<i>Mycobacterium avium</i> Invades the Intestinal Mucosa Primarily by Interacting with Enterocytes

Infection and Immunity - Tập 69 Số 3 - Trang 1515-1520 - 2001
Félix J. Sangari1, Joshua Goodman2, Mary Petrofsky3, Peter Kolonoski3, Luiz E. Bermudez3
1Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, California 94115, USA.
2Pediatric Electron Microscopy Laboratory, University of California, San Francisco,2 San Francisco, California
3Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute,1 and

Tóm tắt

ABSTRACT Previous studies have demonstrated that Mycobacterium avium can invade intestinal epithelial cells both in vitro and in vivo. When given to mice orally, M. avium preferentially interacts with the intestinal mucosa at the terminal ileum. We evaluated the mechanism(s) of M. avium binding and invasion of the intestinal mucosa using three different systems: (i) electron microscopy following administration of M. avium into an intestinal loop in mice, (ii) quantitative comparison of the bacterial load in Peyer's patch areas of the terminal ileum versus areas that do not contain Peyer's patches, and (iii) investigation of the ability of M. avium to cause disseminated infection following oral administration using B-cell-deficient mice, lacking Peyer's patches, in comparison with C57BL/6 black mice. By all approaches, M. avium was found to invade the intestinal mucosa by interacting primarily with enterocytes and not with M cells.

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Infection and Immunity

Tập 69 Số 3

1515-1520

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