogenase inhibitors, Bioorg Chem, 76, 528, 10.1016/j.bioorg.2017.12.025
Syeda, 2018, Design, synthesis, and in vitro and in vivo evaluation of ouabain analogues as potent and selective Na, K-ATPase α4 isoform inhibitors for male contraception, J Med Chem, 61, 1800, 10.1021/acs.jmedchem.7b00925