ΔFosB: a molecular switch for long-term adaptation in the brain

Andersson, 1999, Striatal fosB expression is causally linked with l-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease, Neurobiol. Dis, 6, 461, 10.1006/nbdi.1999.0259

Andersson, 2001, cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum, J. Neurosci, 21, 9930, 10.1523/JNEUROSCI.21-24-09930.2001

Andersson, 2003, Time course of deltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment, Eur. J. Neurosci, 17, 661, 10.1046/j.1460-9568.2003.02469.x

Ang, 2001, Induction of NFκB in nucleus accumbens by chronic cocaine administration, J. Neurochem, 79, 221, 10.1046/j.1471-4159.2001.00563.x

Asanuma, 1998, Methamphetamine-induced increase in striatal NF-kappaB DNA-binding activity is attenuated in superoxide dismutase transgenic mice, Mol. Brain Res, 60, 305, 10.1016/S0169-328X(98)00188-0

Atkins, 1999, Region-specific induction of ΔFosB by repeated administration of typical versus atypical antipsychotic drugs, Synapse, 33, 118, 10.1002/(SICI)1098-2396(199908)33:2<118::AID-SYN2>3.0.CO;2-L

Barrot, 2002, CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli, Proc. Natl. Acad. Sci. U. S. A, 99, 11435, 10.1073/pnas.172091899

Berton, 2003, ΔFosB in the dorsal raphe mediates stress-induced transcriptional changes in substance P neurons, and modulates behavioral profiles in the learned helplessness model of depression, Abstr.-Soc. Neurosci, 29, 521.8

Bibb, 2001, Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5, Nature, 410, 376, 10.1038/35066591

Bing, 1997, Long-term expression of Fos-related antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum, J. Neurochem, 68, 272, 10.1046/j.1471-4159.1997.68010272.x

Brown, 1996, A defect in nurturing in mice lacking the immediate early gene fosB, Cell, 86, 297, 10.1016/S0092-8674(00)80101-4

Carle, 2003, Absence of conserved Fos family C-terminal domain in ΔFosB may contribute to its unique stability, Abstr.-Soc. Neurosci, 29, 856.12

Carlezon, 1998, Regulation of cocaine reward by CREB, Science, 282, 2272, 10.1126/science.282.5397.2272

Cenci, 2002, Transcription factors involved in the pathogenesis of l-DOPA-induced dyskinesia in a rat model of Parkinson's disease, Amino Acids, 23, 105, 10.1007/s00726-001-0116-4

Chen, 1995, Regulation of ΔFosB and FosB-like proteins by electroconvulsive seizure (ECS) and cocaine treatments, Mol. Pharmacol, 48, 880

Chen, 1997, Chronic FRAs: stable variants of ΔFosB induced in brain by chronic treatments, J. Neurosci, 17, 4933, 10.1523/JNEUROSCI.17-13-04933.1997

Chen, 1998, Transgenic animals with inducible, targeted gene expression in brain, Mol. Pharmacol, 54, 495, 10.1124/mol.54.3.495

Chen, 2000, Induction of cyclin-dependent kinase 5 in hippocampus by chronic electroconvulsive seizures: role of ΔFosB, J. Neurosci, 20, 8965, 10.1523/JNEUROSCI.20-24-08965.2000

Chen, 2003, Downregulation of the CCAAT-enhancer binding protein beta in deltaFosB transgenic mice and by electroconvulsive seizures, Neuropharmacology, 29, 23

Colby, 2003, ΔFosB enhances incentive for cocaine, J. Neurosci, 23, 2488, 10.1523/JNEUROSCI.23-06-02488.2003

Dobrazanski, 1991, Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts, Mol. Cell. Biol, 11, 5470, 10.1128/MCB.11.11.5470

Doucet, 1996, Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of striatal ΔFosB expression, Eur. J. Neurosci, 8, 365, 10.1111/j.1460-9568.1996.tb01220.x

Ehrlich, 2002, Periadolescent mice show enhanced deltaFosB upregulation in response to cocaine and amphetamine, J. Neurosci, 22, 9155, 10.1523/JNEUROSCI.22-21-09155.2002

Hiroi, 1996, Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum, J. Comp. Neurol, 374, 70, 10.1002/(SICI)1096-9861(19961007)374:1<70::AID-CNE5>3.0.CO;2-K

Hiroi, 1997, FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects, Proc. Natl. Acad. Sci. U. S. A, 94, 10397, 10.1073/pnas.94.19.10397

Hiroi, 1998, Essential role of the fosB gene in molecular, cellular, and behavioral actions of electroconvulsive seizures, J. Neurosci, 18, 6952, 10.1523/JNEUROSCI.18-17-06952.1998

Hiroi, 1999, Involvement of DARPP-32 in induction of ΔFosB variants and development of behavioral sensitization to cocaine, Eur. J. Neurosci, 11, 1114, 10.1046/j.1460-9568.1999.00570.x

Hope, 1992, Regulation of IEG expression and AP-1 binding by chronic cocaine in the rat nucleus accumbens, Proc. Natl. Acad. Sci. U. S. A, 89, 5764, 10.1073/pnas.89.13.5764

Hope, 1994, Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics, J. Neurosci, 14, 4318, 10.1523/JNEUROSCI.14-07-04318.1994

Hope, 1994, Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments, Neuron, 13, 1235, 10.1016/0896-6273(94)90061-2

Kelz, 2000, ΔFosB: a molecular switch underlying long-term neural plasticity, Curr. Opin. Neurol, 13, 715, 10.1097/00019052-200012000-00017

Kelz, 1999, Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine, Nature, 401, 272, 10.1038/45790

Mandelzys, 1997, Absence of a persistently elevated 37 kDa fos-related antigen and AP-1-like DNA-binding activity in the brains of kainic acid-treated fosB null mice, J. Neurosci, 17, 5407, 10.1523/JNEUROSCI.17-14-05407.1997

McClung, 2003, Regulation of gene expression and cocaine reward by CREB and ΔFosB, Nat. Neurosci, 6, 1208, 10.1038/nn1143

Moratalla, 1996, Network-level changes in expression of inducible Fos–Jun proteins in the striatum during chronic cocaine treatment and withdrawal, Neuron, 17, 147, 10.1016/S0896-6273(00)80288-3

Morgan, 1995, Immediate-early genes: ten years on, Trends Neurosci, 18, 66, 10.1016/0166-2236(95)93874-W

Nakabeppu, 19911, A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity, Cell, 64, 751, 10.1016/0092-8674(91)90504-R

Nestler, 2001, ΔFosB: a molecular switch for addiction, Proc. Natl. Acad. Sci. U. S. A, 98, 11042, 10.1073/pnas.191352698

Norrholm, 2003, Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of the neuronal kinase Cdk5, Neuroscience, 116, 19, 10.1016/S0306-4522(02)00560-2

Nye, 1996, Induction of chronic Fras (Fos-related antigens) in rat brain by chronic morphine administration, Mol. Pharmacol, 49, 636

Nye, 1995, Pharmacological studies of the regulation by cocaine of chronic Fra (Fos-related antigen) induction in the striatum and nucleus accumbens, J. Pharmacol. Exp. Ther, 275, 1671

Olausson, 2002, Enhanced incentive motivation for food in ΔFosB overexpressing mice, Abstr.-Soc. Neurosci, 28, 502.14

Peakman, 2003, Inducible, brain region specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine, Brain Res, 970, 73, 10.1016/S0006-8993(03)02230-3

Perez-Otano, 1998, MPTP-Parkinsonism is accompanied by persistent expression of a delta-FosB-like protein in dopaminergic pathways, Brain Res, 53, 41, 10.1016/S0169-328X(97)00269-6

Perrotti, 2003, Induction of ΔFosB in reward-related brain structures after chronic stress, Abstr.-Soc. Neurosci, 29, 112.15

Pich, 1997, Common neural substrates for the addictive properties of nicotine and cocaine, Science, 275, 83, 10.1126/science.275.5296.83

Robinson, 1997, Persistent structural modifications in nucleus accumbens and prefrontal neurons produced by previous experience with amphetamine, J. Neurosci, 17, 8491, 10.1523/JNEUROSCI.17-21-08491.1997

Schwartz, 2000, Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus, Neuroscience, 98, 535, 10.1016/S0306-4522(00)00140-8

Shaw, 2000, Regulation of neuropeptide expression by DfFosB in striatum, Abstr.-Soc. Neurosci, 26, 525

Tekumalla, 2001, Elevated levels of ΔFosB and RGS9 in striatum in Parkinson's disease, Biol. Psychiatry, 50, 813, 10.1016/S0006-3223(01)01234-3

Thomas, 2001, Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine, Nat. Neurosci, 4, 1217, 10.1038/nn757

Ulery, 2003, Role of phosphorylation of ΔFosB protein stability, Abstr.-Soc. Neurosci, 29, 777.3

Werme, 2002, ΔFosB regulates wheel running, J. Neurosci, 22, 8133, 10.1523/JNEUROSCI.22-18-08133.2002

White, 1995, Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system, J. Pharmacol. Exp. Ther, 273, 445

Yen, 1991, An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins, Proc. Natl. Acad. Sci. U. S. A, 88, 5077, 10.1073/pnas.88.12.5077

Zachariou, 2003, ΔFosB in the nucleus accumbens modulates morphine reward, tolerance, and dependence, Abstr.-Soc. Neurosci, 29, 112.16