<i>In Vivo</i> Screening of Traditional Medicinal Plants for Neuroprotective Activity against Aβ42 Cytotoxicity by Using <i>Drosophila</i> Models of Alzheimer’s Disease

Biological and Pharmaceutical Bulletin - Tập 38 Số 12 - Trang 1891-1901 - 2015
Quan Feng Liu1, Jang Ho Lee2, Young‐Mi Kim3, Soojin Lee2, Yoon Ki Hong2, Soojin Hwang2, Youngje Oh1, Kyung‐Ho Lee2, Hye Sup Yun2, Im‐Soon Lee2, Songhee Jeon4, Young‐Won Chin3, Byung‐Soo Koo1, Kyoung Sang Cho2,5
1Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine, Dongguk University
2Department of Biological Sciences, Konkuk University
3College of Pharmacy and BK21PLUS R-FIND Team, Dongguk University-Seoul
4Dongguk University Research Institute of Biotechnology, Dongguk University
5Korea Hemp Institute, Konkuk University

Tóm tắt

Từ khóa


Tài liệu tham khảo

1) Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. <i>Science</i>, <b>297</b>, 353–356 (2002).

2) Mattson MP. Pathways towards and away from Alzheimer’s disease. <i>Nature</i>, <b>430</b>, 631–639 (2004).

3) Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. <i>Cell</i>, <b>140</b>, 918–934 (2010).

4) Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT, Donepezil Study Group. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer’s disease. <i>Neurology</i>, <b>50</b>, 136–145 (1998).

5) Schneider LS, Mangialasche F, Andreasen N, Feldman H, Giacobini E, Jones R, Mantua V, Mecocci P, Pani L, Winblad B, Kivipelto M. Clinical trials and late-stage drug development for Alzheimer’s disease: an appraisal from 1984 to 2014. <i>J. Intern. Med.</i>, <b>275</b>, 251–283 (2014).

6) Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M. Alzheimer’s disease: clinical trials and drug development. <i>Lancet Neurol.</i>, <b>9</b>, 702–716 (2010).

7) Gao C, Liu Y, Li L, Hölscher C. New animal models of Alzheimer’s disease that display insulin desensitization in the brain. <i>Rev. Neurosci.</i>, <b>24</b>, 607–615 (2013).

8) Lee S, Bang SM, Lee JW, Cho KS. Evaluation of traditional medicines for neurodegenerative diseases using <i>Drosophila</i> models. <i>Evid. Based Complement. Alternat. Med.</i>, <b>2014</b>, 967462 (2014). doi: 10.1155/2014/967462

9) Um MY, Choi WH, Aan JY, Kim SR, Ha TY. Protective effect of <i>Polygonum multiflorum</i> Thunb on amyloid β-peptide 25–35 induced cognitive deficits in mice. <i>J. Ethnopharmacol.</i>, <b>104</b>, 144–148 (2006).

10) Zhang L, Xing Y, Ye CF, Ai HX, Wei HF, Li L. Learning-memory deficit with aging in APP transgenic mice of Alzheimer’s disease and intervention by using tetrahydroxystilbene glucoside. <i>Behav. Brain Res.</i>, <b>173</b>, 246–254 (2006).

11) Wang X, Zhao L, Han T, Chen S, Wang J. Protective effects of 2,3,5,4′-tetrahydroxystilbene-2-<i>O</i>-beta-D-glucoside, an active component of <i>Polygonum multiflorum</i> Thunb, on experimental colitis in mice. <i>Eur. J. Pharmacol.</i>, <b>578</b>, 339–348 (2008).

12) Li X, Matsumoto K, Murakami Y, Tezuka Y, Wu Y, Kadota S. Neuroprotective effects of <i>Polygonum multiflorum</i> on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice. <i>Pharmacol. Biochem. Behav.</i>, <b>82</b>, 345–352 (2005).

13) Li X, Li Y, Chen J, Sun J, Li X, Sun X, Kang X. Tetrahydroxystilbene glucoside attenuates MPP<sup>+</sup>-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. <i>Neurosci. Lett.</i>, <b>483</b>, 1–5 (2010).

14) Qin R, Li X, Li G, Tao L, Li Y, Sun J, Kang X, Chen J. Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP<sup>+</sup>: The involvement of PI3K/Akt pathway activation. <i>Toxicol. Lett.</i>, <b>202</b>, 1–7 (2011).

15) Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB. Tauopathy in <i>Drosophila</i>: neurodegeneration without neurofibrillary tangles. <i>Science</i>, <b>293</b>, 711–714 (2001).

16) Iijima K, Liu HP, Chiang AS, Hearn SA, Konsolaki M, Zhong Y. Dissecting the pathological effects of human Aβ<sub>40</sub> and Aβ<sub>42</sub> in <i>Drosophila</i>: a potential model for Alzheimer’s disease. <i>Proc. Natl. Acad. Sci. U.S.A.</i>, <b>101</b>, 6623–6628 (2004).

17) Shulman JM, Feany MB. Genetic modifiers of tauopathy in <i>Drosophila.</i> <i>Genetics</i>, <b>165</b>, 1233–1242 (2003).

18) Blard O, Feuillette S, Bou J, Chaumette B, Frébourg T, Campion D, Lecourtois M. Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in <i>Drosophila.</i> <i>Hum. Mol. Genet.</i>, <b>16</b>, 555–566 (2007).

19) Cao W, Song HJ, Gangi T, Kelkar A, Antani I, Garza D, Konsolaki M. Identification of novel genes that modify phenotypes induced by Alzheimer’s β-amyloid overexpression in <i>Drosophila</i>. <i>Genetics</i>, <b>178</b>, 1457–1471 (2008).

20) Rival T, Page RM, Chandraratna DS, Sendall TJ, Ryder E, Liu B, Lewis H, Rosahl T, Hider R, Camargo LM, Shearman MS, Crowther DC, Lomas DA. Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a <i>Drosophila</i> model of Alzheimer’s disease. <i>Eur. J. Neurosci.</i>, <b>29</b>, 1335–1347 (2009).

21) Iijima-Ando K, Zhao L, Gatt A, Shenton C, Iijima K. A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. <i>Hum. Mol. Genet.</i>, <b>19</b>, 1930–1938 (2010).

22) Wang L, Chiang HC, Wu W, Liang B, Xie Z, Yao X, Ma W, Du S, Zhong Y. Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss. <i>Proc. Natl. Acad. Sci. U.S.A.</i>, <b>109</b>, 16743–16748 (2012).

23) Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ. HDAC6 mutations rescue human tau-induced microtubule defects in <i>Drosophila</i>. <i>Proc. Natl. Acad. Sci. U.S.A.</i>, <b>110</b>, 4604–4609 (2013).

24) Hong YK, Park SH, Lee S, Hwang S, Lee MJ, Kim D, Lee JH, Han SY, Kim ST, Kim YK, Jeon S, Koo BS, Cho KS. Neuroprotective effect of SuHeXiang Wan in <i>Drosophila</i> models of Alzheimer’s disease. <i>J. Ethnopharmacol.</i>, <b>134</b>, 1028–1032 (2011).

25) Park SH, Lee S, Hong YK, Hwang S, Lee JH, Bang SM, Kim YK, Koo BS, Lee IS, Cho KS. Suppressive effects of SuHeXiang Wan on amyloid-β42-induced extracellular signal-regulated kinase hyperactivation and glial cell proliferation in a transgenic <i>Drosophila</i> model of Alzheimer’s disease. <i>Biol. Pharm. Bull.</i>, <b>36</b>, 390–398 (2013).

26) Kim HK, Choi YH, Choi JS, Choi SU, Kim YS, Lee KR, Kim YK, Ryu SY. A new stilbene glucoside gallate from the roots of <i>Polygonum multiflorum.</i> <i>Arch. Pharm. Res.</i>, <b>31</b>, 1225–1229 (2008).

27) Na MK, An RB, Min BS, Lee SM, Kim YH, Bae KH. Chemical constituents from <i>Sorbus commixta</i>. <i>Nat. Prod. Sci.</i>, <b>8</b>, 62–65 (2002).

28) Owusu-Ansah E, Yavari A, Banerjee U. A protocol for <i>in vivo</i> detection of reactive oxygen species. <i>Protoc. Exch.</i>, doi: 10.1038/nprot.2008.23 (2008).

29) Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, Kim HJ, Kim TH, Jung WT, Lee OJ, Lee JS, Shim SG. Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of <i>Polygonum multiflorum</i> Thunb. <i>Gut. Liver</i>, <b>5</b>, 493–499 (2011).

30) Dong H, Slain D, Cheng J, Ma W, Liang W. Eighteen cases of liver injury following ingestion of <i>Polygonum multiflorum</i>. <i>Complement. Ther. Med.</i>, <b>22</b>, 70–74 (2014).

31) Hwang IK, Yoo KY, Kim DW, Jeong SJ, Won CK, Moon WK, Kim YS, Kwon DY, Won MH, Kim DW. An extract of <i>Polygonum multiflorum</i> protects against free radical damage induced by ultraviolet B irradiation of the skin. <i>Braz. J. Med. Biol. Res.</i>, <b>39</b>, 1181–1188 (2006).

32) Shen B, Truong J, Helliwell R, Govindaraghavan S, Sucher NJ. An <i>in vitro</i> study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity. <i>BMC Complement. Altern. Med.</i>, <b>13</b>, 373 (2013).

33) Na MK, An RB, Lee SM, Min BS, Kim YH, Bae KH, Kang SS. Antioxidant compounds from the stem bark of <i>Sorbus commixta</i>. <i>Nat. Prod. Sci.</i>, <b>8</b>, 26–29 (2002).

34) Raudonė L, Raudonis R, Gaivelytė K, Pukalskas A, Viškelis P, Venskutonis PR, Janulis V. Phytochemical and antioxidant profiles of leaves from different <i>Sorbus</i> L. species. <i>Nat. Prod. Res.</i>, <b>29</b>, 281–285 (2015).

35) Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. <i>Science</i>, <b>314</b>, 130–133 (2006).

36) Wirths O, Multhaup G, Bayer TA. A modified β-amyloid hypothesis: intraneuronal accumulation of the β-amyloid peptide the first step of a fatal cascade. <i>J. Neurochem.</i>, <b>91</b>, 513–520 (2004).

37) Borsello T, Forloni G. JNK signalling: a possible target to prevent neurodegeneration. <i>Curr. Pharm. Des.</i>, <b>13</b>, 1875–1886 (2007).

38) Braithwaite SP, Schmid RS, He DN, Sung ML, Cho S, Resnick L, Monaghan MM, Hirst WD, Essrich C, Reinhart PH, Lo DC. Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer’s disease. <i>Neurobiol. Dis.</i>, <b>39</b>, 311–317 (2010).

39) Pandey UB, Nichols CD. Human disease models in <i>Drosophila melanogaster</i> and the role of the fly in therapeutic drug discovery. <i>Pharmacol. Rev.</i>, <b>63</b>, 411–436 (2011).

40) Lee B, Shim I, Lee H, Hahm DH. <i>Rehmannia glutinosa</i> ameliorates scopolamine-induced learning and memory impairment in rats. <i>J. Microbiol. Biotechnol.</i>, <b>21</b>, 874–883 (2011).

41) Cioanca O, Hritcu L, Mihasan M, Hancianu M. Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloidβ<sub>(1–42)</sub> rat model of Alzheimer’s disease. <i>Physiol. Behav.</i>, <b>120</b>, 193–202 (2013).

42) Cioanca O, Hritcu L, Mihasan M, Trifan A, Hancianu M. Inhalation of coriander volatile oil increased anxiolytic-antidepressant-like behaviors and decreased oxidative status in beta-amyloid<sub>(1–42)</sub> rat model of Alzheimer’s disease. <i>Physiol. Behav.</i>, <b>131</b>, 68–74 (2014).

43) Zhou L, Hou Y, Yang Q, Du X, Li M, Yuan M, Zhou Z. Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β<sub>1–42</sub>-injected rats and may be connected to synaptic changes in the hippocampus. <i>Can. J. Physiol. Pharmacol.</i>, <b>90</b>, 1446–1455 (2012).

44) Liu JP, Feng L, Zhang MH, Ma DY, Wang SY, Gu J, Fu Q, Qu R, Ma SP. Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. <i>J. Ethnopharmacol.</i>, <b>150</b>, 371–381 (2013).

45) Mo GL, Li Y, Du RH, Dai DZ, Cong XD, Dai Y. Isoproterenol induced stressful reactions in the brain are characterized by inflammation due to activation of NADPH oxidase and ER stress: attenuated by apocynin, rehmannia complex and triterpene acids. <i>Neurochem. Res.</i>, <b>39</b>, 719–730 (2014).

46) Liang JH, Du J, Xu LD, Jiang T, Hao S, Bi J, Jiang B. Catalpol protects primary cultured cortical neurons induced by Aβ<sub>1–42</sub> through a mitochondrial-dependent caspase pathway. <i>Neurochem. Int.</i>, <b>55</b>, 741–746 (2009).

47) Lu AM, Chen S. Flora Reipublicae Popularis Sinicae. <i>Adoxaceae, Valerianaceae, Dipsacaceae, Cucurbitaceae tomus 73</i>. Science Press (1986).

48) Bae KH. <i>The medicinal plants of Korea</i>. Kyo-Hak Publishing Co. (2000).

49) Sohn EJ, Kang DG, Choi DH, Lee AS, Mun YJ, Woo WH, Kim JS, Lee HS. Effect of methanol extract of <i>Sorbus</i> cortex in a rat model of L-NAME-induced atherosclerosis. <i>Biol. Pharm. Bull.</i>, <b>28</b>, 1239–1243 (2005).

50) Sohn EJ, Kang DG, Mun YJ, Woo WH, Lee HS. Anti-atherogenic effects of the methanol extract of <i>Sorbus</i> cortex in atherogenic-diet rats. <i>Biol. Pharm. Bull.</i>, <b>28</b>, 1444–1449 (2005).

51) Bae JT, Sim GS, Kim JH, Pyo HB, Yun JW, Lee BC. Antioxidative activity of the hydrolytic enzyme treated <i>Sorbus commixta</i> Hedl. and its inhibitory effect on matrix metalloproteinase-1 in UV irradiated human dermal fibroblasts. <i>Arch. Pharm. Res.</i>, <b>30</b>, 1116–1123 (2007).

52) Olszewska MA, Nowak S, Michel P, Banaszczak P, Kicel A. Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus <i>Sorbus sensu</i> Stricto. <i>Molecules</i>, <b>15</b>, 8769–8783 (2010).

53) Yu T, Lee YJ, Jang HJ, Kim AR, Hong S, Kim TW, Kim MY, Lee J, Lee YG, Cho JY. Anti-inflammatory activity of <i>Sorbus commixta</i> water extract and its molecular inhibitory mechanism. <i>J. Ethnopharmacol.</i>, <b>134</b>, 493–500 (2011).

54) Hwang JS, Lee SA, Hong SS, Han XH, Lee C, Lee D, Lee CK, Hong JT, Kim Y, Lee MK, Hwang BY. Inhibitory constituents of <i>Nardostachys chinensis</i> on nitric oxide production in RAW264.7 macrophages. <i>Bioorg. Med. Chem. Lett.</i>, <b>22</b>, 706–708 (2012).

55) Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. <i>Cell</i>, <b>148</b>, 1204–1222 (2012).

56) Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. <i>N. Engl. J. Med.</i>, <b>336</b>, 1216–1222 (1997).

57) Sung S, Yao Y, Uryu K, Yang H, Lee VMY, Trojanowski JQ, Praticò D. Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer’s disease. <i>FASEB J.</i>, <b>18</b>, 323–325 (2004).

58) Garcia-Alloza M, Borrelli LA, Hyman BT, Bacskai BJ. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP : PS1 mice. <i>Neurobiol. Aging</i>, <b>31</b>, 2058–2068 (2010).

59) McGeer PL, McGeer E. The amyloid cascade-inflammatory hypothesis of Alzheimer’s disease: implications for therapy. <i>Acta Neuropathol.</i>, <b>126</b>, 479–497 (2013).