“LUPUS” ANTICOAGULANT AND INHIBITION OF PROSTACYCLIN FORMATION IN PATIENTS WITH REPEATED ABORTION, INTRAUTERINE GROWTH RETARDATION AND INTRAUTERINE DEATH

BJOG: An International Journal of Obstetrics and Gynaecology - Tập 88 Số 9 - Trang 890-894 - 1981
L Carreras1, Jos Vermylen1, Bernard Spitz2, Ado Van Assche2
1Center for Thrombosis and Vascular Research, Department of Medical Research Campus Gasthuisberg, Herestraat 49, B‐3000 Leuven, Belgium
2Department of Obstetrics and Gynaecology, University of Leuven, Belgium

Tóm tắt

SummaryWe discovered a‘lupus’ anticoagulant in 2 out of 24 women with a history of repeated abortions, intrauterine growth retardation and intrauterine death of unknown origin. The‘lupus’ anticoagulant was detected by an abnormal dilute tissue thromboplastin assay (prothrombin time performed with dilute thromboplastin). The production of prostacyclin by fresh or exhausted rings of rat aorta was decreased by the plasma of one of these two patients with a‘lupus’ anticoagulant. In view of the increasing evidence for a physiological role of prostacyclin in pregnancy and fetal life, we suggest that an inhibition of prostacyclin production could compromise fetal outcome.

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Thông tin xuất bản

BJOG: An International Journal of Obstetrics and Gynaecology

Tập 88 Số 9

890-894

Thông tin tác giả