<i>Mycobacterium avium</i>subsp.<i>paratuberculosis</i>in Veterinary Medicine

Clinical Microbiology Reviews - Tập 14 Số 3 - Trang 489-512 - 2001
Natalie Harris1, Raúl G. Barletta1
1Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, 68583-0905

Tóm tắt

SUMMARYMycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiologic agent of a severe gastroenteritis in ruminants known as Johne's disease. Economic losses to the cattle industry in the United States are staggering, reaching $1.5 billion annually. A potential pathogenic role in humans in the etiology of Crohn's disease is under investigation. In this article, we review the epidemiology, pathogenesis, diagnostics, and disease control measures of this important veterinary pathogen. We emphasize molecular genetic aspects including the description of markers used for strain identification, diagnostics, and phylogenetic analysis. Recent important advances in the development of animal models and genetic systems to study M. paratuberculosis virulence determinants are also discussed. We conclude with proposals for the applications of these models and recombinant technology to the development of diagnostic, control, and therapeutic measures.

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10.1006/mpat.1994.1040

10.1006/mpat.1995.0041

Adams J. L. Collins M. T. Czuprynski C. J. Polymerase chain reaction analysis of TNF-α and IL-6 mRNA levels in whole blood from cattle naturally or experimentally infected with Mycobacterium paratuberculosis. Can. J. Vet. Res. 60 1996 257 262

10.1128/iai.59.6.1905-1910.1991

10.1128/iai.62.6.2536-2544.1994

10.1016/S0021-9975(08)80140-5

Baess I. Deoxyribonucleic acid relationships between different serovars of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium scrofulaceum. Acta Pathol. Microbiol. Immunol. Scand. 91 1983 201 203

10.1128/jb.178.1.273-279.1996

10.1099/00221287-143-3-921

10.1128/jb.153.3.1138-1146.1983

10.1073/pnas.94.20.10961

10.1128/jb.178.16.4847-4853.1996

10.1128/JB.180.9.2568-2573.1998

10.1128/iai.65.11.4869-4872.1997

10.1128/jcm.34.7.1617-1621.1996

10.1128/jcm.30.3.613-618.1992

10.20506/rst.12.2.697

Bech-Nielsen S. Shulaw W. P. Frandsen P. L. Jorgensen J. B. Feld N. C. Ahrens P. Comparison of subjective and objective test evaluations for use of Mycobacterium phlei-absorbed serum in a dot-enzyme-linked immunosorbent assay for diagnosis of paratuberculosis in cattle. Am. J. Vet. Res. 53 1993 1386 1391

10.1016/0006-291X(86)90452-3

Berg-Jorgensen J. Survival of Mycobacterium paratuberculosis in slurry. Nord. Vet. Med. 29 1977 267 270

10.1002/jlb.47.2.135

10.1093/infdis/165.1.75

10.1111/j.1751-0813.1992.tb07426.x

10.1016/S0165-2478(98)00127-8

10.1016/0165-2427(92)90170-U

10.1084/jem.167.3.777

10.1177/030098587801500206

10.1354/vp.37-5-428

10.1099/00221287-146-9-2185

Burnside D. M. Rowley B. O. Evaluation of an enzyme-linked immunosorbent assay for diagnosis of paratuberculosis in goats. Am. J. Vet. Res. 55 1994 465 466

10.1016/S0165-2427(98)00201-3

10.1172/JCI114038

10.1099/13500872-140-8-1977

10.1046/j.1525-1381.1999.99236.x

10.1007/s002039900132

Cellier C. De Beenhouwer H. Berger A. Penna C. Carbonnel F. Parc R. Cugnenc P. H. Le Quintrec Y. Gendre J. P. Barbier J. P. Portaels F. Mycobacterium paratuberculosis and Mycobacterium avium subsp. silvaticum DNA cannot be detected by PCR in Crohn's disease tissue. Gastroenterol. Clin. Biol. 22 1998 675 678

Cetinkaya B. Erdogan H. M. Morgan K. L. Relationships between the presence of Johne's disease and farm and management factors in dairy cattle in England Prev. Vet. Med. 32 1997 253 266

10.1084/jem.175.4.1111

10.1016/S0368-1742(61)80029-5

10.1016/S0368-1742(62)80024-1

10.1016/S1097-2765(00)80079-9

Chenuse S. W. Warmingon K. S. Berger A. E. Tracey D. E. Immunohistochemical demonstration of interleukin-1 receptor antagonist protein and interleukin-1 in human lymphoid tissue and granulomas. Am. J. Pathol. 140 1992 269 275

10.1007/s005350050119

Chiodini R. J. Van Kruiningen H. J. Eastern white-tailed deer as a reservoir of ruminant paratuberculosis. J. Am. Vet. Med. Assoc. 182 1983 168 169

10.1128/jcm.20.5.966-971.1984

Chiodini R. J. Van Kruiningen H. J. Merkal R. S. Ruminant paratuberculosis Johne's disease: the current status and future prospects. Cornell Vet. 74 1984 218 262

Chiodini R. J. The genetic relationship between Mycobacterium paratuberculosis and the M. avium complex. Acta Leprol. 7 1989 249 251

10.1128/jcm.28.3.489-494.1990

10.1128/AAC.34.2.366

10.1016/S0021-9975(08)80295-2

10.1006/mpat.1993.1035

10.1128/AAC.37.8.1645

Chiodini R. J. M. paratuberculosis in foods and the public health implications Fifth Colloquium on Paratuberculosis. Chiodini R. J. Hines M. E. Jr. Collins M. T. 1997 353 365 International Association for Paratuberculosis Inc. Rehoboth Mass

10.1016/S0378-1135(98)00252-1

10.1093/clinids/20.4.1001

Clarke C. J. Host responses to Mycobacterium paratuberculosis/M. avium infection Proceedings of the 4th International Colloquium on Paratuberculosis. Chiodini R. J. Collins M. T. Bassey E. O. 1994 345 354 International Association for Paratuberculosis Inc. East Providence R.I

Clarke C. J. Patterson I. A. P. Armstrong K. E. Low J. C. Comparison of the absorbed ELISA and agar gel immunodiffusion test with clinicopathological findings in ovine clinical paratuberculosis. Vet. Rec. 139 1996 618 621

10.1007/BF02238248

10.1084/jem.181.1.257

10.1016/S0378-1135(99)00019-X

10.1128/CMR.7.3.328

10.1128/CDLI.5.4.446-451.1998

10.1128/JCM.38.8.3048-3054.2000

10.1128/jcm.30.7.1829-1836.1992

10.1038/31159

Collins D. M. de Lisle G. W. DNA restriction endonuclease analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG. J. Gen. Microbiol. 130 1984 1019 1021

Collins D. M. de Lisle G. W. Restriction endonuclease analysis of various strains of Mycobacterium paratuberculosis isolated from cattle. Am. J. Vet. Res. 47 1986 2226 2229

10.1111/j.1574-6968.1989.tb03440.x

10.1128/jcm.28.7.1591-1596.1990

10.1111/j.1574-6968.1991.tb04380.x

Collins D. M. Hilbink F. West D. M. Hosie B. D. Cooke M. M. de Lisle G. W. Investigation of Mycobacterium paratuberculosis in sheep by faecal culture, DNA characterisation and polymerase chain reaction. Vet. Rec. 133 1993 599 600

10.1016/0378-1135(93)90095-O

10.1073/pnas.92.17.8036

10.1006/mcpr.1997.0131

Collins M. T. Sockett D. C. Accuracy and economics of the USDA-licensed enzyme-linked immunosorbent assay for bovine paratuberculosis. J. Am. Vet. Med. Assoc. 203 1993 1456 1463

Collins M. T. Clinical approach to control of bovine paratuberculosis. J. Am. Vet. Med. Assoc. 204 1994 208 210

Collins M. T. Sockett D. C. Googdger W. J. Conrad T. A. Thomas C. B. Carr D. J. Herd prevalence and geographic distribution of, and risk factors for, bovine paratuberculosis in Wisconsin. J. Am. Vet. Med. Assoc. 204 1994 636 641

10.1016/S0749-0720(15)30411-4

10.7589/0090-3558-33.3.635

10.1006/mcpr.1999.0275

10.1111/j.1751-0813.1991.tb03167.x

10.1136/vr.133.9.219

10.1530/jrf.0.0880231

Darcel C. Diagnosis of infection with Mycobacterium paratuberculosis. Can. Vet. J. 36 1995 199 200

Darcel C. Logan-Handsaeme B. ELISA testing for antibody to Mycobacterium paratuberculosis. Can. Vet. J. 39 1998 335 336

10.1016/0092-8674(92)90349-H

10.1111/j.1365-3083.1992.tb03092.x

10.1128/jcm.31.4.947-954.1993

de Lisle G. W. Collins D. M. Huchzermeyer H. F. A. K. Characterization of ovine strains of Mycobacterium paratuberculosis by restriction endonuclease analysis and DNA hybridization. Onderstepoort J. Vet. Res. 59 1992 163 165

10.1177/104063879300500411

10.1111/j.1365-2958.1993.tb00970.x

Denny S. L. Brackett N. Y. Mann F. A. Kreeger J. M. Estes D. M. Antigen-specific humoral immune responses to a hapten-carrier conjugate in SCID mice engrafted with bovine fetal hematopoietic tissues. Lab. Anim. Sci. 46 1996 48 55

10.1073/pnas.97.3.1252

10.1038/icb.1994.63

10.1099/00221287-143-2-547

10.1177/104063879500700309

Dubash K. Shulaw W. P. Bech-Nielsen S. Stills H. F. Jr. Slemons R. D. Evaluation of an agar gel immunodiffusion test kit for detection of antibodies to Mycobacterium paratuberculosis in sheep. J. Am. Vet. Med. Assoc. 208 1996 401 403

10.1006/mcpr.1998.0167

10.1006/mcpr.2000.0299

10.1007/BF01570760

10.1128/cdli.2.6.657-664.1995

10.1128/jcm.35.7.1794-1799.1997

10.1111/j.1365-2958.1991.tb00827.x

10.1016/S0732-8893(98)00098-4

10.1128/jcm.34.3.734-737.1996

Falkingham J. O. Crawford J. T. Plasmids Tuberculosis. Bloom B. R. 1994 188 190 ASM Press Washington D.C.

10.1128/JB.181.3.1021-1024.1999

10.1136/vr.136.7.165

10.1006/mpat.1998.0246

10.1136/gut.35.4.506

10.1016/S0140-6736(94)90748-X

10.1099/13500872-141-5-1173

10.1016/0882-4010(90)90059-Y

10.1016/S0368-1742(43)80013-8

10.1017/S0950268897007486

10.1177/030098589002700509

Freytag L. C. Clements J. D. Bacterial toxins as mucosal adjuvants. Curr. Top. Microbiol. Immunol. 236 1999 215 236

10.1046/j.1365-2958.1998.01003.x

10.1177/030098589703400501

10.1054/mehy.1997.0622

Fujimura Y. Owen R. L. M cells as portals of infection: clinical and pathophysiological aspects. Infect. Agents Dis. 5 1996 144 156

10.1128/AAC.39.8.1647

Georgopoulos C. Ang D. Liberek K. Zylicz M. Stress proteins in biology and medicine. 1990 Cold Spring Harbor Laboratory Cold Spring Harbor N.Y

Gezon H. M. Bither H. D. Gibbs H. C. Acker E. J. Hanson L. A. Thompson J. K. Jorgenson R. D. Identification and control of paratuberculosis in a large goat herd. Am. J. Vet. Res. 49 1988 1817 1823

10.1016/0021-9975(73)90067-4

10.1016/S0034-5288(18)33764-0

10.1128/jb.175.15.4930-4935.1993

10.1016/S0378-1135(00)00313-8

10.1046/j.1365-2567.1998.00630.x

10.1016/S0962-8479(97)90024-1

10.1128/JB.181.15.4617-4627.1999

Goodger W. J. Collins M. T. Nordlund K. V. Eisele C. Pelletier J. Thomas C. B. Sockett D. C. Epidemiologic study of on-farm management practices associated with prevalence of Mycobacterium paratuberculosis infections in dairy cattle. J. Am. Vet. Med. Assoc. 208 1996 1877 1881

10.1111/j.1574-6968.1997.tb10221.x

Grange J. M. Gibson J. A. Strain to strain variation in the immunogenicity of BCG. Dev. Biol. Stand. 58 1986 37 41

10.1046/j.1472-765X.1998.00309.x

10.1046/j.1365-2672.1999.00557.x

10.1093/nar/17.22.9063

10.1016/0165-2427(93)90111-G

10.1016/S0165-2427(97)00071-8

10.1136/vr.140.6.141

10.1128/JCM.37.6.1746-1751.1999

10.1083/jcb.108.5.1935

10.1128/jcm.33.2.304-307.1995

10.1111/j.1365-2958.1992.tb00842.x

10.1111/j.1751-0813.2000.tb11902.x

10.1128/iai.57.1.225-230.1989

10.1177/030098589102800207

10.1002/path.1700780117

10.1111/j.1574-6968.1999.tb13597.x

10.1016/0167-5699(91)90109-7

10.1155/2000/798305

10.1111/j.1365-2958.1994.tb01059.x

10.1016/0378-1135(94)90140-6

10.1099/13500872-145-3-519

Hines S. A. Buergelt C. D. Wilson J. H. Bliss E. R. Disseminated Mycobacterium paratuberculosis infection in a cow. J. Am. Vet. Med. Assoc. 190 1987 681 683

10.1016/S0368-1742(56)80027-1

10.1007/BF02014241

10.1073/pnas.92.5.1530

10.1099/00207713-38-2-143

10.1016/S0378-1135(97)00125-9

Jessup D. A. Abbas B. Behymer D. Paratuberculosis in tule elk in California. J. Am. Vet. Med. Assoc. 179 1981 1252 1253

Johnson-Ifearulundu Y. J. Kaneene J. B. Relationship between soil type and Mycobacterium paratuberculosis. J. Am. Vet. Med. Assoc. 210 1997 1735 1740

10.1016/S0167-5877(98)00110-X

Johnson-Ifearulundu Y. Kaneene J. B. Distribution and environmental risk factors for paratuberculosis in dairy cattle herds in Michigan. Am. J. Vet. Res. 5 1999 589 596

Johnson-Ifearulundu Y. Kaneene J. B. Lloyd J. W. Herd-level economic analysis of the impact of paratuberculosis on dairy herds. J. Am. Vet. Med. Assoc. 214 1999 822 825

10.1016/S0021-9975(08)80189-2

10.1007/s005350050244

10.1146/annurev.iy.11.040193.001021

10.1002/jlb.55.6.719

10.1016/0092-8674(89)90676-4

10.1258/002367791780810065

10.1016/0268-960X(95)90038-1

Kopecky K. E. Larsen A. B. Merkal R. S. Uterine infection in bovine paratuberculosis. Am. J. Vet. Res. 28 1967 1043 1045

Kormendy B. Paratuberculosis vaccine in a large dairy herd. Acta Vet. Hung. 40 1992 171 184

10.1016/0378-1135(94)90141-4

10.1177/104063879100300425

10.1111/j.1365-2958.1991.tb02157.x

10.1007/BF01567167

Larsen A. B. Merkal R. S. Vardaman T. H. Survival time of Mycobacterium paratuberculosis. Am. J. Vet. Res. 17 1956 549 551

Larsen A. B. Kopecky K. E. Mycobacterium paratuberculosis in reproductive organs and semen of bulls. Am. J. Vet. Res. 31 1970 255 258

Larsen A. B. Moon H. W. Experimental Mycobacterium paratuberculosis infection in chickens. Am. J. Vet. Res. 33 1972 1231 1235

Larsen A. B. Merkal R. S. Moon H. W. Evaluation of a paratuberculosis vaccine given to calves before infection. Am. J. Vet. Res. 35 1974 367 369

Lawrence W. E. Congenital infection with Mycobacterium johnei in cattle. Vet. Rec. 68 1956 312

Le J. Vilcek J. Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab. Investig. 56 1987 234 248

10.1093/nar/18.18.5558

10.1016/0014-5793(91)80372-A

10.1002/path.1700710127

10.1016/S0368-1742(44)80013-3

10.1046/j.1440-1711.1999.00836.x

10.1016/0008-8749(90)90165-N

10.1128/MMBR.62.3.725-774.1998

10.1128/IAI.67.1.74-79.1999

10.1046/j.1365-2958.1999.01212.x

Manning E. J. Steinberg H. Rossow K. Ruth G. R. Collins M. T. Epizootic of paratuberculosis in farmed elk. J. Am. Vet. Med. Assoc. 213 1998 1320 1322

10.1128/jb.177.21.6100-6105.1995

10.1006/mcpr.1999.0227

10.1111/j.1751-0813.1999.tb11679.x

10.1128/jcm.30.12.3070-3073.1992

McNab W. B. Meek A. H. Duncan J. R. Brooks B. W. Van Dreumel A. A. Martin S. W. Nielsen K. H. Sugden E. A. Turcotte C. An evaluation of selected screening tests for bovine paratuberculosis. Can. J. Vet. Res. 55 1991 252 259

McNab W. B. Meek A. H. Martin S. W. Duncan J. R. Associations between dairy production indices and lipoarabinomannan enzyme-immunoassay results for paratuberculosis. Can. J. Vet. Res. 55 1991 356 361

10.1046/j.1365-2958.1998.00774.x

10.1006/abio.1995.1232

10.1177/104063879700900304

10.1073/pnas.93.18.9816

10.1128/iai.57.12.3798-3807.1989

Mokresh A. H. Butler D. G. Granulomatous enteritis following oral inoculation of newborn rabbits with Mycobacterium paratuberculosis of bovine origin. Can. J. Vet. Res. 54 1990 313 319

10.1016/0147-9571(95)00022-4

10.1177/030098588802500205

10.1136/gut.32.4.395

10.1099/00221287-138-1-139

Mowat A. M. Hutton A. K. Garside P. Steel M. A role for interleukin-1 in immunologically mediated intestinal pathology. Immunology 80 1993 110 115

10.1016/S0962-8479(97)90001-0

10.1111/j.1365-2958.1992.tb02201.x

10.1128/iai.65.2.387-394.1997

10.1128/iai.60.10.4074-4079.1992

Mutwiri G. K. Butler D. G. Rosendal S. Woodward B. The role of restricted food intake in the pathogenesis of cachexia in severe combined immunodeficient beige mice infected with Mycobacterium paratuberculosis. Can. J. Vet. Res. 59 1995 40 45

10.1007/s002849900396

10.1006/mcpr.1999.0261

National Animal Health Monitoring System Johne's disease on U.S. dairy operations. Report N245.1087. USDA:APHIS:VS CEAH 1997 National Animal Health Monitoring System Fort Collins Colo

10.1023/A:1006482520336

10.1128/iai.64.1.319-325.1996

10.1128/IAI.68.2.801-808.2000

10.1016/S0167-5877(99)00037-9

10.1099/00221287-145-12-3497

10.1099/00221287-146-8-1969

Patterson C. J. La Venture M. Hurley S. S. Davis J. P. Accidental self-inoculation with Mycobacterium paratuberculosis bacterin (Johne's bacterin) by veterinarians in Wisconsin. J. Am. Vet. Med. Assoc. 192 1988 1197 1199

10.1128/JB.181.16.4780-4789.1999

10.1016/0378-1135(94)00130-O

10.1016/S0167-7012(99)00091-3

Pearson J. K. L. McClelland T. G. Uterine infection and congenital Johne's disease in cattle. Vet. Rec. 67 1955 615 616

10.1111/j.1365-2958.1996.tb02533.x

10.1111/j.1574-6968.1996.tb08524.x

10.1073/pnas.94.20.10955

Perez V. Chavez G. Gutierrez M. Tellechea J. Badiola J. J. Garcia-Marin J. F. Evaluation of the AGID and γ-interferon tests in lambs infected with Mycobacterium avium subsp. silvaticum and Mycobacterium avium subsp. paratuberculosis Proceedings of the 4th International Colloquium on Paratuberculosis. Chiodini R. J. Collins M. T. Bassey E. O. 1994 91 96 International Association for Paratuberculosis Inc. East Providence R.I

Perez V. Tellechea J. Badiola J. J. Gutierrez M. Garcia-Marin J. F. Relation between serologic response and pathologic findings in sheep with naturally acquired paratuberculosis. Am. J. Vet. Res. 58 1997 799 803

Perez V. Tellechea J. Corpa J. M. Gutierrez M. Garcia-Marin J. F. Relation between pathologic findings and cellular immune responses in sheep with naturally acquired paratuberculosis. Am. J. Vet. Res. 60 1999 123 127

10.1016/0378-1119(89)90090-5

10.1099/00221287-142-9-2453

10.1099/00207713-47-3-640

10.1038/309030a0

10.1128/jcm.31.6.1601-1605.1993

10.1136/vr.132.9.213

Prescott J. F. Baggot J. D. Miscellaneous antibiotics: ionophores nitrofurans nitroimidazoles rifampin and others Antimicrobial therapy in veterinary medicine Prescott J. F. Baggot J. D. 1993 288 289 Iowa State University Press Ames

10.1099/00221287-145-11-3163

10.1002/path.1700750215

10.1128/AAC.36.12.2843

10.1099/13500872-145-7-1695

10.1016/S0167-5877(99)00069-0

10.1111/j.1751-0813.1995.tb15040.x

Ridley D. S. The histopathological spectrum of the mycobacterioses The biology of the mycobacteria Ratledge C. Stanford J. 2 1983 129 172 Academic Press, Inc. New York, N.Y

10.1099/00207713-40-4-323

Rohonczy E. B. Balachandran A. V. Dukes T. W. Payeur J. B. Rhyan J. C. Saari D. A. Whiting T. L. Wilson S. H. Jarnagin J. L. A comparison of gross pathology, histopathology, and mycobacterial culture for the diagnosis of tuberculosis in elk (Cervus elaphus). Can. J. Vet. Res. 60 1996 108 114

10.1128/jcm.33.5.1389-1391.1995

10.1016/S0749-0720(15)30413-8

10.1111/j.1751-0813.1990.tb07730.x

10.1128/jcm.27.5.994-997.1989

10.1136/gut.33.7.890

10.1136/vr.116.16.439

10.1111/j.1699-0463.1988.tb05335.x

10.1128/jb.169.3.1080-1088.1987

Shulaw W. P. Gordon J. C. Bech-Nielsen S. Pretzman C. I. Hoffsis G. F. Evidence of paratuberculosis in Ohio's white-tailed deer, as determined by an enzyme-linked immunosorbent assay. Am. J. Vet. Res. 47 1986 2539 2542

Shulaw W. P. Bech-Nielsen S. Rings D. M. Getzy D. M. Woodruff T. S. Serodiagnosis of paratuberculosis in sheep by use of agar gel immunodiffusion. Am. J. Vet. Res. 54 1993 13 19

10.1354/vp.36-6-542

10.1128/IAI.66.11.5576-5579.1998

10.1038/297506a0

10.1093/clinids/11.Supplement_2.S394

10.1054/tuld.1998.0010

10.1002/jlb.65.1.28

10.1128/br.34.2.99-125.1970

10.1128/jcm.30.5.1134-1139.1992

Spangler E. Heider J. E. Bech-Nielsen S. Dorn C. R. Serologic enzyme-linked immunosorbent assay responses of calves vaccinated with a killed Mycobacterium paratuberculosis vaccine. Am. J. Vet. Res. 52 1991 1197 1200

10.1016/0165-2427(94)05342-P

10.1016/0165-2427(94)05348-V

10.1177/104063879600800311

Stabel J. R. Goff J. P. Influence of vitamin D3 infusion and dietary calcium on secretion of interleukin 1, interleukin 6, and tumor necrosis factor in mice infected with Mycobacterium paratuberculosis. Am. J. Vet. Res. 57 1996 825 829

10.1016/0165-2427(95)05484-7

10.1128/aem.63.12.4975-4977.1997

10.1016/S0165-2427(98)00196-2

10.3168/jds.S0022-0302(98)75577-8

10.1128/jb.172.1.116-124.1990

10.1016/S0749-0720(15)31085-9

10.1016/S0007-1935(17)41102-X

10.1126/science.8303277

10.1177/104063879700900413

10.1128/AEM.64.3.999-1005.1998

10.1128/jb.169.2.839-843.1987

10.1128/jb.170.4.1631-1636.1988

Sweeney R. W. Whitlock R. H. Buckley C. L. Spencer P. Rosenberger A. E. Hutchinson L. J. Diagnosis of paratuberculosis in dairy cattle, using enzyme-linked immunosorbent assay for detection of antibodies against Mycobacterium paratuberculosis in milk. Am. J. Vet. Res. 55 1994 905 909

10.1177/104063879500700411

10.1016/S0749-0720(15)30408-4

Sweeney R. W. Jones D. E. Habecker P. Scott P. Interferon-γ and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis. Am. J. Vet. Res. 59 1998 842 847

10.1099/00207713-44-1-159

10.1016/S0021-9975(08)80315-5

Temple R. M. S. Muscoplat C. C. Thoen C. O. Hines E. M. Johnson D. W. Observations on diagnostic tests for paratuberculosis in a deer herd. J. Am. Vet. Assoc. 175 1979 914 915

Thoen C. O. Jarnagin J. L. Richards W. D. Isolation and identification of mycobacteria from porcine tissues: a three-year study. Am. J. Vet. Res. 36 1975 1383 1386

10.1128/iai.55.6.1466-1475.1987

10.1128/iai.56.6.1633-1640.1988

Thorel M. F. Drichevsky M. Lévy-Frébault V. V. Numerical taxonomy of mycobactin-dependent Mycobacteria, amended description of Mycobacterium avium, and description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp. paratuberculosis subsp. nov., and Mycobacterium avium subsp. silvaticum subsp. nov. Int. J. Syst. Bacteriol. 40 1990 254 260

10.1016/0378-1135(94)90118-X

10.1099/00221287-138-8-1729

10.1099/00221287-144-12-3413

Valente C. Cuteri V. Quondam Giandomenico R. Gialletti L. Franciosini M. P. Use of an experimental chicks model for paratuberculosis enteritis (Johne's disease). Vet. Res. 28 1997 239 246

10.1099/13500872-140-5-1103

van Schaik G. Kalis C. H. J. Benedictus G. Dijkhuizen A. A. Huirne R. B. M. Cost-benefit analysis of vaccination against paratuberculosis in dairy cattle. Vet. Rec. 139 1996 624 627

10.1128/jcm.28.5.933-937.1990

10.1016/0378-1135(95)00057-H

10.1016/S0021-9975(05)80071-4

10.1128/IAI.67.8.4243-4250.1999

10.1128/jcm.25.12.2309-2313.1987

10.1128/IAI.67.4.1593-1598.1999

Wayne L. G. Kubica G. P. The mycobacteria Bergey's manual of systematic bacteriology Sneath P. H. A. Mair N. S. Sharpe M. E. Holt J. G. 2 1986 1435 1457 The Williams & Wilkins Co. Baltimore, Md

10.1126/science.184.4140.952

10.1136/vr.132.2.38

10.1111/j.1439-0450.1994.tb00258.x

10.1128/jcm.25.8.1511-1515.1987

10.1016/0378-1135(89)90084-9

10.1128/jcm.28.11.2561-2564.1990

Whipple D. L. Klemens S. P. Cynamon M. H. Development of the beige mouse as an animal model for M. paratuberculosis infection Proceedings of the 3rd international colloquium on paratuberculosis. 1991 551 552 International Association of Paratuberuclosis East Providence R.I

10.1177/104063879200400106

White W. B. Whipple D. L. Stabel J. R. Bolin C. A. Comparison of cellular and extracellular proteins expressed by various isolates of Mycobacterium paratuberculosis and other mycobacterial species. Am. J. Vet. Res. 10 1994 1399 1405

10.1006/mcpr.1998.0194

10.1177/030098588302000304

10.7589/0090-3558-19.3.185

10.1128/JCM.37.2.304-309.1999

Wilson D. J. Rossiter C. Han H. R. Sears P. M. Association of Mycobacterium paratuberculosis infection with reduced mastitis, but with decreased milk production and increased cull rate in clinically normal dairy cows. Am. J. Vet. Res. 54 1993 1851 1857

10.1016/S0034-5288(18)31044-0

10.1292/jvms1939.47.111

10.1128/jcm.26.7.1309-1312.1988

10.1073/pnas.85.12.4267

10.1128/iai.65.5.1761-1766.1997

Zhao B. Y. Czuprynski C. J. Collins M. T. Intracellular fate of Mycobacterium avium subspecies paratuberculosis in monocytes from normal and infected, interferon-responsive cows as determined by a radiometric method. Can. J. Vet. Res. 63 1999 56 61

10.1111/j.0931-1793.1999.00214.x

10.1128/iai.56.7.1692-1697.1988