“Novel chitosan/alginate hydrogels as carriers of phenolic-enriched extracts from saffron floral by-products using natural deep eutectic solvents as green extraction media”

Baysal, 2013, Chitosan/alginate crosslinked hydrogels: preparation, characterization and application for cell growth purposes, Int. J. Biol. Macromol., 59, 342, 10.1016/j.ijbiomac.2013.04.073 Bera, 2017, Encapsulation and release of a bacterial carotenoid from hydrogel matrix: characterization, kinetics and antioxidant study, Eng. Life Sci., 17, 739, 10.1002/elsc.201600238 Boly, 2016 Çam, 2010, Pressurised water extraction of polyphenols from pomegranate peels, Food Chem., 123, 878, 10.1016/j.foodchem.2010.05.011 Cerdá-Bernad, 2022, Evaluation of microwave-assisted extraction as a potential green technology for the isolation of bioactive compounds from saffron (Crocus sativus L.) floral by-products, Foods, 11, 2335, 10.3390/foods11152335 Cerdá-Bernad, 2022, Novel insight into the volatile profile and antioxidant properties of Crocus sativus L. flowers, Antioxidants, 11, 1650, 10.3390/antiox11091650 Cerdá-Bernad, 2022, Saffron against neuro-cognitive disorders: an overview of its main bioactive compounds, their metabolic fate and potential mechanisms of neurological protection, Nutrients, 14, 10.3390/nu14245368 Cerdá-Bernad, 2022, Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action, Crit. Rev. Food Sci. Nutr., 62, 3232, 10.1080/10408398.2020.1864279 Cerdá-Bernad, 2021, Probiotic red quinoa drinks for celiacs and lactose intolerant people: study of functional, physicochemical and probiotic properties during fermentation and gastrointestinal digestion, Int. J. Food Sci. Nutr., 1 Choi, 2011, Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology?, Plant Physiol., 156, 1701, 10.1104/pp.111.178426 Ćorković, 2021, Hydrogels: characteristics and application as delivery systems of phenolic and aroma compounds, Foods, 10, 1252, 10.3390/foods10061252 Cunha, 2018, Bioaccessibility of phenolic compounds of Araucaria angustifolia from seed water extracts during in vitro simulated gastrointestinal conditions, Food Nutr. Sci., 9, 1137 Da Porto, 2018, Extraction kinetic modelling of total polyphenols and total anthocyanins from saffron floral bio-residues: comparison of extraction methods, Food Chem., 258, 137, 10.1016/j.foodchem.2018.03.059 Detsi, 2020, Nanosystems for the encapsulation of natural products: the case of chitosan biopolymer as a matrix, Pharmaceutics, 12, 669, 10.3390/pharmaceutics12070669 1999, Specifications for the saffrons protected by this Denomination of Origin, which includes those saffrons produced in a defined geographical area of the Autonomous Community of Castilla-La Mancha, Official Gazette Castilla-La Mancha, 19, 1098 Ehterami, 2019, Chitosan/alginate hydrogels containing Alpha-tocopherol for wound healing in rat model, J. Drug Deliv. Sci. Technol., 51, 204, 10.1016/j.jddst.2019.02.032 Galanakis, 2018, Phenols recovered from olive mill wastewater as additives in meat products, Trends Food Sci. Technol., 79, 98, 10.1016/j.tifs.2018.07.010 Galanakis, 2022, Sustainable applications for the valorization of cereal processing by-products, Foods, 11, 10.3390/foods11020241 Galanakis, 2020, Food ingredients and active compounds against the Coronavirus disease (COVID-19) pandemic: a comprehensive review, Foods, 9, 10.3390/foods9111701 Galanakis, 2021, Innovations and technology disruptions in the food sector within the COVID-19 pandemic and post-lockdown era, Trends Food Sci. Technol., 110, 193, 10.1016/j.tifs.2021.02.002 Galanakis, 2018, Implementation of phenols recovered from olive mill wastewater as UV booster in cosmetics, Ind. Crop. Prod., 111, 30, 10.1016/j.indcrop.2017.09.058 Gawlik-Dziki, 2009, The effect of simulated digestion in vitro on bioactivity of wheat bread with Tartary buckwheat flavones addition, LWT - Food Sci. Technol. (Lebensmittel-Wissenschaft -Technol.), 42, 137, 10.1016/j.lwt.2008.06.009 Gehrke, 2006, Factors determining hydrogel permeability, Ann. N. Y. Acad. Sci., 831, 179, 10.1111/j.1749-6632.1997.tb52194.x González-Centeno, 2015, Effect of power ultrasound application on aqueous extraction of phenolic compounds and antioxidant capacity from grape pomace (Vitis vinifera L.): experimental kinetics and modeling, Ultrason. Sonochem., 22, 506, 10.1016/j.ultsonch.2014.05.027 Hashemi Gahruie, 2020, Application of innovative processing methods for the extraction of bioactive compounds from saffron (Crocus sativus) petals, J. Appl. Res. Med. Aromatic Plant., 19 Inada, 2015, Screening of the chemical composition and occurring antioxidants in jabuticaba (Myrciaria jaboticaba) and jussara (Euterpe edulis) fruits and their fractions, J. Funct.Foods, 17, 422, 10.1016/j.jff.2015.06.002 Karimi, 2010, Evaluation of Crocus sativus L. stigma phenolic and flavonoid compounds and its antioxidant activity, Molecules, 15, 6244, 10.3390/molecules15096244 Ketnawa, 2022, Changes in bioactive compounds and antioxidant activity of plant-based foods by gastrointestinal digestion: a review, Crit. Rev. Food Sci. Nutr., 62, 4684, 10.1080/10408398.2021.1878100 Koutsoukos, 2019, Choline chloride and tartaric acid, a Natural Deep Eutectic Solvent for the efficient extraction of phenolic and carotenoid compounds, J. Clean. Prod., 241, 10.1016/j.jclepro.2019.118384 Lakka, 2019, Saffron processing wastes as a bioresource of high-value added compounds: development of a green extraction process for polyphenol recovery using a Natural Deep Eutectic Solvent, Antioxidants, 8, 586, 10.3390/antiox8120586 Lv, 2019, Enhanced swelling ratio and water retention capacity for novel super-absorbent hydrogel, Colloids Surf. A Physicochem. Eng. Asp., 583, 10.1016/j.colsurfa.2019.123972 Mathew, 1977, Crocus sativus and its allies (Iridaceae), Plant Systemat. Evol., 128, 89, 10.1007/BF00985174 Melnyk, 2010, Chemical and biological properties of the world's most expensive spice: saffron, Food Res. Int., 43, 1981, 10.1016/j.foodres.2010.07.033 Micale, 2020, Hydrogels for the delivery of plant-derived (poly)phenols, Molecules, 25, 3254, 10.3390/molecules25143254 Nagarajan, 2019, A facile water-induced complexation of lycopene and pectin from pink guava byproduct: extraction, characterization and kinetic studies, Food Chem., 296, 47, 10.1016/j.foodchem.2019.05.135 Ozkan, 2021, Chapter 3 - extraction of bioactive compounds from saffron species, 99 Sánchez-Vioque, 2012, In vitro antioxidant and metal chelating properties of corm, tepal and leaf from saffron (Crocus sativus L.), Ind. Crop. Prod., 39, 149, 10.1016/j.indcrop.2012.02.028 Sarfarazi, 2020, Evaluation of microwave-assisted extraction technology for separation of bioactive components of saffron (Crocus sativus L.), Ind. Crop. Prod., 145, 10.1016/j.indcrop.2019.111978 Shewan, 2013, Review of techniques to manufacture micro-hydrogel particles for the food industry and their applications, J. Food Eng., 119, 781, 10.1016/j.jfoodeng.2013.06.046 Skarpalezos, 2019, Deep eutectic solvents as extraction media for valuable flavonoids from natural sources, Appl. Sci., 9, 4169, 10.3390/app9194169 Stelluti, 2021, Sustainable processing of floral bio-residues of saffron (Crocus sativus L.) for valuable biorefinery products, Plants, 10, 523, 10.3390/plants10030523 Tzani, 2021, Natural deep eutectic solvents (NaDESs) as alternative green extraction media for ginger (Zingiber officinale roscoe), Sustain. Chem., 2, 576, 10.3390/suschem2040032 Wen, 2018, Advances in ultrasound assisted extraction of bioactive compounds from cash crops – a review, Ultrason. Sonochem., 48, 538, 10.1016/j.ultsonch.2018.07.018