α-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease

FEMS Yeast Research - Tập 6 Số 8 - Trang 1107-1116 - 2006
Stephan N. Witt1, Todd R. Flower1
1Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA

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Auluck PK & Bonini NM (2002) Pharmacological prevention of Parkinson disease in Drosophila. Nat Med 8: 1185–1186.

Auluck PK , Chan HY , Trojanowski JQ , Lee VM & Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295: 865–868.

Auluck PK , Meulener MC & Bonini NM (2005) Mechanisms of suppression of alpha-synuclein neurotoxicity by geldanamycin in Drosophila. J Biol Chem 280: 2873–2878.

Baba M , Nakajo S , Tu PH , Tomita T , Nakaya K , Lee VM , Trojanowski JQ & Iwatsubo T (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152: 879–884.

Beere HM , Wolf BB , Cain K , Mosser DD , Mahboubi A , Kuwana T , Tailor P , Morimoto RI , Cohen GM & Green DR . (2000) Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2: 469–475.

Betarbet R , Sherer TB & Greenamyre JT (2005) Ubiquitin-proteasome system and Parkinson's diseases. Exp Neurol 191: S17–S27.

Bito A , Haider M , Hadler I & Breitenbach M (1997) Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins. J Biol Chem 272: 21509–21519.

Caughey B & Lansbury PT (2003) Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 26: 267–298.

Conway KA , Rochet JC , Bieganski RM & Lansbury PT Jr (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294: 1346–1349.

Dawson TM & Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819–822.

Dedmon MM , Christodoulou J , Wilson MR & Dobson CM (2005) Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem 280: 14733–14740.

Ding TT , Lee SJ , Rochet JC & Lansbury PT Jr (2002) Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry 41: 10209–10217.

Dixon C , Mathias N , Zweig RM , Davis DA & Gross DS (2005) alpha-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast. Genetics 170: 47–59.

Elkon H , Don J , Melamed E , Ziv I , Shirvan A & Offen D (2002) Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome c oxidase. J Mol Neurosci 18: 229–238.

Fannjiang Y , Cheng WC , Lee SJ , Qi B , Pevsner J , McCaffery JM , Hill RB , Basanez G & Hardwick JM (2004) Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev 18: 2785–2797.

Flower TR , Chesnokova LS , Froelich CA , Dixon C & Witt SN (2005) Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J Mol Biol 351: 1081–1100.

Fujiwara H , Hasegawa M , Dohmae N , Kawashima A , Masliah E , Goldberg MS , Shen J , Takio K & Iwatsubo T (2002) Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4: 160–164.

Garrido C , Schmitt E , Cande C , Vahsen N , Parcellier A & Kroemer G (2003) HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle 2: 579–584.

Giasson BI , Duda JE , Murray IV , Chen Q , Souza JM , Hurtig HI , Ischiropoulos H , Trojanowski JQ & Lee VM (2000) Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290: 985–989.

Granot D , Levine A & Dor-Hefetz E (2003) Sugar-induced apoptosis in yeast cells. FEMS Yeast Res 4: 7–13.

Griffioen G , Duhamel H , Van Damme N , Pellens K , Zabrocki P , Pannecouque C , van Leuven F , Winderickx J & Wera S (2006) A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential. Biochim Biophys Acta 1762: 312–318.

Herker E , Jungwirth H , Lehmann KA , Maldener C , Frohlich KU , Wissing S , Buttner S , Fehr M , Sigrist S & Madeo F (2004) Chronological aging leads to apoptosis in yeast. J Cell Biol 164: 501–507.

Jenco JM , Rawlingson A , Daniels B & Morris AJ (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry 37: 4901–4909.

Kampranis SC , Damianova R , Atallah M , Toby G , Kondi G , Tsichlis PN & Makris AM (2000) A novel plant glutathione S-transferase/peroxidase suppresses Bax lethality in yeast. J Biol Chem 275: 29207–29216.

Kim S , Jeon BS , Heo C et al. (2004) Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson's disease. FASEB J 18: 1615–1617.

Kruger R , Kuhn W , Muller T , Woitalla D , Graeber M , Kosel S , Przuntek H , Epplen JT , Schols L & Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18: 106–108.

Langston JW , Ballard P , Tetrud JW & Irwin I (1983) Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219: 979–980.

Levine A , Belenghi B , Damari-Weisler H & Granot D (2001) Vesicle-associated membrane protein of Arabidopsis suppresses Bax-induced apoptosis in yeast downstream of oxidative burst. J Biol Chem 276: 46284–46289.

Li N , Ragheb K , Lawler G , Sturgis J , Rajwa B , Melendez JA & Robinson JP (2003) Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem 278: 8516–8525.

Lindersson E , Beedholm R , Hojrup P , Moos T , Gai W , Hendil KB & Jensen PH (2004) Proteasomal inhibition by alpha-synuclein filaments and oligomers. J Biol Chem 279: 12924–12934.

Liu CW , Giasson BI , Lewis KA , Lee VM , Demartino GN & Thomas PJ (2005) A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem 280: 22670–22678.

Lucking CB & Brice A (2000) Alpha-synuclein and Parkinson's disease. Cell Mol Life Sci 57: 1894–1908.

Ludovico P , Rodrigues F , Almeida A , Silva MT , Barrientos A & Côrte-Real M (2002) Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol Biol Cell 13: 2598–2606.

Madeo F , Fröhlich E , Ligr M , Grey M , Sigrist SJ , Wolf DH & Fröhlich KU (1999) Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol 145: 757–767.

Madeo F , Herker E , Maldener C et al. (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9: 911–917.

Madeo F , Herker E , Wissing S , Jungwirth H , Eisenberg T & Fröhlich KU (2004) Apoptosis in yeast. Curr Opin Microbiol 7: 655–660.

Maguire-Zeiss KA , Short DW & Federoff HJ (2005) Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res Mol Brain Res 134: 18–23.

Munch G , Luth HJ , Wong A , Arendt T , Hirsch E , Ravid R & Riederer P (2000) Crosslinking of alpha-synuclein by advanced glycation endproducts – an early pathophysiological step in Lewy body formation? J Chem Neuroanat 20: 253–257.

Narayanan V & Scarlata S (2001) Membrane binding and self-association of alpha-synucleins. Biochemistry 40: 9927–9934.

Outeiro TF & Lindquist S (2003) Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302: 1772–1775.

Polymeropoulos MH , Lavedan C , Leroy E et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045–2047.

Rampello L , Cerasa S , Alvano A , Butta V , Raffaele R , Vecchio I , Cavallaro T , Cimino E , Incognito T & Nicoletti F (2004) Dementia with Lewy bodies: a review. Arch Gerontol Geriatr 39: 1–14.

Rochet JC , Outeiro TF , Conway KA , Ding TT , Volles MJ , Lashuel HA , Bieganski RM , Lindquist SL & Lansbury PT (2004) Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. J Mol Neurosci 23: 23–34.

Saha AR , Ninkina NN , Hanger DP , Anderton BH , Davies AM & Buchman VL (2000) Induction of neuronal death by alpha-synuclein. Eur J Neurosci 12: 3073–3077.

Saleh A , Srinivasula SM , Balkir L , Robbins PD & Alnemri ES (2000) Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol 2: 476–483.

Schagger H (2002) Respiratory chain supercomplexes of mitochondria and bacteria. Biochim Biophys Acta 1555: 154–159.

Scherzer CR & Feany MB (2004) Yeast genetics targets lipids in Parkinson's disease. Trends Genet 20: 273–277.

Sherer TB , Betarbet R , Stout AK , Lund S , Baptista M , Panov AV , Cookson MR & Greenamyre JT (2002) An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 22: 7006–7015.

Sherer TB , Betarbet R , Testa CM , Seo BB , Richardson JR , Kim JH , Miller GW , Yagi T , Matsuno-Yagi A & Greenamyre JT (2003) Mechanism of toxicity in rotenone models of Parkinson's disease. J Neurosci 23: 10756–10764.

Slepenkov SV & Witt SN (2002) The unfolding story of the Escherichia coli Hsp70 DnaK: is DnaK a holdase or an unfoldase? Mol Microbiol 45: 1197–1206.

Smith WW , Jiang H , Pei Z , Tanaka Y , Morita H , Sawa A , Dawson VL , Dawson TM & Ross CA (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 14: 3801–3811.

Souza JM , Giasson BI , Chen Q , Lee VM & Ischiropoulos H (2000) Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J Biol Chem 275: 18344–18349.

Stefanova N , Klimaschewski L , Poewe W , Wenning GK & Reindl M (2001) Glial cell death induced by overexpression of alpha-synuclein. J Neurosci Res 65: 432–438.

Tanaka Y , Engelender S , Igarashi S , Rao RK , Wanner T , Tanzi RE , Sawa A , V LD , Dawson TM & Ross CA (2001) Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet 10: 919–926.

Turnbull S , Tabner BJ , El-Agnaf OM , Moore S , Davies Y & Allsop D (2001) alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro. Free Radical Biol Med 30: 1163–1170.

van Heusden GPH & Steensma HY (2006) Yeast 14-3-3 proteins. Yeast 23: 159–171.

Vila M , Vukosavic S , Jackson-Lewis V , Neystat M , Jakowec M & Przedborski S (2000) Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J Neurochem 74: 721–729.

Wenning GK & Jellinger KA (2005) The role of alpha-synuclein in the pathogenesis of multiple system atrophy. Acta Neuropathol (Berlin) 109: 129–140.

Wheeler GL & Grant CM (2004) Regulation of redox homeostasis in the yeast Saccharomyces cerevisiae. Physiol Plant 120: 12–20.

Willingham S , Outeiro TF , DeVit MJ , Lindquist SL & Muchowski PJ (2003) Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302: 1769–1772.

Wissing S , Ludovico P , Herker E et al. (2004) An AIF orthologue regulates apoptosis in yeast. J Cell Biol 166: 969–974.

Xu J , Kao SY , Lee FJ , Song W , Jin LW & Yankner BA (2002) Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med 8: 600–606.

Zhou Y , Gu G , Goodlett DR , Zhang T , Pan C , Montine TJ , Montine KS , Aebersold RH & Zhang J (2004) Analysis of alpha-synuclein-associated proteins by quantitative proteomics. J Biol Chem 279: 39155–39164.