¿Qué podemos esperar del control de la variabilidad glucémica?

Service, 1970, Mean amplitude of glycaemic excursions, a measure of diabetic instability, Diabetes, 19, 644, 10.2337/diab.19.9.644 Molnar, 1972, Day to day variation of continuously monitored glycaemia: A further measure of diabetic instability, Diabetologia, 8, 342, 10.1007/BF01218495 Rodbard, 2011, Glycemic variability: Measurement and utility in clinical medicine and research — One viewpoint, Diabetes Technol Ther, 13, 1077, 10.1089/dia.2011.0104 Gerstein, 2009, Dysglycemia and cardiovascular risk in the general population, Circulation, 119, 773, 10.1161/CIRCULATIONAHA.108.834408 Lachin, 2008, Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial-revisited, Diabetes, 57, 995, 10.2337/db07-1618 1995, The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial, Diabetes, 44, 968, 10.2337/diab.44.8.968 Brownlee, 2006, Glycemic variability: A hemoglobin A1c-independent risk factor for diabetic complications, JAMA, 295, 1707, 10.1001/jama.295.14.1707 Monnier, 2006, Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes, JAMA, 295, 1681, 10.1001/jama.295.14.1681 Borg, 2010, Real-life glycaemic profiles in non-diabetic individuals with low fasting glucose and normal HbA1c: The A1C-Derived Average Glucose (ADAG) study, Diabetologia, 53, 1608, 10.1007/s00125-010-1741-9 Madhu, 2013, Abnormal glycemic profiles by CGMS in obese first-degree relatives of type 2 diabetes mellitus patients, Diabetes Technol Ther, 15, 461, 10.1089/dia.2012.0333 Kohnert, 2009, Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents, Diabetes Care, 32, 1058, 10.2337/dc08-1956 Ruiz de Adana, 2008, ¿Cómo cuantificar la variabilidad glucémica?, Av Diabetol, 24, 77 Hill, 2011, Normal reference range for mean tissue glucose and glycemic variability derived from continuous glucose monitoring for subjects without diabetes in different ethnic groups, DiabetesTechnol Ther, 13, 921 Frontoni, 2013, Glucose variability: An emerging target for the treatment of diabetes mellitus, Diabetes Res Clin Pract, 102, 86, 10.1016/j.diabres.2013.09.007 Rodbard, 2009, New and improved methods to characterize glycemic variability using continuous glucose monitoring, Diabetes Technol Ther, 11, 551, 10.1089/dia.2009.0015 Monnier, 2008, Glycemic variability: the third component of the dysglycemia in diabetes. Is it important? How to measure it?, J Diabetes Sci Technol, 2, 1094, 10.1177/193229680800200618 Rodbard, 2011, Clinical interpretation of indices of quality of glycemic control and glycemic variability, Postgrad Med, 123, 107, 10.3810/pgm.2011.07.2310 Bergenstal, 2013, Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: The Ambulatory Glucose Profile (AGP), Diabetes Technol Ther, 15, 198, 10.1089/dia.2013.0051 Nathan, 2008, Translating the A1C assay into estimated average glucose values, Diabetes Care, 31, 1473, 10.2337/dc08-0545 Derr, 2003, Is HbA(1c) affected by glycemic instability?, Diabetes Care, 26, 2728, 10.2337/diacare.26.10.2728 McCarter, 2006, Mean blood glucose and biological variation have greater influence on HbA1c levels than glucose instability. An analysis of data from the Diabetes Control and Complications Trial, Diabetes Care, 29, 352, 10.2337/diacare.29.02.06.dc05-1594 Nathan, 2013, Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy, and cardiovascular outcomes in the DCCT/EDIC study, Diabetes, 63, 282, 10.2337/db13-0782 Kohnert, 2007, Chronic hyperglycemia but not glucose variability determines HbA1c levels in well-controlled patients with type 2 diabetes, Diabetes Res Clin Pract, 77, 420, 10.1016/j.diabres.2007.01.021 Kuenen, 2011, Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients?, Diabetes Care, 34, 1843, 10.2337/dc10-2217 Ceriello, 2010, Effect of acute hyperglycaemia, long-term glycaemic control and insulin on endothelial dysfunction and inflammation in type 1 diabetic patients with different characteristics, Diabet Med, 27, 911, 10.1111/j.1464-5491.2009.02928.x Wentholt, 2008, Glucose fluctuations and activation of oxidative stress in patients with type 1 diabetes, Diabetologia, 51, 183, 10.1007/s00125-007-0842-6 Siegelaar, 2009, A randomized clinical trial comparing the effect of basal insulin and inhaled mealtime insulin on glucose variability and oxidative stress, Diabetes Obes Metab, 11, 709, 10.1111/j.1463-1326.2009.01037.x Wakil, 2012, Short-term glucose variability in healthy volunteers is not associated with raised oxidative stress markers, Diabetes Obes Metab, 14, 1047, 10.1111/j.1463-1326.2012.01625.x Monnier, 2010, Regulation of oxidative stress by glycaemic control: Evidence for an independent inhibitory effect of insulin therapy, Diabetologia, 53, 562, 10.1007/s00125-009-1574-6 Siegelaar, 2011, No relevant relationship between glucose variability and oxidative stress in well-regulated type 2 diabetes patients, J Diabetes Sci Technol, 5, 86, 10.1177/193229681100500112 Cox, 1994, Frequency of severe hypoglycemia in insulin-dependent diabetes mellitus can be predicted from self-monitoring blood glucose data, J Clin Endocrinol Metab, 79, 1659 Kilpatrick, 2007, Relating mean blood glucose and glucose variability to the risk of multiple episodes of hypoglycaemia in type 1 diabetes, Diabetologia, 50, 2553, 10.1007/s00125-007-0820-z Murata, 2004, A probabilistic model for predicting hypoglycemia in type 2 diabetes mellitus: The Diabetes Outcomes in Veterans Study (DOVES), Arch Intern Med, 164, 1445, 10.1001/archinte.164.13.1445 Monnier, 2011, The contribution of glucose variability to asymptomatic hypoglycemia in persons with type 2 diabetes, Diabetes Technol Ther, 13, 813, 10.1089/dia.2011.0049 Cox, 2007, Prediction of severe hypoglycemia, Diabetes Care, 30, 1370, 10.2337/dc06-1386 Kilpatrick, 2006, The effect of glucose variability on the risk of microvascular complications in type 1 diabetes, Diabetes Care, 29, 1486, 10.2337/dc06-0293 Bragd, 2008, Can glycaemic variability, as calculated from blood glucose self-monitoring, predict the development of complications in type 1 diabetes over a decade?, Diabetes Metab, 34, 612, 10.1016/j.diabet.2008.04.005 Siegelaar, 2009, Glucose variability does not contribute to the development of peripheral and autonomic neuropathy in type 1 diabetes: Data from the DCCT, Diabetologia, 52, 2229, 10.1007/s00125-009-1473-x Gimeno-Orna, 2003, Fasting plasma glucose variability as a risk factor of retinopathy in type 2 diabetic patients, J Diabetes Complications, 17, 78, 10.1016/S1056-8727(02)00197-6 Standl, 2011, Postprandial hyperglycemia and glycemic variability: Should we care?, Diabetes Care, 34, S120, 10.2337/dc11-s206 Nalysnyk, 2010, Glycaemic variability and complications in patients with diabetes mellitus: Evidence from a systematic review of the literature, Diabetes Obes Metab, 12, 288, 10.1111/j.1463-1326.2009.01160.x Di Flaviani, 2011, Impact of glycemic and blood pressure variability on surrogate measures of cardiovascular outcomes in type 2 diabetic patients, Diabetes Care, 34, 1605, 10.2337/dc11-0034 Su, 2013, Impact of admission glycemic variability, glucose, and glycosylated hemoglobin on major adverse cardiac events after acute myocardial infarction, Diabetes Care, 36, 1026, 10.2337/dc12-0925 Lipska, 2012, Glucose variability and mortality in patients hospitalized with acute myocardial infarction, Circ Cardiovasc Qual Outcomes, 5, 550, 10.1161/CIRCOUTCOMES.111.963298 Siegelaar, 2011, A decrease in glucose variability does not reduce cardiovascular event rates in type 2 diabetic patients after acute myocardial infarction: A reanalysis of the HEART2D study, Diabetes Care, 34, 855, 10.2337/dc10-1684 Borg, 2011, HbA(c) and mean blood glucose show stronger associations with cardiovascular disease risk factors than do postprandial glycaemia or glucose variability in persons with diabetes: the A1C-Derived Average Glucose (ADAG) study, Diabetologia, 54, 69, 10.1007/s00125-010-1918-2 Prince, 2007, Changes in glycaemic control and risk of coronary artery disease in type 1 diabetes mellitus: Findings from the Pittsburgh Epidemiology of Diabetes Complications Study (EDC), Diabetologia, 50, 2280, 10.1007/s00125-007-0797-7 Kilpatrick, 2008, A1C variability and the risk of microvascular complications in type 1 diabetes: Data from the Diabetes Control and Complications Trial, Diabetes Care, 31, 2198, 10.2337/dc08-0864 Wadén, 2009, A1C variability predicts incident cardiovascular events, microalbuminuria, and overt diabetic nephropathy in patients with type 1 diabetes, Diabetes, 58, 2649, 10.2337/db09-0693 Hietala, 2013, HbA1c variability is associated with an increased risk of retinopathy requiring laser treatment in type 1 diabetes, Diabetologia, 56, 737, 10.1007/s00125-012-2816-6 Sugawara, 2012, HbA(1c) variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2, Diabetologia, 55, 2128, 10.1007/s00125-012-2572-7 Penno, 2013, HbA1c variability as an independent correlate of nephropathy, but not retinopathy, in patients with type 2 diabetes: The Renal Insufficiency and Cardiovascular Events (RIACE) Italian multicenter study, Diabetes Care, 36, 2301, 10.2337/dc12-2264 Krinsley, 2013, Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: An international multicenter cohort study, Crit Care, 17, R37, 10.1186/cc12547 Van den Berghe, 2001, Intensive insulin therapy in critically ill patients, N Engl J Med, 345, 1359, 10.1056/NEJMoa011300 Finfer, 2009, Intensive versus conventional glucose control in critically ill patients, N Engl J Med, 360, 1283, 10.1056/NEJMoa0810625 Penckofer, 2012, Does glycemic variability impact mood and quality of life?, Diabetes Technol Ther, 14, 303, 10.1089/dia.2011.0191