β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection

Barth, 1997, Cadherins, catenins, and APC protein: interplay between cytoskeletal complexes and signaling pathways, Curr Opin Cell Biol, 9, 683, 10.1016/S0955-0674(97)80122-6

Behrens, 1996, Functional interaction of β-catenin with the transcription factor LEF-1, Nature, 382, 638, 10.1038/382638a0

Rubinfeld, 1996, Binding of GSK3b to the APC-β-catenin complex and regulation of complex assembly, Science, 272, 1023, 10.1126/science.272.5264.1023

Munemitsu, 1995, Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein, Proc Natl Acad Sci USA, 92, 3046, 10.1073/pnas.92.7.3046

Aberle, 1997, β-Catenin is a target for the ubiquitin-proteasome pathway, EMBO J, 16, 3797, 10.1093/emboj/16.13.3797

Orford, 1997, Serine phosphorylation-regulated ubiquitination and degradation of β-catenin, J Biol Chem, 272, 24735, 10.1074/jbc.272.40.24735

Polakis, 1999, The oncogenic activation of β-catenin, Curr Opin Genet Dev, 9, 15, 10.1016/S0959-437X(99)80003-3

Kinzler, 1996, Lessons from hereditary colorectal cancer, Cell, 87, 159, 10.1016/S0092-8674(00)81333-1

Sparks, 1998, Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer, Cancer Res, 58, 1130

Buendia, 1992, Hepatitis B viruses and hepatocellular carcinoma, Adv Cancer Res, 59, 167, 10.1016/S0065-230X(08)60306-1

Ng, 1994, p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese, Oncogene, 9, 985

Caselmann, 1996, Hepatitis C virus infection as a major risk factor for hepatocellular carcinoma, J Hepatol, 24, 61

Idilman, 1998, Pathogenesis of hepatitis B and C-induced hepatocellular carcinoma, J Viral Hepatol, 5, 285, 10.1046/j.1365-2893.1998.00116.x

Montesano, 1997, Hepatocellular carcinoma: from gene to public health, J Natl Cancer Inst, 89, 1844, 10.1093/jnci/89.24.1844

Brechot, 1996, Hepatitis B, C viruses, and primary liver cancer, Baillieres Clin Gastroenterol, 10, 335, 10.1016/S0950-3528(96)90010-X

Bisceglie, 1997, Hepatitis C and hepatocellular carcinoma, Hepatology, 26, 34S, 10.1002/hep.510260706

Tabor, 1998, Viral hepatitis and liver cancer, 161

Wang, 1994, Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3, Proc Natl Acad Sci USA, 91, 2230, 10.1073/pnas.91.6.2230

Okuda, 1991, Hepatitis C virus and hepatocellular carcinoma, 119

Ray, 1996, Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype, J Virol, 70, 4438, 10.1128/JVI.70.7.4438-4443.1996

Ray, 1996, Suppression of apoptotic cell death by hepatitis C virus core protein, Virology, 226, 176, 10.1006/viro.1996.0644

Ray, 1997, Transcriptional repression of p53 promoter by hepatitis C virus core protein, J Biol Chem, 272, 10983, 10.1074/jbc.272.17.10983

Moriya, 1998, The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice, Nature Med, 4, 1065, 10.1038/2053

Nishida, 1994, Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma, Cancer Res, 54, 3107

Peng, 1993, Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance, J Formos Med Assoc, 92, 866

Kanai, 1997, The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas, Int J Cancer, 71, 355, 10.1002/(SICI)1097-0215(19970502)71:3<355::AID-IJC8>3.0.CO;2-X

Hirohashi, 1998, Inactivation of the E-cadherin-mediated cell adhesion system in human cancers, Am J Pathol, 153, 333, 10.1016/S0002-9440(10)65575-7

Miyoshi, 1998, Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3, Cancer Res, 58, 2524

De La Coste, 1998, Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas, Proc Natl Acad Sci USA, 95, 8847, 10.1073/pnas.95.15.8847

Ishak KG, Anthony PP, Sobin LH: Histological typing of tumors of the liver. International Histological Classification of Tumors. World Health Organization 1994. Berlin, Heidelberg, Springer-Verlag

Watanabe, 1996, Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas, Brain Pathol, 6, 217, 10.1111/j.1750-3639.1996.tb00848.x

Miyoshi, 1992, Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients, Proc Natl Acad Sci USA, 89, 4452, 10.1073/pnas.89.10.4452

Miyoshi, 1992, Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene, Hum Mol Genet, 1, 229, 10.1093/hmg/1.4.229

Miyaki, 1994, Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors, Cancer Res, 54, 3011

Iwao, 1998, Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations, Cancer Res, 58, 1021

Samowitz, 1999, β-Catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas, Cancer Res, 59, 1442

Fukuchi, 1998, β-Catenin mutation in carcinoma of the uterine endometrium, Cancer Res, 58, 3526

Palacios, 1998, Mutations in the β-catenin gene (CTNNB1) in endometrioid ovarian carcinomas, Cancer Res, 58, 1344

Zurawel, 1998, Sporadic medulloblastomas contain oncogenic β-catenin mutations, Cancer Res, 58, 896

Voeller, 1998, Beta-catenin mutations in human prostate cancer, Cancer Res, 58, 2520

Iwao, 1999, Frequent β-catenin abnormalities in bone and soft-tissue tumors, Jpn J Cancer Res, 90, 205, 10.1111/j.1349-7006.1999.tb00734.x

Chan, 1999, A common human skin tumour is caused by activating mutations in β-catenin, Nature Genet, 21, 410, 10.1038/7747

Garcia-Rostan, 1999, Frequent mutation and nuclear localization of β-catenin in anaplastic thyroid carcinoma, Cancer Res, 59, 1811

Koch, 1999, Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the β-catenin gene, Cancer Res, 59, 269

Anna, 1999, β-Catenin mutations in chemically induced mouse hepatocellular adenomas and carcinomas, Proc Am Assoc Cancer Res, 40, 505

Sheu, 1997, Molecular mechanism of hepatocarcinogenesis, J Gastroenterol Hepatol, 12, S309, 10.1111/j.1440-1746.1997.tb00514.x

Kawai, 1995, Clonality in hepatocellular carcinoma: analysis of methylation pattern of polymorphic X-chromosome-linked phosphoglycerate kinase gene in females, Hepatology, 22, 112

Aihara, 1994, Clonal analysis of regenerative nodules in hepatitis C virus-induced liver cirrhosis, Gastroenterology, 107, 1805, 10.1016/0016-5085(94)90824-9

Sheu, 1993, Multiple hepatocellular carcinomas at the early stage have different clonality, Gastroenterology, 105, 1471, 10.1016/0016-5085(93)90153-4

Blum, 1987, Hepatocellular carcinoma and hepatitis B virus infection: molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes, J Cancer Res Clin Oncol, 113, 466, 10.1007/BF00390041

Willert, 1998, β-Catenin: a key mediator of Wnt signaling, Curr Opin Genet Dev, 8, 95, 10.1016/S0959-437X(98)80068-3

Ding, 1991, Loss of constitutional heterozygosity on chromosome 5q in hepatocellular carcinoma without cirrhosis, Br J Cancer, 64, 1083, 10.1038/bjc.1991.468

Ding, 1993, The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes, Cancer Detect Prev, 17, 405

Fujimori, 1991, Allelotype study of primary hepatocellular carcinoma, Cancer Res, 51, 89

Horii, 1992, Frequent somatic mutations of the APC gene in human pancreatic cancer, Cancer Res, 52, 6696

Laken, 1997, Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC, Nature Genet, 17, 79, 10.1038/ng0997-79

Laurent-Puig, 1998, APC gene: database of germline and somatic mutations in human tumors and cell lines, Nucleic Acids Res, 26, 269, 10.1093/nar/26.1.269

White, 1998, Excess risk of colon cancer associated with a polymorphism of the APC gene?, Cancer Res, 58, 4038