COMT and OPRM1 genotype associations with daily knee pain variability and activity induced pain

Scandinavian Journal of Pain - Tập 10 - Trang 6-12 - 2016
Lynn M. Martire1, Stephanie J. Wilson1, Brent J. Small2, Yvette P. Conley3, Piotr K. Janicki4, Martin J. Sliwinski1
1The Pennsylvania State University, United States
2University of South Florida, United States
3University of Pittsburgh, United States
4Penn State College of Medicine, United States

Tóm tắt

Abstract Background Osteoarthritis (OA) of the knee is a common and increasingly prevalent condition that is one of the primary causes of chronic pain. Staying physically active protects against disability from knee OA but is also very challenging. A critical but unexamined question is whether patients at greatest risk for becoming less active are those with a genetic predisposition for greater sensitivity to daily pain. Aims We examined day-to-day variability in knee OA pain for patients with different variants of catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) single nucleotide polymorphisms (SNPs), and whether patients with a specific genotype experience more pain following daily physical activity. We predicted that patients having one or more copies of the Met158 allele of COMT rs4680 (A-A or A-G) and one or more copies of the Asp40 allele of OPRM1 rs1799971 (A-G or G-G) would show greater pain variability. We expected to see the same pattern for these SNPs with regard to moderation (i.e., exacerbation) of the activity-pain association. Methods A total of 120 knee OA patients reported on their pain 3 times per day over 22 days using handheld computers, and wore an accelerometer to capture daily physical activity. Multilevel modelling was used to examine the magnitude of within-person variability in pain by genetic group. We also examined whether lagged, within-patient associations between level of activity in the afternoon (i.e., minutes of moderate intensity activity, and number of steps) and knee pain at the end-of-day were moderated by between-patient differences in genotype. Results Regarding OPRM1 rs1799971 (Asn40Asp), patients with two copies of the Asn40 allele showed the greatest day-to-day pain variability. Regarding COMT rs4680 (Val158Met), patients with the Val/Val genotype showed the greatest pain variability and also experienced the greatest increase in pain as a result of physical activity. A similar pattern of findings across bi-directional temporal lags was consistent with a negative feedback loop between daily physical activity and pain according to genotype. Consistent with some previous studies, there were no significant between-person differences in daily pain when comparing patients according to COMTrs4680, or OPRM1 rs1799971. Conclusions This study provides preliminary evidence that patients with certain genotypes for COMT rs4680 and OPRM1 rs1799971 (G-G and A-A, respectively) experience more variability in their day-today pain and exacerbation of pain after daily physical activity compared to patients with other genotypes. Our findings should be replicated in larger study populations. Implications Previous clinical research has focused primarily on differences in average level of pain between patients with and without a specific genotype. Assessment of within-person variability through repeated measurements in daily life enhances the reliability, power, and ecological validity of phenotypic measurement. Perspective This study provides preliminary evidence that patients with certain variations in the COMT and OPRM1 SNPs experience more variability in their day-to-day pain and exacerbation of pain after daily physical activity.

Tài liệu tham khảo

Murphy L, Schwartz TA, Helmick CG, Renner JB, Tudor G, Koch G, Dragomir A, Kalsbeek WD, Luta G, Jordan JM. Lifetime riskof symptomatic knee osteoarthritis. Arthritis Care Res 2008;59:1207–13.10.1002/art.24021 Dunlop D, Semanik P, Song J, Manheim L, Shih V, Chang R. Risk factors for functional decline in older adults with arthritis. Arthritis Rheum 2005;52:1274–82, http://dx.doi.org/10.1002/art.20968.10.1002/art.2096815818691 Messier SP, Loeser RF, Miller GD, Morgan TM, Rejeski WJ, Sevick MA, Ettinger Jr WH, Pahor M, Williamson JD. Exercise and dietaryweight loss in overweight and obese older adults with knee osteoarthritis: the arthritis, diet, and activity promotiontrial. Arthritis Rheumatol 2004;50(5):1501–10.10.1002/art.20256 Van Muers JB, Uitterlinden AG, Stolk L, Kerkhof HJ, Hofman A, Pols HA, Bierma-Zeinstra SM. A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. Arthritis Rheumatol 2009;60(2):628–9.10.1002/art.24175 Neogi T, Soni A, Doherty SA, Laslett LL, Maciewicz RA, Hart DJ, Zhang W, Muir KR, Wheeler M, Cooper C, Spector TD, Cicuttini F, Jones G, Nevitt M, Liu Y, Arden NK, Doherty M, Valdes AM. Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis. Ann Rheum Dis 2014;73(1):315–7.10.1136/annrheumdis-2013-20383623852765 Henker RA, Lewis A, Dai F, Lariviere WR, Meng L, Gruen GS, Sereika SM, Pape H, Tarkin IS, Gowda I, Conley YP. The associations between OPRM1 and COMT genotypes and postoperative pain, opioid use, and opioidi-induced sedation. Biol Res Nurs 2013;15(3):309–17, http://dx.doi.org/10.1177/1099800411436171.2271852710.1177/1099800411436171 Janicki PK, Schuler G, Francis D, Bohr A, Gordon V, Jarzembowski T, Ruiz-Velasco V, Mets B. A genetic association study of the functional A118G polymorphism of the human - µ opioid receptor gene in patients with acute and chronic pain. Anesth Analg 2006;103(4):1011–7, http://dx.doi.org/10.1213/01.ane.0000231634.20341.88.10.1213/01.ane.0000231634.20341.88 Chou W-Y, Yang L-C, Lu H-F, Ko J-Y, Wang C-H, Lin S-H, Lee T-H, Concejero A, Hsu C-J. Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiol Scand 2006;50(7):787–92, http://dx.doi.org/10.1111/j.1399-6576.2006.01058.x.1687945910.1111/j.1399-6576.2006.01058.x Finan PH, Tennen H, Thoemmes F, Zautra AJ, Davis MC. Ambulatory monitoring in the genetics of psychosomatic medicine. Psychosom Med 2012;74(4):349–55, http://dx.doi.org/10.1097/PSY.0b013e3182544a74.2258233210.1097/PSY.0b013e3182544a74 Finan PH, Zautra AJ, Davis MC, Lemery-Chalfant K, Covault J, Tennen H. Genetic influences on the dynamics of pain and affect in fibromyalgia. Health Psychol 2010;29(2):134–42, http://dx.doi.org/10.1037/a0018647.2023008610.1037/a0018647 Finan PH, Zautra AJ, Davis MC, Lemery-Chalfant K, Covault J, Tennen H. COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. Pain 2011;152:300–7, http://dx.doi.org/10.1016Zj.pain.2010.10.024.2113057310.1016/j.pain.2010.10.024 Wideman TH, Finan PH, Edwards RR, Quartana PJ, Buenaver LF, Haythornth-waite JA, Smith MT. Increased sensitivityto physical activity among individuals with kne osteoarthritis relation to pain outcomes, psychological factors, and responsesto quantitative sensorytesting. Pain 2014;155(4):703–11.10.1016/j.pain.2013.12.028 Martire LM, Stephens MAP, Mogle J, Schulz R, Brach J, Keefe FJ. Daily spousal influence on physical activity in knee osteoarthritis. Ann Behav Med 2013;45(2):213–23, http://dx.doi.org/10.1007/s12160-012-9442-x.2316147210.1007/s12160-012-9442-x Mason JH, Anderson J, Meenan R, Haralson K, Lewis-Stevens D, Kaine J. The rapid assessment of disease activity in rheumatology (RADAR) questionnaire: validity and sensitivity to change of a patient self-report measure of joint count and clinical status. Arthritis Rheum 1992;35(2):156–62, http://dx.doi.org/10.1002/art.1780350206.173490510.1002/art.1780350206 Ewald B, McEvoy M, Attia J. Pedometer counts superior to physical activity scale for identifying health markers in older adults. Br J Sports Med 2010;44(10):756–61, http://dx.doi.org/10.1136/bjsm.2008.048827.10.1136/bjsm.2008.04882718625631 Matthews CE, Ainsworth B, Thompson R, Bassett D Jr. Sources of variance in daily physical activity levels as measured by an accelerometer. Med Sci Sports Exerc 2002;34:1376–81, http://dx.doi.org/10.1097/00005768-200208000-00021.10.1097/00005768-200208000-0002112165695 Troiano R, Berrigan D, Dodd K, Masse L, Tilert T, McDowell M. Physical activity in the United States measured by accelerometer. Med Sci Sports Exerc 2008;40:181–8, http://dx.doi.org/10.1249/mss.0b013e31815a51b3.10.1249/mss.0b013e31815a51b318091006 Swartz AM, Strath SJ, Bassett Jr DR, O′Brien WL, King GA, Ainsworth BE. Estimation of energy expenditure using CSA accelerometers at hip and wrist sites. Med Sci Sports Exerc 2000;32:450–6, http://dx.doi.org/10.1097/00005768-200009001-00003.10.1097/00005768-200009001-00003 Brach JS, Wert D, VanSwearingen JM, Studenski SA. The compendium of physical activity underestimates walking intensity in old more so than in young. J Am GeriatrSoc 2009;57:S110. Matthews CE. Calibration of accelerometer output for adults. Med Sci Sports Exerc 2005;37:S512-22, http://dx.doi.org/10.1249/01.mss.0000185659.11982.3d.10.1249/01.mss.0000185659.11982.3d16294114 Raudenbush SW, Bryk AS. Hierarchical linear models: applications and data analysis methods. Thousand Oaks, CA: Sage Publications; 2002. Hoffman L. Multilevel models for examining individual differences in within-person variation and covariation over time. Multivar Behav Res 2007;42(4):609–29, http://dx.doi.org/10.1080/00273170701710072.10.1080/00273170701710072 Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988;15(12): 1833–40. Curran PJ, Bauer DJ. The disaggregation of within-person and between-person effects in longitudinal models of change. Annu Rev Psychol 2011;62:583–619, http://dx.doi.org/10.1146/annurev.psych.093008.100356.10.1146/annurev.psych.093008.10035619575624 Nicholl BI, Holliday KL, Macfarlane GJ, Thomson W, Davies KA, O'Neill TW, Bartfai G, Boonen S, Casanueva F, Finn JD, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Silman AJ, Vanderschueren D, Wu FC, McBeth J, European Male Ageing Study Group. No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain. Ann Rheum Dis 2010;69:2009–12.10.1136/ard.2009.126086
Thông tin
Thông tin xuất bản

Scandinavian Journal of Pain

Tập 10

6-12

Thông tin tác giả