<i>Acinetobacter baumannii</i> : Emergence of a Successful Pathogen

Clinical Microbiology Reviews - Tập 21 Số 3 - Trang 538-582 - 2008
Anton Y. Peleg1,2,1,3,4, Harald Seifert5,2,1,3,4, David L. Paterson6,2,1,3,4
1Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany
2Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
3Pathology Queensland, Brisbane, Queensland, Australia
4University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
5Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
6; and Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Tóm tắt

SUMMARY Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.

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