γδ and αβ T cell lineage choice: Resolution by a stronger sense of being

Seminars in Immunology - Tập 22 - Trang 228-236 - 2010
Gladys W. Wong1, Juan Carlos Zúñiga-Pflücker1
1Sunnybrook Research Institute, and Department of Immunology, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada

Tài liệu tham khảo

Hedrick, 1984, Isolation of cDNA clones encoding T cell-specific membrane-associated proteins, Nature, 308, 149, 10.1038/308149a0 Saito, 1984, Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences, Nature, 309, 757, 10.1038/309757a0 Hannum, 1984, Immunoglobulin-like nature of the alpha-chain of a human T-cell antigen/MHC receptor, Nature, 312, 65, 10.1038/312065a0 Robertson, 1984, The capture of the snark, Nature, 312, 16, 10.1038/312016a0 Hayday, 1985, Structure, organization, and somatic rearrangement of T cell gamma genes, Cell, 40, 259, 10.1016/0092-8674(85)90140-0 Ishida, 1990, T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells, Proc Natl Acad Sci USA, 87, 3067, 10.1073/pnas.87.8.3067 Bonneville, 1989, Blockage of alpha beta T-cell development by TCR gamma delta transgenes, Nature, 342, 931, 10.1038/342931a0 Thompson, 1990, Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors, Proc Natl Acad Sci USA, 87, 5583, 10.1073/pnas.87.14.5583 Pardoll, 1987, Differential expression of two distinct T-cell receptors during thymocyte development, Nature, 326, 79, 10.1038/326079a0 Kang, 2001, Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling, J Exp Med, 193, 689, 10.1084/jem.193.6.689 Haks, 2005, Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage, Immunity, 22, 595, 10.1016/j.immuni.2005.04.003 Hayes, 2005, TCR signal strength influences alphabeta/gammadelta lineage fate, Immunity, 22, 583, 10.1016/j.immuni.2005.03.014 Pennington, 2005, Gammadelta T cell development—having the strength to get there, Curr Opin Immunol, 17, 108, 10.1016/j.coi.2005.01.009 Livak, 1995, In-frame TCR delta gene rearrangements play a critical role in the alpha beta/gamma delta T cell lineage decision, Immunity, 2, 617, 10.1016/1074-7613(95)90006-3 Godfrey, 1993, A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple negative adult mouse thymocytes defined by CD44 and CD25 expression, J Immunol, 150, 4244 Petrie, 1992, Commitment to the T cell receptor-alpha beta or -gamma delta lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes, Eur J Immunol, 22, 2185, 10.1002/eji.1830220836 Dudley, 1995, Alpha beta and gamma delta T cells can share a late common precursor, Curr Biol, 5, 659, 10.1016/S0960-9822(95)00131-X Livak, 1999, Characterization of TCR gene rearrangements during adult murine T cell development, J Immunol, 162, 2575 Capone, 1998, Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes, Proc Natl Acad Sci USA, 95, 12522, 10.1073/pnas.95.21.12522 Hoffman, 1996, Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo, Genes Dev, 10, 948, 10.1101/gad.10.8.948 Mallick, 1993, Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development, Cell, 73, 513, 10.1016/0092-8674(93)90138-G Dudley, 1994, T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice, Immunity, 1, 83, 10.1016/1074-7613(94)90102-3 von Boehmer, 1997, Structure and function of the pre-T cell receptor, Ann Rev Immunol, 15, 433, 10.1146/annurev.immunol.15.1.433 Saint-Ruf, 1994, Analysis and expression of a cloned pre-T cell receptor gene, Science, 266, 1208, 10.1126/science.7973703 Mombaerts, 1992, Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491], Nature, 360, 225, 10.1038/360225a0 Kang, 1998, The developmental fate of T cells is critically influenced by TCRgammadelta expression, Immunity, 8, 427, 10.1016/S1074-7613(00)80548-8 Passoni, 1997, Intrathymic delta selection events in gammadelta cell development, Immunity, 7, 83, 10.1016/S1074-7613(00)80512-9 Pennington, 2003, The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells, Nat Immunol, 4, 991, 10.1038/ni979 Pereira, 1992, Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice, EMBO J, 11, 25, 10.1002/j.1460-2075.1992.tb05023.x Silva-Santos, 2005, Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors, Science, 307, 925, 10.1126/science.1103978 Burtrum, 1996, TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development, J Immunol, 157, 4293 Schmitt, 2002, Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro, Immunity, 17, 749, 10.1016/S1074-7613(02)00474-0 Zuniga-Pflucker, 2004, T-cell development made simple, Nat Rev Immunol, 4, 67, 10.1038/nri1257 Ciofani, 2006, Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation, Immunity, 25, 105, 10.1016/j.immuni.2006.05.010 Kreslavsky, 2008, T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis, J Exp Med, 205, 1173, 10.1084/jem.20072425 Saint-Ruf, 2000, Different initiation of pre-TCR and gammadeltaTCR signalling, Nature, 406, 524, 10.1038/35020093 Livak, 1997, Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain, Eur J Immunol, 27, 2948, 10.1002/eji.1830271130 Fehling, 1995, Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells, Nature, 375, 795, 10.1038/375795a0 Terrence, 2000, Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells, J Exp Med, 192, 537, 10.1084/jem.192.4.537 Bruno, 1996, The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells, Immunity, 5, 343, 10.1016/S1074-7613(00)80260-5 Hayes, 2002, Distinct structure and signaling potential of the gamma delta TCR complex, Immunity, 16, 827, 10.1016/S1074-7613(02)00320-5 Delgado, 2000, CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection, Nature, 406, 426, 10.1038/35019102 Werlen, 2000, A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity, Nature, 406, 422, 10.1038/35019094 Love, 1993, T cell development in mice that lack the zeta chain of the T cell antigen receptor complex, Science, 261, 918, 10.1126/science.7688481 Shores, 1994, Role of TCR zeta chain in T cell development and selection, Science, 266, 1047, 10.1126/science.7526464 Bhandoola, 2002, CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain, Eur J Immunol, 32, 1811, 10.1002/1521-4141(200206)32:6<1811::AID-IMMU1811>3.0.CO;2-G Azzam, 1998, CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity, J Exp Med, 188, 2301, 10.1084/jem.188.12.2301 Tarakhovsky, 1995, A role for CD5 in TCR-mediated signal transduction and thymocyte selection, Science, 269, 535, 10.1126/science.7542801 Washburn, 1997, Notch activity influences the alphabeta versus gammadelta T cell lineage decision, Cell, 88, 833, 10.1016/S0092-8674(00)81929-7 Grusby, 1995, Immune responses in MHC class II-deficient mice, Ann Rev Immunol, 13, 417, 10.1146/annurev.iy.13.040195.002221 Koller, 1990, Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells, Science, 248, 1227, 10.1126/science.2112266 Panigada, 2002, Constitutive endocytosis and degradation of the pre-T cell receptor, J Exp Med, 195, 1585, 10.1084/jem.20020047 Yamasaki, 2006, Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development, Nat Immunol, 7, 67, 10.1038/ni1290 Prinz, 2006, Visualization of the earliest steps of gammadelta T cell development in the adult thymus, Nat Immunol, 7, 995, 10.1038/ni1371 Lewis, 2006, Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant, Nat Immunol, 7, 843, 10.1038/ni1363 Chien, 2007, Antigen recognition by gammadelta T cells, Immunol Rev, 215, 46, 10.1111/j.1600-065X.2006.00470.x Wells, 1991, Requirement for positive selection of gamma delta receptor-bearing T cells, Science, 253, 903, 10.1126/science.1831565 Schweighoffer, 1996, Positive selection is not required for thymic maturation of transgenic gamma delta T cells, J Exp Med, 183, 2033, 10.1084/jem.183.5.2033 Crowley, 1997, The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gammadelta T cell, G8, J Exp Med, 185, 1223, 10.1084/jem.185.7.1223 Adams, 2005, Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22, Science, 308, 227, 10.1126/science.1106885 Penninger, 1993, Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells, Science, 260, 358, 10.1126/science.8469988 Quong, 2002, E protein function in lymphocyte development, Annu Rev Immunol, 20, 301, 10.1146/annurev.immunol.20.092501.162048 Greenbaum, 2002, Regulation of early lymphocyte development by E2A family proteins, Semin Immunol, 14, 405, 10.1016/S1044532302000751 Murre, 2005, Helix-loop-helix proteins and lymphocyte development, Nat Immunol, 6, 1079, 10.1038/ni1260 Heemskerk, 1997, Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3, J Exp Med, 186, 1597, 10.1084/jem.186.9.1597 Murre, 1989, A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins, Cell, 56, 777, 10.1016/0092-8674(89)90682-X Murre, 1989, Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence, Cell, 58, 537, 10.1016/0092-8674(89)90434-0 Voronova, 1990, Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains, Proc Natl Acad Sci USA, 87, 4722, 10.1073/pnas.87.12.4722 Takeuchi, 2001, E2A and HEB activate the pre-TCR alpha promoter during immature T cell development, J Immunol, 167, 2157, 10.4049/jimmunol.167.4.2157 Schwartz, 2006, Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development, Proc Natl Acad Sci USA, 103, 9976, 10.1073/pnas.0603728103 Bain, 1997, E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas, Mol Cell Biol, 17, 4782, 10.1128/MCB.17.8.4782 Barndt, 2000, Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB, Mol Cell Biol, 20, 6677, 10.1128/MCB.20.18.6677-6685.2000 Wojciechowski, 2007, E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression, J Immunol, 178, 5717, 10.4049/jimmunol.178.9.5717 Engel, 2001, Early thymocyte development is regulated by modulation of e2a protein activity, J Exp Med, 194, 733, 10.1084/jem.194.6.733 Engel, 2004, E2A proteins enforce a proliferation checkpoint in developing thymocytes, EMBO J, 23, 202, 10.1038/sj.emboj.7600017 Benezra, 1990, The protein Id: a negative regulator of helix-loop-helix DNA binding proteins, Cell, 61, 49, 10.1016/0092-8674(90)90214-Y Taghon, 2006, Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus, Immunity, 24, 53, 10.1016/j.immuni.2005.11.012 Rivera, 2000, Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3, Immunity, 12, 17, 10.1016/S1074-7613(00)80155-7 Blom, 1999, Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors, EMBO J, 18, 2793, 10.1093/emboj/18.10.2793 Ueda-Hayakawa, 2009, Id3 restricts the developmental potential of gammadelta lineage during thymopoiesis, J Immunol, 182, 5306, 10.4049/jimmunol.0804249 Agata, 2007, Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47, Immunity, 27, 871, 10.1016/j.immuni.2007.11.015 Bain, 1999, Positive and negative regulation of V(D)J recombination by the E2A proteins, J Exp Med, 189, 289, 10.1084/jem.189.2.289 Lauritsen, 2009, Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent, Immunity, 31, 565, 10.1016/j.immuni.2009.07.010 Ferrick, 1994, Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice, Int Rev Immunol, 11, 295, 10.3109/08830189409051176 Alonzo, 2010, Development of promyelocytic zinc finger and ThPOK-expressing innate gammadelta T cells is controlled by strength of TCR signaling and Id3, J Immunol, 184, 1268, 10.4049/jimmunol.0903218 Bendelac, 2001, Autoreactivity by design: innate B and T lymphocytes, Nat Rev Immunol, 1, 177, 10.1038/35105052 Bendelac, 2004, Nondeletional pathways for the development of autoreactive thymocytes, Nat Immunol, 5, 557, 10.1038/ni0604-557 Rothenberg, 2008, Launching the T-cell-lineage developmental programme, Nat Rev Immunol, 8, 9, 10.1038/nri2232 Artavanis-Tsakonas, 1999, Notch signaling: cell fate control and signal integration in development, Science, 284, 770, 10.1126/science.284.5415.770 Lai, 2004, Notch signaling: control of cell communication and cell fate, Development, 131, 965, 10.1242/dev.01074 Deftos, 2000, Notch signaling in T cell development, Curr Opin Immunol, 12, 166, 10.1016/S0952-7915(99)00067-9 Weinmaster, 1997, The ins and outs of notch signaling, Mol Cell Neurosci, 9, 91, 10.1006/mcne.1997.0612 Struhl, 1998, Nuclear access and action of notch in vivo, Cell, 93, 649, 10.1016/S0092-8674(00)81193-9 Deftos, 1998, Correlating notch signaling with thymocyte maturation, Immunity, 9, 777, 10.1016/S1074-7613(00)80643-3 Fryer, 2002, Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex, Genes Dev, 16, 1397, 10.1101/gad.991602 Mumm, 2000, Notch signaling: from the outside in, Dev Biol, 228, 151, 10.1006/dbio.2000.9960 Nam, 2003, Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex, J Biol Chem, 278, 21232, 10.1074/jbc.M301567200 Wallberg, 2002, p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro, Mol Cell Biol, 22, 7812, 10.1128/MCB.22.22.7812-7819.2002 Davis, 2001, Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning, Oncogene, 20, 8342, 10.1038/sj.onc.1205094 Iso, 2003, HES and HERP families: multiple effectors of the Notch signaling pathway, J Cell Physiol, 194, 237, 10.1002/jcp.10208 Yamamoto, 2001, Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor, J Biol Chem, 276, 45031, 10.1074/jbc.M105245200 Michie, 2007, Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals, Int Immunol, 19, 1421, 10.1093/intimm/dxm113 Radtke, 1999, Deficient T cell fate specification in mice with an induced inactivation of Notch1, Immunity, 10, 547, 10.1016/S1074-7613(00)80054-0 Wolfer, 2002, Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta lineage thymocytes, Immunity, 16, 869, 10.1016/S1074-7613(02)00330-8 Radtke, 2004, Notch regulation of lymphocyte development and function, Nat Immunol, 5, 247, 10.1038/ni1045 Tanigaki, 2004, Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling, Immunity, 20, 611, 10.1016/S1074-7613(04)00109-8 Ciofani, 2004, Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation, J Immunol, 172, 5230, 10.4049/jimmunol.172.9.5230 Ciofani, 2005, Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism, Nat Immunol, 6, 881, 10.1038/ni1234 Maillard, 2006, The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor, J Exp Med, 203, 2239, 10.1084/jem.20061020 Doerfler, 2001, Presenilin-dependent gamma-secretase activity modulates thymocyte development, Proc Natl Acad Sci USA, 98, 9312, 10.1073/pnas.161102498 Garbe, 2006, Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate, J Exp Med, 203, 1579, 10.1084/jem.20060474 Reynaud-Deonauth, 2002, Notch signaling is involved in the regulation of Id3 gene transcription during Xenopus embryogenesis, Differentiation, 69, 198, 10.1046/j.1432-0436.2002.690413.x Ordentlich, 1998, Notch inhibition of E47 supports the existence of a novel signaling pathway, Mol Cell Biol, 18, 2230, 10.1128/MCB.18.4.2230 Nie, 2003, Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities, EMBO J, 22, 5780, 10.1093/emboj/cdg567 Deed, 1997, Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation, Mol Cell Biol, 17, 6815, 10.1128/MCB.17.12.6815 Yashiro-Ohtani, 2009, Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A, Genes Dev, 23, 1665, 10.1101/gad.1793709 Ikawa, 2006, E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment, J Exp Med, 203, 1329, 10.1084/jem.20060268 Lockhart, 2006, IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection, J Immunol, 177, 4662, 10.4049/jimmunol.177.7.4662 Roark, 2008, gammadelta T cells: an important source of IL-17, Curr Opin Immunol, 20, 353, 10.1016/j.coi.2008.03.006 Jensen, 2008, Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma, Immunity, 29, 90, 10.1016/j.immuni.2008.04.022 Serwold, 2007, Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes, J Immunol, 179, 928, 10.4049/jimmunol.179.2.928 Adams, 2008, An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells, Nat Immunol, 9, 777, 10.1038/ni.1620 Shin, 2005, Antigen recognition determinants of gammadelta T cell receptors, Science, 308, 252, 10.1126/science.1106480 Dent, 1990, Self-reactive gamma delta T cells are eliminated in the thymus, Nature, 343, 714, 10.1038/343714a0 Yoshimura, 1990, Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity, Nature, 348, 647, 10.1038/348647a0 Martin, 2009, Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals, Immunity, 31, 321, 10.1016/j.immuni.2009.06.020 Sutton, 2009, Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity, Immunity, 31, 331, 10.1016/j.immuni.2009.08.001