In vitro antiplasmodial activity of Central American medicinal plants

Tropical Medicine and International Health - Tập 4 Số 9 - Trang 611-615 - 1999
Kristina Jenett‐Siems1, Frank P. Mockenhaupt2, Ulrich Bienzle2, Mahabir P. Gupta3, Eckart Eich1
1Institut für Pharmazie, Pharmazeutische Biologie, Freie Universität Berlin, Berlin, Germany
2Institut für Tropenmedizin und Medizinische Fakultät Charité der Humboldt Universität zu Berlin, Berlin, Germany
3Centro de Investigaciones Farmacognosticas de la Flora Panameña (CIFLORPAN), Universidad de Panama, Panamá, Republica de Panama

Tóm tắt

Summary The in vitro antiplasmodial activities of 14 plant species traditionally used in Central America for the treatment of malaria or fever were evaluated. Lipophilic extracts of Piper hispidum, Siparuna andina, S. pauciflora, S. tonduziana, and Xylopia cf. frutescens, proved to be active against both a chloroquine‐sensitive and a resistant strain of Plasmodium falciparum. IC50 values ranged between 3.0 μg/ml and 21.9 μg/ml; however, moderate cytotoxicity of active extracts was observed. Bioactivity‐guided fractionation of Piper hispidum yielded 2′,4,6′‐trihydroxy‐4′‐methoxydihydrochalcone (asebogenin) as an active compound.

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Thông tin xuất bản

Tropical Medicine and International Health

Tập 4 Số 9

611-615

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