Swapna Mandal1, Joseph Barnett2, Simon Brill1, Jeremy Brown3,4, Emma Denneny3, Samanjit S Hare2, Melissa Heightman3, Toby Hillman3, Joseph Jacob5,6, Hannah C. Jarvis1, Marc Lipman1,4, SB Naidu1, Arjun Nair6, Joanna C. Porter3,4, Gillian S. Tomlinson7,3, John R. Hurst8
1Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK
2Department of Radiology, Royal Free London NHS Foundation Trust, London, UK
3Respiratory Medicine, University College London Hospitals NHS Foundation Trust, London, UK
4UCL Respiratory, University College London, London, UK
5Centre for Medical Image Computing, University College London, London, UK
6Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK
7Infection and Immunity, University College London, London, UK
8UCL Respiratory, University College London, London, London NW3 2PF, UK
Tóm tắt
Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.
