Leishmaniasis recidivans among school children in Bam, South‐east Iran, 1994–2006

International Journal of Dermatology - Tập 49 Số 5 - Trang 557-561 - 2010
Iraj Sharifi1, Alireza Fekri1, Mohammad Reza Aflatoonian1, Ali Khamesipour2, Fereidoun Mahboudi3, Yahya Dowlati2, A Nadim4, Farrokh Modabber2,5
1Leishmaniasis Research Center, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
3Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
4School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5London School of Hygiene & Tropical Medicine (LSHTM), Keppel Street, London, UK and Drugs for Neglected Diseases Initiatives (DNDi),15 Chemin Louis-Dunant, Geneva, Switzerland

Tóm tắt

AbstractBackground  Leishmaniasis recidivans (LR) is a rare phenomenon in the world with high morbidity in children.Methods  Overall 22 838 school children were examined during 1994–2006. Diagnosis was performed by combination of methods as clinical appearance, direct smears, cultures, polymerase chain reaction (PCR) and histology.Results  Ninety‐eight cases were diagnosed as LR with duration of lesions varying from 2 to 8 years and diameter of lesions 1–5 cm, yellowish‐brown appearance with papules around or in the scar. Most of the lesions (95%) were on the face. No amastigote was found in direct smears. Identification of nine random isolates by PCR confirmed all species to be L. tropica. Tissue sections showed typical granulomatous reactions with various inflammatory cells but no visible amastigote was seen.Conclusions  The presence of LR as an important cause of morbidity has future implications for treatment regimens and immunoprophylaxis.

Từ khóa


Tài liệu tham khảo

10.1016/j.cimid.2004.03.004

Nadim A, 1971, Brief review of the epidemiology of various types of leishmaniasis in Iran, Acta Med Iran, 14, 99

Nadim A, 1995, Anthroponotic cuetaneous leishmaniasis in Bam, southeast Iran, Iran J Public Health, 24, 15

10.1016/S0140-6736(98)09552-X

Sharifi I, Multiple doses of autoclaved Leishmania major vaccine against anthroponotic cutaneous leishmaniasis in Bam, Iran

10.1016/0035-9203(68)90140-5

World Health Organization, 1984, The leishmaniasis, WHO Tech Rep Ser, 701, 9

Paes‐Olivera M, 1977, Leishmaniasis recidiva cutis, An Bras Dermatol, 52, 353

10.1111/j.1365-4632.2007.03086.x

World Health Organization, 1990, Control of the leishmaniasis. Report of a WHO Expert Committee, WHO Tech Series, 793, 12

Sharifi I, 1997, Identification and characterization of Leishmania isolates in school children in Bam, southeastern Iran, Iran J Med Sci, 22, 82

10.1080/00365540110026746

10.1046/j.1365-4362.2000.00687.x

10.1111/j.1365-4632.2004.02518.x

10.1016/S0190-9622(96)80121-6

10.1093/clind/15.6.924

10.1080/00034983.1980.11687365

Momeni AZ, 1996, Chronic Leishmaniasis recidivans. Evaluation by polymerase chain reaction, Arch Dermatol, 132, 198, 10.1001/archderm.1996.03890260100015

10.1046/j.1365-4362.1998.00478.x

Thông tin
Thông tin xuất bản

International Journal of Dermatology

Tập 49 Số 5

557-561

Thông tin tác giả