Ácido tranexámico en cirugía cardíaca: ¿las dosis bajas son suficientes?

Williams, 2017, Practical use of thromboelastometry in the management of perioperative coagulopathy and bleeding, Transfus Med Rev., 31, 11, 10.1016/j.tmrv.2016.08.005 Raphael, 2019, Society of Cardiovascular Anesthesiologists clinical practice improvement advisory for management of perioperative bleeding and hemostasis in cardiac surgery patients [published correction appears in J Cardiothorac Vasc Anesth. 2020;34:840-841], J Cardiothorac Vasc Anesth, 33, 2887, 10.1053/j.jvca.2019.04.003 Ranucci, 2015, Hemostatic and thrombotic issues in cardiac surgery, Semin Thromb Hemost., 41, 84, 10.1055/s-0034-1398383 Maeda, 2018, Evaluating the effect on mortality of a no-tranexamic acid (TXA) policy for cardiovascular surgery, J Cardiothorac Vasc Anesth., 32, 1627, 10.1053/j.jvca.2017.10.018 Taam, 2020, Current evidence and future directions of tranexamic acid use efficacy, and dosing for major surgical procedures, J Cardiothorac Vasc Anesth., 34, 782, 10.1053/j.jvca.2019.06.042 Hessel, 2019, What's new in cardiopulmonary bypass, J Cardiothorac Vasc Anesth., 33, 2296, 10.1053/j.jvca.2019.01.039 Gerstein, 2017, Antifibrinolytic agents in cardiac and noncardiac surgery: A comprehensive overview and update, J Cardiothorac Vasc Anesth., 31, 2183, 10.1053/j.jvca.2017.02.029 Picetti, 2019, What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies, Blood Coagul Fibrinolysis., 30, 1, 10.1097/MBC.0000000000000789 Lecker, 2016, Tranexamic acid-associated seizures: Causes and treatment, Ann Neurol., 79, 18, 10.1002/ana.24558 Pagano, 2018, 2017 EACTS/EACTA guidelines on patient blood management for adult cardiac surgery, Eur J Cardiothorac Surg., 53, 79, 10.1093/ejcts/ezx325 Dowd, 2002, Pharmacokinetics of tranexamic acid during cardiopulmonary bypass, Anesthesiology., 97, 390, 10.1097/00000542-200208000-00016 Horrow, 1995, The dose-response relationship of tranexamic acid, Anesthesiology., 82, 383, 10.1097/00000542-199502000-00009 Görlinger, 2019, The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management, Korean J Anesthesiol., 72, 297, 10.4097/kja.19169 Dyke, 2014, Universal definition of perioperative bleeding in adult cardiac surgery, J Thorac Cardiovasc Surg., 147, 1458, 10.1016/j.jtcvs.2013.10.070 Fiechtner, 2001, Plasma tranexamic acid concentrations during cardiopulmonary bypass, Anesth Analg., 92, 1131, 10.1097/00000539-200105000-00010 Koster, 2015, Antifibrinolytic therapy for cardiac surgery: An update, Anesthesiology., 123, 21, 10.1097/ALN.0000000000000688 Myles, 2017, Tranexamic acid in patients undergoing coronary-artery surgery [published correction appears in N Engl J Med. 2018;378:782], N Engl J Med., 376, 136, 10.1056/NEJMoa1606424 Longstaff, 2018, Measuring fibrinolysis: From research to routine diagnostic assays, J Thromb Haemost., 16, 652, 10.1111/jth.13957 Levy, 2018, Antifibrinolytic therapy and perioperative considerations, Anesthesiology., 128, 657, 10.1097/ALN.0000000000001997 Faraoni, 2015, Experimental model of hyperfibrinolysis designed for rotational thromboelastometry in children with congenital heart disease, Blood Coagul Fibrinolysis., 26, 290, 10.1097/MBC.0000000000000238 Ng, 2015, Tranexamic acid: A clinical review, Anaesthesiol Intensive Ther., 47, 339, 10.5603/AIT.a2015.0011 Faraoni, 2014, Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: A randomised, controlled study, Eur J Anaesthesiol., 31, 491, 10.1097/EJA.0000000000000051 Ide, 2010, Lessons from the aprotinin saga: Current perspective on antifibrinolytic therapy in cardiac surgery, J Anesth., 24, 96, 10.1007/s00540-009-0866-9 Shi, 2020, Outcome impact of different tranexamic acid regimens in cardiac surgery with cardiopulmonary bypass (OPTIMAL): Rationale, design, and study protocol of a multicenter randomized controlled trial, Am Heart J., 222, 147, 10.1016/j.ahj.2019.09.010 Guo, 2019, Different dose regimes and administration methods of tranexamic acid in cardiac surgery: A meta-analysis of randomized trials, BMC Anesthesiol., 19, 129, 10.1186/s12871-019-0772-0 Besser, 2015, Haemostatic management of cardiac surgical haemorrhage, Anaesthesia., 70, 87, 10.1111/anae.12898 Paparella, 2004, Coagulation disorders of cardiopulmonary bypass: A review, Intensive Care Med., 30, 1873, 10.1007/s00134-004-2388-0 Zaky, 2017, Thromboelastometry versus rotational thromboelastography in cardiac surgery, Semin Cardiothorac Vasc Anesth., 21, 206, 10.1177/1089253217697146 Draxler, 2019, Tranexamic acid modulates the immune response and reduces postsurgical infection rates, Blood Adv., 3, 1598, 10.1182/bloodadvances.2019000092 Mou, 2018, Blood clot parameters: Prejudgment of fibrinolysis in thromboelastography, Clin Chim Acta., 479, 94, 10.1016/j.cca.2018.01.023