‘Sensing’ autoimmunity in type 1 diabetes

Anderson, 2005, The NOD mouse: a model of immune dysregulation, Annu. Rev. Immunol., 23, 447, 10.1146/annurev.immunol.23.021704.115643 Lieberman, 2003, A comprehensive guide to antibody and T-cell responses in type 1 diabetes, Tissue Antigens, 62, 359, 10.1034/j.1399-0039.2003.00152.x Winer, 2001, Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis, J. Immunol., 166, 2831, 10.4049/jimmunol.166.4.2831 Nielsen, 2006, Type 1 diabetes and multiple sclerosis: A Danish population-based cohort study, Arch. Neurol., 63, 1001, 10.1001/archneur.63.7.1001 Marrosu, 2002, Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study, Lancet, 359, 1461, 10.1016/S0140-6736(02)08431-3 Salomon, 2001, Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice, J. Exp. Med., 194, 677, 10.1084/jem.194.5.677 Setoguchi, 2005, Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization, J. Exp. Med., 201, 723, 10.1084/jem.20041982 Mei, 2002, Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats, Diabetes, 51, 2997, 10.2337/diabetes.51.10.2997 Carrillo, 2005, Islet-infiltrating B-cells in nonobese diabetic mice predominantly target nervous system elements, Diabetes, 54, 69, 10.2337/diabetes.54.1.69 Tsui, 2003, Neuronal elements in the pathogenesis of type 1 diabetes, Rev. Endocr. Metab. Disord., 4, 301, 10.1023/A:1025374531151 Winer, 2003, Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive, Nat. Med., 9, 198, 10.1038/nm818 Fudge, 2005, Chronic inflammatory demyelinating polyradiculoneuropathy in two children with type 1 diabetes mellitus, Pediatr. Diabetes, 6, 244, 10.1111/j.1399-543X.2005.00130.x Cabarrocas, 2003, Role of enteric glial cells in inflammatory bowel disease, Glia, 41, 81, 10.1002/glia.10169 Fields, 2002, New insights into neuron-glia communication, Science, 298, 556, 10.1126/science.298.5593.556 Garcia-Segura, 2004, Minireview: Role of glia in neuroendocrine function, Endocrinology, 145, 1082, 10.1210/en.2003-1383 Chaparro, 2006, Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes, Proc. Natl Acad. Sci. USA, 103, 12475, 10.1073/pnas.0604317103 Persson-Sjogren, 2001, Neuroinsular complex type I: morphology and frequency in lean and genetically obese mice, Pancreas, 23, 40, 10.1097/00006676-200107000-00006 Caterina, 2007, Transient receptor potential ion channels as participants in thermosensation and thermoregulation, Am. J. Physiol. Regul. Integr. Comp. Physiol., 292, R64, 10.1152/ajpregu.00446.2006 Ramsey, 2006, An introduction to TRP channels, Annu. Rev. Physiol., 68, 619, 10.1146/annurev.physiol.68.040204.100431 Szolcsanyi, 2004, Forty years in capsaicin research for sensory pharmacology and physiology, Neuropeptides, 38, 377, 10.1016/j.npep.2004.07.005 Winston, 2005, Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain, Pain, 117, 214, 10.1016/j.pain.2005.06.013 Gram, 2007, Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes, Eur. J. Neurosci., 25, 213, 10.1111/j.1460-9568.2006.05261.x Calixto, 2005, Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions, Pharmacol. Ther., 106, 179, 10.1016/j.pharmthera.2004.11.008 Razavi, 2006, TRPV1+ sensory neurons control β cell stress and islet Inflammation in autoimmune diabetes, Cell, 127, 1, 10.1016/j.cell.2006.10.038 Steinman, 2004, Elaborate interactions between the immune and nervous systems, Nat. Immunol., 5, 575, 10.1038/ni1078 Brogden, 2005, The nervous system and innate immunity: the neuropeptide connection, Nat. Immunol., 6, 558, 10.1038/ni1209 Khachatryan, 1997, Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice, J. Immunol., 158, 1409, 10.4049/jimmunol.158.3.1409 Delgado, 2003, Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P, Neuropeptides, 37, 355, 10.1016/j.npep.2003.09.005 Weinstock, 2003, IL-18 and IL-12 signal through the NF-kappa B pathway to induce NK-1R expression on T cells, J. Immunol., 170, 5003, 10.4049/jimmunol.170.10.5003 Corcoran, 2007, Stromal derived growth factor-1alpha: another mediator in neural-emerging immune system through Tac1 expression in bone marrow stromal cells, J. Immunol., 178, 2075, 10.4049/jimmunol.178.4.2075 Goto, 2007, Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors, Neuropeptides, 41, 25, 10.1016/j.npep.2006.11.002 Silva, 2006, Evolutionary conservation of neuropeptide expression in the thymus of different species, Immunology, 118, 131, 10.1111/j.1365-2567.2006.02351.x Reinke, 2006, Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides, Immunol. Lett., 104, 102, 10.1016/j.imlet.2005.11.009 Svensson, 2005, Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection, J. Immunol., 175, 6802, 10.4049/jimmunol.175.10.6802 Seiffert, 2006, Neuroendocrine regulation of skin dendritic cells, Ann. NY Acad. Sci., 1088, 195, 10.1196/annals.1366.011 Levite, 2000, Nerve-driven immunity. The direct effects of neurotransmitters on T-cell function, Ann. NY Acad. Sci., 917, 307, 10.1111/j.1749-6632.2000.tb05397.x Lang, 2003, Neurotransmitters regulate the migration and cytotoxicity in natural killer cells, Immunol. Lett., 90, 165, 10.1016/j.imlet.2003.09.004 Castro-Obregon, 2004, Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77, J. Biol. Chem., 279, 17543, 10.1074/jbc.M312363200 Zhang, 2006, Tachykinins in the immune system, Curr. Drug Targets, 7, 1011, 10.2174/138945006778019363 Van Buren, 2005, Sensitization and translocation of TRPV1 by insulin and IGF-I, Mol. Pain, 1, 17, 10.1186/1744-8069-1-17 Sathianathan, 2003, Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons, Eur. J. Neurosci., 18, 2477, 10.1046/j.1460-9568.2003.03004.x Barakat, 1994, Calcitonin gene-related peptide and islet amyloid polypeptide stimulate insulin secretion in RINm5F cells through a common receptor coupled to a generation of cAMP, Biosci. Rep., 14, 1, 10.1007/BF01901633 Bretherton-Watt, 1992, The physiology of calcitonin gene-related peptide in the islet compared with that of islet amyloid polypeptide (amylin), Ann. NY Acad. Sci., 657, 299, 10.1111/j.1749-6632.1992.tb22777.x Hermansen, 1990, Dual effects of calcitonin gene-related peptide on insulin secretion in the perfused dog pancreas, Regul. Pept., 27, 149, 10.1016/0167-0115(90)90213-G Persson-Sjogren, 2000, Peptides and other neuronal markers in transplanted pancreatic islets, Peptides, 21, 741, 10.1016/S0196-9781(00)00186-8 Winzell, M.S. and Ahren, B. Role of VIP and PACAP in islet function. Peptides (in press) Homo-Delarche, 2004, Neuroendocrine immuno-ontogeny of the pathogenesis of autoimmune disease in the nonobese diabetic (NOD) mouse, ILAR J., 45, 237, 10.1093/ilar.45.3.237 Mathis, 2001, beta-Cell death during progression to diabetes, Nature, 414, 792, 10.1038/414792a Zhang, 2007, Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity, Circ. Res., 100, 1063, 10.1161/01.RES.0000262653.84850.8b Bartness, 2007, Brain-adipose tissue neural crosstalk, Physiol. Behav., 91, 343, 10.1016/j.physbeh.2007.04.002 Karagiannides, 2006, Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes, Proc. Natl Acad. Sci. USA, 103, 5207, 10.1073/pnas.0600821103 Gonzalez, 2003, Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes, Diabetologia, 46, 1291, 10.1007/s00125-003-1168-7 Ikegami, 2004, Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes, ILAR J., 45, 268, 10.1093/ilar.45.3.268 Gilliam, 2005, Autoimmunity and clinical course in children with type 1, type 2, and type 1, 5 diabetes. J. Autoimmun., 25, 244, 10.1016/j.jaut.2005.09.013 Pozzilli, 2007, A new expression of diabetes: double diabetes, Trends Endocrinol. Metab., 18, 52, 10.1016/j.tem.2006.12.003 Kramer, 2004, The pancreas of the naked mole-rat (Heterocephalus glaber): an ultrastructural and immunocytochemical study of the endocrine component of thermoneutral and cold acclimated animals, Gen. Comp. Endocrinol., 139, 206, 10.1016/j.ygcen.2004.09.006 Park, 2003, Somatosensory organization and behavior in naked mole-rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain, J. Comp. Neurol., 465, 104, 10.1002/cne.10824 Jaap, 1997, Relationship of insulin resistance to microvascular dysfunction in subjects with fasting hyperglycaemia, Diabetologia, 40, 238, 10.1007/s001250050669 Loos, 2003, Obesity–is it a genetic disorder?, J. Intern. Med., 254, 401, 10.1046/j.1365-2796.2003.01242.x Basu, 2005, Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells, Proc. Natl Acad. Sci. USA, 102, 5120, 10.1073/pnas.0407780102 Gallucci, 1999, Natural adjuvants: endogenous activators of dendritic cells, Nat. Med., 5, 1249, 10.1038/15200 Nilius, 2007, Transient receptor potential cation channels in disease, Physiol. Rev., 87, 165, 10.1152/physrev.00021.2006 Paus, 2006, Neuroimmunoendocrine circuitry of the ’brain-skin connection’, Trends Immunol., 27, 32, 10.1016/j.it.2005.10.002 Geppetti, 2006, The transient receptor potential vanilloid 1: role in airway inflammation and disease, Eur. J. Pharmacol., 533, 207, 10.1016/j.ejphar.2005.12.063 Nathan, 2002, Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats, Am. J. Physiol. Gastrointest. Liver Physiol., 283, G938, 10.1152/ajpgi.00105.2002 Kimball, 2004, Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice, Neurogastroenterol. Motil., 16, 811, 10.1111/j.1365-2982.2004.00549.x Keeble, 2005, Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation, Arthritis Rheum., 52, 3248, 10.1002/art.21297 Chavolla-Calderon, 2003, Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation, J. Clin. Invest., 111, 973, 10.1172/JCI200317458 Neuhuber, 2004, Innervation of immune cells: evidence for neuroimmunomodulation in the liver, Anat. Rec. A Discov. Mol. Cell. Evol. Biol., 280, 884, 10.1002/ar.a.20093 Li, 2003, Effect of neonatal capsaicin treatment on haemodynamics and renal function in cirrhotic rats, Gut, 52, 293, 10.1136/gut.52.2.293 Avelino, 2006, TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications, Naunyn Schmiedebergs Arch. Pharmacol., 373, 287, 10.1007/s00210-006-0073-2 Batbayar, 2004, Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjogren's syndrome, Arch. Oral Biol., 49, 529, 10.1016/j.archoralbio.2004.02.001 Okajima, 2006, Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications, Curr. Med. Chem., 13, 2241, 10.2174/092986706777935131 De Swert, 2006, Extending the understanding of sensory neuropeptides, Eur. J. Pharmacol., 533, 171, 10.1016/j.ejphar.2005.12.066 Siebenhaar, 2007, Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata), J. Invest. Dermatol., 127, 1489, 10.1038/sj.jid.5700704 van Houwelingen, 2002, Mast cell-derived TNF-alpha primes sensory nerve endings in a pulmonary hypersensitivity reaction, J. Immunol., 168, 5297, 10.4049/jimmunol.168.10.5297 Skogvall, 2007, Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants, Pulm. Pharmacol. Ther., 20, 273, 10.1016/j.pupt.2006.03.002 Nessler, 2006, Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist–a putative role for substance P in CNS inflammation, J. Neuroimmunol., 179, 1, 10.1016/j.jneuroim.2006.06.026 Nakayama, 2005, Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice, Nature, 435, 220, 10.1038/nature03523 Ridderstrale, 2006, Impaired capacity for stimulated fibrinolysis in primary hypertension is restored by antihypertensive therapy, Hypertension, 47, 686, 10.1161/01.HYP.0000210540.35296.62 Webb, 2000, 17beta-estradiol decreases endothelin-1 levels in the coronary circulation of postmenopausal women with coronary artery disease, Circulation, 102, 1617, 10.1161/01.CIR.102.14.1617 Witherow, 2001, Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure, Circulation, 104, 2177, 10.1161/hc4301.098252 Gram, 2007, Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rats, an animal model for some aspects of human type 2 diabetes, Eur. J. Neurosci., 25, 213, 10.1111/j.1460-9568.2006.05261.x